Go to
JCI Insight
Citations to this article
R I Sperling, … , K F Austen, D R Robinson
Published February 1, 1993
Citation Information: J Clin Invest. 1993;91(2):651-660. https://doi.org/10.1172/JCI116245.
Citation Information: J Clin Invest. 1993;91(2):651-660. https://doi.org/10.1172/JCI116245.
Abstract
Earlier studies demonstrated that dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation attenuates the chemotactic response of neutrophils and the generation of leukotriene (LT) B4 by neutrophils stimulated with calcium ionophore; however, the mechanisms and relationship of these effects were not examined. Neutrophils and monocytes from eight healthy individuals were examined before and after 3 and 10 wk of dietary supplementation with 20 g SuperEPA daily, which provides 9.4 g eicosapentaenoic acid (EPA) and 5 g docosahexaenoic acid. The maximal neutrophil chemotactic response to LTB4, assessed in Boyden microchambers, decreased by 69% after 3 wk and by 93% after 10 wk from prediet values. The formation of [3H]inositol tris-phosphate (IP3) by [3H]inositol-labeled neutrophils stimulated by LTB4 decreased by 71% after 3 wk (0.033 +/- 0.013% [3H] release, mean +/- SEM) and by 90% after 10 wk (0.011 +/- 0.011%) from predict values (0.114 +/- 0.030%) as quantitated by beta-scintillation counting after resolution on HPLC. LTB4-stimulated neutrophil chemotaxis and IP3 formation correlated significantly (P < 0.0001); each response correlated closely and negatively with the EPA content of the neutrophil phosphatidylinositol (PI) pool (P = 0.0003 and P = 0.0005, respectively). Neither the affinities and densities of the high and low affinity LTB4 receptors on neutrophils nor LTB4-mediated diglyceride formation changed appreciably during the study. Similar results were observed in neutrophils activated with platelet-activating factor (PAF). The summed formation of LTB4 plus LTB5 was selectively inhibited in calcium ionophore-stimulated neutrophils and was also inhibited in zymosan-stimulated neutrophils. The inhibition of the summed formation of LTB4 plus LTB5 in calcium ionophore-stimulated neutrophils and in zymosan-stimulated neutrophils did not correlate significantly with the EPA content of the PI pool. The data indicate that dietary omega-3 PUFA supplementation inhibits the autoamplification of the neutrophil inflammatory response by decreasing LTB4 formation through the inactivation of the LTA epoxide hydrolase and independently by inhibiting LTB4- (and PAF) stimulated chemotaxis by attenuating the formation of IP3 by the PI-selective phospholipase C. This is the initial demonstration that dietary omega-3 PUFA supplementation can suppress signal transduction at the level of the PI-specific phospholipase C in humans.
Authors
R I Sperling, A I Benincaso, C T Knoell, J K Larkin, K F Austen, D R Robinson
Total citations by year
Citation information
Citations to this article (255)
| Title and authors | Publication | Year |
|---|---|---|
|
Interplay of n-3 Polyunsaturated Fatty Acids, Intestinal Inflammation, and Gut Microbiota in Celiac Disease Pathogenesis
Bascuñán KA, Araya M, Rodríguez JM, Roncoroni L, Elli L, Alvarez JD, Valenzuela R |
Nutrients | 2025 |
|
Immunomodulatory Effects of Omega-3 Fatty Acids: Mechanistic Insights and Health Implications.
Bodur M, Yilmaz B, Ağagündüz D, Ozogul Y |
Molecular nutrition & food research | 2025 |
|
Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation.
Jin X, Tang J, Qiu X, Nie X, Ou S, Wu G, Zhang R, Zhu J |
Cell Death Discovery | 2024 |
|
The Protective Role of Interleukin-37 in Cardiovascular Diseases through Ferroptosis Modulation
Cruz-Gregorio A, Amezcua-Guerra LM, Fisher-Bautista B, Romero-Beltrán A, Fonseca-Camarillo G |
International Journal of Molecular Sciences | 2024 |
|
Characteristic alterations of gut microbiota and serum metabolites in patients with chronic tinnitus: a multi-omics analysis
Wang J, Xiang JH, Peng XY, Liu M, Sun LJ, Zhang M, Zhang LY, Chen ZB, Tang ZQ, Cheng L |
Microbiology Spectrum | 2024 |
|
Biomarkers identification in follicular fluid of women with OHSS by using UPLC-MS method.
Wu Z, Fang L, Liu B, Jia Q, Cheng JC, Sun YP |
Frontiers in Endocrinology | 2023 |
|
A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus
He K, Zhou X, Du H, Zhao J, Deng R, Wang J |
PeerJ | 2023 |
|
Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review
EA Miles, CE Childs, PC Calder |
Nutrients | 2021 |
|
Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer’s disease
SE Desale, S Chinnathambi |
Cell Communication and Signaling | 2021 |
|
Effects of Omega-3 Fatty Acid on Endotoxin-induced Acute Lung Injury in Rabbits
EA Jang, SK Son, JH Kang, S Lee, SH Kwak |
Biomedical Science Letters | 2021 |
|
Carotenoids content and lipid nutritional quality variation in tissues of male and female polymorphic (golden and brown) noble scallops Chlamys nobilis
T Karsoon, L Helu, Z Hongkuan, L Shengkang, M Hongyu, Z Huaiping |
Aquaculture | 2021 |
|
Mobilization efficiency is critically regulated by fat via marrow PPARδ
T Suzuki, S Ishii, M Shinohara, Y Kawano, K Wakahashi, H Kawano, A Sada, K Minagawa, M Hamada, S Takahashi, T Furuyashiki, NS Tan, T Matsui, Y Katayama |
Haematologica | 2020 |
|
Marine-Derived Biologically Active Compounds for the Potential Treatment of Rheumatoid Arthritis
M Bilal, M Qindeel, LV Nunes, MT Duarte, LF Ferreira, RN Soriano, HM Iqbal |
Marine drugs | 2020 |
|
Lipidmediatoren und ihre Rolle bei Entzündungen und Allergien
Stockert K |
2020 | |
|
Role of diet in regulating the gut microbiota and multiple sclerosis
JM Sanchez, AB DePaula-Silva, JE Libbey, RS Fujinami |
Clinical Immunology | 2020 |
|
Allergieprävention: Moderne Strategien der Allergieforschung im Dialog mit der TCM
K Stockert |
2020 | |
|
The emerging role of ferroptosis in inflammation
