Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.
T C Wang, … , E V Schmidt, S J Brand
T C Wang, … , E V Schmidt, S J Brand
Published September 1, 1993
Citation Information: J Clin Invest. 1993;92(3):1349-1356. https://doi.org/10.1172/JCI116708.
View: Text | PDF
Research Article Article has an altmetric score of 9

Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.

  • Text
  • PDF
Abstract

Authors

T C Wang, S Bonner-Weir, P S Oates, M Chulak, B Simon, G T Merlino, E V Schmidt, S J Brand

×

Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1990 1988 1969 Total
Citations: 3 2 2 6 3 5 1 8 8 10 13 10 5 10 9 13 5 9 8 7 4 9 11 7 10 8 4 5 7 8 3 1 1 1 1 217
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (217)

Title and authors Publication Year
Long-Term Administration of Omeprazole-Induced Hypergastrinemia and Changed Glucose Homeostasis and Expression of Metabolism-Related Genes
Kabaliei A, Palchyk V, Izmailova O, Shynkevych V, Shlykova O, Kaidashev I
BioMed Research International 2024
Modeling human gastric cancers in immunocompetent mice
Zhang W, Wang S, Zhang H, Meng Y, Jiao S, An L, Zhou Z
Cancer biology & medicine 2024
IL-17 signaling protects against Helicobacter pylori-induced gastric cancer
Brackman LC, Jung MS, Green EH, Joshi N, Revetta FL, McClain MS, Markham NO, Piazuelo MB, Scott Algood HM
Gut Microbes 2024
Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity
Jeeyeon Cha, Xin Tong, Emily Walker, Tehila Dahan, Veronica Cochrane, Sudipta Ashe, Ronan Russell, Anna Osipovich, Alex Mawla, Min Guo, Jin-hua Liu, Mark Huising, Mark Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein
JCI Insight 2023
The intestine as an endocrine organ and the role of gut hormones in metabolic regulation.
Bany Bakar R, Reimann F, Gribble FM
Nature reviews. Gastroenterology & hepatology 2023
β cell regeneration and novel strategies for treatment of diabetes (Review)
Ji Z, Lu M, Xie H, Yuan H, Chen Q
Biomedical Reports 2022
Preclinical Models of Neuroendocrine Neoplasia
Sedlack AJ, Saleh-Anaraki K, Kumar S, Ear PH, Lines KE, Roper N, Pacak K, Bergsland E, Quelle DE, Howe JR, Pommier Y, del Rivero J
Cancers 2022
Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes
MA Miranda, JF Macias-Velasco, HA Lawson
American journal of physiology. Endocrinology and metabolism 2021
Stem/progenitor cells in normal physiology and disease of the pancreas
ME Fallas, S Pedraza-Arevalo, AM Cujba, T Manea, C Lambert, R Morrugares, R Sancho
Molecular and Cellular Endocrinology 2021
Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challenges
W Wang, C Zhang
Endocrine Connections 2021
Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass
E Spears, I Serafimidis, AC Powers, A Gavalas
Frontiers in Endocrinology 2021
Islet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus
E Westholm, A Wendt, L Eliasson
Clinical Medicine Insights. Endocrinology and Diabetes 2021
Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes.
Gaudreau MC, Gudi RR, Li G, Johnson BM, Vasu C
Autoimmunity 2021
Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway
R Khatri, S Mazurek, SF Petry, T Linn
Stem Cell Research & Therapy 2020
The De-, Re-, and trans-differentiation of β-cells: Regulation and function
J Zhang, F Liu
Seminars in Cell & Developmental Biology 2020
The entero-insular axis: a journey in the physiopathology of diabetes
R Malaguarnera, A Scamporrino, A Filippello, SD Mauro, A Minardo, F Purrello, S Piro
2020
Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro
A Lenz, G Lenz, HT Ku, K Ferreri, F Kandeel, N Irwin
PloS one 2019
High expression of acidic chitinase and chitin digestibility in the stomach of common marmoset (Callithrix jacchus), an insectivorous nonhuman primate
E Tabata, A Kashimura, M Uehara, S Wakita, M Sakaguchi, Y Sugahara, T Yurimoto, E Sasaki, V Matoska, PO Bauer, F Oyama
Scientific Reports 2019
Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence
KS Cheung, WK Leung
Therapeutic advances in gastroenterology 2019
Premises for Cholecystokinin and Gastrin Peptides in Diabetes Therapy
JF Rehfeld
Clinical Medicine Insights. Endocrinology and Diabetes 2019
Gastrin analogue administration adds no significant glycaemic benefit to a glucagon‐like peptide‐1 receptor agonist acutely or after washout of both analogues
K Bokvist, Y Ding, WH Landschulz, V Sinha, A Pastrak, RM Belin
Diabetes, obesity & metabolism 2019
Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway
N Gunawardhana, S Jang, YH Choi, YA Hong, YE Jeon, A Kim, H Su, JH Kim, YJ Yoo, DS Merrell, J Kim, JH Cha
Frontiers in Cellular and Infection Microbiology 2018
Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes
C Aguayo-Mazzucato, S Bonner-Weir
Cell Metabolism 2017
Regenerative medicine and cell-based approaches to restore pancreatic function
C Ellis, A Ramzy, TJ Kieffer
Nature Reviews Gastroenterology & Hepatology 2017
Salivary Gland Development and Regeneration
S Cha
Salivary Gland Development and Regeneration 2017
Chitosan-assisted differentiation of porcine adipose tissue-derived stem cells into glucose-responsive insulin-secreting clusters
HY Liu, CC Chen, YY Lin, YJ Chen, BH Liu, SC Wong, CY Wu, YT Chang, HY Chou, ST Ding, I Kerkis
