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Citations to this article

Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.
M Sato, … , E Golub, G A Rodan
M Sato, … , E Golub, G A Rodan
Published December 1, 1991
Citation Information: J Clin Invest. 1991;88(6):2095-2105. https://doi.org/10.1172/JCI115539.
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Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.

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Abstract

Studies of the mode of action of the bisphosphonate alendronate showed that 1 d after the injection of 0.4 mg/kg [3H]alendronate to newborn rats, 72% of the osteoclastic surface, 2% of the bone forming, and 13% of all other surfaces were densely labeled. Silver grains were seen above the osteoclasts and no other cells. 6 d later the label was 600-1,000 microns away from the epiphyseal plate and buried inside the bone, indicating normal growth and matrix deposition on top of alendronate-containing bone. Osteoclasts from adult animals, infused with parathyroid hormone-related peptide (1-34) and treated with 0.4 mg/kg alendronate subcutaneously for 2 d, all lacked ruffled border but not clear zone. In vitro alendronate bound to bone particles with a Kd of approximately 1 mM and a capacity of 100 nmol/mg at pH 7. At pH 3.5 binding was reduced by 50%. Alendronate inhibited bone resorption by isolated chicken or rat osteoclasts when the amount on the bone surface was around 1.3 x 10(-3) fmol/microns 2, which would produce a concentration of 0.1-1 mM in the resorption space if 50% were released. At these concentrations membrane leakiness to calcium was observed. These findings suggest that alendronate binds to resorption surfaces, is locally released during acidification, the rise in concentration stops resorption and membrane ruffling, without destroying the osteoclasts.

Authors

M Sato, W Grasser, N Endo, R Akins, H Simmons, D D Thompson, E Golub, G A Rodan

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T Aghaloo, R Hazboun, S Tetradis
Oral and Maxillofacial Surgery Clinics of North America 2015
Dual-therapy with αvβ3-targeted Sn2 lipase-labile fumagillin-prodrug nanoparticles and zoledronic acid in the Vx2 rabbit tumor model
AK Esser, AH Schmieder, MH Ross, J Xiang, X Su, G Cui, H Zhang, X Yang, JS Allen, T Williams, SA Wickline, D Pan, GM Lanza, KN Weilbaecher
Nanomedicine: Nanotechnology, Biology and Medicine 2015
Bone Sarcomas in Pediatrics: Progress in Our Understanding of Tumor Biology and Implications for Therapy
RK Rivera-Valentin, L Zhu, DP Hughes
Pediatric Drugs 2015
The effect of nitrogen containing bisphosphonates, zoledronate and alendronate, on the production of pro-angiogenic factors by osteoblastic cells
S Ishtiaq, S Edwards, A Sankaralingam, BA Evans, C Elford, ML Frost, I Fogelman, G Hampson
Cytokine 2015
Effects of Alendronate on Osteoclast Formation and Activity In Vitro
CA Martins, G Leyhausen, J Volk, W Geurtsen
Journal of Endodontics 2015
Effects of zoledronic acid and docetaxel on small GTP-binding proteins in prostate cancer
RM Jones, C Morgan, G Bertelli
Tumor Biology 2015
