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Citations to this article

Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis.
A E Koch, … , R M Pope, R M Strieter
A E Koch, … , R M Pope, R M Strieter
Published September 1, 1992
Citation Information: J Clin Invest. 1992;90(3):772-779. https://doi.org/10.1172/JCI115950.
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Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis.

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Abstract

Cells within the synovial tissue may recruit mononuclear phagocytes into the synovial fluid and tissues of arthritic patients. We investigated the production of the chemotactic cytokine monocyte chemoattractant protein-1 (MCP-1) using sera, synovial fluid, synovial tissue, as well as macrophages and fibroblasts isolated from synovial tissues from 80 arthritic patients. MCP-1 levels were significantly higher (P less than 0.05) in synovial fluid from RA patients (mean 25.5 +/- 8.1 ng/ml [SE]) compared to synovial fluid from osteoarthritis (OA) patients (0.92 +/- 0.08), or from patients with other arthritides (2.9 +/- 1.5). MCP-1 levels in RA sera (8.44 +/- 2.33) were significantly greater than MCP-1 in normal sera (0.16 +/- 0.06). The quantities of RA synovial fluid IL-8, which is chemotactic for neutrophils and lymphocytes, and MCP-1 were strongly positively correlated (P less than 0.05). To examine the cellular source of MCP-1, RA synovial tissue macrophages and fibroblasts were isolated. Synovial tissue fibroblasts did not express MCP-1 mRNA, but could be induced to produce MCP-1 by stimulation with either IL-1 beta, tumor necrosis factor-alpha (TNF-alpha), or LPS. In contrast, unlike normal peripheral blood monocytes or alveolar macrophages, RA synovial tissue macrophages constitutively expressed MCP-1 mRNA and antigen. Immunohistochemical analysis of synovial tissue showed that a significantly greater percentage of RA macrophages (50 +/- 8%) as compared to either OA macrophages (5 +/- 2) or normal macrophages (1 +/- 0.3) reacted with anti-MCP-1 antibodies. In addition, the synovial lining layer reacted with MCP-1 in both RA and OA synovial tissues. In contrast, only a minority of synovial fibroblasts (18 +/- 8%) from RA synovium were positive for immunolocalization of MCP-1. These results suggest that synovial production of MCP-1 may play an important role in the recruitment of mononuclear phagocytes during inflammation associated with RA and that synovial tissue macrophages are the dominant source of this cytokine.

Authors

A E Koch, S L Kunkel, L A Harlow, B Johnson, H L Evanoff, G K Haines, M D Burdick, R M Pope, R M Strieter

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HC Lin, TH Lin, MY Wu, YC Chiu, CH Tang, MJ Hour, HC Liou, HJ Tu, RS Yang, WM Fu, CM Yang
PloS one 2014
The degradation of chondrogenic pellets using cocultures of synovial fibroblasts and U937 cells
DJ Blasioli, GL Matthews, DL Kaplan
Biomaterials 2014
Non-Myeloid Cells are Major Contributors to Innate Immune Responses via Production of Monocyte Chemoattractant Protein-1/CCL2
T Yoshimura, C Galligan, M Takahashi, K Chen, M Liu, L Tessarollo, JM Wang
Frontiers in immunology 2014
Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation
KY Choi, S Napper, N Mookherjee
Immunology 2014
Mouse Monocyte Chemoattractant Protein 1 (MCP1) Functions as a Monomer
Y Yao, SE Tsirka
The International Journal of Biochemistry & Cell Biology 2014
Fucosyltransferase 1 Mediates Angiogenesis in Rheumatoid Arthritis: α(1,2)-Fucosylation by FUT1 is Expressed in RA
T Isozaki, MA Amin, JH Ruth, PL Campbell, PS Tsou, CM Ha, WA Stinson, SE Domino, AE Koch
Arthritis & Rheumatology 2014
Impact of periodontitis on chemokines in smokers
O Haytural, D Yaman, EC Ural, A Kantarci, K Demirel
Clinical Oral Investigations 2014
Helicobacter pylori protein HP0986 (TieA) interacts with mouse TNFR1 and triggers proinflammatory and proapoptotic signaling pathways in cultured macrophage cells (RAW 264.7)
SA Ansari, S Devi, S Tenguria, A Kumar, N Ahmed
Cytokine 2014
GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeutics
A Mujić-Delić, RH de Wit, F Verkaar, MJ Smit
Trends in Pharmacological Sciences 2014
Bone Disease in Newly Diagnosed Lupus Nephritis Patients
AL Resende, LM Reis, CB Dias, MR Custódio, V Jorgetti, V Woronik, NO Câmara
PloS one 2014
Synovial Joints: from Development to Homeostasis
L Longobardi, T Li, L Tagliafierro, JD Temple, HH Willcockson, P Ye, A Esposito, F Xu, A Spagnoli
Current Osteoporosis Reports 2014
Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis
OI Eseonu, CD Bari
Rheumatology 2014
Citrullination of Epithelial Neutrophil-Activating Peptide 78/CXCL5 Results in Conversion From a Non-Monocyte-Recruiting Chemokine to a Monocyte-Recruiting Chemokine: Citrullinated ENA-78/CXCL5 in Rheumatoid Arthritis
K Yoshida, O Korchynskyi, PP Tak, T Isozaki, JH Ruth, PL Campbell, DL Baeten, DM Gerlag, MA Amin, AE Koch
Arthritis & Rheumatology 2014
Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis
K Chakravarthy, R Faltus, G Robinson, R Sevilla, J Shin, M Zielstorff, A Byford, E Leccese, MJ Caniga, SC Hseih, S Zhang, CS Chiu, J Zhang-Hoover, LY Moy, RL McLeod, D Stoffregen, W Zhang, A Murtaza, M Cicmil
BMC musculoskeletal disorders 2014
The active metabolite of spleen tyrosine kinase inhibitor fostamatinib abrogates the CD4+ T cell-priming capacity of dendritic cells
AM Platt, RA Benson, R McQueenie, JP Butcher, M Braddock, JM Brewer, IB McInnes, P Garside
Rheumatology 2014
Chemokines: Chemokines and Their Receptors in Drug Discovery
N Tschammer
2014
CC Chemokine Receptors and Chronic Inflammation—Therapeutic Opportunities and Pharmacological Challenges
GE White, AJ Iqbal, DR Greaves, CJ Garland
Pharmacological reviews 2013
Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis
DE Sanford, BA Belt, RZ Panni, A Mayer, AD Deshpande, D Carpenter, JB Mitchem, SM Plambeck-Suess, LA Worley, BD Goetz, A Wang-Gillam, TJ Eberlein, DG Denardo, SP Goedegebuure, DC Linehan
Clinical cancer research 2013
Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain
ML Selenica, JA Alvarez, KR Nash, DC Lee, C Cao, X Lin, P Reid, PR Mouton, D Morgan, MN Gordon
Journal of Neuroinflammation 2013
Genetic component of giant cell arteritis
FD Carmona, MA Gonzalez-Gay, J Martin
Rheumatology 2013
The Roles of Catabolic Factors in the Development of Osteoarthritis
DJ Blasioli, DL Kaplan
Tissue Engineering Part B: Reviews 2013
Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function
C Blanchetot, D Verzijl, A Mujić-Delić, L Bosch, L Rem, R Leurs, CT Verrips, M Saunders, H Haard, MJ Smit
The Journal of biological chemistry 2013
Neutralizing Nanobodies Targeting Diverse Chemokines Effectively Inhibit Chemokine Function*
C Blanchetot, D Verzijl, A Mujić-Delić, L Bosch, L Rem, R Leurs, CT Verrips, M Saunders, H Haard, MJ Smit
The Journal of biological chemistry 2013
The role of circulating fibrocytes in inflammation and autoimmunity
CL Galligan, EN Fish
Journal of leukocyte biology 2013
Genetic and cellular evidence of decreased inflammation associated with reduced post-traumatic arthritis in MRL/MpJ mice
JS Lewis, BD Furman, E Zeitler, JL Huebner, VB Kraus, F Guilak, SA Olson
Arthritis & Rheumatism 2012
3D-QSAR studies on CCR2B receptor antagonists: Insight into the structural requirements of (R)-3-aminopyrrolidine series of molecules based on CoMFA/CoMSIA models
S Gade, S Mahmood
Journal of Pharmacy & Bioallied Sciences 2012
MicroRNAs in Rheumatoid Arthritis : Potential Role in Diagnosis and Therapy
M Filková, A Jüngel, RE Gay, S Gay
BioDrugs 2012
Minocycline Controls Clinical Outcomes and Inflammatory Cytokines in Moderate and Severe Meibomian Gland Dysfunction
H Lee, K Min, EK Kim, TI Kim
American Journal of Ophthalmology 2012
RANTES, MCP-1 chemokines and factors describing rheumatoid arthritis
MP Goldbergova, J Lipkova, N Pavek, J Gatterova, A Vasku, M Soucek, P Nemec
Molecular Immunology 2012
Apoptosis signal-regulating kinase 1 is mediated in TNF-α-induced CCL2 expression in human synovial fibroblasts
HK Tsou, HT Chen, CH Chang, WY Yang, CH Tang
Journal of Cellular Biochemistry 2012
Circulating fibrocytes contribute to the pathogenesis of collagen antibody-induced arthritis
CL Galligan, EN Fish
Arthritis & Rheumatism 2012
CTGF induces monocyte chemoattractant protein-1 expression to enhance monocyte migration in human synovial fibroblasts
SC Liu, CJ Hsu, YC Fong, SM Chuang, CH Tang
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2012
The role of a chemokine receptor, CCR2, in suppressing the development of arthritis in IL-1 receptor antagonist-deficient mice
H Fujii, T Baba, M Yamagishi, M Kawano, N Mukaida
Inflammation and Regeneration 2012
Suppression of endothelial cell activity by inhibition of TNFα
Q Shu, MA Amin, JH Ruth, PL Campbell, AE Koch
Arthritis Research & Therapy 2012
The CCL2/CCR2 Axis Enhances Vascular Cell Adhesion Molecule-1 Expression in Human Synovial Fibroblasts
YM Lin, CJ Hsu, YY Liao, MC Chou, CH Tang, S Grundmann
PloS one 2012
Cytokine biomarkers and chronic pain: Association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness
GD Slade, MS Conrad, L Diatchenko, NU Rashid, S Zhong, S Smith, J Rhodes, A Medvedev, S Makarov, W Maixner, AG Nackley
PAIN 2011
Evaluation of SV40-transformed synovial fibroblasts in the study of rheumatoid arthritis pathogenesis
KL Wagoner, RA Bader
Rheumatology International 2011
Targeting chemokine receptors in chronic inflammatory diseases: An extensive review
PJ Koelink, SA Overbeek, S Braber, P Kruijf, G Folkerts, MJ Smit, AD Kraneveld
Pharmacology & Therapeutics 2011
Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis
BS Qazi, K Tang, A Qazi
International Journal of Inflammation 2011
Targeting interferon regulatory factors to inhibit activation of the type I IFN response: Implications for treatment of autoimmune disorders
SE Sweeney
Cellular Immunology 2011
Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts
E Turner-Brannen, KY Choi, DN Lippert, JP Cortens, RE Hancock, H El-Gabalawy, N Mookherjee
Arthritis Research & Therapy 2011
Methods and Principles in Medicinal Chemistry
AD Kraneveld, S Braber, S Overbeek, P Kruijf, P Koelink, MJ Smit
Chemokine Receptors as Drug Targets 2011
Cytokines
L Cassetta, G Poli, M Alfano
Cytokines 2011
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné
Advances in Immunology Volume 110 2011
First Pharmacophore Model of CCR3 Receptor Antagonists and its Homology Model-Assisted, Stepwise Virtual Screening
V Jain, P Saravanan, A Arvind, CG Mohan
Chemical Biology & Drug Design 2011
Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis
DP Chen, CK Wong, PC Leung, KP Fung, CB Lau, CP Lau, EK Li, LS Tam, CW Lam
Journal of Ethnopharmacology 2011
Interaction between oxidative stress and chemokines: Possible pathogenic role in systemic lupus erythematosus and rheumatoid arthritis
D Shah, A Wanchu, A Bhatnagar
Immunobiology 2011
Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes
PZ Chao, MS Hsieh, CW Cheng, YF Lin, CH Chen
Journal of Biomedical Science 2011
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee
Annual Reports in Medicinal Chemistry Volume 46 2011
Interleukin-17A induction of angiogenesis, cell migration, and cytoskeletal rearrangement
EM Moran, M Connolly, W Gao, J McCormick, U Fearon, DJ Veale
Arthritis & Rheumatism 2011
Pulsed acoustic cellular expression as a protective therapy against I/R injury in a cremaster muscle flap model
L Krokowicz, A Klimczak, J Cwykiel, M Mielniczuk, C Grykien, M Siemionow
Microvascular Research 2011
Monocyte Chemoattractant Protein 1 Expression in Synovial Fluid of Patients With Total Hip Arthroplasty : MCP-1 EXPRESSION IN SYNOVIAL FLUID
M Montesi, A Beraudi, S Stea, C Ancarani, F Traina, A Toni
Artificial Organs 2011
Targeting Chemokines and Angiogenesis in Rheumatoid Arthritis
Z Szekanecz, AE Koch
Pharmaceutical Sciences Encyclopedia Drug Discovery Development and Manufacturing 2011
Natural Killer-22 Cells in the Synovial Fluid of Patients with Rheumatoid Arthritis Are an Innate Source of Interleukin 22 and Tumor Necrosis Factor-α
J Ren, Z Feng, Z Lv, XI Chen, J Li
The Journal of rheumatology 2011
Discovery, Optimization, and Pharmacological Characterization of Novel Heteroaroylphenylureas Antagonists of C−C Chemokine Ligand 2 Function
E Laborde, RW Macsata, F Meng, BT Peterson, L Robinson, SR Schow, RJ Simon, H Xu, K Baba, H Inagaki, Y Ishiwata, T Jomori, Y Matsumoto, A Miyachi, T Nakamura, M Okamoto, TM Handel, CC Bernard
Journal of Medicinal Chemistry 2011
Joint Tissues Amplify Inflammation and Alter Their Invasive Behavior via Leukotriene B 4 in Experimental Inflammatory Arthritis
M Chen, BK Lam, AD Luster, S Zarini, RC Murphy, AM Bair, RJ Soberman, DM Lee
Journal of immunology (Baltimore, Md. : 1950) 2010
Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint
U Fiocco, P Sfriso, F Oliviero, P Roux-Lombard, E Scagliori, L Cozzi, F Lunardi, F Calabrese, M Vezzù, S Dainese, B Molena, A Scanu, R Nardacchione, L Rubaltelli, JM Dayer, L Punzi
Arthritis Research & Therapy 2010
Pan–CC Chemokine Neutralization Restricts Splenocyte Egress and Reduces Inflammation in a Model of Arthritis
V Buatois, S Fagète, G Magistrelli, L Chatel, N Fischer, MH Kosco-Vilbois, WG Ferlin
Journal of immunology (Baltimore, Md. : 1950) 2010
Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis
CK Wong, DP Chen, LS Tam, EK Li, YB Yin, CW Lam
Arthritis Research & Therapy 2010
Burger's Medicinal Chemistry and Drug Discovery
S Bruno, L Ronda, S Faggiano, S Bettati, A Mozzarelli
Burger's Medicinal Chemistry and Drug Discovery 2010
Antiangiogenic phytochemicals and medicinal herbs
SJ Jeong, W Koh, EO Lee, HJ Lee, HJ Lee, H Bae, J Lü, SH Kim
Phytotherapy Research 2010
In vivo MR evaluation of the effect of the CCR2 antagonist on macrophage migration
Y Lee, JW Ryu, H Chang, JY Sohn, KW Lee, CW Woo, HJ Kang, SY Jeong, EK Choi, JS Lee
Magnetic Resonance in Medicine 2010
Effect of a phytotherapeutic agent, Eviprostat®, on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis
M Sugimoto, M Oka, H Tsunemori, M Yamashita, Y Kakehi
The Prostate 2010
Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3
SE Sweeney, TB Kimbler, GS Firestein
Journal of immunology (Baltimore, Md. : 1950) 2010
Rationally evolving MCP-1/CCL2 into a decoy protein with potent anti-inflammatory activity in vivo
AM Piccinini, K Knebl, A Rek, G Wildner, M Diedrichs-Möhring, AJ Kungl
The Journal of biological chemistry 2010
Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis
Y Liu, R Mu, S Wang, L Long, X Liu, R Li, J Sun, J Guo, X Zhang, J Guo, P Yu, C Li, X Liu, Z Huang, D Wang, H Li, Z Gu, B Liu, Z Li
Arthritis Research & Therapy 2010
Chemokines and chemokine receptors in arthritis
Z Szekanecz, A Vegvari, Z Szabo, AE Koch
Frontiers in bioscience (Scholar edition) 2010
Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population
DQ Chen, Y Zeng, J Zhou, L Yang, S Jiang, JD Huang, L Lu, BJ Zheng
Journal of Medical Virology 2010
Characterization of the KRN Cell Transfer Model of Rheumatoid Arthritis (KRN-CTM), a Chronic Yet Synchronized Version of the K/BxN Mouse
TP LaBranche, CL Hickman-Brecks, DM Meyer, CE Storer, MI Jesson, KM Shevlin, FA Happa, RA Barve, DJ Weiss, JC Minnerly, JL Racz, PM Allen
The American Journal of Pathology 2010
MCP-1: Chemoattractant with a role beyond immunity: A review
A Yadav, V Saini, S Arora
Clinica Chimica Acta 2010
Effects of hesperetin on the production of inflammatory mediators in IL-1β treated human synovial cells
EM Choi, YS Lee
Cellular Immunology 2010
Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood
H Eda, J Zhang, RH Keith, M Michener, DR Beidler, JB Monahan
Cytokine 2010
Comparative quantitative structure–activity relationship study of some 1-aminocyclopentyl-3-carboxyamides as CCR2 inhibitors using stepwise MLR, FA-MLR, and GA-PLS
M Shahlaei, A Madadkar-Sobhani, A Fassihi, L Saghaie, D Shamshirian, H Sakhi
Medicinal Chemistry Research 2010
The role of microRNA in rheumatoid arthritis and other autoimmune diseases
V Furer, JD Greenberg, M Attur, SB Abramson, MH Pillinger
Clinical Immunology 2010
Current Topics in Membranes
TC Wagenknecht, Z Liu
Structure and Function of Calcium Release Channels 2010
Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni
D Silveira-Lemos, A Teixeira-Carvalho, OA Martins-Filho, AL Souza-Soares, P Castro-Silva, MF Costa-Silva, PH Guimarães, HB Ferraz, LA Oliveira-Fraga, MM Teixeira, R Corrêa-Oliveira
Memórias do Instituto Oswaldo Cruz 2010
Rationally Evolving MCP-1/CCL2 into a Decoy Protein with Potent Anti-inflammatory Activity in Vivo
AM Piccinini, K Knebl, A Rek, G Wildner, M Diedrichs-Möhring, AJ Kungl
The Journal of biological chemistry 2010
MCP-1 Production in Temporomandibular Joint Inflammation
N Ogura, K Satoh, M Akutsu, M Tobe, K Kuyama, N Kuboyama, H Sakamaki, H Kujiraoka, T Kondoh
Journal of dental research 2010
The C Terminus of Mouse Monocyte Chemoattractant Protein 1 (MCP1) Mediates MCP1 Dimerization while Blocking Its Chemotactic Potency
Y Yao, SE Tsirka
The Journal of biological chemistry 2010
CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance training
BT Harmon, EF Orkunoglu-Suer, K Adham, JS Larkin, H Gordish-Dressman, PM Clarkson, PD Thompson, TJ Angelopoulos, PM Gordon, NM Moyna, LS Pescatello, PS Visich, RF Zoeller, MJ Hubal, LL Tosi, EP Hoffman, JM Devaney
Journal of applied physiology 2010
Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways
A Filer, M Bik, GN Parsonage, J Fitton, E Trebilcock, K Howlett, M Cook, K Raza, DL Simmons, AM Thomas, M Salmon, D Scheel-Toellner, JM Lord, GA Rabinovich, CD Buckley
Arthritis & Rheumatism 2009
Inhalation of Carbon Monoxide Ameliorates Collagen-induced Arthritis in Mice and Regulates the Articular Expression of IL-1β and MCP-1
T Takagi, Y Naito, M Inoue, S Akagiri, K Mizushima, O Handa, S Kokura, H Ichikawa, T Yoshikawa
Inflammation 2009
Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis
H Marotte, JH Ruth, PL Campbell, AE Koch, S Ahmed
Rheumatology 2009
Etanercept reduces the serum levels of macrophage chemotactic protein-1 in patients with rheumatoid arthritis
Y Kageyama, H Kobayashi, N Kato, M Shimazu
Modern Rheumatology 2009
