Recent evidence suggests that the potent constrictor peptide, endothelin (ET) has a mediating role in cyclosporine A (CsA)-related renal vasoconstriction. However, the nature of the CsA-ET interaction and effect on the renal vasculature is uncertain. The purpose of the present study was twofold: (a) to determine if CsA exposure caused direct local release of ET from the endothelium of the renal microvasculature and (b) to determine if locally generated ET has paracrine effects on the underlying vascular smooth muscle to induce vasoconstriction. Experiments were performed in isolated rat renal arterioles. First it was determined that both afferent arteriole (AA) and efferent arteriole (EA) exhibited concentration-dependent decreases in lumen diameter to increasing molar concentrations of CsA. The AA was more sensitive to the vasoconstrictive effects of CsA than the EA. Next, the blocking effect of a recently synthesized putative ETA receptor antagonist was verified in both the AA and EA, where it was found that the cyclic peptide cyclo D-Asp-L-Pro-D-Val-L-Leu-D-Trp totally inhibited the vasoconstriction observed with ET addition. Finally, the role of locally stimulated ET in CsA-induced vasoconstriction was tested by determining the effect of the ETA receptor antagonist on CsA-induced AA and EA constriction. In the AA the vasoconstrictor effect of 10(-11) M CsA was completely blocked by the ETA receptor antagonist. However, in contrast to AA, 10(-11) M CsA in EA in the presence of the ETA receptor antagonist decreased EA lumen diameter by a mean of 41% from baseline (4.80 +/- 0.75 microns vs 7.80 +/- 0.84 microns, P < 0.05). This change in lumen diameter was similar to that induced by CsA alone. These data suggest that CsA directly constricts renal microvessels. This effect is mediated by ET in the AA but not the EA.
D M Lanese, J D Conger
Title and authors | Publication | Year |
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Haq K, Lin S, Dasgupta A, Obaidi Z, Bagnasco S, Maggiore U, Alachkar N |
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The Association of Tacrolimus Formulation on Cerebral Blood Flow and Cognitive Function.
Mahaparn I, Lepping RJ, Montgomery RN, Mukherjee R, Billinger SA, Brooks WM, Gupta A |
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Substitution of calcineurin inhibitors with corticosteroids after allogeneic hematopoietic cell transplantation.
Matsumi S, Kimura SI, Nakamura Y, Kawamura M, Takeshita J, Kawamura S, Yoshino N, Misaki Y, Yoshimura K, Gomyo A, Okada Y, Akahoshi Y, Tamaki M, Kusuda M, Kameda K, Wada H, Tanihara A, Sato M, Nakasone H, Kako S, Kanda Y |
International Journal of Hematology | 2023 |
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Duan Y, Bai Y, Guo W, Wang L, Dai W, Guo W, Huang H, Liu W, Diao Z |
Nephrology Dialysis Transplantation | 2023 |
New onset hypertension after transplantation.
Nassar M, Nso N, Lakhdar S, Kondaveeti R, Buttar C, Bhangoo H, Awad M, Sheikh NS, Soliman KM, Munira MS, Radparvar F, Rizzo V, Daoud A |
World Journal of Transplantation | 2022 |
Long-lasting renal dysfunction following tacrolimus induction therapy in ulcerative colitis patients.
Cha N, Oshima N, Kishimoto K, Kotani S, Okimoto E, Yazaki T, Sonoyama H, Oka A, Mishima Y, Shibagaki K, Tobita H, Kawashima K, Ishimura N, Ishihara S |
Journal of Clinical Biochemistry and Nutrition | 2022 |
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HM Hennawy, AS Faifi, WE Nazer, A Mahedy, A Kamal, IS Faifi, H Abdulmalik, O Safar, MF Zaitoun, AE Fahmy |
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LM Souza, N Ghahramani, C Abendroth, G Kaur |
Cureus | 2021 |
Immunosuppressive drugs modes of action
M Meneghini, O Bestard, JM Grinyo |
Best practice & research. Clinical gastroenterology | 2021 |
Approach and Management of Hypertension After Kidney Transplantation
E Tantisattamo, MZ Molnar, BT Ho, UG Reddy, DC Dafoe, H Ichii, AJ Ferrey, RM Hanna, K Kalantar-Zadeh, A Amin |
Frontiers in Medicine | 2020 |
Acute Kidney Injury and Regenerative Medicine
Y Terada, T Wada, K Doi |
2020 | |
The Many Faces of Calcineurin Inhibitor Toxicity—What the FK?