Quantitative computed tomographic assessment of bone mineral density changes associated with administration of prednisolone or prednisolone and alendronate sodium in dogs
S Park, J Oh, KY Son, KO Cho, J Choi
American Journal of Veterinary Research 2015
Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model
K Ogata, W Katagiri, M Osugi, T Kawai, Y Sugimura, H Hibi, S Nakamura, M Ueda
Bone 2015
pH-Activated Nanoparticles for Controlled Topical Delivery of Farnesol To Disrupt Oral Biofilm Virulence
B Horev, MI Klein, G Hwang, Y Li, D Kim, H Koo, DS Benoit
ACS Nano 2015
Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages
M Ueno, T Maeno, S Nishimura, F Ogata, H Masubuchi, K Hara, K Yamaguchi, F Aoki, T Suga, R Nagai, M Kurabayashi
Nature Communications 2015
Bisphosphonate-modified biomaterials for drug delivery and bone tissue engineering
DA Ossipov
Expert Opinion on Drug Delivery 2015
Histochemical evidence of zoledronate inhibiting c-src expression and interfering with CD44/OPN-mediated osteoclast adhesion in the tibiae of mice
H Liu, J Cui, J Sun, J Du, W Feng, B Sun, J Li, X Han, B Liu, Yimin, K Oda, N Amizuka, M Li
Journal Of Molecular Histology 2015
Bisphosphonate treatment of type I diabetic mice prevents early bone loss but accentuates suppression of bone formation: ALENDRONATE RESCUES DIABETIC BONE LOSS
LM Coe, SA Tekalur, Y Shu, MJ Baumann, LR McCabe
Journal of Cellular Physiology 2015
Local Application of Ibandronate/Gelatin Sponge Improves Osteotomy Healing in Rabbits
Z Yang, W Chen, Z Xia, Y Liu, S Peggrem, T Geng, Z Yang, H Li, B Xu, C Zhang, JT Triffitt, Y Zhang, J Cray
PloS one 2015
Bone Cancer
PG Fournier, P Juárez, TA Guise
Bone Cancer 2015
Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity
R Bosco, M Iafisco, A Tampieri, JA Jansen, SC Leeuwenburgh, JJ van Beucken
Applied Surface Science 2015
The Effect of Local Delivery Doxycycline and Alendronate on Bone Repair
PH Limirio, FS Rocha, JD Batista, JC Guimarães-Henriques, GB de Melo, P Dechichi
AAPS PharmSciTech 2015
Removal of pamidronate from bone in rats using systemic and local chelation
RN Howie, M Bhattacharyya, ME Salama, ME Refaey, C Isales, J Borke, A Daoudi, F Medani, ME Elsalanty
Archives of Oral Biology 2015
Extracellular matrix networks in bone remodeling
AI Alford, KM Kozloff, KD Hankenson
The International Journal of Biochemistry & Cell Biology 2015
Molecular Aspects of Bone Resorption in β-Thalassemia Major
Najmaldin Saki, Saeid Abroun, Fatemeh Salari, Fakher Rahim, Mohammad Shahjahani, Mohammadi-Asl Javad
Cell Journal (Yakhteh) 2015
Medication-Related Osteonecrosis of the Jaw
MR Allen
Oral and Maxillofacial Surgery Clinics of North America 2015
Recognition of the Causative Agent of “Phossy Jaw” and “Fragile Femur” in Fumes Arising from White Phosphorus
WB Hinshaw, LD Quin
Phosphorus, Sulfur, and Silicon and the Related Elements 2015
Vγ9Vδ2 T cells and zoledronate mediate antitumor activity in an orthotopic mouse model of human chondrosarcoma
L Sun, Y Li, Z Jiang, J Zhang, H Li, B Li, Z Ye
Tumor Biology 2015
Management of Root Resorption Using Chemical Agents: A Review
Zahed Mohammadi, Zafer C. Cehreli, Sousan Shalavi, Luciano Giardino, Flavio Palazzi, Saeed Asgary
Iranian Endodontic Journal 2015