PloS one 2017
No Association of Proton Pump Inhibitor Use with Fasting or Postload Glycaemia in Patients with Cardiovascular Disease: A Cross-Sectional Retrospective Study
O Kruszelnicka, M Kuźma, IZ Pena, IB Perera, B Chyrchel, E Wieczorek-Surdacka, A Surdacki
International journal of medical sciences 2017
Pepsinogen C expression, regulation and its relationship with cancer
S Shen, J Jiang, Y Yuan
Cancer Cell International 2017
Phenotypic plasticity in the pancreas: new triggers, new players
TI Demcollari, AM Cujba, R Sancho
Current Opinion in Cell Biology 2017
Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice
LM Lemos, F Miyajima, GR Castilho, DT Martins, DM Pritchard, MD Burkitt
Frontiers in pharmacology 2017
Pancreatic regulation of glucose homeostasis
PV Röder, B Wu, Y Liu, W Han
Experimental & molecular medicine 2016
Histone chaperone ASF1B promotes human β -cell proliferation via recruitment of histone H3.3
PK Paul, ME Rabaglia, CY Wang, DS Stapleton, N Leng, C Kendziorski, PW Lewis, MP Keller, AD Attie
Cell cycle (Georgetown, Tex.) 2016
Stem cells versus plasticity in liver and pancreas regeneration
JL Kopp, M Grompe, M Sander
Nature Cell Biology 2016
Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes
T Dahan, O Ziv, E Horwitz, H Zemmour, J Lavi, A Swisa, G Leibowitz, FM Ashcroft, PI Veld, B Glaser, Y Dor
Diabetes 2016
Regenerative Medicine - from Protocol to Patient
LC Zelarayán, MP Zafiriou, WH Zimmermann
Regenerative Medicine - from Protocol to Patient 2016
Gastrin and upper GI cancers
Y Hayakawa, W Chang, G Jin, TC Wang
Current Opinion in Pharmacology 2016
Acidic mammalian chitinase is a proteases-resistant glycosidase in mouse digestive system
M Ohno, M Kimura, H Miyazaki, K Okawa, R Onuki, C Nemoto, E Tabata, S Wakita, A Kashimura, M Sakaguchi, Y Sugahara, N Nukina, PO Bauer, F Oyama
Scientific Reports 2016
Histone chaperone ASF1B promotes human β -cell proliferation via recruitment of histone H3.3
PK Paul, ME Rabaglia, CY Wang, DS Stapleton, N Leng, C Kendziorski, PW Lewis, MP Keller, AD Attie
Cell cycle (Georgetown, Tex.) 2016
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes
S Xue, A Posgai, C Wasserfall, C Myhr, M Campbell-Thompson, CE Mathews, T Brusko, A Rabinovitch, A Savinov, M Battaglia, D Schatz, M Haller, MA Atkinson
Diabetes 2015
Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists
B Finan, C Clemmensen, TD Müller
Molecular and Cellular Endocrinology 2015
Transgenic and gene knockout mice in gastric cancer research
Y Jiang, Y Yu
Oncotarget 2015
Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice
S Sasaki, T Miyatsuka, T Matsuoka, M Takahara, Y Yamamoto, T Yasuda, H Kaneto, Y Fujitani, MS German, H Akiyama, H Watada, I Shimomura
Diabetologia 2015
Expression of cholecystokinin2-receptor in rat and human L cells and the stimulation of glucagon-like peptide-1 secretion by gastrin treatment
Y Cao, X Cao, XM Liu
Acta Histochemica 2015
In vitro evaluation of different protocols for the induction of mesenchymal stem cells to insulin-producing cells
F Seyedi, A Farsinejad, M Moshrefi, SN Nematollahi-Mahani
In vitro cellular & developmental biology. Animal 2015
Effect of proton pump inhibitors on glycemic control in patients with diabetes
K Takebayashi
World journal of diabetes 2015
The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition
JF Pierre, JC Neuman, AL Brill, HK Brar, MF Thompson, MT Cadena, KM Connors, RA Busch, AF Heneghan, CM Cham, EK Jones, CR Kibbe, DB Davis, GE Groblewski, KA Kudsk, ME Kimple
AJP Gastrointestinal and Liver Physiology 2015
Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line
M Lizio, Y Ishizu, M Itoh, T Lassmann, A Hasegawa, A Kubosaki, J Severin, H Kawaji, Y Nakamura, H Suzuki, Y Hayashizaki, P Carninci, AR Forrest
Frontiers in Genetics 2015
FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation
M Li, P Page-McCaw, W Chen
Diabetes 2015
Mouse models of gastric carcinogenesis
S Yu, M Yang, KT Nam
Journal of Gastric Cancer 2014
CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis
Y Hayakawa, G Jin, H Wang, X Chen, CB Westphalen, S Asfaha, BW Renz, H Ariyama, ZA Dubeykovskaya, Y Takemoto, Y Lee, A Muley, Y Tailor, D Chen, S Muthupalani, JG Fox, A Shulkes, DL Worthley, S Takaishi, TC Wang
Gut 2014
Novel roles of gastrin: Novel roles of gastrin
R Dimaline, A Varro
The Journal of Physiology 2014
Macrophage/epithelium cross-talk regulates cell cycle progression and migration in pancreatic progenitors
K Mussar, A Tucker, L McLennan, A Gearhart, AJ Jimenez-Caliani, V Cirulli, L Crisa
PloS one 2014
Lansoprazole enhances the antidiabetic effect of sitagliptin in mice with diet-induced obesity and healthy human subjects: Coadministration of lansoprazole and sitagliptin
SJ Hao, JH Sun, XK Tian, X Sun, ZX Zhang, Y Gao
Journal of Pharmacy and Pharmacology 2014
A network map of the gastrin signaling pathway
Y Subbannayya, K Anuja, J Advani, UK Ojha, V Nanjappa, B George, A Sonawane, RV Kumar, G Ramaswamy, A Pandey, BL Somani, R Raju
Journal of Cell Communication and Signaling 2014
Should we still be concerned about the potential side effects of glucagon-like peptide-1 receptor agonists on thyroid C cells?