Protein biochip array technology to monitor rituximab in rheumatoid arthritis
S Fabre, C Guisset, L Tatem, N Dossat, AM Dupuy, JD Cohen, JP Cristol, JP Daures, C Jorgensen
Clinical & Experimental Immunology 2009
Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule
M Suzuki, M Hashizume, H Yoshida, M Mihara
Rheumatology International 2009
Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1
AL Hammons, CM Summers, JV Woodside, H McNulty, JJ Strain, IS Young, L Murray, CA Boreham, JM Scott, LE Mitchell, AS Whitehead
Clinical Immunology 2009
Detection of Experimentally Induced Pulmonary Granuloma Inflammation in Monocyte Chemoattractant Protein-1 Reporter Mice
S Rajasekaran, VY Kao, MR Chen, AL Yang, CH Hsu, CT Chen, KM Lin
Molecular Imaging and Biology 2009
Serum chemokines in patients with rheumatoid arthritis treated with etanercept
PA Klimiuk, S Sierakowski, I Domyslawska, J Chwiecko
Rheumatology International 2009
MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis
Y Nakamachi, S Kawano, M Takenokuchi, K Nishimura, Y Sakai, T Chin, R Saura, M Kurosaka, S Kumagai
Arthritis & Rheumatism 2009
Systemic inflammation as a driver of vascular calcification: a proof of concept
E Shantsila, GY Lip
Journal of Internal Medicine 2009
Galectin-1 stimulates monocyte chemotaxis via the p44/42 MAP kinase pathway and a pertussis toxin-sensitive pathway
RK Malik, RR Ghurye, DJ Lawrence-Watt, HJ Stewart
Glycobiology 2009
MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner
K Miyamoto, K Ninomiya, KH Sonoda, Y Miyauchi, H Hoshi, R Iwasaki, H Miyamoto, S Yoshida, Y Sato, H Morioka, K Chiba, K Egashira, T Suda, Y Toyama, T Miyamoto
Biochemical and Biophysical Research Communications 2009
Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis
J Öckinger, P Stridh, AD Beyeen, F Lundmark, M Seddighzadeh, A Oturai, PS Sørensen, ÅR Lorentzen, EG Celius, V Leppä, K Koivisto, PJ Tienari, L Alfredsson, L Padyukov, J Hillert, I Kockum, M Jagodic, T Olsson
Genes and Immunity 2009
Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1β through the NF-κB and MAPK pathways in rheumatoid arthritis
W Zheng, R Li, H Pan, D He, R Xu, TB Guo, Y Guo, JZ Zhang
Arthritis & Rheumatism 2009
Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models
JD Lee, JE Huh, GS Jeon, HR Yang, HS Woo, DY Choi, DS Park
International Immunopharmacology 2009
Synovial Fibroblasts: Important Players in the Induction of Inflammation and Joint Destruction
C Ospelt, T Pap, S Gay
Rheumatoid Arthritis 2009
Chemokines
JE Pease, TJ Williams
Asthma and COPD 2009
Monocyte Chemotactic Protein-1 (MCP-1) and Growth Factors Called into Question as Markers of Prolonged Psychosocial Stress
IH Jonsdottir, DA Hägg, K Glise, R Ekman, O Rotzschke
PloS one 2009
CXCL 9 and CXCL 10 as Sensitive Markers of Disease Activity in Patients with Rheumatoid Arthritis
WP Kuan, LS Tam, CK Wong, FW Ko, T Li, T Zhu, EK Li
The Journal of rheumatology 2009
New Therapeutic Targets in Rheumatoid Arthritis
PP Tak
2009
Gender Differences in Abdominal Aortic Aneurysms
KK Hannawa, JL Eliason, GR Upchurch
Vascular 2009
The Development of Novel Therapies for Rheumatoid Arthritis
LD Quan, GM Thiele, J Tian, D Wang
Expert Opinion on Therapeutic Patents 2008
Inhibition of Monocyte Chemoattractant Protein-1 Ameliorates Rat Adjuvant-Induced Arthritis
S Shahrara, AE Proudfoot, CC Park, MV Volin, GK Haines, JM Woods, CH Aikens, TM Handel, RM Pope
Journal of immunology (Baltimore, Md. : 1950) 2008
Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitis
MJ Mattapallil, A Augello, C Cheadle, D Teichberg, KG Becker, CC Chan, JJ Mattapallil, G Pennesi, RR Caspi
Investigative ophthalmology & visual science 2008
Human Immunodeficiency Virus (HIV) Infects Human Arterial Smooth Muscle Cells in Vivo and in Vitro
EA Eugenin, S Morgello, ME Klotman, A Mosoian, PA Lento, JW Berman, AD Schecter
The American Journal of Pathology 2008
Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients
T Iwamoto, H Okamoto, Y Toyama, S Momohara
FEBS Journal 2008
Monocyte Chemoattractant Protein-1 and Macrophage Inflammatory Protein-1α as Possible Biomarkers for the Chronic Pelvic Pain Syndrome
NV Desireddi, PL Campbell, JA Stern, R Sobkoviak, S Chuai, S Shahrara, P Thumbikat, RM Pope, JR Landis, AE Koch, AJ Schaeffer
The Journal of Urology 2008
Common inflammatory mediators orchestrate pathophysiological processes in rheumatoid arthritis and atherosclerosis
F Montecucco, F Mach
Rheumatology 2008
Pathway analysis of seven common diseases assessed by genome-wide association
A Torkamani, EJ Topol, NJ Schork
Genomics 2008
Protein biochip array technology for cytokine profiling predicts etanercept responsiveness in rheumatoid arthritis
S Fabre, AM Dupuy, N Dossat, C Guisset, JD Cohen, JP Cristol, JP Daures, C Jorgensen
Clinical & Experimental Immunology 2008
The role of chemokines in leucocyte-stromal interactions in rheumatoid arthritis
A Filer, K Raza, M Salmon, CD Buckley
Frontiers in bioscience : a journal and virtual library 2008
The changes in serum chemokines following leflunomide therapy in patients with rheumatoid arthritis
PA Klimiuk, J Kita, J Chwiecko, S Sierakowski
Clinical Rheumatology 2008
Localization of S100A8 and S100A9 expressing neutrophils to spinal cord during peripheral tissue inflammation
K Mitchell, HY Yang, PA Tessier, WT Muhly, WD Swaim, I Szalayova, JM Keller, E Mezey, MJ Iadarola
PAIN 2008
Activation of peroxisome proliferator-activated receptor γ inhibits TNF-α-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of monocyte chemoattractant protein-1 expression
H Hounoki, E Sugiyama, SG Mohamed, K Shinoda, H Taki, HO Abdel-Aziz, M Maruyama, M Kobayashi, T Miyahara
Bone 2008
Modulation of CCR2 in rheumatoid arthritis: A double‐blind, randomized, placebo‐controlled clinical trial
CE Vergunst, DM Gerlag, L Lopatinskaya, L Klareskog, MD Smith, F Bosch, HJ Dinant, Y Lee, T Wyant, EW Jacobson, D Baeten, PP Tak
Arthritis & Rheumatism 2008
Investigational C-C chemokine receptor 2 antagonists for the treatment of autoimmune diseases
A Kalinowska, J Losy
Expert Opinion on Investigational Drugs 2008
Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists
A Pasternak, SD Goble, PP Vicario, JD Salvo, JM Ayala, M Struthers, JA DeMartino, SG Mills, L Yang
Bioorganic & Medicinal Chemistry Letters 2008
Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists
A Pasternak, SD Goble, GA Doss, NN Tsou, G Butora, PP Vicario, JM Ayala, M Struthers, JA DeMartino, SG Mills, L Yang
Bioorganic & Medicinal Chemistry Letters 2008
Anti-inflammatory Activity of an Ethanol Extract of Caesalpinia sappan L. in LPS-induced RAW 264.7 Cells
IY Jeong, CH Jin, YD Park, HJ Lee, DS Choi, MW Byun, YJ Kim
Journal of Food Science and Nutrition 2008
Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism
Y Kimura, M Sumiyoshi, K Samukawa, N Satake, M Sakanaka
European Journal of Pharmacology 2008
Efficient Inhibition of Hepatitis B Virus ReplicationIn Vivo, Using Polyethylene Glycol-Modified Adenovirus Vectors
C Crowther, A Ely, J Hornby, S Mufamadi, F Salazar, P Marion, P Arbuthnot
Human Gene Therapy 2008
Effects of ginsenoside Rb1 at low doses on histamine, substance P, and monocyte chemoattractant protein 1 in the burn wound areas during the process of acute burn wound repair
K Kawahira, M Sumiyoshi, M Sakanaka, Y Kimura
Journal of Ethnopharmacology 2008
Cells of the synovium in rheumatoid arthritis. Dendritic cells
V Lutzky, S Hannawi, R Thomas
Arthritis Research & Therapy 2007
Interferon-gamma protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints
AS Williams, PJ Richards, E Thomas, S Carty, MA Nowell, RM Goodfellow, CM Dent, BD Williams, SA Jones, N Topley
Arthritis & Rheumatism 2007
Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis
H Brühl, J Cihak, J Plachý, L Kunz-Schughart, M Niedermeier, A Denzel, MR Gomez, Y Talke, B Luckow, M Stangassinger, M Mack
Arthritis & Rheumatism 2007
Antiviral gene expression in rheumatoid arthritis: Role of IKKε and interferon regulatory factor 3
SE Sweeney, L Mo, GS Firestein
Arthritis & Rheumatism 2007
Nutraceutical Science and Technology
N Bhaskar, K Miyashita
Anti-Angiogenic Functional and Medicinal Foods 2007
MECHANISMS OF OXIDANT REGULATION OF MONOCYTE CHEMOTACTIC PROTEIN 1 PRODUCTION IN HUMAN WHOLE BLOOD AND ISOLATED MONONUCLEAR CELLS
L Xing, DG Remick
Shock 2007
Hepatocyte growth factor induction of macrophage chemoattractant protein-1 and osteophyte-inducing factors in osteoarthritis
B Dankbar, K Neugebauer, C Wunrau, CO Tibesku, A Skwara, T Pap, S Fuchs-Winkelmann
Journal of Orthopaedic Research 2007
Downregulation of Monocyte Chemoattractant Protein-1 Involving Short Interfering RNA Attenuates Hapten-induced Contact Hypersensitivity
T Ishimoto, Y Takei, Y Yuzawa, K Hanai, S Nagahara, Y Tarumi, S Matsuo, K Kadomatsu
Molecular Therapy 2007
Primary central nervous system lymphoma secretes monocyte chemoattractant protein 1
R Kitai, K Ishisaka, K Sato, T Sakuma, T Yamauchi, Y Imamura, H Matsumoto, T Kubota
Medical Molecular Morphology 2007
Update on cytokines in rheumatoid arthritis
F Brennan, J Beech
Current Opinion in Rheumatology 2007