Y Sun, P Chen, B Zhai, M Zhang, Y Xiang, J Fang, S Xu, Y Gao, X Chen, X Sui, G Li |
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie | 2020 |
|
Fatty acids of human milk – a review
R Bobiński, J Bobińska |
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition | 2020 |
|
Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder
A Kumar, T Behl, S Jamwal, I Kaur, A Sood, P Kumar |
Molecular Biology Reports | 2020 |
|
Impact of omega-3 fatty acid oral therapy on healing of chronic venous leg ulcers in older adults: Study protocol for a randomized controlled single-center trial
JC McDaniel, J Rausch, A Tan |
Trials | 2020 |
|
The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin
A Vijayan, LV Maele, D Fougeron, D Cayet, JC Sirard |
Journal of immunology (Baltimore, Md. : 1950) | 2020 |
|
The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin
A Vijayan, LV Maele, D Fougeron, D Cayet, JC Sirard |
Journal of immunology (Baltimore, Md. : 1950) | 2020 |
|
Selection breeding program of Nan'ao Golden Scallop Chlamys nobilis with higher nutritional values and less susceptible to stress
K Tan, H Zhang, L Lim, H Zheng |
Aquaculture | 2020 |
|
The Importance of Maintaining a Low Omega-6/Omega-3 Ratio for Reducing the Risk of Inflammatory Cytokine Storms
James J DiNicolantonio, James O'Keefe |
Missouri Medicine | 2020 |
|
Mechanisms for Reducing Neuropathic Pain
DP Kuffler |
Molecular Neurobiology | 2019 |
|
Insights into the cardioprotective properties of n-3 PUFAs against ischemic heart disease via modulation of the innate immune system
AM Darwesh, DK Sosnowski, TY Lee, H Keshavarz-Bahaghighat, JM Seubert |
Chemico-Biological Interactions | 2019 |
|
Dietary Fatty Acids and Host–Microbial Crosstalk in Neonatal Enteric Infection
C Quin, DL Gibson |
Nutrients | 2019 |
|
Amaranth ( Amaranthus cruentus L.) and canola ( Brassica napus L.) oil impact on the oxidative metabolism of neutrophils in the obese patients*
D Kanikowska, A Kanikowska, R Rutkowski, M Włochal, Z Orzechowska, A Juchacz, A Zawada, M Grzymisławski, M Roszak, M Sato, A Bręborowicz, J Witowski |
Pharmaceutical Biology | 2019 |
|
The effect of adjunctive nutraceuticals in bipolar disorder: A systematic review of randomized placebo-controlled trials
L Fusar-Poli, T Surace, A Vanella, V Meo, F Patania, R Furnari, MS Signorelli, E Aguglia |
Journal of Affective Disorders | 2019 |
|
Arachidonic Acid Metabolism and Kidney Inflammation
T Wang, X Fu, Q Chen, JK Patra, D Wang, Z Wang, Z Gai |
International journal of molecular sciences | 2019 |
|
The effects of omega-3 fatty acids on the newborn rat hyperoxic lung injury
M Kul, E Gönül, AB Akcan, Z Küçükodacı, S Süleymanoğlu |
Journal of Maternal-Fetal and Neonatal Medicine | 2019 |
|
Lipidomic methodologies for biomarkers of chronic inflammation in nutritional research: ω-3 and ω-6 lipid mediators
G Dasilva, I Medina |
Free radical biology & medicine | 2019 |
|
Anti-inflammatory and Immunomodulatory Effects of Marine n-3 Polyunsaturated Fatty Acids on Human Health and Diseases
Y Zhang, J Min, L Zhang |
Journal of Ocean University of China | 2019 |
|
Altered immune system in frailty: Genetics and diet may influence inflammation
O Pansarasa, C Pistono, A Davin, M Bordoni, MC Mimmi, A Guaita, C Cereda |
Ageing Research Reviews | 2019 |
|
Omega-6 fatty acids and inflammation
JK Innes, PC Calder |
Prostaglandins, leukotrienes, and essential fatty acids | 2018 |
|
Omega-3 polyunsaturated fatty acids exert anti-oxidant effects through the nuclear factor (erythroid-derived 2)-related factor 2 pathway in immortalized mouse Schwann cells
Y Tatsumi, A Kato, K Sango, T Himeno, M Kondo, Y Kato, H Kamiya, J Nakamura, K Kato |
Journal of Diabetes Investigation | 2018 |
|
Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology
S Layé, A Nadjar, C Joffre, RP Bazinet, R Dantzer |
Pharmacological reviews | 2017 |
|
Kelley and Firestein's Textbook of Rheumatology
PE di Cesare, DR Haudenschild, J Samuels, SB Abramson |
Kelley and Firestein's Textbook of Rheumatology | 2017 |
|
Lupus
WA Khan |
Lupus | 2017 |
|
The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives
E Scaioli, E Liverani, A Belluzzi |
International journal of molecular sciences | 2017 |
|
Nutrition, Immunity, and Infection
PC Calder, AD Kulkarni |
Nutrition, Immunity, and Infection | 2017 |
|
Review of Cardiometabolic Effects of Prescription Omega-3 Fatty Acids
MF Burke, FM Burke, DE Soffer |
Current Atherosclerosis Reports | 2017 |
|
Dietary supplementation with low-dose omega-3 fatty acids reduces salivary tumor necrosis factor-α levels in patients with chronic periodontitis: a randomized controlled clinical study
I Keskiner, I Saygun, V Bal, M Serdar, A Kantarci |
Journal of Periodontal Research | 2017 |
|
Effect of Nutritional Supplementation Enriched with Eicosapentaenoic Acid on Inflammatory Profile of Patients With Oral Cavity Cancer in Antineoplastic Pretreatment: A Controlled and Randomized Clinical Trial
TC Carvalho, BC Cruz, MS Viana, RB Martucci, DC Saraiva, PF Reis |
Nutrition and Cancer | 2017 |
|
EPA + DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double-blind, controlled study: EPA+DHA supplementation reduces PMN activation
JC McDaniel, L Szalacha, M Sales, S Roy, S Chafee, N Parinandi |
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society | 2017 |
|
Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid: Immunosenescence in obese mice is reversed by 2-hydroxyoleic acid
A Gheorghe, FP de Heredia, C Hunsche, N Redondo, LE Díaz, O Hernández, A Marcos, MD la Fuente |
Experimental Physiology | 2017 |
|
The Thermodynamic Overlapping pKa of the Antitumor Drug Ibrutinib Using Multiwavelength UV/VIS-Spectroscopy and Potentiometry
M Meloun |
2017 | |
|
EPA + DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double-blind, controlled study.