Y Cao, XM Liu
Endocrine 2014
Hes3 Is Expressed in the Adult Pancreatic Islet and Regulates Gene Expression, Cell Growth, and Insulin Release
J Masjkur, C Arps-Forker, SW Poser, P Nikolakopoulou, L Toutouna, R Chenna, T Chavakis, A Chatzigeorgiou, LS Chen, A Dubrovska, P Choudhary, I Uphues, M Mark, SR Bornstein, A Androutsellis-Theotokis
The Journal of biological chemistry 2014
Emerging Roles of Dipeptidyl Peptidase 4 Inhibitors: Anti-Inflammatory and Immunomodulatory Effect and Its Application in Diabetes Mellitus
L Yang, J Yuan, Z Zhou
Canadian Journal of Diabetes 2014
Macrophage/Epithelium Cross-Talk Regulates Cell Cycle Progression and Migration in Pancreatic Progenitors
K Mussar, A Tucker, L McLennan, A Gearhart, AJ Jimenez-Caliani, V Cirulli, L Crisa, K Maedler
PloS one 2014
Gastrin induces ductal cell dedifferentiation and  -cell neogenesis after 90% pancreatectomy
N Tellez, E Montanya
Journal of Endocrinology 2014
Islets of Langerhans, 2. ed
MS Islam
Islets of Langerhans, 2. ed. 2014
Islets of Langerhans
S Islam
2014
TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice
F Wu, L Guo, A Jakubowski, L Su, WC Li, S Bonner-Weir, LC Burkly
PloS one 2013
Mouse Models of Gastric Cancer
Y Hayakawa, J Fox, T Gonda, D Worthley, S Muthupalani, T Wang
Cancers 2013
PDX1 in Ducts Is Not Required for Postnatal Formation of  -Cells but Is Necessary for Their Subsequent Maturation
L Guo, A Inada, C Aguayo-Mazzucato, J Hollister-Lock, Y Fujitani, GC Weir, CV Wright, A Sharma, S Bonner-Weir
Diabetes 2013
Emerging combinatorial hormone therapies for the treatment of obesity and T2DM
SA Sadry, DJ Drucker
Nature Reviews Endocrinology 2013
Dietary Factors Modulate Helicobacter-associated Gastric Cancer in Rodent Models
JG Fox, TC Wang
Toxicologic pathology 2013
Omeprazole improves the anti-obesity and antidiabetic effects of exendin-4 in db/db mice (奥美拉唑改善唾液素-4 对 db/db 小鼠的减肥与降糖作用)*: Omeprazole improves exendin-4 activity
V Patel, A Joharapurkar, T Gandhi, K Patel, N Dhanesha, S Kshirsagar, V Dhote, J Detroja, R Bahekar, M Jain
Journal of Diabetes 2013
Survival in hostile territory: the microbiota of the stomach
I Yang, S Nell, S Suerbaum
FEMS Microbiology Reviews 2013
Proposal for generating new beta cells in a muted immune environment for type 1 diabetes: Generating Immune Protected Beta Cells
C Levetan, P Pozzilli, L Jovanovic, D Schatz
Diabetes/Metabolism Research and Reviews 2013
Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice
V Patel, A Joharapurkar, N Dhanesha, S Kshirsagar, J Detroja, K Patel, T Gandhi, K Patel, R Bahekar, M Jain
Pharmacological Reports 2013
Gastrin: A Distinct Fate of Neurogenin3 Positive Progenitor Cells in the Embryonic Pancreas
Y Suissa, J Magenheim, M Stolovich-Rain, A Hija, P Collombat, A Mansouri, L Sussel, B Sosa-Pineda, K McCracken, JM Wells, RS Heller, Y Dor, B Glaser, FC Lynn
PloS one 2013
Regenerative Medicine
S Ricco, L Boone, JF Peroni
Equine Surgery 2012
Proton pump inhibitors: impact on glucose metabolism
D Boj-Carceller
Endocrine 2012
Signaling pathways regulating murine pancreatic development
P Serup
Seminars in Cell & Developmental Biology 2012
Islet neogenesis: a possible pathway for beta-cell replenishment
S Bonner-Weir, L Guo, WC Li, L Ouziel-Yahalom, PA Lysy, GC Weir, A Sharma
The review of diabetic studies : RDS 2012
Regenerative Medicine and Cell Therapy
H Baharvand, N Aghdami
2012
Distinct human progenitor subtypes promote islet regeneration via activation of endogenous angiogenic or neogenic programs
Gillian Bell, Heather Broughton, Krysta Levac, Debra Robson, David Allan, Anargyros Xenocostas, David Hess