SS Farouk, JL Rein |
Advances in Chronic Kidney Disease | 2020 |
Cognitive Function in Kidney Transplantation
A Jurgensen, AA Qannus, A Gupta |
Current Transplantation Reports | 2020 |
Renal Repercussions of Medications
R Shaddock, KV Anderson, R Beyth |
Primary care | 2020 |
Calcineurin dephosphorylates Kelch-like 3, reversing phosphorylation by angiotensin II and regulating renal electrolyte handling
K Ishizawa, Q Wang, J Li, O Yamazaki, Y Tamura, Y Fujigaki, S Uchida, RP Lifton, S Shibata |
Proceedings of the National Academy of Sciences | 2019 |
Kidney Transplantation in Patients With Chronic Kidney Disease After a Previous Lung Transplantation
M Serrano-Salazar, L Medina-Zahonero, D Janeiro-Marín, C Contreras-Lorenzo, M Aguilar-Pérez, B Sánchez-Sobrino, P López-Sánchez, P Ussetti-Gil, J Portoles-Perez |
Transplantation Proceedings | 2019 |
Cyclosporine A induces endothelin-converting enzyme-1: Studies in vivo and in vitro
SN Heyman, Z Abassi, C Rosenberger, H Yaseen, G Skarjinski, A Shina, S Mathia, N Krits, M Khamaisi |
Acta physiologica (Oxford, England) | 2018 |
Should a patient with rheumatoid arthritis be a kidney donor?
R Seto, LM Mathias, A Kelly, RS Panush |
Clinical Rheumatology | 2018 |
Tacrolimus-induced Segmental Renal Artery Vasoconstriction in the Setting of Nicardipine Administration after Renal Transplantation
M Goldooz, A Kennedy, J Campsen |
2018 | |
Comparison of graft and patient outcomes following kidney transplantation in extended hour and conventional haemodialysis patients
EJ See, CM Hawley, Y Cho, ND Toussaint, JW Agar, EM Pascoe, WH Lim, RS Francis, MG Collins, DW Johnson |
Nephrology (Carlton, Vic.) | 2018 |
Metastatic lung adenocarcinoma- associated thrombotic microangiopathy in a renal transplant recipient
E Vilayur, J de Malmanche, P Trevillian, D Ferreira |
BMJ case reports | 2018 |
Enhanced immunosuppression improves early allograft function in a porcine kidney transplant model of donation after circulatory death
M Xu, S Garcia-Aroz, B Banan, X Wang, BJ Rabe, F Zhou, DK Nayak, Z Zhang, J Jia, GA Upadhya, PT Manning, JP Gaut, Y Lin, WC Chapman |
American Journal of Transplantation | 2018 |
Low-dose cyclosporine in treatment of membranous nephropathy with nephrotic syndrome: effectiveness and renal safety
X Yu, L Ruan, Z Qu, Z Cui, Y Zhang, X Wang, L Meng, X Liu, F Wang, Y Zhang, G Liu, L Yang |
Renal Failure | 2017 |
Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study
P Gatault, N Kamar, M Büchler, C Colosio, D Bertrand, A Durrbach, L Albano, J Rivalan, YL Meur, M Essig, N Bouvier, C Legendre, B Moulin, AE Heng, PF Weestel, J Sayegh, B Charpentier, L Rostaing, E Thervet, Y Lebranchu |
American Journal of Transplantation | 2017 |
Acute Calcineurin Inhibitor Nephrotoxicity Secondary to Turmeric Intake: A Case Report
A Nayeri, S Wu, E Adams, C Tanner, J Meshman, I Saini, W Reid |
Transplantation Proceedings | 2017 |
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AD Moes, DA Hesselink, AH van Meiracker, R Zietse, EJ Hoorn |
American journal of kidney diseases : the official journal of the National Kidney Foundation | 2017 |
Pathophysiological Mechanisms of Calcineurin Inhibitor-Induced Nephrotoxicity and Arterial Hypertension
L Hošková, I Málek, L Kopkan, J Kautzner |
Physiological research / Academia Scientiarum Bohemoslovaca | 2017 |
Incidence and risk factors for early renal dysfunction after liver transplantation
P Wiesen, PB Massion, J Joris, O Detry, P Damas |
World Journal of Transplantation | 2016 |
Advantageous effects of immunosuppression with tacrolimus in comparison with cyclosporine A regarding renal function in patients after heart transplantation
A Doesch, M Helmschrott, R Rivinius, A Ruhparwar, B Schmack, C Erbel, CA Gleissner, M Akhavanpoor, L Frankenstein, P Ehlermann, T Bruckner, HA Katus |
Drug design, development and therapy | 2015 |
A systematic review of acute kidney injury in pediatric allogeneic hematopoietic stem cell recipients
MS Didsbury, FE Mackie, SE Kennedy |
Pediatric Transplantation | 2015 |
Myocardial perfusion is impaired in asymptomatic renal and liver transplant recipients: a cardiovascular magnetic resonance study
