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Research Article Free access | 10.1172/JCI117337

Compensatory lung growth occurs in adult dogs after right pneumonectomy.

C C Hsia, L F Herazo, F Fryder-Doffey, and E R Weibel

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034.

Find articles by Hsia, C. in: PubMed | Google Scholar

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034.

Find articles by Herazo, L. in: PubMed | Google Scholar

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034.

Find articles by Fryder-Doffey, F. in: PubMed | Google Scholar

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034.

Find articles by Weibel, E. in: PubMed | Google Scholar

Published July 1, 1994 - More info

Published in Volume 94, Issue 1 on July 1, 1994
J Clin Invest. 1994;94(1):405–412. https://doi.org/10.1172/JCI117337.
© 1994 The American Society for Clinical Investigation
Published July 1, 1994 - Version history
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Abstract

We investigated the structural changes in the left lung of five adult male foxhounds 5 mo (n = 2) or 16 mo (n = 3) after right pneumonectomy (approximately 54% of lung resected) and five sex- and age-matched foxhounds 15-16 mo after right thoracotomy without pneumonectomy. Lungs were fixed by intratracheal instillation of glutaraldehyde and analyzed by standard morphometric techniques. After right pneumonectomy, volume of the left lung increased by 72%. Volumes of all septal structures increased significantly and were more pronounced at 5 than at 16 mo after pneumonectomy. At 16 mo, the relative increases in volume with respect to the control left lung were as follows: epithelium 73%, interstitium 100%, endothelium 55%, and capillary blood volume 43%. Surface areas of alveoli and capillary increased significantly by 52% and 34%, respectively. At 5 mo after pneumonectomy, harmonic mean thickness of the tissue-plasma barrier was significantly greater but at 16 mo it was not different from controls. There was a significant increase in diffusing capacity for oxygen (33% above controls) at 16 mo after pneumonectomy. These data suggest that, in contrast to previous findings after left pneumonectomy, compensatory lung growth does occur in adult dogs after resection of > 50% of lung.

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Referenced in 1 clinical guideline sources
37 readers on Mendeley
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