A Practical Method to Synthesize 1,2,3-Triazole-Amino-Bisphosphonate Derivatives
S Liu, W Bi, X Li, X Chen, L Qu, Y Zhao
Phosphorus, Sulfur, and Silicon and the Related Elements 2015
Ultrastructural alterations of the inferior alveolar nerve in wistar rats after alendronate administration per os: hypothesis for the generation of the "numb chin syndrome"
EM Dietrich, P Theodora, S Antonia, K Georgios, N Esthelle
Journal of Histology and Histopathology 2015
Onconephrology
KD Jhaveri, AK Salahudeen
2015
Bisphosphonate Associated Osteonecrosis of the Jaw: An Update on Pathophysiology, Risk Factors, and Treatment
L Rasmusson, J Abtahi
International journal of dentistry 2014
Influence of Alendronate and Endplate Degeneration to Single Level Posterior Lumbar Spinal Interbody Fusion
SM Kim, W Rhee, S Ha, JH Lim, IT Jang
Korean Journal of Spine 2014
The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes: DPP-IV inhibition and bone
EJ Gallagher, H Sun, C Kornhauser, A Tobin-Hess, S Epstein, S Yakar, D LeRoith
Diabetes/Metabolism Research and Reviews 2014
Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing's sarcoma via inhibition of cell migration
G Odri, PP Kim, F Lamoureux, C Charrier, S Battaglia, J Amiaud, D Heymann, F Gouin, F Redini
BMC Cancer 2014
Histomorphologic characteristics of bisphosphonate-related osteonecrosis of the jaw
S Koerdt, S Dax, H Grimaldi, O Ristow, AC Kuebler, T Reuther
Journal of Oral Pathology & Medicine 2014
Advances in Noninvasive Functional Imaging of Bone
SM Lan, YN Wu, PC Wu, CK Sun, DB Shieh, RM Lin
Academic Radiology 2014
Alendronate-induced atypical bone fracture: evidence that the drug inhibits osteogenesis
S Patntirapong, W Singhatanadgit, S Arphavasin
Journal of Clinical Pharmacy and Therapeutics 2014
In Vitro Effect of Bisphosphonates on Oral Keratinocytes and Fibroblasts
NM McLeod, KA Moutasim, PA Brennan, G Thomas, V Jenei
Journal of Oral and Maxillofacial Surgery 2014
Periprosthetic bone loss: diagnostic and therapeutic approaches
L Cavalli, ML Brandi
F1000Research 2014
The Local Effect of Alendronate with Intra-alveolar Collagen Sponges on Post Extraction Alveolar ridge Resorption: A Clinical Trial
AD Sarkar, N Singhvi, JN Shetty, T Ramakrishna, O Shetye, M Islam, H Keerthy
Journal of Maxillofacial and Oral Surgery 2014
CSF-1 blockade impairs breast cancer osteoclastogenic potential in co-culture systems
C Liverani, L Mercatali, C Spadazzi, FL Manna, AD Vita, N Riva, S Calpona, M Ricci, A Bongiovanni, E Gunelli, M Zanoni, F Fabbri, W Zoli, D Amadori, T Ibrahim
Bone 2014
Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting
S D'Souza, H Murata, MV Jose, S Askarova, Y Yantsen, JD Andersen, CD Edington, WP Clafshenkel, RR Koepsel, AJ Russell
Biomaterials 2014
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes
2014
Bifosfonati e terapia ortodontica: implicazioni cliniche
RD Bari, C Grippaudo, R Deli
Dental Cadmos 2014
Zoledronic Acid and Leuprorelin Acetate, Alone or in Combination, Similarly Reduce Proliferation and Migration of Prostate Cancer Cells In Vitro
B Mognetti, GL Montagna, MG Perrelli, S Marino, P Pagliaro, CM Cracco, C Penna
International Journal of Medical Biology 2014