S Parnham, JM Gleadle, D Leong, S Grover, C Bradbrook, RJ Woodman, CG de Pasquale, JB Selvanayagam |
Journal of Cardiovascular Magnetic Resonance | 2015 |
Chronic Kidney Disease and Related Long-Term Complications After Liver Transplantation
P Sharma, K Bari |
Advances in Chronic Kidney Disease | 2015 |
Psoriasis during pregnancy: characteristics and important management recommendations
MB Hoffman, M Farhangian, SR Feldman |
Expert Review of Clinical Immunology | 2015 |
The role of medications and their management in acute kidney injury
M Bentley, B McDaniel |
Integrated Pharmacy Research and Practice | 2015 |
Endothelin-1, but not angiotensin II, induces afferent arteriolar myosin diphosphorylation as a potential contributor to prolonged vasoconstriction
K Takeya, X Wang, I Kathol, K Loutzenhiser, R Loutzenhiser, MP Walsh |
Kidney International | 2014 |
Sirolimus conversion efficacy for graft function improvement and histopathology in renal recipients with mild to moderate renal insufficiency
DJ Joo, CW Yang, HJ Jeong, BJ Lim, KH Huh, BH Chung, YJ Choi, SW Kang, YS Kim |
Journal of Korean Medical Science | 2014 |
Chronic Renal Insufficiency in Heart Transplant Recipients: Risk Factors and Management Options
F González-Vílchez, JA de Prada |
Drugs | 2014 |
Renoprotective Effect of Dietary Fish Oil on Cyclosporine A: Induced Nephrotoxicity in Rats
SA Hussei, OA Ragab, MA El-Eshm |
Asian Journal of Biochemistry | 2014 |
Determining Renal Resistive and Pulsatility Indexes Long-Term After Kidney Transplantation in Kidney Transplant Recipients on Cyclosporine A-, Tacrolimus-, or Sirolimus-Based Regimens
M Boran, M Tola, M Boran, E Boran, F Gönenç |
Transplantation Proceedings | 2014 |
Usefulness of tacrolimus for refractory adult-onset still's disease: Report of six cases
H Nakamura, T Odani, Y Shimizu, T Takeda, H Kikuchi |
Modern Rheumatology | 2014 |
Differential impact of belatacept and cyclosporine A on central aortic blood pressure and arterial stiffness after renal transplantation
FS Seibert, J Steltzer, E Melilli, G Grannas, N Pagonas, F Bauer, W Zidek, J Grinyó, TH Westhoff |
Clinical Transplantation | 2014 |
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes |
2014 | |
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich |
Seldin and Giebisch's The Kidney | 2013 |
Improvement of Renal Graft Function After Conversion From a Calcineurin Inhibitor Including Immunosuppression to a Mycophenolate Sodium Including Regimen: A 4-year Follow-up
MH Heeg, GA Mueller, C Bramlage, K Homayounfar, J Muehlhausen, A Leha, MJ Koziolek |
Transplantation Proceedings | 2013 |
A review of renal disease in cystic fibrosis
D Nazareth, M Walshaw |
Journal of Cystic Fibrosis | 2013 |
A new twist on an old idea: a two-dimensional speckle tracking assessment of cyclosporine as a therapeutic alternative for heart failure with preserved ejection fraction
JA Hiemstra, S Liu, MA Ahlman, KH Schuleri, AC Lardo, CP Baines, KC Dellsperger, DA Bluemke, CA Emter |
Physiological Reports | 2013 |
Long-Term Belatacept Exposure Maintains Efficacy and Safety at 5 Years: Results From the Long-Term Extension of the BENEFIT Study: BENEFIT Long-Term Extension
L Rostaing, F Vincenti, J Grinyó, KM Rice, B Bresnahan, S Steinberg, S Gang, LE Gaite, MC Moal, GA Mondragón-Ramirez, J Kothari, L Pupim, CP Larsen |
American Journal of Transplantation | 2013 |
Cardiovascular disease: Prevention and treatment in renal transplant recipients
S Varughese |
Clinical Queries Nephrology | 2013 |
Hypertension: The Neglected Complication of Transplantation
LS Aparicio, J Alfie, J Barochiner, PE Cuffaro, M Rada, M Morales, C Galarza, GD Waisman |
ISRN Hypertension | 2013 |
Renal complications following lung and heart-lung transplantation
PD Robinson, RC Shroff, H Spencer |
Pediatric Nephrology | 2012 |
Endocrine-Metabolic Pathophysiology and Treatment Approaches Following Kidney Transplantation: a Review
EO Gosmanova, V Tangpricha, AR Gosmanov |
Endocrine Practice | 2012 |
Brenner and Rector's The Kidney
C Brugnara, KU Eckardt |
Brenner and Rector's The Kidney | 2012 |
Endocrine-Metabolic Pathophysiologic Conditions and Treatment Approaches after Kidney Transplantation