McDaniel JC, Szalacha L, Sales M, Roy S, Chafee S, Parinandi N |
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society | 2017 |
|
Omega-3 Fatty Acids and Mood Stabilizers Alter Behavioural and Energy Metabolism Parameters in Animals Subjected to an Animal Model of Mania Induced by Fenproporex
K Cancelier, LM Gomes, M Carvalho-Silva, LJ Teixeira, J Rebelo, IT Mota, CO Arent, E Mariot, LW Kist, MR Bogo, J Quevedo, G Scaini, EL Streck |
Molecular Neurobiology | 2016 |
|
The impact of an omega-3 fatty acid rich lipid emulsion on fatty acid profiles in critically ill septic patients
TC Hall, DK Bilku, CP Neal, J Cooke, HL Fisk, PC Calder, AR Dennison |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2016 |
|
The delta 6 desaturase knock out mouse reveals that immunomodulatory effects of essential n-6 and n-3 polyunsaturated fatty acids are both independent of and dependent upon conversion
JM Monk, DM Liddle, DJ Cohen, DH Tsang, LM Hillyer, SA Abdelmagid, MT Nakamura, KA Power, DW Ma, LE Robinson |
The Journal of Nutritional Biochemistry | 2016 |
|
Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials
J Jiang, K Li, F Wang, B Yang, Y Fu, J Zheng, D Li, AP Sampson |
PloS one | 2016 |
|
Lipophilic index, kidney function, and kidney function decline
H Xu, J Ärnlöv, B Sandhagen, U Risérus, B Lindholm, L Lind, JJ Carrero |
Nutrition, Metabolism and Cardiovascular Diseases | 2016 |
|
Rosuvastatin, lycopene and omega-3 fatty acids: A potential treatment for systemic inflammation in COPD; a pilot study
EJ Williams, KJ Baines, JM Smart, PG Gibson, LG Wood |
Journal of Nutrition & Intermediary Metabolism | 2016 |
|
Variation in fatty acids throughout the developmental stages of Vigna unguiculata (L.) Walp. leaves
U Malik, A Karmakar, A Barik |
Botany Letters | 2016 |
|
Potential Role of Omega n-3 Polyunsaturated Fatty Acids and Its Use in Rheumatoid Arthritis
, |
2016 | |
|
Fish Oil and Adjuvant-Induced Arthritis: Inhibitory Effect on Leukocyte Recruitment
CF Estevão-Silva, FQ Ames, FM de Silva-Comar, R Kummer, RP Tronco, RK Cuman, CA Bersani-Amado |
Inflammation | 2015 |
|
Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial
M Hecker, T Linder, J Ott, HD Walmrath, J Lohmeyer, I Vadász, LM Marsh, S Herold, M Reichert, A Buchbinder, RE Morty, B Bausch, T Fischer, R Schulz, F Grimminger, M Witzenrath, M Barnes, W Seeger, K Mayer |
Critical Care | 2015 |
|
Membrane fatty acid heterogeneity of leukocyte classes is altered during in vitro cultivation but can be restored with ad-hoc lipid supplementation
P Poggi, R Mirabella, S Neri, E Assirelli, P Dolzani, E Mariani, PC Calder, A Chatgilialoglu |
Lipids in Health and Disease | 2015 |
|
Antagonizing arachidonic Acid-derived eicosanoids reduces inflammatory th17 and Th1 cell-mediated inflammation and colitis severity
JM Monk, HF Turk, YY Fan, E Callaway, B Weeks, P Yang, DN McMurray, RS Chapkin |
Mediators of Inflammation | 2014 |
|
The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A 2 via GPR120 receptor to produce prostaglandin E 2 and plays an anti-inflammatory role in macrophages
Y Liu, LY Chen, M Sokolowska, M Eberlein, S Alsaaty, A Martinez-Anton, C Logun, HY Qi, JH Shelhamer |
Immunology | 2014 |
|
Handbook of Nutrition, Diet and the Eye
W Abbott-Johnson, P Kerlin |
Handbook of Nutrition, Diet and the Eye | 2014 |
|
Food Allergy: Adverse Reactions to Foods and Food Additives
S Agarwal, L Mayer |
Food Allergy: Adverse Reactions to Foods and Food Additives | 2014 |
|
Omega-3 Fatty Acids: A Growing Ocean of Choices
H Fares, CJ Lavie, JJ DiNicolantonio, JH O’Keefe, RV Milani |
Current Atherosclerosis Reports | 2014 |
|
Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease
CM Yates, PC Calder, GE Rainger |
Pharmacology & Therapeutics | 2014 |
|
Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome
M Hecker, J Ott, C Sondermann, M Schaefer, M Obert, A Hecker, RE Morty, I Vadasz, S Herold, B Rosengarten, M Witzenrath, W Seeger, K Mayer |
Critical Care | 2014 |
|
Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance
PC Calder |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2014 |
|
Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: A randomized, controlled study
M Doi, K Nosaka, T Miyoshi, M Iwamoto, M Kajiya, K Okawa, R Nakayama, W Takagi, K Takeda, S Hirohata, H Ito |
International Journal of Cardiology | 2014 |
|
Effect of conjugated linoleic acid mixture supplemented daily after carcinogen application on linoleic and arachidonic acid metabolites in rat serum and induced tumours
M Jelińska, A Białek, H Mojska, I Gielecińska, A Tokarz |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2014 |
|
Very long chain omega-3 (n-3) fatty acids and human health: Omega-3 fatty acids and health
PC Calder |
European Journal of Lipid Science and Technology | 2014 |
|
Omega-3s and cardiovascular health
James J DiNicolantonio, Asfandyar K Niazi, Mark F McCarty, James H O'Keefe, Pascal Meier, Carl J Lavie |
The Ochsner journal | 2014 |
|
Pharma-Nutrition
G Folkerts, J Garssen |
2014 | |
|
Omega-3 Fatty Acids: A Growing Ocean of Choices
H Fares, CJ Lavie, JJ DiNicolantonio, JH OKeefe, RV Milani |
Current Atherosclerosis Reports | 2014 |
|
Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
PC Calder |
British Journal of Clinical Pharmacology | 2013 |
|
The Multifaceted Effects of Omega-3 Polyunsaturated Fatty Acids on the Hallmarks of Cancer
JA Stephenson, O Al-Taan, A Arshad, B Morgan, MS Metcalfe, AR Dennison |
Journal of Lipids | 2013 |
|
Nutrient-Based Therapies for Bipolar Disorder: A Systematic Review
LG Sylvia, AT Peters, T Deckersbach, AA Nierenberg |
Psychotherapy and Psychosomatics | 2013 |
|
Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease
R Sharma, RK Tandon |
Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease | 2013 |
|
Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases
A Sabetisoofyani |
Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases | 2013 |
|
n-3 Fatty acids, inflammation and immunity: new mechanisms to explain old actions
PC Calder |
Proceedings of the Nutrition Society | 2013 |
|
The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal
CJ Ade, SK Rosenkranz, CA Harms |
European Journal of Applied Physiology | 2013 |
|
Diet, Immunity and Inflammation
SR Kuvibidila, SB Baliga, LC Chandra, CL French |
Diet, Immunity and Inflammation | 2013 |
|
REVIEW OF NUTRITIONAL SUPPLEMENTS FOR THE TREATMENT OF BIPOLAR DEPRESSION: Bipolar Depression and Nutritional Supplements
JJ Rakofsky, BW Dunlop |
Depression and Anxiety | 2013 |
|
Dietary modulation of the inflammatory cascade: Dietary modulation of the inflammatory cascade
DR Dawson, G Branch-Mays, OA Gonzalez, JL Ebersole |
Periodontology 2000 | 2013 |
|
Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?: Omega-3 fatty acids and inflammation
PC Calder |
British Journal of Clinical Pharmacology | 2013 |
|
Plasma Phospholipid Fatty Acid and Ex Vivo Neutrophil Responses are Differentially Altered in Dogs Fed Fish- and Linseed-Oil Containing Diets at the Same n-6:n-3 Fatty Acid Ratio
MK Waldron, SS Hannah, JE Bauer |
Lipids | 2012 |
|
Can enhanced recovery programmes be further improved by the addition of omega three fatty acids?