Diaryl substituted pyrazoles as potent CCR2 receptor antagonists
AB Pinkerton, D Huang, RV Cube, JH Hutchinson, M Struthers, JM Ayala, PP Vicario, SR Patel, T Wisniewski, JA DeMartino, JM Vernier
Bioorganic & Medicinal Chemistry Letters 2007
Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses
J Menetski, S Mistry, M Lu, JS Mudgett, RM Ransohoff, JA DeMartino, DE MacIntyre, C Abbadie
Neuroscience 2007
Cell surface CCR5 density determines the intensity of T cell migration towards rheumatoid arthritis synoviocytes
C Desmetz, YL Lin, C Mettling, P Portalès, D Noël, J Clot, C Jorgensen, P Corbeau
Clinical Immunology 2007
Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways
MA Amin, PJ Mansfield, A Pakozdi, PL Campbell, S Ahmed, RJ Martinez, AE Koch
Arthritis & Rheumatism 2007
Handbook of Neurochemistry and Molecular Neurobiology
VH Routh, JJ McArdle, NM Sanders, Z Song, R Wang
Handbook of Neurochemistry and Molecular Neurobiology 2007
Association of the −2510A/G chemokine (C–C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population
HJ Park, SH Yoon, LT Zheng, KH Lee, JW Kim, JH Chung, YA Lee, SJ Hong
Scandinavian Journal of Rheumatology 2007
Toll-Like Receptor 2-Dependent NF-κB Activation Is Involved in Nontypeable Haemophilus influenzae -Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear
SK Moon, JI Woo, HY Lee, R Park, J Shimada, H Pan, R Gellibolian, DJ Lim
Infection and immunity 2007
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
Jingsong Wang, John W. Fathman, Geanncarlo Lugo-Villarino, Lucila Scimone, Ulrich von Andrian, David M. Dorfman, and Laurie H. Glimcher
Journal of Clinical Investigation 2006
CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway
JH Ruth, CS Haas, CC Park, MA Amin, RJ Martinez, GK 3rd, S Shahrara, PL Campbell, AE Koch
Arthritis & Rheumatism 2006
Involvement of TNF-Like Weak Inducer of Apoptosis in the Pathogenesis of Collagen-Induced Arthritis
K Kamata, S Kamijo, A Nakajima, A Koyanagi, H Kurosawa, H Yagita, K Okumura
Journal of immunology (Baltimore, Md. : 1950) 2006
Differential effect of methotrexate on the increased CCR2 density on circulating CD4 T lymphocytes and monocytes in active chronic rheumatoid arthritis, with a down regulation only on monocytes in responders
T Ellingsen, N Hornung, BK Møller, JH Poulsen, K Stengaard-Pedersen
Annals of the rheumatic diseases 2006
IL-20: biological functions and clinical implications
CC Wei, YH Hsu, HH Li, YC Wang, MY Hsieh, WY Chen, CH Hsing, MS Chang
Journal of Biomedical Science 2006
Essential role of neutrophils in anti-type II collagen antibody and lipopolysaccharide-induced arthritis
D Tanaka, T Kagari, H Doi, T Shimozato
Immunology 2006
Allelic frequency of the MCP-1 promoter −2518 polymorphism in the Turkish population and in Turkish patients with juvenile rheumatoid arthritis
AR Özyürek, D Gürses, Z Ülger, E Levent, AR Bakiler, A Berdeli
Clinical Rheumatology 2006
The CCR2 receptor as a therapeutic target
M Feria, F Díaz-González
Expert Opinion on Therapeutic Patents 2006
Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis
YH Hsu, HH Li, MY Hsieh, MF Liu, KY Huang, LS Chin, PC Chen, HH Cheng, MS Chang
Arthritis & Rheumatism 2006
Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis
S Rantapää-Dahlqvist, K Boman, A Tarkowski, G Hallmans
Annals of the rheumatic diseases 2006
T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFkappaB: implications for rheumatoid arthritis
JT Beech, E Andreakos, CJ Ciesielski, P Green, BM Foxwell, FM Brennan
Arthritis Research & Therapy 2006
Anti-tumor necrosis factor-alpha antibody treatment reduces serum CXCL16 levels in patients with rheumatoid arthritis
Y Kageyama, E Torikai, A Nagano
Rheumatology International 2006
Chemokine inhibition in inflammatory arthritis
PP Tak
Best Practice & Research Clinical Rheumatology 2006
RANTES and monocyte chemoattractant protein 1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: A six-year longitudinal study
TC Yao, ML Kuo, LC See, LS Ou, WI Lee, CK Chan, JL Huang
Arthritis & Rheumatism 2006
Novel therapies for rheumatoid arthritis
AH Tremoulet, S Albani
Expert Opinion on Investigational Drugs 2006
Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis
Y Wang, D Wei, Z Lai, Y Le
International Immunopharmacology 2006
Dynamics of Bone and Cartilage Metabolism
JE Mulder, CA Kulak, E Shane
Dynamics of Bone and Cartilage Metabolism 2006
Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/6
Y Nonomura, K Nagasaka, H Hagiyama, C Sekine, T Nanki, M Tamamori-Adachi, N Miyasaka, H Kohsaka
Arthritis & Rheumatism 2006
A New “Kine” of Pain: MCP-1 and Sensory Neuron Excitability . Focus on “MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia”
CM Hingtgen
Journal of neurophysiology 2006
Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints
RV der Voort, AW van Lieshout, LW Toonen, AW Slöetjes, WB van Berg, CG Figdor, TR Radstake, GJ Adema
Arthritis & Rheumatism 2005
Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis
S Cuzzocrea, E Ayroldi, RD Paola, M Agostini, E Mazzon, S Bruscoli, T Genovese, S Ronchetti, AP Caputi, C Riccardi
The FASEB Journal 2005
Chemokines: Their role in rheumatoid arthritis
CE Vergunst, PP Tak
Current Rheumatology Reports 2005
The role of chemokines in rheumatoid arthritis and osteoarthritis
CE Vergunst, MG van de Sande, MC Lebre, PP Tak
Scandinavian Journal of Rheumatology 2005
HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: Possible role in NeuroAIDS
EA Eugenin, G Dyer, TM Calderon, JW Berman
Glia 2005
Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice
S García, A Bodaño, A González, J Forteza, JJ Gómez-Reino, C Conde
Arthritis Research & Therapy 2005
Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis
O Grimsholm, S Rantapää-Dahlqvist, S Forsgren
Arthritis Research & Therapy 2005
Expression of interleukin-22 in rheumatoid arthritis: Potential role as a proinflammatory cytokine
H Ikeuchi, T Kuroiwa, N Hiramatsu, Y Kaneko, K Hiromura, K Ueki, Y Nojima
Arthritis & Rheumatism 2005
An angiotensin receptor blocker suppresses monocyte chemoattractant protein 1 production from rheumatoid synovial fibroblasts: Comment on the article by Sagawa et al
N Iikuni, H Okamoto, M Kasahara, N Kamatani
Arthritis & Rheumatism 2005
Tumor necrosis factor-alpha increases chemokine gene expression and production in synovial fibroblasts from human temporomandibular joint
N Ogura, M Tobe, H Sakamaki, H Nagura, Y Abiko, T Kondoh
Journal of Oral Pathology and Medicine 2005
The expression of CCL2 by T lymphocytes of mammary tumor bearers: Role of tumor-derived factors
JL Owen, DM Lopez, JF Grosso, KM Guthrie, LM Herbert, M Torroella-Kouri, V Iragavarapu-Charyulu
Cellular Immunology 2005
Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis
MM Barsante, E Roffê, CM Yokoro, WL Tafuri, DG Souza, V Pinho, MS de Castro, MM Teixeira
European Journal of Pharmacology 2005
MCP-1-stimulated chemotaxis of monocytic and endothelial cells is dependent on activation of different signaling cascades
TI Arefieva, NB Kukhtina, OA Antonova, TL Krasnikova
Cytokine 2005
NeuroImmune Biology
R Solana, G Pawelec
NeuroImmune Biology 2005
Chemokines and their receptors in rheumatoid arthritis: Future targets?
AE Koch
Arthritis & Rheumatism 2005
Inhibition of the angiogenesis by the MCP-1 (monocyte chemoattractant protein-1) binding peptide
MY Kim, CW Byeon, KH Hong, KH Han, S Jeong
FEBS Letters 2005
Chemokines in rheumatoid arthritis
P Loetscher
Drug Discovery Today: Disease Mechanisms 2005
Profiling of differentially expressed chemotactic-related genes in MCP-1 treated macrophage cell line using human cDNA arrays
Guang-Xing Bian, Hong Miao, Lei Qiu, Dong-Mei Cao, Bao-Yu Guo
World journal of gastroenterology : WJG 2005
A CCR-5 antagonist inhibits the development of adjuvant arthritis in rats
H Okamoto, N Kamatani
Rheumatology (Oxford, England) 2005
AGIX-4207 [2-[4-[[1-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic Acid], a Novel Antioxidant and Anti-Inflammatory Compound: Cellular and Biochemical Characterization of Antioxidant Activity and Inhibition of Redox-Sensitive Inflammatory Gene Expression
C Kunsch, J Luchoomun, , GL Dodd, KS Karu, CQ Meng, EM Marino, LK Olliff, JD Piper, FH Qiu, JA Sikorski, PK Somers, KL Suen, S Thomas, AM Whalen, MA Wasserman, CL Sundell
The Journal of pharmacology and experimental therapeutics 2005
IL-18 Induces Monocyte Chemotactic Protein-1 Production in Macrophages through the Phosphatidylinositol 3-Kinase/Akt and MEK/ERK1/2 Pathways
JK Yoo, H Kwon, LY Khil, L Zhang, HS Jun, JW Yoon
Journal of immunology (Baltimore, Md. : 1950) 2005
Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells
H Brühl, J Cihak, MA Schneider, J Plachý, T Rupp, I Wenzel, M Shakarami, S Milz, JW Ellwart, M Stangassinger, D Schlöndorff, M Mack
Journal of immunology (Baltimore, Md. : 1950) 2004
Key Roles of CD4 + T Cells and IFN-γ in the Development of Abdominal Aortic Aneurysms in a Murine Model
W Xiong, Y Zhao, A Prall, TC Greiner, BT Baxter
Journal of immunology (Baltimore, Md. : 1950) 2004
Chemokines in joint disease: the key to inflammation?
