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Citations to this article

Effects of endothelin receptor antagonist on cyclosporine-induced vasoconstriction in isolated rat renal arterioles.
D M Lanese, J D Conger
D M Lanese, J D Conger
Published May 1, 1993
Citation Information: J Clin Invest. 1993;91(5):2144-2149. https://doi.org/10.1172/JCI116440.
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Effects of endothelin receptor antagonist on cyclosporine-induced vasoconstriction in isolated rat renal arterioles.

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Abstract

Recent evidence suggests that the potent constrictor peptide, endothelin (ET) has a mediating role in cyclosporine A (CsA)-related renal vasoconstriction. However, the nature of the CsA-ET interaction and effect on the renal vasculature is uncertain. The purpose of the present study was twofold: (a) to determine if CsA exposure caused direct local release of ET from the endothelium of the renal microvasculature and (b) to determine if locally generated ET has paracrine effects on the underlying vascular smooth muscle to induce vasoconstriction. Experiments were performed in isolated rat renal arterioles. First it was determined that both afferent arteriole (AA) and efferent arteriole (EA) exhibited concentration-dependent decreases in lumen diameter to increasing molar concentrations of CsA. The AA was more sensitive to the vasoconstrictive effects of CsA than the EA. Next, the blocking effect of a recently synthesized putative ETA receptor antagonist was verified in both the AA and EA, where it was found that the cyclic peptide cyclo D-Asp-L-Pro-D-Val-L-Leu-D-Trp totally inhibited the vasoconstriction observed with ET addition. Finally, the role of locally stimulated ET in CsA-induced vasoconstriction was tested by determining the effect of the ETA receptor antagonist on CsA-induced AA and EA constriction. In the AA the vasoconstrictor effect of 10(-11) M CsA was completely blocked by the ETA receptor antagonist. However, in contrast to AA, 10(-11) M CsA in EA in the presence of the ETA receptor antagonist decreased EA lumen diameter by a mean of 41% from baseline (4.80 +/- 0.75 microns vs 7.80 +/- 0.84 microns, P < 0.05). This change in lumen diameter was similar to that induced by CsA alone. These data suggest that CsA directly constricts renal microvessels. This effect is mediated by ET in the AA but not the EA.