DK Bilku, TC Hall, D Al-Leswas, AR Dennison |
Irish Journal of Medical Science | 2012 |
|
Advances in Food and Nutrition Research
N Siriwardhana, NS Kalupahana, N Moustaid-Moussa |
Marine Medicinal Foods - Implications and Applications - Animals and Microbes | 2012 |
|
Long-chain fatty acids and inflammation
PC Calder |
Proceedings of the Nutrition Society | 2012 |
|
Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat : n-3 PUFAs and inflammation following SCI
JC Hall, JV Priestley, VH Perry, AT Michael-Titus |
Journal of Neurochemistry | 2012 |
|
Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis
EA Miles, PC Calder |
British Journal of Nutrition | 2012 |
|
Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions
J Noel, S Chatterjee |
Chronic Inflammation: Molecular Pathophysiology, Nutritional and Therapeutic Interventions | 2012 |
|
Omega-3 and Menopause
TH Kim, DW Byun, Y Park |
The Journal of Korean Society of Menopause | 2012 |
|
Polyunsaturated fatty acids and their metabolites in the pathobiology of schizophrenia
UN Das |
Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2012 |
|
Comparative Effects of Sandalwood Seed Oil on Fatty Acid Profiles and Inflammatory Factors in Rats
G Li, A Singh, Y Liu, B Sunderland, D Li |
Lipids | 2012 |
|
The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability
PC Calder |
Molecular Nutrition & Food Research | 2012 |
|
Bioactive Fatty Acids Reduce Development of Gastric Cancer Following Duodenogastric Reflux in Rats
BJ Christensen, K Berge, H Wergedahl, P Bohov, RK Berge, E Svendsen, A Viste |
Surgical Science | 2012 |
|
Fatty acids and inflammation: The cutting edge between food and pharma
PC Calder |
European Journal of Pharmacology | 2011 |
|
Fish Oil Supplementation Improves Neutrophil Function During Cancer Chemotherapy
SJ Bonatto, HH Oliveira, EA Nunes, D Pequito, F Iagher, I Coelho, K Naliwaiko, M Kryczyk, GA Brito, J Repka, LV Sabóia, G Fukujima, PC Calder, LC Fernandes |
Lipids | 2011 |
|
Omega-3 Fatty Acids and Cardiovascular Disease
D Mozaffarian, JH Wu |
Journal of the American College of Cardiology | 2011 |
|
n-3 polyunsaturated fatty acids prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model
Z Zhang, C Zhang, H Wang, J Zhao, L Liu, J Lee, Y He, Q Zheng |
International Journal of Cardiology | 2011 |
|
EFFECT OF FISH OIL ON LEVELS OF R- AND S-ENANTIOMERS OF 5-, 12- AND 15-HYDROXYEICOSATETRAENOIC ACIDS IN MOUSE COLONIC MUCOSA
AP Neilson, J Ren, YH Hong, A Sen, WL Smith, DE Brenner, Z Djuric |
Nutrition and Cancer | 2011 |
|
Nutrition Modulation of Gastrointestinal Toxicity Related to Cancer Chemotherapy: From Preclinical Findings to Clinical Strategy
H Xue, MB Sawyer, PE Wischmeyer, VE Baracos |
JPEN. Journal of parenteral and enteral nutrition | 2011 |
|
Essential Fatty Acids and Psychiatric Disorders
MM Perica, I Delaš |
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition | 2011 |
|
(n-3) Long-Chain PUFA Differentially Affect Resistance to Pseudomonas aeruginosa Infection of Male and Female cftr–/– Mice
H Tiesset, H Bernard, N Bartke, C Beermann, E Flachaire, JL Desseyn, F Gottrand, MO Husson |
The Journal of nutrition | 2011 |
|
Molecular Basis of Health and Disease
UN Das |
2011 | |
|
Omega-3 Fatty Acids and Inflammatory Processes
PC Calder |
Nutrients | 2010 |
|
Dietary DHA: time course of tissue uptake and effects on cytokine secretion in mice
J Lefils, A Géloën, H Vidal, M Lagarde, N Bernoud-Hubac |
British Journal of Nutrition | 2010 |
|
Marine omega-3 fatty acids and inflammation
P Calder |
Journal of Lipid Nutrition | 2010 |
|
The 2008 ESPEN Sir David Cuthbertson lecture: Fatty acids and inflammation – From the membrane to the nucleus and from the laboratory bench to the clinic
PC Calder |
Clinical Nutrition | 2010 |
|
The effects of dietary fish oil on inflammation, fibrosis and oxidative stress associated with obstructive renal injury in rats
JM Peake, GC Gobe, RG Fassett, JS Coombes |
Molecular Nutrition & Food Research | 2010 |
|
Omega-3 Polyunsaturated Fatty Acids in the Treatment of Kidney Disease
RG Fassett, GC Gobe, JM Peake, JS Coombes |
American Journal of Kidney Diseases | 2010 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
|
Long-chain n-3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease
B Roos, Y Mavrommatis, IA Brouwer |
British Journal of Pharmacology | 2009 |
|
Dietary supplementation of omega-3 fatty acid-containing fish oil suppresses F2-isoprostanes but enhances inflammatory cytokine response in a mouse model of ovalbumin-induced allergic lung inflammation
H Yin, W Liu, K Goleniewska, NA Porter, JD Morrow, RS Peebles |
Free radical biology & medicine | 2009 |
|
Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study
R Farzaneh-Far, WS Harris, S Garg, B Na, MA Whooley |
Atherosclerosis | 2009 |
|
Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids
K Mayer, A Kiessling, J Ott, MB Schaefer, M Hecker, I Henneke, R Schulz, A Günther, J Wang, L Wu, J Roth, W Seeger, JX Kang |
American journal of respiratory and critical care medicine | 2009 |
|
Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale
PC Calder |
Biochimie | 2009 |
|
Fatty Acids and Immune Function: Relevance to Inflammatory Bowel Diseases
PC Calder |
International Reviews of Immunology | 2009 |
|
Early Inhibition of Prostaglandin Synthesis by n-3 Fatty Acids Determinates Histologic Severity of Necrotizing Pancreatitis
M Kilian, JI Gregor, I Heukamp, C Wagner, MK Walz, I Schimke, G Kristiansen, FA Wenger |
Pancreas | 2009 |
|
Fortification of reduced-fat Cheddar cheese with n-3 fatty acids: Effect on off-flavor generation
S Martini, JE Thurgood, C Brothersen, R Ward, DJ McMahon |
Journal of Dairy Science | 2009 |
|
Kelley's Textbook of Rheumatology
J Degroot, AM Zuurmond, PP Tak |
Kelley's Textbook of Rheumatology | 2009 |
|
Membrane Omega-3 Fatty Acid Deficiency as a Preventable Risk Factor for Comorbid Coronary Heart Disease in Major Depressive Disorder
RK McNamara |
Cardiovascular Psychiatry and Neurology | 2009 |
|
Using Parenteral Fish Oil to Modulate Inflammatory Response
A Pontes-Arruda |
JPEN. Journal of parenteral and enteral nutrition | 2009 |
|
Intensive Care Medicine
JL Vincent |
Intensive Care Medicine | 2009 |
|
Dietary Omega-3 Polyunsaturated Fatty Acids and Cancer
G Calviello, S Serini |
2009 | |
|
Differential Effects of Arachidonic and Eicosapentaenoic Acid-Derived Eicosanoids on Polymorphonuclear Transmigration Across Endothelial Cell Cultures
JJ Moreno |
The Journal of pharmacology and experimental therapeutics | 2009 |
|
Omega-3 Fatty Acids and PPARgamma in Cancer
IJ Edwards, JT O'Flaherty |
PPAR Research | 2008 |
|
Modern Nutrition
K LaPoint, M McIntosh |
Handbook of Nutrition in the Aged, Fourth Edition | 2008 |
|
Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets
M Dona, G Fredman, JM Schwab, N Chiang, M Arita, A Goodarzi, G Cheng, UH von Andrian, CN Serhan |
Blood | 2008 |
|
Leukocyte numbers and function in subjects eating n-3 enriched foods: selective depression of natural killer cell levels
VR Mukaro, M Costabile, KJ Murphy, CS Hii, PR Howe, A Ferrante |
Arthritis Research & Therapy | 2008 |
|
Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers
F Stanke-Labesque, P Molière, J Bessard, M Laville, E Véricel, M Lagarde |
British Journal of Nutrition | 2008 |
|
The relationship between the fatty acid composition of immune cells and their function
PC Calder |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2008 |
|
The opposing effects of n−3 and n−6 fatty acids
G Schmitz, J Ecker |
Progress in Lipid Research | 2008 |
|
Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
PC Calder |
Molecular Nutrition & Food Research | 2008 |
|
Fatty acids differentially influence phosphatidylinositol 3-kinase signal transduction in endothelial cells: Impact on adhesion and apoptosis
MB Schaefer, A Wenzel, T Fischer, RC Braun-Dullaeus, F Renner, H Dietrich, CA Schaefer, W Seeger, K Mayer |
Atherosclerosis | 2008 |
|
Perinatal n-3 fatty acid deficiency selectively reduces myo -inositol levels in the adult rat PFC: an in vivo 1 H-MRS study
RK McNamara, J Able, R Jandacek, T Rider, P Tso, DM Lindquist |
Journal of lipid research | 2008 |
|
Food Science and Technology
M Vemuri, D Kelley |
Fatty Acids in Foods and their Health Implications,Third Edition | 2007 |
|
Optimizing Women's Health through Nutrition
T Wolever, J Vogt |
Optimizing Women's Health through Nutrition | 2007 |
|
Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease
JW Sijben, PC Calder |
Proceedings of the Nutrition Society | 2007 |
|
n-3 Polyunsaturated Fatty Acids and Atopy in Korean Preschoolers
I Hwang, A Cha, H Lee, H Yoon, T Yoon, B Cho, S Lee, Y Park |
Lipids | 2007 |
|
Immunomodulation by n-3- versus n-6-rich lipid emulsions in murine acute lung injury???Role of platelet-activating factor receptor
MB Schaefer, J Ott, A Mohr, MH Bi, A Grosz, N Weissmann, S Ishii, F Grimminger, W Seeger, K Mayer |
Critical Care Medicine | 2007 |
|
Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview
M Mazza, M Pomponi, L Janiri, P Bria, S Mazza |
Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2007 |
|
Immunomodulation by omega-3 fatty acids
PC Calder |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2007 |
|
Anticonvulsant efficacy of valproate-like carboxylic acids: a potential target for anti-bipolar therapy
AN Azab, ML Greenberg |
Bipolar Disorders | 2007 |
|
Traité de nutrition artificielle de l’adulte
N Cano, D Barnoud, SM Schneider, MP Vasson, M Hasselmann, X Leverve |
2007 | |
|
Modulation of phosphoinositide–protein kinase C signal transduction by omega-3 fatty acids: Implications for the pathophysiology and treatment of recurrent neuropsychiatric illness