JJ Haringman, J Ludikhuize, PP Tak
Annals of the rheumatic diseases 2004
Inhibition of TNF alpha during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF alpha blockade in rheumatoid arthritis
AW van Lieshout, P Barrera, RL Smeets, GJ Pesman, PL van Riel, WB van Berg, TR Radstake
Annals of the rheumatic diseases 2004
Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid arthritis synovial fibroblasts
K Bradley, JC Scatizzi, S Fiore, E Shamiyeh, AE Koch, GS Firestein, LL Gorges, K Kuntsman, RM Pope, TL Moore, J Han, H Perlman
Arthritis & Rheumatism 2004
Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation
YH Hsu, MS Hsieh, YC Liang, CY Li, MT Sheu, DT Chou, TF Chen, CH Chen
Journal of Cellular Biochemistry 2004
Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts
DJ Min, ML Cho, SH Lee, SY Min, WU Kim, JK Min, SH Park, CS Cho, HY Kim
Arthritis & Rheumatism 2004
Type II Collagen Autoimmunity in Rheumatoid Arthritis
WU Kim, ML Cho, YO Jung, SY Min, SW Park, DJ Min, JH Yoon, HY Kim
The American Journal of the Medical Sciences 2004
Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Protects Against Focal Brain Ischemia in Hypertensive Rats
Y Kumai, H Ooboshi, J Takada, M Kamouchi, T Kitazono, K Egashira, S Ibayashi, M Iida
Journal of Cerebral Blood Flow & Metabolism 2004
N-Benzylindole-2-carboxylic acids: potent functional antagonists of the CCR2b chemokine receptor
JG Kettle, AW Faull, AJ Barker, DH Davies, MA Stone
Bioorganic & Medicinal Chemistry Letters 2004
Matrix metalloproteinases and the immune response
KA Szabo, RJ Ablin, G Singh
Clinical and Applied Immunology Reviews 2004
Development of a microplate bioassay for monocyte chemoattractant protein-1 based on activation of p44/42 mitogen-activated protein kinase
JH Terra, I Montaño, A Schilb, TA Millward
Analytical Biochemistry 2004
Hypoxia Selectively Inhibits Monocyte Chemoattractant Protein-1 Production by Macrophages
MC Bosco, M Puppo, S Pastorino, Z Mi, G Melillo, S Massazza, A Rapisarda, L Varesio
Journal of immunology (Baltimore, Md. : 1950) 2004
IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts
H Perlman, K Bradley, H Liu, S Cole, E Shamiyeh, RC Smith, K Walsh, S Fiore, AE Koch, GS Firestein, GK 3rd, RM Pope
Journal of immunology (Baltimore, Md. : 1950) 2003
Gene transfer of a cell cycle modulator exerts anti-inflammatory effects in the treatment of arthritis
Y Nonomura, H Kohsaka, K Nagasaka, N Miyasaka
Journal of immunology (Baltimore, Md. : 1950) 2003
Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood–brain barrier
EA Eugenin, JW Berman
Methods 2003
Targeting monocyte chemoattractant protein-1 signalling in disease
J Dawson, W Miltz, AK Mir, C Wiessner
Expert Opinion on Therapeutic Targets 2003
The therapeutic potential of costimulatory blockade with CTLA4Ig in rheumatoid arthritis
P Emery
Expert Opinion on Investigational Drugs 2003
Chemokines and chemokine receptors in rheumatoid arthritis
Z Szekanecz, J Kim, AE Koch
Seminars in Immunology 2003
Pathophysiological roles for IL-18 in inflammatory arthritis
K Matsui, H Tsutsui, K Nakanishi
Expert Opinion on Therapeutic Targets 2003
Hydrodynamic guiding for addressing subsets of immobilized cells and molecules in microfluidic systems
T Brevig, U Krühne, RA Kahn, T Ahl, M Beyer, LH Pedersen
BMC Biotechnology 2003
Impaired hepatic granuloma formation in mice deficient in C–C chemokine receptor 2
K Jinnouchi, Y Terasaki, S Fujiyama, K Tomita, WA Kuziel, N Maeda, K Takahashi, M Takeya
The Journal of Pathology 2003
MCP-1 promoter polymorphism in spanish patients with rheumatoid arthritis
MF González-Escribano, B Torres, F Aguilar, R Rodríguez, A García, Á Valenzuela, A Núñez-Roldán
Human Immunology 2003
The role of the beta chemokines in experimental obliterative bronchiolitis
AS Farivar, B Krishnadasan, BV Naidu, SM Woolley, MS Mulligan
Experimental and Molecular Pathology 2003
Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor gamma
S Cuzzocrea, E Mazzon, L Dugo, NS Patel, I Serraino, RD Paola, T Genovese, D Britti, MD Maio, AP Caputi, C Thiemermann
Arthritis & Rheumatism 2003
Effects of bacterial cell wall components (PAMPs) on the expression of monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1α (MIP-1α) and the chemokine receptor CCR2 by purified human blood monocytes
AS Møller, R Øvstebø, ÅB Westvik, GB Joø, KB Haug, P Kierulf
Journal of Endotoxin Research 2003
Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and the type 1 tight-skin mouse
VH Ong, LA Evans, X Shiwen, IB Fisher, V Rajkumar, DJ Abraham, CM Black, CP Denton
Arthritis & Rheumatism 2003
The Macrophage as Therapeutic Target
S Gordon
2003
Mice lacking monocyte chemoattractant protein 1 have enhanced susceptibility to an interstitial polymicrobial infection due to impaired monocyte recruitment
P Chae, M Im, F Gibson, Y Jiang, DT Graves
Infection and immunity 2002
Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID Mice
MC Blades, F Ingegnoli, SK Wheller, A Manzo, S Wahid, GS Panayi, M Perretti, C Pitzalis
Arthritis & Rheumatism 2002
Stromal cell-derived factor 1 (CXCL12) induces monocyte migration into human synovium transplanted onto SCID Mice
MC Blades, F Ingegnoli, SK Wheller, A Manzo, S Wahid, GS Panayi, M Perretti, C Pitzalis
Arthritis & Rheumatism 2002
Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases
E Bodolay, AE Koch, J Kim, G Szegedi, Z Szekanecz
Journal of Cellular and Molecular Medicine 2002
Monocyte Chemoattractant Protein-1-Induced Activation of p42/44 MAPK and c-Jun in Murine Peritoneal Macrophages: A Potential Pathway for Macrophage Activation
A Sodhi, SK Biswas
Journal of Interferon & Cytokine Research 2002
Expression of the Duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium
AM Patterson, H Siddall, G Chamberlain, L Gardner, J Middleton
The Journal of Pathology 2002
Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression
GA Auger, JE Pease, X Shen, G Xanthou, MD Barker
European Journal of Immunology 2002
Slit proteins, potential endogenous modulators of inflammation
N Havlioglu, L Yuan, H Tang, JY Wu
Journal of Neurovirology 2002
Leucocyte chemotaxis: Examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by Monocyte Chemoattractant Proteins-1, -2, -3 and -4
JH Wain, JA Kirby, S Ali
Clinical & Experimental Immunology 2002
Interleukin-13 Gene Therapy Reduces Inflammation, Vascularization, and Bony Destruction in Rat Adjuvant-Induced Arthritis
JM Woods, MA Amin, KJ Katschke, MV Volin, JH Ruth, MA Connors, DC Woodruff, H Kurata, KI Arai, GK Haines, P Kumar, AE Koch
Human Gene Therapy 2002
Differential production of RANTES and MCP-1 in synovial fluid from the inflamed human knee
P Conti, M Reale, RC Barbacane, ML Castellani, C Orso
Immunology Letters 2002
Differential Expression of the Isoforms for the Monocyte Chemoattractant Protein-1 Receptor, CCR2, in Monocytes
S Tanaka, SR Green, O Quehenberger
Biochemical and Biophysical Research Communications 2002
Tyrosine phosphorylation-mediated signal transduction in MCP-1-induced macrophage activation: role for receptor dimerization, focal adhesion protein complex and JAK/STAT pathway
SK Biswas, A Sodhi
International Immunopharmacology 2002
The Effect of Sulfasalazine on Rheumatoid Arthritic Synovial Tissue Chemokine Production
MV Volin, PL Campbell, MA Connors, DC Woodruff, AE Koch
Experimental and Molecular Pathology 2002
Chemokines in synovial inflammation in rheumatoid arthritis: basic and clinical aspects
K Tani, T Shimizu, Y Motoki, S Sone
Modern Rheumatology 2002
CCR2 REGULATES THE LEVEL OF MCP-1/CCL2 IN VITRO AND AT INFLAMMATORY SITES AND CONTROLS T CELL ACTIVATION IN RESPONSE TO ALLOANTIGEN
LA Tylaska, L Boring, W Weng, R Aiello, IF Charo, BJ Rollins, RP Gladue
Cytokine 2002
Sensitization of IFN-γ Jak-STAT signaling during macrophage activation
X Hu, C Herrero, WP Li, TT Antoniv, E Falck-Pedersen, AE Koch, JM Woods, GK Haines, LB Ivashkiv
Nature Immunology 2002
The New Angiotherapy
TP Fan, EC Kohn
2002
Monocyte Chemoattractant Protein-1 Selectively Inhibits the Acquisition of CD40 Ligand-Dependent IL-12-Producing Capacity of Monocyte-Derived Dendritic Cells and Modulates Th1 Immune Response
N Omata, M Yasutomi, A Yamada, H Iwasaki, M Mayumi, Y Ohshima
Journal of immunology (Baltimore, Md. : 1950) 2002
The Importance of IL-1β and TNF-α, and the Noninvolvement of IL-6, in the Development of Monoclonal Antibody-Induced Arthritis
T Kagari, H Doi, T Shimozato
Journal of immunology (Baltimore, Md. : 1950) 2002
Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients
K Shi, K Hayashida, M Kaneko, J Hashimoto, T Tomita, PE Lipsky, H Yoshikawa, T Ochi
Journal of immunology (Baltimore, Md. : 1950) 2001
Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: Findings in a double-blind, placebo-controlled study
L Young, A Katrib, C Cuello, U Vollmer-Conna, JV Bertouch, PJ Roberts-Thomson, MJ Ahern, MD Smith, PP Youssef
Arthritis & Rheumatism 2001
Involvement of chemokine receptor 2 and its ligand, monocyte chemoattractant protein-1, in the development of atherosclerosis: lessons from knockout mice
W Peters, IF Charo
Current Opinion in Lipidology 2001
Regulation of Nitric Oxide Production by Murine Peritoneal Macrophages Treated in Vitro with Chemokine Monocyte Chemoattractant Protein 1
SK Biswas, A Sodhi, S Paul
Nitric Oxide 2001
The role of C-C chemokines and their receptors in osteoarthritis
GH Yuan, K Masuko-Hongo, M Sakata, JI Tsuruha, H Onuma, H Nakamura, H Aoki, T Kato, K Nishioka
Arthritis & Rheumatism 2001
Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis
K Tsuneyama, K Harada, M Yasoshima, K Hiramatsu, CR Mackay, IR Mackay, ME Gershwin, Y Nakanuma
The Journal of Pathology 2001
CXCR3 and CCR5 Ligands in Rheumatoid Arthritis Synovium
DD Patel, JP Zachariah, LP Whichard
Clinical Immunology 2001
Selective lymphocyte chemokine receptor expression in the rheumatoid joint
JH Ruth, JB Rottman, KJ Katschke, S Qin, L Wu, G LaRosa, P Ponath, RM Pope, AE Koch
Arthritis & Rheumatism 2001
Chemokines and angiogenesis
Z Szekanecz, AE Koch
Current Opinion in Rheumatology 2001
Surface expression of CC- and CXC-chemokine receptors on leucocyte subsets in inflammatory joint diseases
H Brühl, K Wagner, H Kellner, M Schattenkirchner, D Schlöndorff, M Mack
Clinical & Experimental Immunology 2001
The pan-chemokine inhibitor NR58-3.14.3 abolishes tumour necrosis factor-alpha accumulation and leucocyte recruitment induced by lipopolysaccharide in vivo
J Reckless, LM Tatalick, DJ Grainger
Immunology 2001
Multimerization of monocyte chemoattractant protein-1 is not required for glycosaminoglycan-dependent transendothelial chemotaxis
S Ali, AC Palmer, SJ Fritchley, Y Maley, JA Kirby
Biochemical Journal 2001
PATHOGENESIS OF RHEUMATOID ARTHRITIS
Z Zhang, SL Bridges
Rheumatic Disease Clinics of North America 2001
Dynamic changes in cytokine levels in serum and synovial fluid following filtration leukocytapheresis therapy in patients with rheumatoid arthritis
T Hidaka, K Suzuki, M Kawakami, M Okada, K Kataharada, T Shinohara, M Takamizawa-Matsumoto, F Ohsuzu
Journal of Clinical Apheresis 2001
Overexpression of monocyte chemoattractant protein 1 in systemic sclerosis: Role of platelet-derived growth factor and effects on monocyte chemotaxis and collagen synthesis
O Distler, T Pap, O Kowal-Bielecka, R Meyringer, S Guiducci, M Landthaler, J Sch�lmerich, BA Michel, RE Gay, M Matucci-Cerinic, S Gay, U M�ller-Ladner
Arthritis & Rheumatism 2001
Identification of New Regulatory Sequences Far Upstream of the Mouse Monocyte Chemoattractant Protein-1 Gene
K Wagner, U Dendorfer, S Chilla, D Schlöndorff, B Luckow
Genomics 2001
Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis
A Katrib, PP Tak, JV Bertouch, C Cuello, HP McNeil, TJ Smeets, MC Kraan, PP Youssef
Rheumatology (Oxford, England) 2001
Soluble E-selectin Induces Monocyte Chemotaxis through Src Family Tyrosine Kinases
P Kumar, S Hosaka, AE Koch
The Journal of biological chemistry 2001
Serum Level of Macrophage Migration Inhibitory Factor as a Useful Parameter of Clinical Course in Patients with Wegener's Granulomatosis and Relapsing Polychondritis
R Ohwatari, Y Inuyama, S Fukuda, K Onoé, K Iwabuchi, J Nishihira
The Annals of otology, rhinology, and laryngology 2001
Enhancing Effect of IL-1, IL-17, and TNF-α on Macrophage Inflammatory Protein-3α Production in Rheumatoid Arthritis: Regulation by Soluble Receptors and Th2 Cytokines
M Chabaud, G Page, P Miossec
Journal of immunology (Baltimore, Md. : 1950) 2001
Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8
K Hayashida, T Nanki, H Girschick, S Yavuz, T Ochi, PE Lipsky
Arthritis Research & Therapy 2001
MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythematosus: MCP-1 promoter polymorphism and SLE
F Aguilar, MF González-Escribano, J Sánchez-Román, A Núñez-Roldán
Tissue Antigens 2001
Chemokines Regulate IL-6 and IL-8 Production by Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis
T Nanki, K Nagasaka, K Hayashida, Y Saita, N Miyasaka
Journal of immunology (Baltimore, Md. : 1950) 2001
Paracrine interactions of chondrocytes and macrophages in cartilage degradation: articular chondrocytes provide factors that activate macrophage-derived pro-gelatinase B (pro-MMP-9)
R Dreier, S Wallace, S Fuchs, P Bruckner, S Grässel
Journal of cell science 2001
Chemokine Receptor Antagonists
R Horuk, HP Ng
Medicinal Research Reviews 2000
DIFFERENTIAL INDUCTION OF JE/MCP-1 IN SUBCLONES FROM A MURINE MACROPHAGE CELL LINE, RAW 264.7: ROLE OF κB-3 BINDING PROTEIN
M Ueno
Cytokine 2000
REGULATION OF TNF-α EXPRESSION IN NORMAL MACROPHAGES: THE ROLE OF C/EBPβ
R Pope, S Mungre, H Liu, B Thimmapaya
Cytokine 2000
The pathogenesis and prevention of joint damage in rheumatoid arthritis: Advances from synovial biopsy and tissue analysis
PP Tak, B Bresnihan
Arthritis & Rheumatism 2000
Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA)
MM Luchetti, G Piccinini, A Mantovani, G Peri, C Matteucci, G Pomponio, M Fratini, P Fraticelli, P Sambo, CD Loreto, A Doni, M Introna, A Gabrielli
Clinical & Experimental Immunology 2000
The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)
MC Kraan, DD Patel, JJ Haringman, MD Smith, H Weedon, MJ Ahern, FC Breedveld, PP Tak
Arthritis research 2000
Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability
H Perlman, C Georganas, LJ Pagliari, AE Koch, KH 3rd, RM Pope
Journal of immunology (Baltimore, Md. : 1950) 2000
Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats
WA Kuziel, SJ Morgan, TC Dawson, S Griffin, O Smithies, K Ley, N Maeda
Investigative ophthalmology & visual science 2000
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression
R Salcedo, ML Ponce, HA Young, K Wasserman, JM Ward, HK Kleinman, JJ Oppenheim, WJ Murphy
Blood 2000
Expression of monocyte chemoattractant protein 1 in pig-to-primate cardiac xenografts
T Zhang, J Suzuki, M Kawauchi, H Nakano, H Kuroda, N Koide, H Kitahara, K Ohta, Y Wada, K Tsukioka, K Takayama, M Endoh, S Takamoto, M Isobe, J Amano
Transplantation Proceedings 2000
Identification of the Binding Site for a Novel Class of CCR2b Chemokine Receptor Antagonists: BINDING TO A COMMON CHEMOKINE RECEPTOR MOTIF WITHIN THE HELICAL BUNDLE
T Mirzadegan, F Diehl, B Ebi, S Bhakta, I Polsky, D McCarley, M Mulkins, GS Weatherhead, JM Lapierre, J Dankwardt, D Morgans, R Wilhelm, K Jarnagin
The Journal of biological chemistry 2000
Cutaneous Injection of Human Subjects with Macrophage Inflammatory Protein-1α Induces Significant Recruitment of Neutrophils and Monocytes
SC Lee, ME Brummet, S Shahabuddin, TG Woodworth, SN Georas, KM Leiferman, SC Gilman, C Stellato, RP Gladue, RP Schleimer, LA Beck
Journal of immunology (Baltimore, Md. : 1950) 2000
A Mechanism for the Impaired IFN-γ Production in C-C Chemokine Receptor 2 (CCR2) Knockout Mice: Role of CCR2 in Linking the Innate and Adaptive Immune Responses
W Peters, M Dupuis, IF Charo
Journal of immunology (Baltimore, Md. : 1950) 2000
Gelenkpathologie
W Mohr
2000
Regulation of IL-6 and IL-8 Expression in Rheumatoid Arthritis Synovial Fibroblasts: the Dominant Role for NF-κB But Not C/EBPβ or c-Jun
C Georganas, H Liu, H Perlman, A Hoffmann, B Thimmapaya, RM Pope
Journal of immunology (Baltimore, Md. : 1950) 2000
Macrophage Inflammatory Protein-2 and KC Induce Chemokine Production by Mouse Astrocytes
Y Luo, FR Fischer, WW Hancock, ME Dorf
Journal of immunology (Baltimore, Md. : 1950) 2000
Reduction of Inflammatory Cytokines and Prostaglandin E 2 by IL-13 Gene Therapy in Rheumatoid Arthritis Synovium
JM Woods, KJ Katschke, M Tokuhira, H Kurata, KI Arai, PL Campbell, AE Koch
Journal of immunology (Baltimore, Md. : 1950) 2000
Synovial fluid neutrophil expression of interleukin-8 in rheumatoid arthritis
T Kasama, H Iwabuchi, R Hanaoka, HT Takeuchi, Y Miwa, L Jing, Y Mori, K Kobayashi, M Negishi, H Ide, M Adachi
Japanese Journal of Rheumatology 1999
C/EBPβ in Rheumatoid Arthritis: Correlation with Inflammation, Not Disease Specificity1
RM Pope, R Lovis, S Mungre, H Perlman, AE Koch, GK Haines
Clinical Immunology 1999
On the edge: the physiological and pathophysiological role of chemokines during inflammatory and immunological responses
ME DeVries, L Ran, DJ Kelvin
Seminars in Immunology 1999
The MCP/eotaxin subfamily of CC chemokines
EV Coillie, JV Damme, G Opdenakker
Cytokine & Growth Factor Reviews 1999
Current perspectives on synovitis
PP Tak, FC Breedveld
Arthritis research 1999
Augmented production of chemokines (monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta) in patients with systemic sclerosis: MCP-1 and MIP-1alpha may be involved in the development of pulmonary fibrosis
M Hasegawa, S Sato, K Takehara
Clinical & Experimental Immunology 1999
Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis
Y Hatano, T Kasama, H Iwabuchi, R Hanaoka, HT Takeuchi, L Jing, Y Mori, K Kobayashi, M Negishi, H Ide, M Adachi
Annals of the rheumatic diseases 1999
Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines
J Reckless, DJ Grainger
Biochemical Journal 1999
Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation: analysis of cellular recruitment and cytokine responses
KS Warmington, L Boring, JH Ruth, J Sonstein, CM Hogaboam, JL Curtis, SL Kunkel, IR Charo, SW Chensue
The American Journal of Pathology 1999
The Participation of IL-8 in the Synovial Lesions at an Early Stage of Rheumatoid Arthritis
Y Takahashi, T Kasahara, T Sawai, A Rikimaru, N Mukaida, K Matsushima, T Sasaki
The Tohoku Journal of Experimental Medicine 1999
CD154 (CD40L) Induces Human Endothelial Cell Chemokine Production and Migration of Leukocyte Subsets
U Thienel, J Loike, MJ Yellin
Cellular Immunology 1999
A Novel Polymorphism in the MCP-1 Gene Regulatory Region That Influences MCP-1 Expression
BH Rovin, L Lu, R Saxena
Biochemical and Biophysical Research Communications 1999
Liposome encapsulated aurothiomalate reduces collagen-induced arthritis in DBA/1J mice
P Konigsberg
Biochimica et Biophysica Acta (BBA) - Biomembranes 1999
Chemokines: extracellular messengers for all occasions?