EO Gosmanova, V Tangpricha, AR Gosmanov |
Endocrine Practice | 2012 |
The Pathophysiology of Endothelin in Complications After Solid Organ Transplantation: A Potential Novel Therapeutic Role for Endothelin Receptor Antagonists
A Raina, ET Horn, RL Benza |
Transplantation | 2012 |
Pathogenesis of calcineurin inhibitor-induced hypertension
EJ Hoorn, SB Walsh, JA McCormick, R Zietse, RJ Unwin, DH Ellison |
Journal of Nephrology | 2012 |
Clinical Decisions in Nephrology, Hypertension and Kidney Transplantation
EV Lerma, M Rosner |
2012 | |
The management of hypertensive emergencies in children after stem cell transplantation
DG Horn, MN Trame, G Hempel |
International Journal of Clinical Pharmacy | 2011 |
Protective Effect of Mycophenolate Mofetil on Endothelial Function in an Aortic Allograft Model
C Fréguin-Bouilland, M Godin, J Bellien, V Richard, I Remy-Jouet, B Dautreaux, JP Henry, P Compagnon, C Thuillez, D Plissonnier, R Joannidès |
Transplantation | 2011 |
Challenges in diagnosing acute calcineurin-inhibitor induced nephrotoxicity: From toxicogenomics to emerging biomarkers
N Pallet, A Djamali, C Legendre |
Pharmacological Research | 2011 |
Differential effects of cyclosporine and tacrolimus on arterial function
F Seibert, C Behrendt, S Schmidt, M der Giet, W Zidek, TH Westhoff |
Transplant International | 2011 |
Mycophenolate Mofetil Initiation in Renal Transplant Patients at Different Times Posttransplantation: The TranCept Switch Study
HU Meier-Kriesche, P Merville, H Tedesco-Silva, U Heemann, P Kes, H Haller, L Rostaing, N Gafner, C Bernasconi |
Transplantation | 2011 |
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee |
Annual Reports in Medicinal Chemistry Volume 46 | 2011 |
Glomerulotubular Dysfunction and Acute Kidney Injury
S Rajasekaran, NJ Maxvold, TE Bunchman |
Pediatric Critical Care | 2011 |
Biomarkers in Kidney Disease
AS Cerdeira, SA Karumanchi |
Biomarkers in Kidney Disease | 2011 |
New insights into postrenal transplant hemolytic uremic syndrome
J Zuber, ML Quintrec, R Sberro-Soussan, C Loirat, V Frémeaux-Bacchi, C Legendre |
Nature Reviews Nephrology | 2010 |
Deciphering calcineurin inhibitor nephrotoxicity: a pharmacological approach
N Pallet, C Legendre |
Pharmacogenomics | 2010 |
Drug-induced acute kidney injury in the critically ill adult: Recognition and prevention strategies
ML Bentley, HL Corwin, J Dasta |
Critical Care Medicine | 2010 |
Investigating the Protective Effects of Astragalus Membranaceus on Nephrotoxicity in Cyclosporine A-treated Rats
AE El-Kenawy |
Kidney | 2010 |
Role of tacrolimus combination therapy with mycophenolate mofetil in the prevention of organ rejection in kidney transplant patients
P Dalal, G Shah, D Chhabra, L Gallon |
International journal of nephrology and renovascular disease | 2010 |
Predictors of acute kidney injury associated with intravenous colistin treatment
JA Kwon, JE Lee, W Huh, KR Peck, YG Kim, DJ Kim, HY Oh |
International Journal of Antimicrobial Agents | 2010 |
Calcineurin inhibitor-induced renal allograft nephrotoxicity
K Krejci, T Tichy, P Bachleda, J Zadrazil |
Biomedical Papers | 2010 |
Comprehensive Toxicology
JM Sands, JW Verlander |
Comprehensive Toxicology | 2010 |
RGS4 Controls Renal Blood Flow and Inhibits Cyclosporine-Mediated Nephrotoxicity
A Siedlecki, JR Anderson, X Jin, JR Garbow, TS Lupu, AJ Muslin |
American Journal of Transplantation | 2009 |
Report of the first international liver transplantation society expert panel consensus conference on renal insufficiency in liver transplantation
MR Charlton, WJ Wall, AO Ojo, P Ginés, S Textor, FS Shihab, P Marotta, M Cantarovich, JD Eason, RH Wiesner, MA Ramsay, JC Garcia-Valdecasas, JM Neuberger, S Feng, CL Davis, TA Gonwa |
Liver Transplantation | 2009 |
Intrarenal vascular resistance parameters in kidney transplant patients receiving calcineurin inhibitor-based or sirolimus-based regimens
PC Lee, CY Lee, RH Hu, C Lo, MK Tsai, PH Lee |
Nephrology Dialysis Transplantation | 2009 |
Serum neutrophil gelatinase-associated lipocalin correlates with kidney function in renal allograft recipients
J Malyszko, JS Malyszko, M Mysliwiec |