2011
β-Cell regeneration: the pancreatic intrinsic faculty
R Desgraz, C Bonal, PL Herrera
Trends in Endocrinology & Metabolism 2011
Incretin physiology beyond glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides
JF Rehfeld
Acta Physiologica 2011
Gastrin in Gastrointestinal Diseases
D Fourmy, V Gigoux, JC Reubi
Gastroenterology 2011
Extrinsic factors involved in the differentiation of stem cells into insulin-producing cells: an overview
RS Wong
Experimental Diabetes Research 2011
Murine models of H. pylori-induced gastritis and gastric adenocarcinoma
S Krueger, A Roessner, D Kuester
Pathology - Research and Practice 2011
Epidermal growth factor induces adult human islet cell dedifferentiation
SC Hanley, B Assouline-Thomas, J Makhlin, L Rosenberg
Journal of Endocrinology 2011
Fetal and Neonatal Physiology
LH Johnson, VK Bhutani
Fetal and Neonatal Physiology 2011
Combination Therapy with a Dipeptidyl Peptidase-4 Inhibitor and a Proton Pump Inhibitor Induces β-Cell Neogenesis from Adult Human Pancreatic Duct Cells Implanted in Immunodeficient Mice
WL Suarez-Pinzon, A Rabinovitch
Cell Transplantation 2011
Gastrin Treatment Stimulates β-Cell Regeneration and Improves Glucose Tolerance in 95% Pancreatectomized Rats
N Téllez, G Joanny, J Escoriza, M Vilaseca, E Montanya
Endocrinology 2011
Combination treatment of db/db mice with exendin‐4 and gastrin preserves β‐cell mass by stimulating β‐cell growth and differentiation
M Tamaki, Y Fujitani, T Uchida, T Hirose, R Kawamori, H Watada
Journal of Diabetes Investigation 2010
The quest for tissue stem cells in the pancreas and other organs, and their application in beta-cell replacement
I Houbracken, L Bouwens
The review of diabetic studies : RDS 2010
 -Cell Growth and Regeneration: Replication Is Only Part of the Story
S Bonner-Weir, WC Li, L Ouziel-Yahalom, L Guo, GC Weir, A Sharma
Diabetes 2010
Lack of commensal flora in H. pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia
JL Lofgren, MT Whary, Z Ge, S Muthupalani, NS Taylor, M Mobley, A Potter, A Varro, D Eibach, S Suerbaum, TC Wang, JG Fox
Gastroenterology 2010
Gastrointestinal hormones and the regulation of β-cell mass
JA Lavine, AD Attie
Annals of the New York Academy of Sciences 2010
Gastrin
C Seva, A FERRAND
AfCS-Nature Molecule Pages 2010
Different effects of islet transplantation and Detemir treatment on the reversal of streptozotocin-induced diabetes associated with β-cell regeneration
A Inada, O Inada, H Fujii, T Akashi, K Sueishi, A Fukatsu, S Nagafuchi
Diabetology International 2010
Progastriscin: Structure, Function, and Its Role in Tumor Progression
MI Hassan, A Toor, F Ahmad
Journal of Molecular Cell Biology 2010
New Formation of β Cells
A Inada
Journal of The Society of Japanese Women Scientists 2010
Slow and steady is the key to β-cell replication
K Brennand, D Melton
Journal of Cellular and Molecular Medicine 2009
Developmental pathways during in vitro progression of human islet neogenesis
R Dodge, C Loomans, A Sharma, S Bonner-Weir
Differentiation 2009
Importance of gastrin in the pathogenesis and treatment of gastric tumors
MD Burkitt, A Varro, DM Pritchard
World journal of gastroenterology : WJG 2009
Pancreatic β-Cell Mass as a Pharmacologic Target in Diabetes
S Hanley
McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students 2009
Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse
R Kikugawa, H Katsuta, T Akashi, S Yatoh, GC Weir, A Sharma, S Bonner-Weir
Diabetologia 2009
Bioactive peptides, networks and systems biology
K Boonen, JW Creemers, L Schoofs
BioEssays 2009
Adult human beta-cell neogenesis?
