Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
Article has an altmetric score of 3

See more details

Referenced in 3 patents
24 readers on Mendeley
  • Article usage
  • Citations to this article (141)

Advertisement

Research Article Free access | 10.1172/JCI115707

Autoantibodies to the ribosomal P proteins react with a plasma membrane-related target on human cells.

E Koren, M W Reichlin, M Koscec, R D Fugate, and M Reichlin

Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.

Find articles by Koren, E. in: PubMed | Google Scholar

Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.

Find articles by Reichlin, M. in: PubMed | Google Scholar

Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.

Find articles by Koscec, M. in: PubMed | Google Scholar

Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.

Find articles by Fugate, R. in: PubMed | Google Scholar

Arthritis and Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104.

Find articles by Reichlin, M. in: PubMed | Google Scholar

Published April 1, 1992 - More info

Published in Volume 89, Issue 4 on April 1, 1992
J Clin Invest. 1992;89(4):1236–1241. https://doi.org/10.1172/JCI115707.
© 1992 The American Society for Clinical Investigation
Published April 1, 1992 - Version history
View PDF
Abstract

Autoantibodies to ribosomal P-proteins are present in 12-16% of patients with systemic lupus erythematosus and are associated with neuropsychiatric disease. As the ribosomal P proteins are located in the cytoplasm, the pathogenic effects of their cognate autoantibodies are unclear. In this study affinity-purified anti-P autoantibodies were used to explore the cell surface of several types of human and animal cells. Immunofluorescence as well as EM immunogold analysis demonstrated, on the surface of human hepatoma cells, the presence of an epitope that is antigenically related to the immunodominant carboxy terminus of P-proteins. The presence of this epitope was also demonstrated on the surface of human neuroblastoma cells and, to a lesser extent, on human fibroblasts. Furthermore, the Western blot technique revealed in purified human and animal plasma membranes a 38-kD protein that is closely related or identical with ribosomal P0 protein. The availability of reactive P peptide on the surface of cells makes possible the direct effect of autoantibodies on the function and viability of cells that express this antigenic target. This delineates one of the possible impacts of anti-P antibodies in disease expression.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1236
page 1236
icon of scanned page 1237
page 1237
icon of scanned page 1238
page 1238
icon of scanned page 1239
page 1239
icon of scanned page 1240
page 1240
icon of scanned page 1241
page 1241
Version history
  • Version 1 (April 1, 1992): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

Article has an altmetric score of 3
  • Article usage
  • Citations to this article (141)

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 3 patents
24 readers on Mendeley
See more details