Clinical Transplantation | 2009 |
Complex Interplay Between Insulinemia, Glycemia, and Glomerular Filtration Rate in Nondiabetic Renal Transplant Recipients
A Sharif, V Ravindran, RH Moore, K Baboolal, G Dunseath, S Luzio, DR Owens |
Transplantation | 2009 |
Neutrophil Gelatinase-Associated Lipocalin Is a New and Sensitive Marker of Kidney Function in Chronic Kidney Disease Patients and Renal Allograft Recipients
J Malyszko, JS Malyszko, H Bachorzewska-Gajewska, B Poniatowski, S Dobrzycki, M Mysliwiec |
Transplantation Proceedings | 2009 |
Therapy in Nephrology & Hypertension
WL Whittier, JB Lewis, EJ Lewis |
Therapy in Nephrology & Hypertension | 2008 |
An overview of drug-induced acute kidney injury
N Pannu, MK Nadim |
Critical Care Medicine | 2008 |
Endothelin A receptor-like immunoreactivity on the basal infoldings of rat renal tubules and collecting ducts
T Yamamoto, H Suzuki, Y Kubo, A Matsumoto, H Uemura |
Archives of Histology and Cytology | 2008 |
Cyclosporine
NK Russell, SR Knight, PJ Morris |
Kidney Transplantation | 2008 |
Comprehensive Pediatric Nephrology
R Gbadegesin, WE Smoyer |
Comprehensive Pediatric Nephrology | 2008 |
Clinical Nephrotoxins
ME Broe, GA Porter, WM Bennett, G Deray |
2008 | |
Cardiovascular Disease in Transplant Recipients: Current and Future Treatment Strategies
JS Gill |
Clinical journal of the American Society of Nephrology : CJASN | 2008 |
Treatment of Psoriasis
JM Weinberg |
2008 | |
Increased Vascular Resistance and Not Salt Retention Characterizes Cyclosporine A?Induced Hypertension: Report in an Anuric Patient
IM Wahba, WM Bennett |
American Journal of Transplantation | 2007 |
Time-Dependent Effects of Cadaveric Renal Transplantation on Arterial Compliance in Patients with End-Stage Renal Disease
TH Westhoff, H Straub-Hohenbleicher, M Basdorf, S der Giet, S Schmidt, G Offermann, P Schlattmann, W Zidek, M der Giet |
Transplantation | 2006 |
Kidney Disease After Heart and Lung Transplantation
RD Bloom, AM Doyle |
American Journal of Transplantation | 2006 |
Reverse Diastolic Intrarenal Flow Due to Calcineurin Inhibitor (CNI) Toxicity
CA Boger, P Rummele, MJ Mihatsch, B Banas, BK Kramer |
American Journal of Transplantation | 2006 |
Cardiovascular Complications After Renal Transplantation and Their Prevention
AO Ojo |
Transplantation | 2006 |
Spirulina attenuates cyclosporine-induced nephrotoxicity in rats
M Khan, JC Shobha, IK Mohan, MU Naidu, A Prayag, VK Kutala |
Journal of Applied Toxicology | 2006 |
Sirolimus therapy following early cyclosporine withdrawal in transplant patients: mechanisms of action and clinical results
E Thervet |
International Journal of Nanomedicine | 2006 |
Time-Dependent Effects of Cadaveric Renal Transplantation on Arterial Compliance in Patients with End-Stage Renal Disease:
TH Westhoff, H Straub-Hohenbleicher, M Basdorf, S der Giet, S Schmidt, G Offermann, P Schlattmann, W Zidek, M der Giet |
Transplantation | 2006 |
Distribution of Endothelin Receptor Subtypes ET A and ET B in the Rat Kidney
M Wendel, L Knels, W Kummer, T Koch |
Journal of Histochemistry & Cytochemistry | 2006 |
Review article: how and when to use ciclosporin in ulcerative colitis
D Durai, AB Hawthorne |
Alimentary Pharmacology and Therapeutics | 2005 |
Mechanisms of Hypertension After Liver Transplantation
DA Neal, MJ Brown, IB Wilkinson, GJ Alexander |
Transplantation | 2005 |
Endothelin activation and postoperative renal failure after human liver transplantation
H Hetz, M Bauer, D Lahner, P Faybik, J Winning, HJ Ankersmit, A Bacher, CG Krenn |
Liver Transplantation | 2005 |
Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys
N Tirkey, G Kaur, G Vij, K Chopra |
BMC pharmacology | 2005 |
Cyclosporine A induces vascular fibrosis and heat shock protein expression in rat
R Rezzani, L Rodella, B Buffoli, L Giugno, A Stacchiotti, R Bianchi |
International Immunopharmacology | 2005 |
In vitro prevention of cyclosporin-induced cell contraction by mycophenolic acid
I Dubus, S Sena, JP Labouyrie, J Bonnet, C Combe |
Life Sciences | 2005 |
Withdrawal of Cyclosporine or Tacrolimus After Addition of Mycophenolate Mofetil in Patients With Chronic Allograft Nephropathy