Vγ9Vδ2 T lymphocytes activation in osteoporotic patients treated with bisphosphonates
Delia Sprini, Laura Di Stefano, Giovam Battista Rini, Luisella Cianferotti, Nicola Napoli
Clinical Cases in Mineral and Bone Metabolism 2014
Effect of Bisphosphonate on Osteoclast of Bone
S Ralte, A Bhattacharyya
Forensic Medicine and Anatomy Research 2014
Implant failure caused by non-union of bisphosphonate-associated subtrochanteric femur fracture
BJ O'Neill, S O'hEireamhoin, DI Morrissey, P Keogh
BMJ case reports 2014
Knochenmetastasen
A Stenzl, T Fehm, LC Hofbauer, F Jakob
2014
Kidney Transplantation
MR Weir, EV Lerma
Kidney Transplantation 2014
Medication-Related Osteonecrosis of the Jaws
S Otto
2014
Medicines For Women
M Harrison-Woolrych
2014
Population pharmacokinetic and pharmacodynamic modeling for assessing risk of bisphosphonate-related osteonecrosis of the jaw
PP Sedghizadeh, AC Jones, C LaVallee, RW Jelliffe, AD Le, P Lee, A Kiss, M Neely
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology 2013
Immobilization of pamidronic acids on the nanotube surface of titanium discs and their interaction with bone cells
TH Koo, JS Borah, ZC Xing, SM Moon, Y Jeong, IK Kang
Nanoscale Research Letters 2013
In Vitro and In Vivo Responses to High and Low Doses of Nitrogen-Containing Bisphosphonates Suggest Engagement of Different Mechanisms for Inhibition of Osteoclastic Bone Resorption
JE Fisher, E Rosenberg, AC Santora, AA Reszka
Calcified Tissue International 2013
Biomedical applications of bisphosphonates
EV Giger, B Castagner, JC Leroux
Journal of Controlled Release 2013
1% Alendronate Gel as Local Drug Delivery in the Treatment of Class II Furcation Defects: A Randomized Controlled Clinical Trial
AR Pradeep, M Kumari, NS Rao, SB Naik
Journal of Periodontology 2013
Oral Health Risk Factors for Bisphosphonate-Associated Jaw Osteonecrosis
C Tsao, I Darby, PR Ebeling, K Walsh, N O'Brien-Simpson, E Reynolds, G Borromeo
Journal of Oral and Maxillofacial Surgery 2013
Simple, efficient one-pot method for synthesis of novel N-attached 1,2,3-triazole containing bisphosphonates
X Chen, X Li, J Yuan, L Qu, S Wang, H Shi, Y Tang, L Duan
Tetrahedron 2013
Improved dosage form of the combined alendronate and calcitriol (Maxmarvil®) on the absorption of alendronate in Korean postmenopausal women
YS Chung, YJ Choi, SH Kim
Archives of Pharmacal Research 2013
Proline modulates the effect of bisphosphonate on calcium levels and adenosine triphosphate production in cell lines derived from bovine Echinococcus granulosus protoscoleces
AG Fuchs, CI Echeverría, FG Rojo, EA González, EJ Roldán
Journal of Helminthology 2013
Bisphosphonatassoziierte Kiefernekrose: Pathogenese und Prävention
S Otto, T Ziebart
Der MKG-Chirurg 2013
Preparation, characterization, release kinetics, and in vitro cytotoxicity of calcium silicate cement as a risedronate delivery system: Calcium Silicate Cement as Risedronate Delivery System
T Gong, Z Wang, Y Zhang, C Sun, Q Yang, T Troczynski, UO Häfeli
Journal of Biomedical Materials Research Part A 2013
Basic research and clinical applications of bisphosphonates in bone disease: what have we learned over the last 40 years?