C Demeterco, E Hao, SH Lee, P Itkin-Ansari, F Levine
Diabetes, Obesity and Metabolism 2009
Effect of antrectomy in hypergastrinaemic female Japanese cotton rats
K Bakkelund, R Fossmark, IS Nordrum, HL Waldum
Scandinavian Journal of Gastroenterology 2009
Importance of gastrin in the pathogenesis and treatment of gastric tumors
MD Burkitt, A Varro, DM Pritchard
World journal of gastroenterology : WJG 2009
The Biology of Gastric Cancers
TC Wang, JG Fox, AS Giraud
2009
Stem Cell Therapy for Diabetes
S Efrat
2009
Endocrine Pathology:
RV Lloyd
2009
Prospects for therapy aimed at restoring the beta-cell pool in patients with diabetes mellitus (review of the literature)
VA Peterkova, DN Laptev
Diabetes mellitus 2009
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
A Inada, C Nienaber, H Katsuta, Y Fujitani, J Levine, R Morita, A Sharma, S Bonner-Weir
Proceedings of the National Academy of Sciences 2008
The Reg Family Member INGAP Is a Marker of Endocrine Patterning in the Embryonic Pancreas
NS Hamblet, W Shi, AI Vinik, DA Taylor-Fishwick
Pancreas 2008
Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice
WL Suarez-Pinzon, RF Power, Y Yan, C Wasserfall, M Atkinson, A Rabinovitch
Diabetes 2008
Combination Therapy with Glucagon-Like Peptide-1 and Gastrin Induces β-Cell Neogenesis from Pancreatic Duct Cells in Human Islets Transplanted in Immunodeficient Diabetic Mice
WL Suarez-Pinzon, JR Lakey, A Rabinovitch
Cell Transplantation 2008
9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic β Cell Protection and Replication
H Stukenbrock, R Mussmann, M Geese, Y Ferandin, O Lozach, T Lemcke, S Kegel, A Lomow, U Burk, C Dohrmann, L Meijer, M Austen, C Kunick
Journal of Medicinal Chemistry 2008
Protein Kinase C-  Activation Markedly Enhances  -Cell Proliferation: An Essential Role in Growth Factor Mediated  -Cell Mitogenesis
RC Vasavada, L Wang, Y Fujinaka, KK Takane, TC Rosa, JM Mellado-Gil, PA Friedman, A Garcia-Ocana
Diabetes 2007
The role of Islet Neogenesis-Associated Protein (INGAP) in islet neogenesis
M Lipsett, S Hanley, M Castellarin, E Austin, WL Suarez-Pinzon, A Rabinovitch, L Rosenberg
Cell Biochemistry and Biophysics 2007
Acinar Plasticity
MA Lipsett, ML Castellarin, L Rosenberg
Pancreas 2007
Prospects and challenges for islet regeneration as a treatment for diabetes: a review of islet neogenesis associated protein
A Fleming, L Rosenberg
Journal of diabetes science and technology 2007
Lessons from the gastrin knockout mice
L Friis-Hansen
Regulatory Peptides 2007
Copper deprivation in rats induces islet hyperplasia and hepatic metaplasia in the pancreas
D Tosh, CN Shen, MR Alison, CE Sarraf, JM Slack
Biology of the Cell 2007
Differentiation of Affinity-Purified Human Pancreatic Duct Cells to  -Cells
S Yatoh, R Dodge, T Akashi, A Omer, A Sharma, GC Weir, S Bonner-Weir
Diabetes 2007
Immunoelectron Study of Pancreatic Carcinomas Using Antibodies to Gastrointestinal Hormones
EC Seretis, AN Gavriil, VC Golematis, IE Voloudakis-Baltatzis
Ultrastructural Pathology 2007
Inducible cAMP early repressor suppresses gastrin-mediated activation of cyclin D1 and c- fos gene expression
TS Steigedal, T Bruland, K Misund, L Thommesen, A Lægreid
AJP Gastrointestinal and Liver Physiology 2007
Pancreatic Cancer
J Kleeff, C Michalski, H Friess, MW B??chler
Pancreas 2006
Generation of Human Islets Through Expansion and Differentiation of Non-islet Pancreatic Cells Discarded (Pancreatic Discard) After Islet Isolation
I Todorov, K Omori, M Pascual, J Rawson, I Nair, L Valiente, T Vuong, T Matsuda, C Orr, K Ferreri, CV Smith, F Kandeel, Y Mullen
Pancreas 2006
Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model
TH El-Metwally, MR Hussein, SK Abd-El-Ghaffar, MM Abo-El-Naga, AB Ulrich, PM Pour
Journal of clinical pathology 2006
Therapeutic Approaches to Preserve Islet Mass in Type 2 Diabetes
LL Baggio, DJ Drucker
Annual Review of Medicine 2006
Generation of Human Islets Through Expansion and Differentiation of Non-islet Pancreatic Cells Discarded (Pancreatic Discard) After Islet Isolation:
I Todorov, K Omori, M Pascual, J Rawson, I Nair, L Valiente, T Vuong, T Matsuda, C Orr, K Ferreri, CV Smith, F Kandeel, Y Mullen
Pancreas 2006
Histomorphology and ultrastructure of pancreatic islet tissue during in vivo maturation of rat pancreas
CP de Carvalho, JC Martins, DA da Cunha, AC Boschero, CB Collares-Buzato
Annals of Anatomy - Anatomischer Anzeiger 2006
A Distinctive Set of Genes Is Upregulated During the Inflammation-Carcinoma Sequence in Mouse Stomach Infected by Helicobacter felis
M Kobayashi, H Lee, L Schaffer, TJ Gilmartin, SR Head, S Takaishi, TC Wang, J Nakayama, M Fukuda
Journal of Histochemistry & Cytochemistry 2006
Stem Cell and Gene-Based Therapy
A Battler, J Leor
2006
Regulation of pancreatic beta-cell mass
L Bouwens, I Rooman
Physiological reviews 2005
Synergistic Inhibitory Effects of Gastrin and Histamine Receptor Antagonists on Helicobacter-Induced Gastric Cancer
S Takaishi, G Cui, DM Frederick, JE Carlson, JM Houghton, A Varro, GJ Dockray, Z Ge, MT Whary, AB Rogers, JG Fox, TC Wang
Gastroenterology 2005
Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression
SL Cowey, M Quast, LM Belalcazar, J Wei, X Deng, R Given, P Singh
Cancer 2005
Development of Islet-Like Cell Clusters After Pancreas Transplantation in the Spontaneously Diabetic Torri Rat
G Miao, T Ito, F Uchikoshi, M Tanemura, K Kawamoto, K Shimada, M Nozawa, H Matsuda
American Journal of Transplantation 2005
Stem cells in the treatment of diabetes
T Otonkoski, R Gao, K Lundin
Annals of Medicine 2005
Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?