B Suwelack, U Gerhardt, H Hohage |
American Journal of Transplantation | 2004 |
Amelioration of Cyclosporine Nephrotoxicity by Irbesartan, A Selective AT1Receptor Antagonist
V Chander, D Singh, N Tirkey, H Chander, K Chopra |
Renal Failure | 2004 |
Effect of Immunosuppressive Agents on Long-Term Survival of Renal Transplant Recipients: Focus on the Cardiovascular Risk
JM Boots, MH Christiaans, JP van Hooff |
Drugs | 2004 |
Benefit-Risk Assessment of Ciclosporin Withdrawal in Renal Transplant Recipients:
E Thervet, F Martinez, C Legendre |
Drug Safety | 2004 |
Tacrolimus-Induced Neurotoxicity and Nephrotoxicity Is Ameliorated by Administration in the Dark Phase in Rats
A Yamauchi, R Oishi, Y Kataoka |
Cellular and Molecular Neurobiology | 2004 |
Role of endothelin-1 in microvascular dysfunction caused by cyclosporin a
C Wilasrusmee, MD Silva, J Siddiqui, D Bruch, S Kittur, S Wilasrusmee, DS Kittur |
Journal of the American College of Surgeons | 2003 |
Attenuation of Cyclosporine-Induced Renal Dysfunction by Catechin: Possible Antioxidant Mechanism
M Anjaneyulu, N Tirkey, K Chopra |
Renal Failure | 2003 |
Ciclosporin and refractory colitis
AB Hawthorne |
European Journal of Gastroenterology & Hepatology | 2003 |
Hypertension after Kidney Transplantation: Impact, Pathogenesis and Therapy
R Zhang, B Leslie, E Reisin, JP Boudreaux, D Frey |
The American Journal of the Medical Sciences | 2003 |
Rho-Kinase Inhibition Blunts Renal Vasoconstriction Induced by Distinct Signaling Pathways In Vivo
A Cavarape, N Endlich, R Assaloni, E Bartoli, M Steinhausen, N Parekh, K Endlich |
Journal of the American Society of Nephrology : JASN | 2003 |
Conversion to tacrolimus for the treatment of cyclosporine-associated nephrotoxicity in heart transplant recipients
A Israni, S Brozena, O Pankewycz, R Grossman, R Bloom |
American Journal of Kidney Diseases | 2002 |
Selective angiotensin II type 1 receptor blockade ameliorates cyclosporine nephrotoxicity
SS Padi, K Chopra |
Pharmacological Research | 2002 |
Pan Vascular Medicine
P Lanzer, EJ Topol |
2002 | |
Endothelins: vasoactive modulators of renal function in health and disease
S Naicker, KD Bhoola |
Pharmacology & Therapeutics | 2001 |
Involvement of Tyrosine Hydroxylase Upregulation in Cyclosporine-Induced Hypertension
H Shimizu, T Kumai, S Kobayashi |
The Japanese Journal of Pharmacology | 2001 |
Effect of anti-transforming growth factor-beta antibodies in cyclosporine-induced renal dysfunction
M Islam, JF Burke, TA McGowan, Y Zhu, SR Dunn, P McCue, J Kanalas, K Sharma |
Kidney International | 2001 |
Oliguria
WC Wilson, S Aronson |
Anesthesiology Clinics of North America | 2001 |
Effect of tacrolimus on the gene expression of renin and endothelin in the rat kidney
T Nakatani, J Uchida, T Asai, R Yoshimura, T Kim, K Miura, T Kishimoto |
Transplantation Proceedings | 2001 |
Novel approaches to the treatment of acute renal failure
R Venkataraman, JA Kellum |
Expert Opinion on Investigational Drugs | 2000 |
Comparison of enalapril and valsartan in cyclosporine A-induced hypertension and nephrotoxicity in spontaneously hypertensive rats on high-sodium diet
M Lassila, P Finckenberg, AK Pere, L Krogerus, J Ahonen, H Vapaatalo, ML Nurminen |
British Journal of Pharmacology | 2000 |
The renoprotective potential of endothelin receptor antagonists
T Knoll, M Schaub, R Birck, C Braun, KP Juenemann, P Rohmeiss |
Expert Opinion on Investigational Drugs | 2000 |
Endothelins in the urinary tract
ME Sullivan, FH Mumtaz, MA Khan, MR Dashwood, CS Thompson, DP Mikhailidis, RJ Morgan |
BJU International | 2000 |
Endothelin antagonists in renal disease
A Benigni |
Kidney International | 2000 |
Renal hemodynamics and pharmacokinetics of bosentan with and without cyclosporine A
I Binet, A Wallnöfer, C Weber, R Jones, G Thiel |
Kidney International | 2000 |
Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension
Y Takeda, S Inaba, K Furukawa, A Fujimura, I Miyamori, H Mabuchi |
Journal of Hypertension | 2000 |
Effects of fish oil in cyclosporine-treated renal transplant recipients
J Santos, J Queirós, F Silva, A Cabrita, A Rodrigues, AC Henriques, AM Sarmento, MC Pereira, S Guimarães |