Authors

D M Lanese, J D Conger

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BJU International 2000
Endothelin antagonists in renal disease
A Benigni
Kidney International 2000
Renal hemodynamics and pharmacokinetics of bosentan with and without cyclosporine A
I Binet, A Wallnöfer, C Weber, R Jones, G Thiel
Kidney International 2000
Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension
Y Takeda, S Inaba, K Furukawa, A Fujimura, I Miyamori, H Mabuchi
Journal of Hypertension 2000
Effects of fish oil in cyclosporine-treated renal transplant recipients
J Santos, J Queirós, F Silva, A Cabrita, A Rodrigues, AC Henriques, AM Sarmento, MC Pereira, S Guimarães
Transplantation Proceedings 2000
Enalapril and valsartan improve cyclosporine A-induced vascular dysfunction in spontaneously hypertensive rats
M Lassila, P Finckenberg, AK Pere, H Vapaatalo, ML Nurminen
European Journal of Pharmacology 2000
CyA and OxLDL cause endothelial dysfunction in isolated arteries through endothelin-mediated stimulation of O2− formation
J Galle, C Lehmann-Bodem, U Hübner, A Heinloth, C Wanner
Nephrology Dialysis Transplantation 2000
Textbook of Angiology
JB Chang
2000
Cyclosporine-induced coronary artery constriction—dissociation between thromboxane release and coronary vasospasm
RC Braun-Dullaeus, M Feussner, G Walker, H Hopmann, HJ Kraemer, F Grimminger, H Tillmanns, W Haberbosch
The Journal of Heart and Lung Transplantation 1999
ADRENOCORTICOTROPHIC HORMONE-INDUCED HYPERTENSION IN THE RAT: EFFECTS OF THE ENDOTHELIN ANTAGONIST BOSENTAN
TB Fraser, GJ Mangos, SW Turner, JA Whitworth
Clinical and Experimental Pharmacology and Physiology 1999
Mechanisms of cyclosporine-induced nephrotoxicity
A Ishikawa, K Suzuki, K Fujita
Transplantation Proceedings 1999
Cyclosporine-induced renal artery smooth muscle contraction is associated with increases in the phosphorylation of specific contractile regulatory proteins
A Beall, A Epstein, D Woodrum, C M Brophy
Biochimica et Biophysica Acta 1999
Dietary Glycine and Renal Denervation Prevents Cyclosporin A-Induced Hydroxyl Radical Production in Rat Kidney
Z Zhong, HD Connor, M Yin, N Moss, RP Mason, H Bunzendahl, DT Forman, RG Thurman
Molecular pharmacology 1999
Immunosuppressant-Induced Nephropathy: Pathophysiology, Incidence and Management
AJ Olyaei, AM de Mattos, WM Bennett
Drug Safety 1999
Cyclosporin-Induced Hypertension: Incidence, Pathogenesis and Management
SJ Taler, SC Textor, VJ Canzanello, L Schwartz
Drug Safety 1999
Heparin Suppresses Cyclosporine-Induced Endothelin-1 Synthesis in Rat Endothelial Cells
K Yokokawa, M Kohno, M Minami, K Yasunari, AK Mandal, J Yoshikawa
Journal of Cardiovascular Pharmacology 1998
Contribution of endothelin receptors in renal microvessels in acute cyclosporine-mediated vasoconstriction in rats
A Cavarape, K Endlich, F Feletto, N Parekh, E Bartoli, M Steinhausen
Kidney International 1998
Endothelin release by rabbit proximal tubule cells: Modulatory effects of cyclosporine A, tacrolimus, HGF and EGF
C Haug, C Grill, A Schmid-Kotsas, A Gruenert, PM Jehle
Kidney International 1998
Elevated neointimal endothelin-1 in transplantation-associated arteriosclerosis of renal allograft recipients
MS Simonson, SN Emancipator, T Knauss, DE Hricik
Kidney International 1998
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis
SE Thomas, TF Andoh, RH Pichler, SJ Shankland, WG Couser, WM Bennett, RJ Johnson
Kidney International 1998
Cyclosporine, but not FK506, selectively induces renal and coronary artery smooth muscle contraction
A Epstein, A Beall, J Wynn, L Mulloy, CM Brophy
Surgery 1998
Effect of the Endothelin Receptor Antagonist, SB 209670 on Cyclosporine-Induced Nephrotoxicity
A Ishikawa, K Suzuki, K Fujita
Transplantation Proceedings 1998
Verapamil prevents cyclosporine-induced hypertension by modulating endothelin a receptor expression in rat kidney membranes
L Giovannini, M Migliori, D Taccola, V Panichi, B Andreini, SD Pietro, C Filippi, SD Ry, MG Andreassi, MG Colombo, A Biagini, D Giannessi, R Palla
Transplantation Proceedings 1998
Renal Endothelin in FK506-Induced Nephrotoxicity in Spontaneously Hypertensive Rats
J Uchida, K Miura, S Yamanaka, S Kim, H Iwao, T Nakatani, T Kishimoto
The Japanese Journal of Pharmacology 1998
Endocrinology of Cardiovascular Function
ER Levin, JL Nadler
1998
Endothelins in the normal and diseased kidney