LM Gale, SR McColl
BioEssays 1999
Semiquantitation of human chemokine mRNA levels with a newly constructed multispecific competitor fragment
FL Dumoulin, M Altfeld, JK Rockstroh, L Leifeld, T Sauerbruch, U Spengler
Journal of Immunological Methods 1999
Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis
RM Borzı̀, I Mazzetti, S Macor, T Silvestri, A Bassi, L Cattini, A Facchini
FEBS Letters 1999
Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis
MS Lombardi, A Kavelaars, M Schedlowski, JW Bijlsma, KL Okihara, MV de Pol, S Ochsmann, C Pawlak, RE Schmidt, CJ Heijnen
The FASEB Journal 1999
Regional differences on production of chemokines in gastric mucosa between Helicobacter pylori-positive duodenal ulcer and gastric ulcer
Y Sato, K Sugimura, T Mochizuki, T Honma, H Suriki, K Tashiro, K Ishizuka, R Narisawa, T Ichida, DH van Thiel, H Asakura
Digestive Diseases and Sciences 1999
Chemokines in Rheumatoid Arthritis
A Koch
Arthritis research 1999
TGF-Beta Downmodulates Cytokine-Induced Monocyte Chemoattractant Protein (MCP)-1 Expression in Human Endothelial Cells. A Putative Role for TGF-Beta in the Modulation of TNF Receptor Expression
JM Weiss, CA Cuff, JW Berman
Endothelium : journal of endothelial cell research 1999
Treatment with sulfasalazine or sulfapyridine, but not 5-aminosalicylic acid, inhibits basic fibroblast growth factor-induced endothelial cell chemotaxis
MV Volin, LA Harlow, JM Woods, PL Campbell, MA Amin, M Tokuhira, AE Koch
Arthritis & Rheumatism 1999
Effects of reactive oxygen and nitrogen metabolites on MCP-1-induced monocyte chemotactic activity in vitro
E Sato, KL Simpson, MB Grisham, S Koyama, RA Robbins
American journal of physiology. Lung cellular and molecular physiology 1999
Cloning and Functional Characterization of the 5′-Flanking Region of the Human Monocyte Chemoattractant Protein-1 Receptor (CCR2) Gene: ESSENTIAL ROLE OF 5′-UNTRANSLATED REGION IN TISSUE-SPECIFIC EXPRESSION
K Yamamoto, H Takeshima, K Hamada, M Nakao, T Kino, T Nishi, M Kochi, JI Kuratsu, T Yoshimura, Y Ushio
The Journal of biological chemistry 1999
Chemokines in Disease
CA Hébert
1999
Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential effects of plasma lipoproteins on monocyte function
KH Han, KO Han, SR Green, O Quehenberger
Journal of lipid research 1999
Antigen-presenting cells in rheumatoid arthritis
R Thomas
Springer Seminars in Immunopathology 1998
The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease
RP MacDermott, IR Sanderson, HC Reinecker
Inflammatory Bowel Diseases 1998
Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy
PP Youssef, M Kraan, F Breedveld, B Bresnihan, N Cassidy, G Cunnane, P Emery, O Fitzgerald, D Kane, S Lindblad, R Reece, D Veale, PP Tak
Arthritis & Rheumatism 1998
Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice
B Lu, BJ Rutledge, L Gu, J Fiorillo, NW Lukacs, SL Kunkel, R North, C Gerard, BJ Rollins
Journal of Experimental Medicine 1998
Simultaneous Elevation of the Levels of Circulating Monocyte Chemoattractant Protein-1 and Tissue Factor in Acute Coronary Syndromes
K Nishiyama, H Ogawa, H Yasue, H Soejima, K Misumi, K Takazoe, M Yoshimura, K Kugiyama, I Tsuji, K Kumeda
Japanese Circulation Journal 1998
Mapping of MCP-1 functional domains by peptide analysis and site-directed mutagenesis
SA Steitz, K Hasegawa, SL Chiang, RR Cobb, MA Castro, TJ Lobl, M Yamada, E Lazarides, PM Cardarelli
FEBS Letters 1998
The Central Role of Chemokines (Chemotactic Cytokines) in the Immunopathogenesis of Ulcerative Colitis and Crohnʼs Disease:
RP MacDermott, IR Sanderson, HC Reinecker
Inflammatory Bowel Diseases 1998
RANTES expression and contribution to monocyte chemotaxis in arthritis
M V Volin, M R Shah, M Tokuhira, G K Haines, J M Woods, A E Koch
Clinical Immunology and Immunopathology 1998
Lysine 58 and Histidine 66 at the C-terminal α-Helix of Monocyte Chemoattractant Protein-1 Are Essential for Glycosaminoglycan Binding
L Chakravarty, L Rogers, T Quach, S Breckenridge, PE Kolattukudy
The Journal of biological chemistry 1998
The CC Chemokine Monocyte Chemotactic Peptide-1 Activates both the Class I p85/p110 Phosphatidylinositol 3-Kinase and the Class II PI3K-C2α
SJ Turner, J Domin, MD Waterfield, SG Ward, J Westwick
The Journal of biological chemistry 1998
Role of pro-inflammatory cytokines in rheumatoid arthritis
FM Brennan, RN Maini, M Feldmann
Springer Seminars in Immunopathology 1998
The monocyte chemotactic protein a (MCP-1) and interleukin 8 (IL-8) in Hodgkin's disease and in solid tumours
MG Luciani, A Stoppacciaro, G Peri, A Mantovani, LP Ruco
Molecular Pathology 1998
Cytokines in Rheumatoid Arthritis: Potential Targets for Pharmacological Intervention
Z Szekanecz, AE Koch, SL Kunkel, RM Strieter
Drugs & Aging 1998
Chemokines in rheumatoid arthritis.
Szekanecz Z, Strieter RM, Kunkel SL, Koch AE
Springer Seminars in Immunopathology 1998
Functional CD40 ligand is expressed by T cells in rheumatoid arthritis
KP MacDonald, Y Nishioka, PE Lipsky, R Thomas
Journal of Clinical Investigation 1997
Lymphocytic airway infiltration as a precursor to fibrous obliteration in a rat model of bronchiolitis obliterans
L Boring, J Gosling, SW Chensue, SL Kunkel, RV Farese, HE Broxmeyer, IF Charo
Journal of Clinical Investigation 1997
Mononuclear phagocytes and rheumatoid synovitis. Mastermind or workhorse in arthritis?
GR Burmester, B Stuhlmüller, G Keyszer, RW Kinne
Arthritis & Rheumatism 1997
THE ROLE OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) IN THE PATHOGENESIS OF COLLAGEN-INDUCED ARTHRITIS IN RATS
H Ogata, M Takeya, T Yoshimura, K Takagi, K Takahashi
The Journal of Pathology 1997
Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease
E Gemmell, RI Marshall, GJ Seymour
Periodontology 2000 1997
Monocyte recruitment in cryoglobulinemic membranoproliferative glomerulonephritis: A pathogenetic role for monocyte chemotactic peptide-1
L Gesualdo, G Grandaliano, E Ranieri, R Monno, V Montinaro, C Manno, FP Schena
Kidney International 1997
Oncostatin M stimulates monocyte chemoattractant protein-1- and interleukin-1-induced matrix metalloproteinase-1 production by human synovial fibroblasts in vitro
C Langdon, J Leith, CD Richards, F Smith
Arthritis & Rheumatism 1997
An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model
JH Gong, LG Ratkay, JD Waterfield, I Clark-Lewis
Journal of Experimental Medicine 1997
Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism
CM McKee, CJ Lowenstein, MR Horton, J Wu, C Bao, BY Chin, AM Choi, PW Noble
The Journal of biological chemistry 1997
Lymphocytic airway infiltration as a precursor to fibrous obliteration in a rat model of bronchiolitis obliterans
L Boring, J Gosling, SW Chensue, SL Kunkel, RV Farese, HE Broxmeyer, IF Charo
Transplantation 1997
Low-Level Production of Interleukin-13 in Synovial Fluid and Tissue from Patients with Arthritis
JM Woods, GK Haines, MR Shah, G Rayan, AE Koch
Clinical Immunology and Immunopathology 1997
MONOCYTE CHEMOTACTIC PEPTIDE-1 EXPRESSION AND MONOCYTE INFILTRATION IN ACUTE RENAL TRANSPLANT REJECTION1:
G Grandaliano, L Gesualdo, E Ranieri, R Monno, G Stallone, FP Schena
Transplantation 1997
Target effector role of vascular endothelium in the inflammatory response: insights from the clinical trial of anti-TNF alpha antibody in rheumatoid arthritis
E Paleolog
Molecular Pathology 1997
Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrès des recherches pharmaceutiques
RM Eglen, MR Juchau, G Edwards, AH Weston, H Wise, MD Murray, DC Brater, O Valdenaire, P Vernier, A Polak, E Jucker
1997
Interleukin-15 (IL-15) Induces IL-8 and Monocyte Chemotactic Protein 1 Production in Human Monocytes
R Badolato, AN Ponzi, M Millesimo, LD Notarangelo, T Musso
Blood 1997
Activation of human monocytes for enhanced production of interleukin 8 during transendothelial migration in vitro
M Takahashi, U Ikeda, T Kasahara, S Kitagawa, Y Takahashi, K Shimada, S Kano, C Morimoto, J Masuyama
Journal of Clinical Immunology 1997
Cytokine and nitric oxide production in the acute phase of bacterial cell wall-induced arthritis
J W Fuseler, E M Conner, J M Davis, R E Wolf, M B Grisham
Inflammation 1997
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.