E Bertelli, M Bendayan
Journal of Histochemistry & Cytochemistry 2005
Combination Therapy with Epidermal Growth Factor and Gastrin Induces Neogenesis of Human Islet β-Cells from Pancreatic Duct Cells and an Increase in Functional β-Cell Mass
WL Suarez-Pinzon, JR Lakey, SJ Brand, A Rabinovitch
The Journal of clinical endocrinology and metabolism 2005
The pancreatic ductal epithelium serves as a potential pool of progenitor cells
S Bonner-Weir, E Toschi, A Inada, P Reitz, SY Fonseca, T Aye, A Sharma
Pediatric Diabetes 2004
Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency
Y Chen, MM Chong, R Darwiche, HE Thomas, TW Kay
The American Journal of Pathology 2004
Role of small GTP binding proteins in the growth-promoting and antiapoptotic actions of gastrin
V Stepan
AJP Gastrointestinal and Liver Physiology 2004
Cocaine- and Amphetamine-regulated Transcript (CART) Is Expressed in Several Islet Cell Types During Rat Development
N Wierup, M Kuhar, BO Nilsson, H Mulder, E Ekblad, F Sundler
Journal of Histochemistry & Cytochemistry 2004
Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan
I Rooman, L Bouwens
Diabetologia 2003
Analysis of Expression Profiles of Islet-associated Transcription and Growth Factors During β-Cell Neogenesis from Duct Cells in Partially Duct-ligated Mice
M Li, J Miyagawa, M Moriwaki, M Yuan, Q Yang, J Kozawa, K Yamamoto, A Imagawa, H Iwahashi, Y Tochino, K Yamagata, Y Matsuzawa
Pancreas 2003
Neurogenin3 triggers beta-cell differentiation of retinoic acid-derived endoderm cells
A Vetere, E Marsich, MD Piazza, R Koncan, F Micali, S Paoletti
Biochemical Journal 2003
Transcriptional regulation of the human trefoil factor, TFF1, by gastrin1 1The authors thank Dr. Kazunari Yokoyama for providing the MAZ antibody, Dr. Marie-Christine Rio for the TFF1 antibody, Professor Sue Watson for the gastrin/CCKBR antibody, Professor Andrea Varro for the AGS-GR cells, and Dr. D. K. Podolsky for the TFF3 construct as well as Ian McEvoy for skilled technical assistance
ZE Khan, TC Wang, G Cui, AL Chi, R Dimaline
Gastroenterology 2003
Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene1 1The authors thank Emmy De Blay and Luc Bouwens for generous assistance with islet immunohistochemistry
RP Boushey, A Abadir, D Flamez, LL Baggio, Y Li, V Berger, BA Marshall, D Finegood, TC Wang, F Schuit, DJ Drucker
Gastroenterology 2003
Retinoic acid increases the length and volume density of ducts in the rat embryonic pancreas
C Erasmus, C Penny, B Kramer
Development, Growth and Differentiation 2003
Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to β-cells in streptozotocin-treated mice
L Li, M Seno, H Yamada, I Kojima
American journal of physiology. Endocrinology and metabolism 2003
Modulation of Specific Beta Cell Gene (Re)Expression during In Vitro Expansion of Human Pancreatic Islet Cells
T Bouckenooghe, B Vandewalle, B Lukowiak, J Kerr-Conte, S Beläich, V Gmyr, M Dubois, R Riachy, F Pattou
Cell Transplantation 2003
The analysis of immunophenotype of gastrin-producing tumors of the pancreas and gastrointestinal tract
L Gurevich, I Kazantseva, VA Isakov, N Korsakova, A Egorov, V Kubishkin, G Bulgakov
Cancer 2003
Pancreatic stem cells
S Bonner-Weir, A Sharma
The Journal of Pathology 2002
Alternatives to unmodified human islets for transplantation
A Hayek, GM Beattie
Current Diabetes Reports 2002
Pharmacological Treatment of Chronic Diabetes by Stimulating Pancreatic beta-Cell Regeneration with Systemic Co-administration of EGF and Gastrin
SJ Brand, S Tagerud, P Lambert, SG Magil, K Tatarkiewicz, K Doiron, Y Yan
Pharmacology and Toxicology 2002
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
N Wierup, H Svensson, H Mulder, F Sundler
Regulatory Peptides 2002
Expression of CCK2 receptors in the murine pancreas: Proliferation, transdifferentiation of acinar cells, and neoplasia
P Clerc, S Leung–Theung–Long, TC Wang, GJ Dockray, M Bouisson, MB Delisle, N Vaysse, L Pradayrol, D Fourmy, M Dufresne
Gastroenterology 2002
Hepatocyte Nuclear Factor-1  Modulates Pancreatic  -Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells
Q Yang, K Yamagata, K Fukui, Y Cao, T Nammo, H Iwahashi, H Wang, I Matsumura, T Hanafusa, R Bucala, CB Wollheim, J Miyagawa, Y Matsuzawa
Diabetes 2002
Gastrin Stimulates  -Cell Neogenesis and Increases Islet Mass From Transdifferentiated but Not From Normal Exocrine Pancreas Tissue
I Rooman, J Lardon, L Bouwens
Diabetes 2002
Prospects for the Prevention and Reversal of Type 1 Diabetes Mellitus:
N Petrovsky, D Silva, DA Schatz
Drugs 2002
Functional Maturation of Fetal Porcine β-Cells by Glucagon-Like Peptide 1 and Cholecystokinin