DE Kohan
American Journal of Kidney Diseases 1997
Acute effect of a selective endothelin-A receptor antagonist, S-0139, against cyclosporine-induced reduction in renal cortical blood flow
A Ishikawa, K Suzuki, K Fujita
Clinical and Experimental Nephrology 1997
Cyclosporine A -induced contraction of isolated rat aortic smooth muscle cells
J Medina, A Cordier, A Wolf
Life Sciences 1997
SYMPOSIUM Experimental Biology 1995 Endothelin Receptors: Role in Renal Function and Dysfunction ROLE OF ENDOTHELIN IN RENAL FUNCTION AND DYSFUNCTION
DP Brooks
Clinical and Experimental Pharmacology and Physiology 1996
Endothelin in organ transplantation
B Watschinger, MH Sayegh
American Journal of Kidney Diseases 1996
Chronic cyclosporine nephropathy: The Achilles' heel of immunosuppressive therapy
WM Bennett, A DeMattos, MM Meyer, T Andoh, JM Barry
Kidney International 1996
Localization of endothelin ETA and ETB receptor-mediated constriction in the renal microcirculation of rats
K Endlich, J Hoffend, M Steinhausen
The Journal of Physiology 1996
Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: possible lack of relationship to immunosuppressive activity
AL Russo, AC Passaquin, P André, M Skutella, UT Rüegg
British Journal of Pharmacology 1996
Regulation of Vascular Tone during Treatment with Cyclosporine A: Modulation of Endothelial and Vascular Smooth Muscle Function
S Götze, W Auch-Schwelk, E Duske, E Fleck
Endothelium : journal of endothelial cell research 1996
Bosentan Ameliorates Cyclosporin A–Induced Hypertension in Rats and Primates
B Bartholomeusz, KJ Hardy, AS Nelson, PA Phillips
Hypertension 1996
Chronic treatment with cyclosporine A in New Zealand rabbit: aortic and erectile tissue alterations
E Ragazzi, C Meggiato, A Chinellato, G Italiano, F Pagano, A Calabro
Urological Research 1996
Endocrinology of the Vasculature
JR Sowers
1996
Endothelin and endothelin antagonists: Potential role in cardiovascular and renal disease
G Noll, RR Wenzel, TF Lscher
Molecular and Cellular Biochemistry 1996
Increase in number of Weibel-Palade bodies and endothelin-1 release from endothelial cells in the cadmium-treated rat thoracic aorta
Y Doi, T Ozaka, H Fukushige, S Fujimoto, H Furukawa, M Yoshizuka
Virchows Archiv 1996
Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity
BA Young, EA Burdmann, RJ Johnson, CE Alpers, CM Giachelli, E Eng, T Andoh, WM Bennett, WG Couser, J Lindsley, J Duyn
Kidney International 1995
Cyclosporine A induced arteriolopathy in a rat model of chronic cyclosporine nephropathy
BA Young, EA Burdmann, RJ Johnson, T Andoh, WM Bennett, WG Couser, CE Alpers
Kidney International 1995
Regional differences in vasculotoxic effects of cyclosporin in rats
M Verbeke, L Ridder, JV de Voorde, N Lameire
Canadian Journal of Physiology and Pharmacology 1995
Characterization of endothelin receptor subtypes in isolated rat renal preglomerular microvessels
HD León, R Garcia
Regulatory Peptides 1995
Cardiac natriuretic peptides inhibit cyclosporine-induced production of endothelin in cultured rat mesangial cells
M Kohno, K Yokokawa, AK Mandal, T Horio, K Yasunari, T Takeda
Metabolism 1995
Signal sorting by G-protein-linked receptors
G Milligan
Advances in pharmacology (San Diego, Calif.) 1995
Prevention of cyclosporine A-induced renal vasoconstriction by the endothelin receptor antagonist SB 209670
DP Brooks, LC Contino
European Journal of Pharmacology 1995
Effects of an Endothelin Receptor Antagonist in Rats With Cyclosporine-Induced Hypertension
Y Takeda, I Miyamori, P Wu, T Yoneda, K Furukawa, R Takeda
Hypertension 1995
BQ-123, A Selective Endothelin ETAReceptor Antagonist
S Moreland
Cardiovascular Drug Reviews 1994
Divergent expression of EtA and EtB receptors in response to cyclosporine in mesangial cells
M Takeda, S Iwasaki, SE Hellings, H Yoshida, T Homma, V Kon
The American Journal of Pathology 1994
Role of endothelin in hypertension
BK Krämer, M Ackermann, SM Kohler, GA Riegger
Journal of Molecular Medicine 1994
Endothelins: A Potential Target for Pharmacological Intervention in Diseases of the Elderly
H Lévesque, N Moore, N Cailleux, V Richard, C Thuillez, H Courtois
Drugs & Aging 1994
Endothelins
AM Vollmar
Journal of Veterinary Medicine Series A 1992
Cyclosporine nephrotoxicity
BD Myers
Kidney International 1986

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