XL Xu, WL Gou, AY Wang, Y Wang, QY Guo, Q Lu, SB Lu, J Peng
Journal of Translational Medicine 2013
Role of osteoclasts in regulating hematopoietic stem and progenitor cells
T Miyamoto
World Journal of Orthopedics 2013
Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice
B Kang, S Cheong, T Chaichanasakul, O Bezouglaia, E Atti, SM Dry, FQ Pirih, TL Aghaloo, S Tetradis
Journal of Bone and Mineral Research 2013
Pathologic fractures in bisphosphonate-related osteonecrosis of the jaw-review of the literature and review of our own cases
S Otto, C Pautke, S Hafner, R Hesse, LF Reichardt, G Mast, M Ehrenfeld, CP Cornelius
Craniomaxillofacial Trauma & Reconstruction 2013
The osteoblast and osteoclast responses to phosphonic acid containing poly(ε-caprolactone) electrospun scaffolds
AK Ghag, JE Gough, S Downes
Biomaterials Science 2013
Alendronate promotes bone formation by inhibiting protein prenylation in osteoblasts in rat tooth replantation model
K Komatsu, A Shimada, T Shibata, S Wada, H Ideno, K Nakashima, N Amizuka, M Noda, A Nifuji
Journal of Endocrinology 2013
Differential impact of the Bisphosphonate Alendronate on undifferentiated and terminally differentiated human myogenic cells: Impact of Alendronate on human myogenic cell
K Shiomi, Y Nagata, T Kiyono, A Harada, N Hashimoto
Journal of Pharmacy and Pharmacology 2013
Low concentrations of zoledronic acid are better at regulating bone formation and repair
Yang
Intractable & Rare Diseases Research 2013
Anti-Aging Efficacy of a New Alendronate-Pravastatin Cosmetic Combination: A Randomized Double Blind Comparative Study
B Cantecor, MP Savelli, MP Savelli, P Piccerelle, N Lévy, V Bonniol, P Cau
Journal of Cosmetics, Dermatological Sciences and Applications 2013
Are Bisphosphonates Effective in the Treatment of Osteoarthritis Pain? A Meta-Analysis and Systematic Review
AJ Davis, TO Smith, CB Hing, N Sofat, S Eldabe
PloS one 2013
Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages
D Muratsu, D Yoshiga, T Taketomi, T Onimura, Y Seki, A Matsumoto, S Nakamura, Ö Yilmaz
PloS one 2013
The effect of alendronate on the expression of important cell factors in osteoclasts
Q Zhang, M Liu, YI ZHOU, W Liu, J Shen, Y Shen, LI LIU
Molecular medicine reports 2013
Periprosthetic bone loss: diagnostic and therapeutic approaches
L Cavalli, ML Brandi
F1000Research 2013
Pathologic Fractures in Bisphosphonate-Related Osteonecrosis of the Jaw—Review of the Literature and Review of Our Own Cases
S Otto, C Pautke, S Hafner, R Hesse, LF Reichardt, G Mast, M Ehrenfeld, CP Cornelius
Craniomaxillofacial Trauma & Reconstruction 2013
Bisphosphonates: effects on osteoblast
N Maruotti, A Corrado, A Neve, FP Cantatore
European Journal of Clinical Pharmacology 2012
The role of the bone microenvironment in skeletal metastasis
Y Zheng, H Zhou, CR Dunstan, RL Sutherland, MJ Seibel
Journal of Bone Oncology 2012
Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter
SL Chinault, JL Prior, KM Kaltenbronn, A Penly, KN Weilbaecher, D Piwnica-Worms, KJ Blumer
Clinical cancer research 2012
Role of connexin 43 in the mechanism of action of alendronate: dissociation of anti-apoptotic and proliferative signaling pathways
V Lezcano, T Bellido, LI Plotkin, R Boland, S Morelli
Archives of Biochemistry and Biophysics 2012
Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits
J Turek, FH Ebetino, MW Lundy, S Sun, BA Kashemirov, CE McKenna, MA Gallant, LI Plotkin, T Bellido, X Duan, JT Triffitt, RG Russell, DB Burr, MR Allen
Calcified Tissue International 2012
Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
JP Cattalini, AR Boccaccini, S Lucangioli, V Mouriño
Tissue Engineering Part B Reviews 2012
Effects of alendronate on human osteoblast-like MG63 cells and matrix metalloproteinases
J Sun, F Song, W Zhang, BE Sexton, LJ Windsor