AA Hardikar, XY Wang, LJ Williams, J Kwok, R Wong, M Yao, BE Tuch
Endocrinology 2002
Helicobacter pylori Infection and Immunity
Y Yamamoto, H Friedman, PS Hoffman
2002
Regulation of Epithelial Cell Growth by ZBP-89: Potential Relevance in Pancreatic Cancer
L Bai, C Logsdon, JL Merchant
International Journal of Gastrointestinal Cancer 2002
In-vitro differentiation of pancreatic beta-cells
B Soria
Differentiation 2001
Transdifferentiation of Human Islet Cells in a Long-term Culture
BM Schmied, A Ulrich, H Matsuzaki, X Ding, C Ricordi, L Weide, MP Moyer, SK Batra, TE Adrian, PM Pour
Pancreas 2001
Increased c-met Expression During Ductal β Cell Neogenesis in Experimental Autoimmune Diabetes
A Bulotta, E Cesare, E Ponte, M Falchi, S Sciacchitano, D Cucinotta, D Taruscio, U Mario, E Anastasi
Growth Factors 2001
Molecular mechanisms for the antiapoptotic action of gastrin
A Todisco, S Ramamoorthy, T Witham, N Pausawasdi, S Srinivasan, CJ Dickinson, FK Askari, D Krametter
AJP Gastrointestinal and Liver Physiology 2001
Molecular mechanisms involved in gastrin-mediated regulation of cAMP-responsive promoter elements
L Thommesen, E Hofsli, RH Paulssen, MW Anthonsen, A Lægreid
American journal of physiology. Endocrinology and metabolism 2001
Molecular Basis of Pancreas Development and Function
JF Habener, MA Hussain
2001
Impaired pancreatic duct-cell growth in focal areas of regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of non-insulin dependent diabetes mellitus
C Plachot, B Portha
The Histochemical Journal 2001
Developmental biology of gastrin and somatostatin cells in the antropyloric mucosa of the stomach
LI Larsson
Microscopy Research and Technique 2000
Peptidergic Regulation of Maturation of the Stimulus-Secretion Coupling in Fetal Islet ?? Cells
Sj??holm, E Sandberg, CG ??stenson, S Efendi??
Pancreas 2000
Neogenesis of Pancreatic Endocrine Cells in Copper-Deprived Rat Models
IH Al-Abdullah, G Ayala, D Panigrahi, AM Kumar, MS Kumar
Pancreas 2000
Closing the gastrin loop in pancreatic carcinoma
JP Goetze, FC Nielsen, F Burcharth, JF Rehfeld
Cancer 2000
Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
TC Wang, CA Dangler, D Chen, JR Goldenring, T Koh, R Raychowdhury, RJ Coffey, S Ito, A Varro, GJ Dockray, JG Fox
Gastroenterology 2000
Gastrin as a growth factor in the gastrointestinal tract
TJ Koh, D Chen
Regulatory Peptides 2000
Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
A Garcia-Ocaña, KK Takane, MA Syed, WM Philbrick, RC Vasavada, AF Stewart
The Journal of biological chemistry 2000
Isolation and Expression of PASK, a Serine/Threonine Kinase, During Rat Embryonic Development, with Special Emphasis on the Pancreas
N Miao, B Fung, R Sanchez, J Lydon, D Barker, K Pang
Journal of Histochemistry & Cytochemistry 2000
Targeted Expression of Placental Lactogen in the Beta Cells of Transgenic Mice Results in Beta Cell Proliferation, Islet Mass Augmentation, and Hypoglycemia
RC Vasavada, A Garcia-Ocaña, WS Zawalich, RL Sorenson, P Dann, M Syed, L Ogren, F Talamantes, AF Stewart
The Journal of biological chemistry 2000
Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells
VK Ramiya, M Maraist, KE Arfors, DA Schatz, AB Peck, JG Cornelius
Nature Medicine 2000
Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
TJ Koh, GJ Dockray, A Varro, RJ Cahill, CA Dangler, JG Fox, TC Wang
Journal of Clinical Investigation 1999
Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor α
SY Song, M Gannon, MK Washington, CR Scoggins, IM Meszoely, JR Goldenring, CR Marino, EP Sandgren, RJ Coffey, CV Wright, SD Leach
Gastroenterology 1999
Pharmacological effects of epidermal growth factor (EGF) with focus on the urinary and gastrointestinal tracts
L Vinter-Jensen
APMIS 1999
I. Physiological studies with gastrin in transgenic mice
TC Wang, GJ Dockray
AJP Gastrointestinal and Liver Physiology 1999
Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats
DT Finegood, GC Weir, S Bonner-Weir
American journal of physiology. Endocrinology and metabolism 1999
Gastrin induces c- fos gene transcription via multiple signaling pathways
VM Stepan, M Tatewaki, M Matsushima, CJ Dickinson, J Valle, A Todisco
AJP Gastrointestinal and Liver Physiology 1999
Gastrin stimulates the growth of gastric pit with less-differentiated features
Y Konda, H Kamimura, H Yokota, N Hayashi, K Sugano, T Takeuchi
AJP Gastrointestinal and Liver Physiology 1999
Short- and Long-Term Effects of β-Cellulin and Transforming Growth Factor-α on β-Cell Function in Cultured Fetal Rat Pancreatic Islets
AS Kindmark