Kuziel WA, Morgan SJ, Dawson TC, Griffin S, Smithies O, Ley K, Maeda N
Proceedings of the National Academy of Sciences 1997
Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44
CM McKee, MB Penno, M Cowman, MD Burdick, RM Strieter, C Bao, PW Noble
Journal of Clinical Investigation 1996
Alterations of the mucosal immune system in inflammatory bowel disease
RP MacDermoit
Journal of Gastroenterology 1996
Role of cytokines, acute-phase proteins, and chemokinesin the progression of rheumatoid arthritis
R Badolato, JJ Oppenheim
Seminars in Arthritis and Rheumatism 1996
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
M Feldmann, FM Brennan, RN Maini
Annual Review of Immunology 1996
Opposite effects of interleukin-13 and interleukin-12 on the release of inflammatory cytokines, cytokine inhibitors and prostaglandin E from synovial fibroblasts and blood mononuclear cells
M Seitz, P Loetscher, B Dewald, H Towbin, M Baggiolini
European Journal of Immunology 1996
Chemokines: a superfamily of chemotactic cytokines
S Sozzani, M Locati, P Allavena, J Damme, A Mantovani
International Journal of Clinical & Laboratory Research 1996
Hepatocyte growth factor. A cytokine mediating endothelial migration in inflammatory arthritis
AE Koch, MM Halloran, S Hosaka, MR Shah, CJ Haskell, SK Baker, RJ Panos, GK Haines, GL Bennett, RM Pope, N Ferrara
Arthritis & Rheumatism 1996
Monocyte chemoattractant protein-1 levels in patients with glomerular disease
BH Rovin, N Doe, LC Tan
American Journal of Kidney Diseases 1996
Monocyte chemoattractant protein-1 gene expression in prostatic hyperplasia and prostate adenocarcinoma
L Mazzucchelli, P Loetscher, A Kappeler, M Uguccioni, M Baggiolini, JA Laissue, C Mueller
The American Journal of Pathology 1996
Differential effects of protein kinase C inhibitors on chemokine production in human synovial fibroblasts
NJ Jordan, ML Watson, T Yoshimura, J Westwick
British Journal of Pharmacology 1996
Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1
ML Rand, JS Warren, MK Mansour, W Newman, DJ Ringler
The American Journal of Pathology 1996
Protective antibody therapy is associated with reduced chemokine transcripts in herpes simplex virus type 1 corneal infection
YH Su, XT Yan, JE Oakes, RN Lausch
Journal of virology 1996
HCC-1, a novel chemokine from human plasma
P Schulz-Knappe, HJ Mägert, B Dewald, M Meyer, Y Cetin, M Kubbies, J Tomeczkowski, K Kirchhoff, M Raida, K Adermann, A Kist, M Reinecke, R Sillard, A Pardigol, M Uguccioni, M Baggiolini, WG Forssmann
Journal of Experimental Medicine 1996
The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo
ES Yi, DG Remick, Y Lim, W Tang, CE Nadzienko, A Bedoya, S Yin, TR Ulich
Inflammation 1996
The Chemokine Superfamily: Crosstalk with the IL-1 System
A Mantovani, M Locati, P Allavena, S Sozzani
Immunobiology 1996
Essentials of Mucosal Immunology
DK Podolsky
Essentials of Mucosal Immunology 1996
Expression of monocyte chemoattractant protein-1 mRNA and protein in cultured human thyrocytes
K Kasai, N Banba, S Motohashi, Y Hattori, K Manaka, SI Shimoda
FEBS Letters 1996
Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease
BJ Rollins
Molecular Medicine Today 1996
Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC
T Kurihara, R Bravo
The Journal of biological chemistry 1996
Molecular Cloning and Functional Expression of Murine JE (Monocyte Chemoattractant Protein 1) and Murine Macrophage Inflammatory Protein 1 Receptors: EVIDENCE FOR TWO CLOSELY LINKED C-C CHEMOKINE RECEPTORS ON CHROMOSOME 9
L Boring, J Gosling, FS Monteclaro, AJ Lusis, CL Tsou, IF Charo
The Journal of biological chemistry 1996
Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
T Kasama, RM Strieter, NW Lukacs, PM Lincoln, MD Burdick, SL Kunkel
Journal of Clinical Investigation 1995
Role of Macrophage-Like Synovial Lining Cells in Localization and Expression of Experimental Arthritis
PL van Lent, AE Holthuysen, L Bersselaar, N Rooijen, LB van de Putte, WB van Berg
Scandinavian Journal of Rheumatology 1995
Chemokine expression in rheumatoid arthritis (RA): evidence of RANTES and macrophage inflammatory protein (MIP)-1β production by synovial T cells
E Robinson, EC Keystone, TJ Schall, N Gillett, EN Fish
Clinical & Experimental Immunology 1995
Identification of MIP-1α/LD78 as a Monocyte Chemoattractant Released by the HTLV-I-Transformed Cell Line MT4
R Bertini, W Luini, S Sozzani, B Bottazzi, P Ruggiero, D Boraschi, D Saggioro, L Chieco-Bianchi, P Proost, JV Damme, A Mantovani
AIDS Research and Human Retroviruses 1995
Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa
HC Reinecker, EY Loh, DJ Ringler, A Mehta, JL Rombeau, RP MacDermott
Gastroenterology 1995
Production of monocyte chemoattractant protein-1 by bovine glomerular endothelial cells
Y Kakizaki, S Waga, K Sugimoto, H Tanaka, K Nukii, M Takeya, T Yoshimura, M Yokoyama
Kidney International 1995
Keratinocyte-Derived Monocyte Chemoattractant Protein 1 (MCP-1): Analysis in a Transgenic Model Demonstrates MCP-1 Can Recruit Dendritic and Langerhans Cells to Skin
K Nakamura, IR Williams, TS Kupper
Journal of Investigative Dermatology 1995
Induction of human monocyte motility by lysyl oxidase
HM Lazarus, WW Cruikshank, N Narasimhan, HM Kagan, DM Center
Matrix Biology 1995
Expression of a Human Mutant Monocyte Chemotactic Protein 3 inPichia pastorisand Characterization as an MCP-3 Receptor Antagonist
S Masure, L Paemen, P Proost, JV Damme, G Opdenakker
Journal of Interferon & Cytokine Research 1995
Modulation of JE/MCP-1 expression in dermal wound repair
LA DiPietro, PJ Polverini, SM Rahbe, EJ Kovacs
The American Journal of Pathology 1995
Chemokine expression in rheumatoid arthritis (RA): evidence of RANTES and macrophage inflammatory protein (MIP)-1 beta production by synovial T cells
E Robinson, EC Keystone, TJ Schall, N Gillett, EN Fish
Clinical & Experimental Immunology 1995
The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells
H Tanaka, T Minoshima, N Endo
British Journal of Pharmacology 1995
Regulatory roles of tumor necrosis factor-alpha and interleukin-1 beta in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat
CM Flory, ML Jones, BF Miller, JS Warren
The American Journal of Pathology 1995
Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues
JH Gong, I Clark-Lewis
Journal of Experimental Medicine 1995
A dominant negative inhibitor indicates that monocyte chemoattractant protein 1 functions as a dimer
Y Zhang, BJ Rollins
Molecular and cellular biology 1995
Porphyromonas gingivalis lipopolysaccharide is poorly recognized by molecular components of innate host defense in a mouse model of early inflammation
RA Reife, RA Shapiro, BA Bamber, KK Berry, GE Mick, RP Darveau
Infection and immunity 1995
The protein phosphatase inhibitor calyculin A stimulates chemokine production by human synovial cells
NJ Jordan, ML Watson, J Westwick
Biochemical Journal 1995
Tumor necrosis factor α and transforming growth factor β upregulate astrocyte expression of monocyte chemoattractant protein-1
AA Hurwitz, WD Lyman, JW Herman
Journal of Neuroimmunology 1995
Chemokines of the α, β-subclass inhibit human basophils' responsiveness to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1
P Kuna, SR Reddigari, D Rucinskia, TJ Schall, AP Kaplan
Journal of Allergy and Clinical Immunology 1995
Immunopharmacology of Free Radical Species
C Rice-Evans
Immunopharmacology of Free Radical Species 1995
The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection
IF Charo, SJ Myers, A Herman, C Franci, AJ Connolly, SR Coughlin
Journal of immunology (Baltimore, Md. : 1950) 1995
Neutrophil-macrophage Interaction: a paradigm for chronic inflammation
DL Lefkowitz, K Mills, SS Lefkowitz, A Bollen, N Moguilevsky
Medical Hypotheses 1995
Suppressive Role of Endogenous Endothelial Monocyte Chemoattractant Protein–1 on Monocyte Transendothelial Migration In Vitro
M Takahashi, JI Masuyama, U Ikeda, SI Kitagawa, T Kasahara, M Saito, S Kano, K Shimada
Arteriosclerosis, thrombosis, and vascular biology 1995
Effects of Th1 and Th2 cytokines on cytokine production and ICAM-1 expression on synovial fibroblasts
JF Schlaak, A Schwarting, P Knolle, KH zum Buschenfelde, W Mayet
Annals of the rheumatic diseases 1995
Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis
AE Koch, SL Kunkel, LA Harlow, DD Mazarakis, GK Haines, MD Burdick, RM Pope, RM Strieter
Journal of Clinical Investigation 1994
Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis
AE Koch, SL Kunkel, LA Harlow, DD Mazarakis, GK Haines, MD Burdick, RM Pope, A Walz, RM Strieter
Journal of Clinical Investigation 1994
C/EBP beta regulation of the tumor necrosis factor alpha gene
RM Pope, A Leutz, SA Ness
Journal of Clinical Investigation 1994
Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs
P Loetscher, B Dewald, M Baggiolini, M Seitz
Cytokine 1994
Detection of monocyte chemotactic and activating factor (MCAF) in normal blood and urine using a sensitive ELISA
N Ida, S Sakurai, G Kawano
Cytokine 1994
Interferon-gamma Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
JM Liebler, SL Kunkel, RM Allen, MD Burdick, RM Strieter
Mediators of Inflammation 1994
Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant
MW Carr, SJ Roth, E Luther, SS Rose, TA Springer
Proceedings of the National Academy of Sciences 1994
Monocyte chemoattractant protein-1 in idiopathic pulmonary fibrosis and other interstitial lung diseases
K Iyonaga, M Takeya, N Saita, O Sakamoto, T Yoshimura, M Ando, K Takahashi
Human Pathology 1994
The role of tumour necrosis factor-alpha and IL-1 in polymorphonuclear leucocyte and T lymphocyte recruitment to joint inflammation in adjuvant arthritis
A Issekutz, A Meager, I Otterness, T Issekutz
Clinical & Experimental Immunology 1994
A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells
G Peri, C Milanese, C Matteucci, L Ruco, Z Dan, S Silvano, C Isabella, M Alberto
Journal of Immunological Methods 1994
Interleukin-8 and Related Chemotactic Cytokines
M Baggiolini, B Moser, I Clark-Lewis
Chest 1994
Functional role of the cis-acting elements in human monocyte chemotactic protein-1 gene in the regulation of its expression by phorbol ester in human glioblastoma cells
YS Li, PE Kolattukudy
Molecular and Cellular Biochemistry 1994
Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.
Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin SR
Proceedings of the National Academy of Sciences 1994
The Molecular and Cellular Biology of Wound Repair
RA Clark, PM Henson
1988

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