Archives of Oral Biology 2012
Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo
AJ Roelofs, CA Stewart, S Sun, KM Błażewska, BA Kashemirov, CE McKenna, RG Russell, MJ Rogers, MW Lundy, FH Ebetino, FP Coxon
Journal of Bone and Mineral Research 2012
Zoledronic Acid Produces Antitumor Effects on Mesothelioma Through Apoptosis and S-Phase Arrest in p53-Independent and Ras prenylation-Independent Manners :
S Okamoto, K Kawamura, Q Li, M Yamanaka, S Yang, T Fukamachi, Y Tada, K Tatsumi, H Shimada, K Hiroshima, H Kobayashi, M Tagawa
Journal of Thoracic Oncology 2012
Zoledronic acid suppresses mineralization through direct cytotoxicity and osteoblast differentiation inhibition : Effects of zoledronate on mineralization
S Patntirapong, W Singhatanadgit, C Chanruangvanit, K Lavanrattanakul, Y Satravaha
Journal of Oral Pathology and Medicine 2012
Cochrane Database of Systematic Reviews: Protocols
JJ Ho, AS Adnan, Z Darus, NZ Ismail, HV Rostenberghe, JJ Ho
Cochrane Database of Systematic Reviews: Protocols 2012
Efficacy of glucosamine alendronate alone & in combination with dihydroquercetin for treatment of osteoporosis in animal model
NA Muraleva, EN Ofitserov, VP Tikhonov, NG Kolosova
The Indian journal of medical research 2012
Management of bone metastases: recent advances and current status
K Dennis, V Vassiliou, T Balboni, E Chow
Journal of Radiation Oncology 2012
Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid
I Sirisoontorn, H Hotokezaka, M Hashimoto, C Gonzales, S Luppanapornlarp, MA Darendeliler, N Yoshida
American Journal of Orthodontics and Dentofacial Orthopedics 2012
Alendronate promotes plasmin-mediated MMP-9 inactivation by exposing cryptic plasmin degradation sites within the MMP-9 catalytic domain
AR Farina, L Cappabianca, ND Ianni, P Ruggeri, M Ragone, S Merolle, A Gulino, AR Mackay
FEBS Letters 2012
Quantification by energy dispersive x-ray spectroscopy of alendronate in the diseased jaw bone of patients with bisphosphonate-related jaw osteonecrosis
C Schaudinn, A Gorur, P Webster, AC Jones, M Neely, RW Jelliffe, AD Le, PP Sedghizadeh
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology 2012
Incidence and Risk Factors of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients Having Undergone Autologous Stem Cell Transplantation
C Then, N Hörauf, S Otto, C Pautke, E Tresckow, T Röhnisch, P Baumann, R Schmidmaier, I Bumeder, FS Oduncu
Onkologie 2012
Safety of Bisphosphonates
C Orozco, NM Maalouf
Rheumatic Disease Clinics of North America 2012
Inhibition of breast cancer cell proliferation in repeated and non-repeated treatment with zoledronic acid
T Ibrahim, L Mercatali, E Sacanna, A Tesei, S Carloni, P Ulivi, C Liverani, F Fabbri, M Zanoni, W Zoli, D Amadori
Cancer Cell International 2012
Clinical role of bisphosphonate therapy
G Hampson, I Fogelman
International journal of women's health 2012
Zoledronate and pamidronate depress neutrophil functions and survival in mice
JW Kuiper, C Forster, C Sun, S Peel, M Glogauer
British Journal of Pharmacology 2012
Pathophysiology of Bone Remodelling and Current Therapeutic Approaches
I Juhasz-Böss, T Fehm, J Ney, E Solomayer
Geburtshilfe und Frauenheilkunde 2012
Tissue Engineering and Regenerative Medicine: A Nano Approach
J Lai, A Ramasubramanian, S Jeeawoody, F Yang
Tissue Engineering and Regenerative Medicine: A Nano Approach 2012
Simulated resistance training, but not alendronate, increases cortical bone formation and suppresses sclerostin during disuse
BR Macias, JM Swift, MI Nilsson, HA Hogan, SD Bouse, SA Bloomfield
Journal of applied physiology 2012
Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production
EL Scheller, KD Hankenson, JS Reuben, PH Krebsbach
Journal of Cellular Biochemistry 2011
Direct antitumour activity of zoledronic acid: preclinical and clinical data.
