Inhibition of colorectal cancer metastases to the liver by ANGIOZYME. The number of metastases to the liver 41 days after intrasplenic inoculation of KM12L4a cells is shown. ANGIOZYME was administered by continuous s.c. infusion for 28 days starting on day 3 after inoculation. Details are described in ref. 12. AP < 0.05.