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Citations to this article

Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms.
K Brand, … , N Mackman, L K Curtiss
K Brand, … , N Mackman, L K Curtiss
Published May 1, 1993
Citation Information: J Clin Invest. 1993;91(5):2031-2039. https://doi.org/10.1172/JCI116425.
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Research Article

Interferon-gamma inhibits macrophage apolipoprotein E production by posttranslational mechanisms.

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Abstract

Macrophage-derived apolipoprotein (apo) E and multimers of a synthetic apo E-peptide display monokine-like functions by inhibiting mitogen- or antigen-driven lymphocyte proliferation. This study demonstrated how the target lymphocyte itself can modulate macrophage apo E production. The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation. A similar effect was observed when IFN was added to differentiated THP-1 cells. Treatment with IFN did not change the steady-state levels of apo E mRNA. Furthermore, in the presence of IFN no increased degradation or increased uptake of extracellular apo E was detected. Pulse-chase experiments indicated that IFN reduced the accumulation of extracellular apo E and increased the degradation of intracellular apo E. The inhibitory effect of IFN on apo E production also was observed in human monocyte-derived macrophages. Thus, our data demonstrated that IFN inhibited macrophage apo E production by posttranslational mechanisms. This represents a previously uncharacterized immunoregulatory interaction and lends further support to a relationship between lipid metabolism and the immune system.

Authors

K Brand, N Mackman, L K Curtiss

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 Total
Citations: 1 1 2 2 1 2 4 1 2 1 6 1 3 1 1 1 5 2 3 5 3 4 4 2 4 1 2 2 2 69
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