Bosch-Barrera J, Merajver SD, Menéndez JA, Van Poznak C
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2011
Bisphosphonates: The first 40years
RG Russell
Bone 2011
Short-term effects of zoledronate on the histomorphology of osteoclast in young albino rats
S Ralte, K Khatri, M Nagar
Annals of Anatomy - Anatomischer Anzeiger 2011
Bisphosphonate treatment delays stress fracture remodeling in the rat ulna
LJ Kidd, NR Cowling, AC Wu, WL Kelly, MR Forwood
Journal of Orthopaedic Research 2011
Denosumab and bisphosphonates: Different mechanisms of action and effects
R Baron, S Ferrari, RG Russell
Bone 2011
Biochemical and molecular mechanisms of action of bisphosphonates
MJ Rogers, JC Crockett, FP Coxon, J Mönkkönen
Bone 2011
Effect of bisphosphonates on human gingival fibroblast production of mediators of osteoclastogenesis: RANKL, osteoprotegerin and interleukin-6
DA Tipton, BA Seshul, MK Dabbous
Journal of Periodontal Research 2011
Effect of Bisphosphonates on the Progression of Degenerative Aortic Stenosis
AL Innasimuthu, WE Katz
Echocardiography 2011
Bisphosphonates, specific inhibitors of osteoclast function and a class of drugs for osteoporosis therapy
B Li, JF Chau, X Wang, WF Leong
Journal of Cellular Biochemistry 2011
Direct antitumour activity of zoledronic acid: preclinical and clinical data
J Bosch-Barrera, SD Merajver, JA Menéndez, C Poznak
Clinical and Translational Oncology 2011
The Role of Jak/STAT Pathways in Osteoclast Differentiation
YK Lee, HH Kim
Biomolecules and Therapeutics 2011
Effects of Zoledronic Acid on Healing of Mandibular Fractures: An Experimental Study in Rabbits
U Tatlı, Y Üstün, M Kürkçü, Ö Erdoğan, CC Gürbüz, H Özgür, S Polat
Journal of Oral and Maxillofacial Surgery 2011
Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates
S Thiele, M Rauner, C Goettsch, TD Rachner, P Benad, S Fuessel, K Erdmann, C Hamann, GB Baretton, MP Wirth, F Jakob, LC Hofbauer
Journal of Cellular Biochemistry 2011
Bisphosphonate related osteonecrosis of the jaw – Manifestation in a microvascular iliac bone flap
C Pautke, S Otto, S Reu, A Kolk, M Ehrenfeld, S Stürzenbaum, KD Wolff
Oral Oncology 2011
Bisphosphonate-related osteonecrosis of the jaws – Characteristics, risk factors, clinical features, localization and impact on oncological treatment
S Otto, C Schreyer, S Hafner, G Mast, M Ehrenfeld, S Stürzenbaum, C Pautke
Journal of Cranio-Maxillofacial Surgery 2011
Pharmacology of bisphosphonates
S Cremers, S Papapoulos
Bone 2011
The relationship between the chemistry and biological activity of the bisphosphonates
FH Ebetino, AM Hogan, S Sun, MK Tsoumpra, X Duan, JT Triffitt, AA Kwaasi, JE Dunford, BL Barnett, U Oppermann, MW Lundy, A Boyde, BA Kashemirov, CE McKenna, RG Russell
Bone 2011
Consensus on the utility of bone markers in the malignant bone disease setting
R Coleman, L Costa, F Saad, R Cook, P Hadji, E Terpos, P Garnero, J Brown, JJ Body, M Smith, KA Lee, P Major, M Dimopoulos, A Lipton
Critical Reviews in Oncology/Hematology 2011
Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trial
K Nagahama, M Kanayama, D Togawa, T Hashimoto, A Minami
Journal of Neurosurgery: Spine 2011
Bisphosphonates modulate the expression of OPG and M-CSF in hMSC-derived osteoblasts
JY Ohe, YD Kwon, HW Lee
Clinical Oral Investigations 2011