RK McNamara, M Ostrander, W Abplanalp, NM Richtand, SC Benoit, DJ Clegg |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2006 |
|
Polyunsaturated fatty acids and inflammation
PC Calder |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2006 |
|
Omega-3 fatty acids in bipolar disorder: Clinical and research considerations
LB Marangell, T Suppes, TA Ketter, EB Dennehy, H Zboyan, B Kertz, A Nierenberg, J Calabrese, SR Wisniewski, G Sachs |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2006 |
|
Biological effects of a dietary omega-3 polyunsaturated fatty acids supplementation in cystic fibrosis patients: A randomized, crossover placebo-controlled trial
A Panchaud, A Sauty, Y Kernen, LA Decosterd, T Buclin, O Boulat, C Hug, M Pilet, M Roulet |
Clinical Nutrition | 2006 |
|
Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function
R Gorjão, R Verlengia, TM de Lima, FG Soriano, MF Boaventura, CC Kanunfre, CM Peres, SC Sampaio, R Otton, A Folador, EF Martins, TC Curi, ÉP Portiolli, P Newsholme, R Curi |
Clinical Nutrition | 2006 |
|
Fish oil in the critically ill: from experimental to clinical data
K Mayer, MB Schaefer, W Seeger |
Current Opinion in Clinical Nutrition and Metabolic Care | 2006 |
|
Lipid connection to bipolar disorder
AN Azab, ML Greenberg |
Future Neurology | 2006 |
|
Efectos antitrombóticos y antiinflamatorios de los ácidos grasos omega-3
AL Farré, C Macaya |
Revista Española de Cardiología Suplementos | 2006 |
|
Long-chain polyunsaturated fatty acids and inflammation
PC Calder |
Scandinavian Journal of Food & Nutrition | 2006 |
|
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
PC Calder |
The American journal of clinical nutrition | 2006 |
|
Use of fish oil in parenteral nutrition: rationale and reality
PC Calder |
Proceedings of the Nutrition Society | 2006 |
|
Bailey's Industrial Oil and Fat Products
AB Christophe |
Bailey's Industrial Oil and Fat Products | 2005 |
|
The impact of long-chain n-3 polyunsaturated fatty acids on human health
CH Ruxton, PC Calder, SC Reed, MJ Simpson |
Nutrition Research Reviews | 2005 |
|
A validated liquid chromatography–mass spectrometry method for the determination of leukotrienes B4 and B5 produced by stimulated human polymorphonuclear leukocytes
A Panchaud, L Avois, M Roulet, M Pilet, C Hug, M Saugy, LA Decosterd |
Analytical Biochemistry | 2005 |
|
Mucosal Immunology
WR Brown |
Mucosal Immunology | 2005 |
|
Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Markers in COPD
W Matsuyama, H Mitsuyama, M Watanabe, K Oonakahara, I Higashimoto, M Osame, K Arimura |
Chest | 2005 |
|
n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients
PC Calder |
Lipids | 2004 |
|
Functional foods, ageing and degenerative disease
L Ovesen |
Functional foods, ageing and degenerative disease | 2004 |
|
Role of protein kinase C and NF-kappaB in proteolysis-inducing factor-induced proteasome expression in C(2)C(12) myotubes
HJ Smith, SM Wyke, MJ Tisdale |
British Journal of Cancer | 2004 |
|
Fatty acids and the immune system: from basic science to clinical applications
P Yaqoob |
Proceedings of the Nutrition Society | 2004 |
|
n-3 Polyunsaturated fatty acids and colon cancer prevention
CE Roynette, PC Calder, YM Dupertuis, C Pichard |
Clinical Nutrition | 2004 |
|
Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis
JH Dwyer, H Allayee, KM Dwyer, J Fan, H Wu, R Mar, AJ Lusis, M Mehrabian |
New England Journal of Medicine | 2004 |
|
Somatic treatment of bipolar disorder in children and adolescents
EB Weller, AK Danielyan, RA Weller |
Psychiatric Clinics of North America | 2004 |
|
Bioactive lipids
S Pyne |
Bioactive lipids | 2004 |
|
Long-chain n-3 fatty acids and cardiovascular disease: further evidence and insights
PC Calder |
Nutrition Research | 2004 |
|
N-3 polyunsaturated fatty acids and allergic disease:
SL Prescott, PC Calder |
Current Opinion in Clinical Nutrition and Metabolic Care | 2004 |
|
Diet and Human Immune Function
DA Hughes, LG Darlington, A Bendich |
2004 | |
|
Handbook of Nutrition and Immunity
ME Gershwin, P Nestel, CL Keen |
2004 | |
|
n−3 Polyunsaturated fatty acids and inflammation: From molecular biology to the clinic
PC Calder |
Lipids | 2003 |
|
Fatty acids as gatekeepers of immune cell regulation
P Yaqoob |
Trends in Immunology | 2003 |
|
Effect of γ-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation
M Usami, T Komurasaki, A Hanada, K Kinoshita, A Ohata |
Nutrition | 2003 |
|
Docosahexaenoic acid inhibits cytokine-induced expression of P-selectin and neutrophil adhesion to endothelial cells
Y Wang, Q Liu, H Thorlacius |
European Journal of Pharmacology | 2003 |
|
Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid
D Miyazawa, A Ikemoto, Y Fujii, H Okuyama |
Life Sciences | 2003 |
|
Polyunsaturated fatty acids and cytokine profiles: a clue to the changing prevalence of atopy?