Transplantation Proceedings | 2000 |
Enalapril and valsartan improve cyclosporine A-induced vascular dysfunction in spontaneously hypertensive rats
M Lassila, P Finckenberg, AK Pere, H Vapaatalo, ML Nurminen |
European Journal of Pharmacology | 2000 |
CyA and OxLDL cause endothelial dysfunction in isolated arteries through endothelin-mediated stimulation of O2− formation
J Galle, C Lehmann-Bodem, U Hübner, A Heinloth, C Wanner |
Nephrology Dialysis Transplantation | 2000 |
Textbook of Angiology
JB Chang |
2000 | |
Cyclosporine-induced coronary artery constriction—dissociation between thromboxane release and coronary vasospasm
RC Braun-Dullaeus, M Feussner, G Walker, H Hopmann, HJ Kraemer, F Grimminger, H Tillmanns, W Haberbosch |
The Journal of Heart and Lung Transplantation | 1999 |
ADRENOCORTICOTROPHIC HORMONE-INDUCED HYPERTENSION IN THE RAT: EFFECTS OF THE ENDOTHELIN ANTAGONIST BOSENTAN
TB Fraser, GJ Mangos, SW Turner, JA Whitworth |
Clinical and Experimental Pharmacology and Physiology | 1999 |
Mechanisms of cyclosporine-induced nephrotoxicity
A Ishikawa, K Suzuki, K Fujita |
Transplantation Proceedings | 1999 |
Cyclosporine-induced renal artery smooth muscle contraction is associated with increases in the phosphorylation of specific contractile regulatory proteins
A Beall, A Epstein, D Woodrum, C M Brophy |
Biochimica et Biophysica Acta | 1999 |
Dietary Glycine and Renal Denervation Prevents Cyclosporin A-Induced Hydroxyl Radical Production in Rat Kidney
Z Zhong, HD Connor, M Yin, N Moss, RP Mason, H Bunzendahl, DT Forman, RG Thurman |
Molecular pharmacology | 1999 |
Immunosuppressant-Induced Nephropathy: Pathophysiology, Incidence and Management
AJ Olyaei, AM de Mattos, WM Bennett |
Drug Safety | 1999 |
Cyclosporin-Induced Hypertension: Incidence, Pathogenesis and Management
SJ Taler, SC Textor, VJ Canzanello, L Schwartz |
Drug Safety | 1999 |
Heparin Suppresses Cyclosporine-Induced Endothelin-1 Synthesis in Rat Endothelial Cells
K Yokokawa, M Kohno, M Minami, K Yasunari, AK Mandal, J Yoshikawa |
Journal of Cardiovascular Pharmacology | 1998 |
Contribution of endothelin receptors in renal microvessels in acute cyclosporine-mediated vasoconstriction in rats
A Cavarape, K Endlich, F Feletto, N Parekh, E Bartoli, M Steinhausen |
Kidney International | 1998 |
Endothelin release by rabbit proximal tubule cells: Modulatory effects of cyclosporine A, tacrolimus, HGF and EGF
C Haug, C Grill, A Schmid-Kotsas, A Gruenert, PM Jehle |
Kidney International | 1998 |
Elevated neointimal endothelin-1 in transplantation-associated arteriosclerosis of renal allograft recipients
MS Simonson, SN Emancipator, T Knauss, DE Hricik |
Kidney International | 1998 |
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis
SE Thomas, TF Andoh, RH Pichler, SJ Shankland, WG Couser, WM Bennett, RJ Johnson |
Kidney International | 1998 |
Cyclosporine, but not FK506, selectively induces renal and coronary artery smooth muscle contraction
A Epstein, A Beall, J Wynn, L Mulloy, CM Brophy |
Surgery | 1998 |
Effect of the Endothelin Receptor Antagonist, SB 209670 on Cyclosporine-Induced Nephrotoxicity
A Ishikawa, K Suzuki, K Fujita |
Transplantation Proceedings | 1998 |
Verapamil prevents cyclosporine-induced hypertension by modulating endothelin a receptor expression in rat kidney membranes
L Giovannini, M Migliori, D Taccola, V Panichi, B Andreini, SD Pietro, C Filippi, SD Ry, MG Andreassi, MG Colombo, A Biagini, D Giannessi, R Palla |
Transplantation Proceedings | 1998 |
Renal Endothelin in FK506-Induced Nephrotoxicity in Spontaneously Hypertensive Rats
J Uchida, K Miura, S Yamanaka, S Kim, H Iwao, T Nakatani, T Kishimoto |
The Japanese Journal of Pharmacology | 1998 |
Endocrinology of Cardiovascular Function
ER Levin, JL Nadler |
1998 | |
Endothelins in the normal and diseased kidney
DE Kohan |
American Journal of Kidney Diseases | 1997 |
Acute effect of a selective endothelin-A receptor antagonist, S-0139, against cyclosporine-induced reduction in renal cortical blood flow
A Ishikawa, K Suzuki, K Fujita |
Clinical and Experimental Nephrology | 1997 |
Cyclosporine A -induced contraction of isolated rat aortic smooth muscle cells