Endocrine 1999
Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model
L Rosenberg
Microscopy Research and Technique 1998
On the development of the Islets of Langerhans
LI Larsson
Microscopy Research and Technique 1998
G-Cells in Regenerating Adult Pancreatic Tissue After Pancreatic Fragment Autotransplantation in Dog Spleens
ML Madureira
Transplantation Proceedings 1998
Growth Factor-Mediated Proliferation and Differentiation of Insulin-Producing INS-1 and RINm5F Cells: Identification of Betacellulin as a Novel β-Cell Mitogen*
MA Huotari, J Palgi, T Otonkoski
Endocrinology 1998
Characterization of a novel protein kinase C response element in the glucagon gene
U Fürstenau, M Schwaninger, R Blume, I Kennerknecht, W Knepel
Molecular and cellular biology 1997
Transient transcriptional activation of gastrin during sodium butyrate-induced differentiation of islet cells
B Simon, JL Merchant, R Eissele, K Köhler, R Arnold
Regulatory Peptides 1997
The Transcriptional Silencer Protein NRF: A Repressor of NF-κB Enhancers
M Nourbakhsh, H Hauser
Immunobiology 1997
Developmental expression of NPY, PYY and PP in the rat pancreas and their coexistence with islet hormones
U Myrsén-Axcrona, E Ekblad, F Sundler
Regulatory Peptides 1997
Molecular mechanisms for the growth factor action of gastrin
A Todisco, Y Takeuchi, A Urumov, J Yamada, VM Stepan, T Yamada
AJP Gastrointestinal and Liver Physiology 1997
Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells
H Mashima, H Ohnishi, K Wakabayashi, T Mine, J Miyagawa, T Hanafusa, M Seno, H Yamada, I Kojima
Journal of Clinical Investigation 1996
Processing and proliferative effects of human progastrin in transgenic mice
TC Wang, TJ Koh, A Varro, RJ Cahill, CA Dangler, JG Fox, GJ Dockray
Journal of Clinical Investigation 1996
Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy
G Xu, S Sumi, M Koike, K Tanigawa, Y Nio, K Tamura
Digestive Diseases and Sciences 1996
Autocrine stimulation of AR4-2J rat pancreatic tumor cell growth by glycine-extended gastrin
F Nègre, P Fagot-Revurat, M Bouisson, JF Rehfeld, N Vaysse, L Pradayrol
International Journal of Cancer 1996
Beta-cell growth in adolescent and adult rats treated with streptozotocin during the neonatal period
RN Wang, L Bouwens, G Klppel
Diabetologia 1996
Effects of transforming growth factor ?, tumor necrosis factor ? and interferon ? on pancreatic islet ?-cell responsiveness to transforming growth factor ?
ke Sjholm
Bioscience Reports 1996
Islet cell neogenesis in the pancreas
L Bouwens, G Klppel
Virchows Archiv 1996
Regulation of terminal differentiation of zymogenic cells by transforming growth factor α in transgenic mice
DE Bockman, R Sharp, G Merlino
Gastroenterology 1995
Regulation of Insulinoma Cell Proliferation and Insulin Accumulation by Peptides and Second Messengers
Å Sjöholm
Upsala Journal of Medical Sciences 1995
The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth
GS Baldwin
Journal of Gastroenterology and Hepatology 1995
Development of insulin secretory function in young obese hyperglycemic mice (Umeå )
A Edvell, P Lindström
Metabolism 1995
In vivo cell transformation: neogenesis of beta cells from pancreatic ductal cells
L Rosenberg
Cell Transplantation 1995
Concise Review: Saliva and Growth Factors: The Fountain of Youth Resides in Us All
T Zelles, KR Purushotham, SP Macauley, GE Oxford, MG Humphreys-Beher
Journal of dental research 1995
Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
RN Wang, G Klppel, L Bouwens
Diabetologia 1995
Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice
R Sharp, MW Babyatsky, H Takagi, S Tagerud, TC Wang, DE Bockman, SJ Brand, G Merlino
Development (Cambridge, England) 1995
Activation of gastrin gene transcription in islet cells by a RAP1-like cis-acting promoter element
B Simon, L Tillotson, SJ Brand
FEBS Letters 1994
Islet cell growth and the growth factors involved
S Bonner-Weir, FE Smith
Trends in Endocrinology & Metabolism 1994
Activation of gastrin transcription in pancreatic insulinoma cells by a CACC promoter element and a 70-kDa sequence-specific DNA-binding protein
LG Tillotson, TC Wang, SJ Brand
The Journal of biological chemistry 1994
Islet growth factors: curing diabetes and preventing chronic pancreatitis?
M Korc
Journal of Clinical Investigation 1993
Endocrine Pathology
RV Lloyd
Endocrine Pathology 1990
Fetal Islet Transplantation
CM Peterson, L Jovanovic-Peterson, B Formby
1988
Pharmacogenetics
BM Watson
Anaesthesia 1969

← Previous 1 2 … 7 8 9 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 21 patents
44 readers on Mendeley
See more details