PC Calder |
Clinical & Experimental Allergy | 2003 |
|
Papel de los lípidos de la dieta en los mecanismos de inflamación, proliferación, diferenciación y muerte celular en el tracto intestinal
X Llor |
Gastroenterología y Hepatología | 2003 |
|
Parenteral Nutrition with Fish Oil Modulates Cytokine Response in Patients with Sepsis
K Mayer, S Gokorsch, C Fegbeutel, K Hattar, S Rosseau, D Walmrath, W Seeger, F Grimminger |
American journal of respiratory and critical care medicine | 2003 |
|
Advances in Management and Treatment of Depression
D Mischoulon, A Nierenberg |
Advances in Management and Treatment of Depression | 2003 |
|
Antiinflammatory effects of ω-3 fatty acids vary at different stages of inflammation
B Nohé, T Johannes, HJ Dieterich |
American journal of physiology. Heart and circulatory physiology | 2003 |
|
Relation between the fatty acid composition of peripheral blood mononuclear cells and measures of immune cell function in healthy, free-living subjects aged 25–72 y
S Kew, T Banerjee, AM Minihane, YE Finnegan, CM Williams, PC Calder |
The American journal of clinical nutrition | 2003 |
|
Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients
PC Calder |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2003 |
|
The Macrophage as Therapeutic Target
S Gordon |
2003 | |
|
Short-Time Infusion of Fish Oil-Based Lipid Emulsions, Approved for Parenteral Nutrition, Reduces Monocyte Proinflammatory Cytokine Generation and Adhesive Interaction with Endothelium in Humans
K Mayer, S Meyer, M Reinholz-Muhly, U Maus, M Merfels, J Lohmeyer, F Grimminger, W Seeger |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
|
Dietary modification of inflammation with lipids
PC Calder |
Proceedings of the Nutrition Society | 2002 |
|
Fatty acids and lymphocyte functions
PC Calder, P Yaqoob, F Thies, FA Wallace, EA Miles |
British Journal of Nutrition | 2002 |
|
Parenteral nutrition with n-3 lipids in sepsis
K Mayer, H Grimm, F Grimminger, W Seeger |
British Journal of Nutrition | 2002 |
|
IN VITRO EFFECTS OF EICOSANOIDS DERIVED FROM DIFFERENT 20-CARBON FATTY ACIDS ON PRODUCTION OF MONOCYTE-DERIVED CYTOKINES IN HUMAN WHOLE BLOOD CULTURES
EA Miles, E Allen, PC Calder |
Cytokine | 2002 |
|
The Effect of Mare's Milk Consumption on Functional Elements of Phagocytosis of Human Neutrophil Granulocytes From Healthy Volunteers
S Ellinger, KP Linscheid, S Jahnecke, R Goerlich, H Enbergs |
Food and Agricultural Immunology | 2002 |
|
Omega-3 Fatty Acids May Be Effective in the Treatment of Depression:
JR Keller |
Topics in clinical nutrition | 2002 |
|
Polypharmacy in Psychiatry
D Mischoulon |
Polypharmacy in Psychiatry | 2002 |
|
ω-3 Fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation
K Mayer, M Merfels, M Muhly-Reinholz, S Gokorsch, S Rosseau, J Lohmeyer, N Schwarzer, M Krüll, N Suttorp, F Grimminger, W Seeger |
American journal of physiology. Heart and circulatory physiology | 2002 |
|
Plasma and neutrophil fatty acid composition in advanced cancer patients and response to fish oil supplementation
VC Pratt, S Watanabe, E Bruera, J Mackey, MT Clandinin, VE Baracos, CJ Field |
British Journal of Cancer | 2002 |
|
In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFα impact of ω-3 versus ω-6 fatty acids
K Mayer, R Schmidt, M Muhly-Reinholz, T Bögeholz, S Gokorsch, F Grimminger, W Seeger |
Journal of lipid research | 2002 |
|
Polyunsaturated fatty acids, inflammation, and immunity
PC Calder |
Lipids | 2001 |
|
Authors' reply
U Heemann, T Philipp |
American Journal of Kidney Diseases | 2001 |
|
More good news about fish oil
PC Calder |
Nutrition | 2001 |
|
Inhibitory Effects of Capsaicinoids on Fatty Acid Desaturation in a Rat Liver Cell Line
N NAKANO, N SHIRASAKA, K MASUOKA, T MURAKAMI, T WATANABE, K KOBATA, S SHIMIZU, H YOSHIZUMI |
Bioscience, Biotechnology, and Biochemistry | 2001 |
|
The ratio of n-6 to n-3 fatty acids in the diet: Impact on T lymphocyte function
PC Calder |
European Journal of Lipid Science and Technology | 2001 |
|
Modulation of human immune and inflammatory responses by dietary fatty acids
DS Kelley |
Nutrition | 2001 |
|
Emerging therapeutic targets in bipolar mood disorder
JC Soares, RB Sassi |
Expert Opinion on Therapeutic Targets | 2001 |
|
Review: the role of omega 3 fatty acids in intestinal inflammation
JE Teitelbaum, WA Walker |
The Journal of Nutritional Biochemistry | 2001 |
|
N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale?
PC Calder |
Nutrition Research | 2001 |
|
Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function
DA Healy, FA Wallace, EA Miles, PC Calder, P Newsholme |
Lipids | 2000 |
|
Parathyroid hormone may be a cancer promoter – an explanation for the decrease in cancer risk associated with ultraviolet light, calcium, and vitamin D
MF McCarty |
Medical Hypotheses | 2000 |
|
n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation
CL Curtis, CE Hughes, CR Flannery, CB Little, JL Harwood, B Caterson |
The Journal of biological chemistry | 2000 |
|
NADPH-oxidase activity and lipid peroxidation in neutrophils from rats fed fat-rich diets
LR Lopes, FR Laurindo, J Mancini-Filho, R Curi, P Sannomiya |
Cell Biochemistry and Function | 1999 |
|
Dietary fatty acids and the immune system
PC Calder |
Lipids | 1999 |
|
The reported clinical utility of taurine in ischemic disorders may reflect a down-regulation of neutrophil activation and adhesion
MF McCarty |
Medical Hypotheses | 1999 |
|
Omega-3 fatty acids and bipolar disorder: a review
AL Stoll, CA Locke, LB Marangell, WE Severus |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1999 |
|
Current Opinion in Clinical Nutrition & Metabolic Care
G Olivecrona, T Olivecrona |
Current Opinion in Clinical Nutrition & Metabolic Care | 1998 |
|
The effects of dietary n-3 polyunsaturated fatty acids on neutrophils
RI Sperling |
Proceedings of the Nutrition Society | 1998 |
|
Functional food science and the cardiovascular system
G Hornstra, CA Barth, C Galli, RP Mensink, M Mutanen, RA Riemersma, M Roberfroid, K Salminen, G Vansant, PM Verschuren |
British Journal of Nutrition | 1998 |
|
Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids
S Kikuchi, T Sakamoto, C Ishikawa, K Yazawa, S Torii |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1998 |
|
Modulation of immune function by dietary fatty acids
EA Miles, PC Calder |
Proceedings of the Nutrition Society | 1998 |
|
Fat chance of immunomodulation
PC Calder |
Immunology Today | 1998 |
|
Effects of dietary fish oil and soy phosphatidylcholine on neutrophil fatty acid composition, superoxide release, and adhesion
P Guarini, P Bellavite, D Biasi, A Carletto, S Galvani, P Caramaschi, L M Bambara, R Corrocher |
Inflammation | 1998 |
|
The effect of 12 months' treatment with eicosapentaenoic acid in five children with cystic fibrosis
N Thies |
Journal of Paediatrics and Child Health | 1997 |
|
Effects of ω3 fatty acids on receptor tyrosine kinase and PLC activities in EMT6 cells
KC Estes, BT Rose, JJ Speck, ML Nutter, RC Reitz |
Journal of Lipid Mediators and Cell Signalling | 1997 |
|
Developing Brain Behaviour
SM Innis |
Developing Brain Behaviour | 1997 |
|
N-3 Polyunsaturated fatty acids and immune cell function
PC Calder |
Advances in Enzyme Regulation | 1997 |
|
Cyclic vs Continuous Enteral Feeding With ω-3 and γ-Linolenic Fatty Acids: Effects on Modulation of Phospholipid Fatty Acids in Rat Lung and Liver Immune Cells
JD Palombo, SJ Demichele, E Lydon, BR Bistrian |
JPEN. Journal of parenteral and enteral nutrition | 1997 |
|
Dietary (n-3) Polyunsaturated Fatty Acids Suppress Murine Lymphoproliferation, Interleukin-2 Secretion, and the Formation of Diacylglycerol and Ceramide
CA Jolly, YH Jiang, RS Chapkin, DN McMurray |
The Journal of nutrition | 1997 |
|
Biology and pathophysiology of leukotrienes
C Denzlinger |
Critical Reviews in Oncology/Hematology | 1996 |
|
Immunomodulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids
PC Calder |
Proceedings of the Nutrition Society | 1996 |
|
Dietary fish oil modulation of macrophagetumoricidal activity
KL Erickson, NE Hubbard |
Nutrition | 1996 |
|
Differential effects of n-6 and n-3 polyunsaturated fatty acids on cell growth and early gene expression in Swiss 3T3 fibroblasts
U Danesch, PC Weber, A Sellmayer |
Journal of Cellular Physiology | 1996 |
|
Gamma -Linolenic Acid: Metabolism and Its Roles in Nutrition and Medicine
R Zurier, P DeLuca, D Rothman |
Gamma -Linolenic Acid: Metabolism and Its Roles in Nutrition and Medicine | 1996 |
|
No effect of a very low dose of n-3 fatty acids on monocyte function in healthy humans
EB Schmidt, K Varming, JM Møller, IB Pedersen, P Madsen, J Dyerberg |
Scandinavian Journal of Clinical & Laboratory Investigation | 1996 |
|
Eicosanoids
GC Folco, B Samuelsson, J Maclouf, GP Velo |
1996 | |
|
Section Review—Cardiovascular & Renal: n-3 Fatty Acids as Adjuvants to Conventional Therapy in Patients with Coronary Artery Disease
EB Schmidt, SD Kristensen, J Dyerberg |
Expert Opinion on Investigational Drugs | 1995 |
|
n-3 Polyunsaturated fatty acids: update 1995
S Endres, RD Caterina, EB Schmidt, SD Kristensenj |
European Journal of Clinical Investigation | 1995 |
|
Potentiation of the hyporeactivity induced by in vivo endothelial injury in the rat carotid artery by chronic treatment with fish oil
GA Joly, VB Schini, H Hughes, PM Vanhoutte |
British Journal of Pharmacology | 1995 |
|
Eicosanoids, fatty acids and neutrophils: Their relevance to the pathophysiology of disease
EJ Bates |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1995 |
|
Validation of a meta-analysis: The effects of fish oil in rheumatoid arthritis
PR Fortin, RA Lew, MH Liang, EA Wright, LA Beckett, TC Chalmers, RI Sperling |
Journal of Clinical Epidemiology | 1995 |
|
Arachidonic acid and eicosanoids as targets and effectors in second messenger interactions
VD Marzo |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1995 |
|
Modulation of the endogenous leukotriene production by fish oil and vitamin E
C Denzlinger, T Mess, S Sagebiel-Kohler, C Lemmen, K Jacob, W Wilmanns, O Adam |
Journal of Lipid Mediators and Cell Signalling | 1995 |
|
MARINE AND BOTANICAL LIPIDS AS IMMUNOMODULATORY AND THERAPEUTIC AGENTS IN THE TREATMENT OF RHEUMATOID ARTHRITIS
P DeLuca, D Rothman, RB Zurier |
Rheumatic diseases clinics of North America | 1995 |
|
EICOSANOIDS IN RHEUMATOID ARTHRITIS
RI Sperling |
Rheumatic diseases clinics of North America | 1995 |
|
Fish oil supplementation and essential fatty acid deficiency reduce nitric oxide synthesis by rat macrophages
V Boutard, B Fouqueray, C Philippe, J Perez, L Baud |
Kidney International | 1994 |
|
Eicosapentaenoic acid modulates neutrophil leukotriene B4 receptor expression in cystic fibrosis
RH Lawrence, TC Sorrell |
Clinical & Experimental Immunology | 1994 |
|
Fatty acid composition of lung, macrophage and surfactant phospholipids after short-term enteral feeding with n−3 lipids
JD Palombo, EE Lydon, PL Chen, BR Bistrian, RA Forse |
Lipids | 1994 |
|
Characterization of platelet-activating factor binding to human airway epithelial cells: modulation by fatty acids and ion-channel blockers
JX Kang, SF Man, AJ Hirsh, MT Clandinin |
Biochemical Journal | 1994 |
|
Regulation of neutrophil activation by oleic acid
AA Higazi, II Barghouti |
Biochimica et Biophysica Acta (BBA) - General Subjects | 1994 |
|
Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells
BA Carmen, R David, A Steina, A Christer, G Lena |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1994 |
|
Airways Smooth Muscle: Biochemical Control of Contraction and Relaxation
D Raeburn, MA Giembycz |
1994 | |
|
Asymmetric incorporation of dietary n-3 fatty acids into membrane aminophospholipids of human erythrocytes
HR Knapp, F Hullin, N Salem |
Journal of lipid research | 1994 |
|
Omega-3 Fatty Acids: Current Status in Cardiovascular Medicine
EB Schmidt, J Dyerberg |
Drugs | 1994 |
|
Eicosapentaenoic acid modulates neutrophil leukotriene B4 receptor expression in cystic fibrosis.
Lawrence RH, Sorrell TC |
Clinical & Experimental Immunology | 1994 |
|
Eicosapentaenoic acid in cystic fibrosis: evidence of a pathogenetic role for leukotriene B4
R Lawrence, T Sorrell |
The Lancet | 1993 |
|
Nutrition and Immunology
DM Klurfeld |
1993 | |
|
New Comprehensive Biochemistry
S Yamamoto |
New Comprehensive Biochemistry | 1983 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)