J Medina, A Cordier, A Wolf |
Life Sciences | 1997 |
SYMPOSIUM Experimental Biology 1995 Endothelin Receptors: Role in Renal Function and Dysfunction ROLE OF ENDOTHELIN IN RENAL FUNCTION AND DYSFUNCTION
DP Brooks |
Clinical and Experimental Pharmacology and Physiology | 1996 |
Endothelin in organ transplantation
B Watschinger, MH Sayegh |
American Journal of Kidney Diseases | 1996 |
Chronic cyclosporine nephropathy: The Achilles' heel of immunosuppressive therapy
WM Bennett, A DeMattos, MM Meyer, T Andoh, JM Barry |
Kidney International | 1996 |
Localization of endothelin ETA and ETB receptor-mediated constriction in the renal microcirculation of rats
K Endlich, J Hoffend, M Steinhausen |
The Journal of Physiology | 1996 |
Effect of cyclosporin A and analogues on cytosolic calcium and vasoconstriction: possible lack of relationship to immunosuppressive activity
AL Russo, AC Passaquin, P André, M Skutella, UT Rüegg |
British Journal of Pharmacology | 1996 |
Regulation of Vascular Tone during Treatment with Cyclosporine A: Modulation of Endothelial and Vascular Smooth Muscle Function
S Götze, W Auch-Schwelk, E Duske, E Fleck |
Endothelium : journal of endothelial cell research | 1996 |
Bosentan Ameliorates Cyclosporin A–Induced Hypertension in Rats and Primates
B Bartholomeusz, KJ Hardy, AS Nelson, PA Phillips |
Hypertension | 1996 |
Chronic treatment with cyclosporine A in New Zealand rabbit: aortic and erectile tissue alterations
E Ragazzi, C Meggiato, A Chinellato, G Italiano, F Pagano, A Calabro |
Urological Research | 1996 |
Endocrinology of the Vasculature
JR Sowers |
1996 | |
Endothelin and endothelin antagonists: Potential role in cardiovascular and renal disease
G Noll, RR Wenzel, TF Lscher |
Molecular and Cellular Biochemistry | 1996 |
Increase in number of Weibel-Palade bodies and endothelin-1 release from endothelial cells in the cadmium-treated rat thoracic aorta
Y Doi, T Ozaka, H Fukushige, S Fujimoto, H Furukawa, M Yoshizuka |
Virchows Archiv | 1996 |
Cellular proliferation and macrophage influx precede interstitial fibrosis in cyclosporine nephrotoxicity
BA Young, EA Burdmann, RJ Johnson, CE Alpers, CM Giachelli, E Eng, T Andoh, WM Bennett, WG Couser, J Lindsley, J Duyn |
Kidney International | 1995 |
Cyclosporine A induced arteriolopathy in a rat model of chronic cyclosporine nephropathy
BA Young, EA Burdmann, RJ Johnson, T Andoh, WM Bennett, WG Couser, CE Alpers |
Kidney International | 1995 |
Regional differences in vasculotoxic effects of cyclosporin in rats
M Verbeke, L Ridder, JV de Voorde, N Lameire |
Canadian Journal of Physiology and Pharmacology | 1995 |
Characterization of endothelin receptor subtypes in isolated rat renal preglomerular microvessels
HD León, R Garcia |
Regulatory Peptides | 1995 |
Cardiac natriuretic peptides inhibit cyclosporine-induced production of endothelin in cultured rat mesangial cells
M Kohno, K Yokokawa, AK Mandal, T Horio, K Yasunari, T Takeda |
Metabolism | 1995 |
Signal sorting by G-protein-linked receptors
G Milligan |
Advances in pharmacology (San Diego, Calif.) | 1995 |
Prevention of cyclosporine A-induced renal vasoconstriction by the endothelin receptor antagonist SB 209670
DP Brooks, LC Contino |
European Journal of Pharmacology | 1995 |
Effects of an Endothelin Receptor Antagonist in Rats With Cyclosporine-Induced Hypertension
Y Takeda, I Miyamori, P Wu, T Yoneda, K Furukawa, R Takeda |
Hypertension | 1995 |
BQ-123, A Selective Endothelin ETAReceptor Antagonist
S Moreland |
Cardiovascular Drug Reviews | 1994 |
Divergent expression of EtA and EtB receptors in response to cyclosporine in mesangial cells
M Takeda, S Iwasaki, SE Hellings, H Yoshida, T Homma, V Kon |
The American Journal of Pathology | 1994 |
Role of endothelin in hypertension
BK Krämer, M Ackermann, SM Kohler, GA Riegger |
Journal of Molecular Medicine | 1994 |
Endothelins: A Potential Target for Pharmacological Intervention in Diseases of the Elderly
H Lévesque, N Moore, N Cailleux, V Richard, C Thuillez, H Courtois |
Drugs & Aging | 1994 |
Endothelins
AM Vollmar |
Journal of Veterinary Medicine Series A | 1992 |
Cyclosporine nephrotoxicity
BD Myers |
Kidney International | 1986 |