Cancellous bone formation response to simulated resistance training during disuse is blunted by concurrent alendronate treatment
JM Swift, SN Swift, MI Nilsson, HA Hogan, SD Bouse, SA Bloomfield
Journal of Bone and Mineral Research 2011
Alendronate and raloxifene affect the osteoprotegerin/RANKL system in human osteoblast primary cultures from patients with osteoporosis and osteoarthritis
M Giner, MJ Rios, MJ Montoya, MA Vázquez, C Miranda, R Pérez-Cano
European Journal of Pharmacology 2011
Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices — A simple method for identifying polarized osteoclasts
T Nakayama, T Mizoguchi, S Uehara, T Yamashita, I Kawahara, Y Kobayashi, Y Moriyama, S Kurihara, N Sahara, H Ozawa, N Udagawa, N Takahashi
Bone 2011
Novel mineral contrast agent for magnetic resonance studies of bone implants grown on a chick chorioallantoic membrane
IE Chesnick, CB Fowler, JT Mason, K Potter
Magnetic Resonance Imaging 2011
Up-regulation of inhibitors of DNA binding/differentiation gene during alendronate-induced osteoblast differentiation
AR Kang, YR Oh, HY Kim, MJ Park, BS Joo, WJ Choi, JY Lee, MH Jung, YI Ji, JS Choi
Archives of Gynecology and Obstetrics 2011
Impact of oncopediatric dosing regimen of zoledronic acid on bone growth: Preclinical studies and case report of an osteosarcoma pediatric patient
S Battaglia, S Dumoucel, J Chesneau, MF Heymann, G Picarda, F Gouin, N Corradini, D Heymann, F Redini
Journal of Bone and Mineral Research 2011
Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: Role of the akt pathway and the ERK/Bim axis
T Matsumoto, Y Nagase, M Iwasawa, T Yasui, H Masuda, Y Kadono, K Nakamura, S Tanaka
Arthritis & Rheumatism 2011
Preventive Effects of Zoledronic Acid on Bone Metastasis in Mice Injected with Human Breast Cancer Cells
J Jeong, KS Lee, YK Choi, YJ Oh, HD Lee
Journal of Korean Medical Science 2011
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee
Annual Reports in Medicinal Chemistry Volume 46 2011
Antiangiogenic effects of zoledronate on cancer neovasculature
S Metcalf, HS Pandha, R Morgan
Future Oncology 2011
Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures
Y Wang, A Panasiuk, DW Grainger
Molecular Pharmaceutics 2011
The Role of Bisphosphonates in Multiple Myeloma: Mechanisms, Side Effects, and the Future
S Pozzi, N Raje
The oncologist 2011
Zoledronic acid induces S-phase arrest via a DNA damage response in normal human oral keratinocytes
H Ohnuki, K Izumi, M Terada, T Saito, H Kato, A Suzuki, Y Kawano, K Nozawa-Inoue, R Takagi, T Maeda
Archives of Oral Biology 2011
Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro
E Heervä, S Peltonen, E Svedström, HT Aro, K Väänänen, J Peltonen
Bone 2011
DC-like cell-dependent activation of human natural killer cells by the bisphosphonate zoledronic acid is regulated by γδ T lymphocytes
O Nussbaumer, G Gruenbacher, H Gander, M Thurnher
Blood 2011
Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study
F Öztürk, H Babacan, S İnan, C Gümüş
American Journal of Orthodontics and Dentofacial Orthopedics 2011
The Influence of Alendronate on Spine Fusion in an Osteoporotic Animal Model:
S Nakao, A Minamide, M Kawakami, SD Boden, M Yoshida
Spine 2011
Comparison of the Effects of Local Application of Hydroxyapatite Graft Soaked with Alendronate Solution and Pure Hydroxyapatite Graft in the Mandible of Ovariectomized Rats
A Arslan, H Altundal, O Cevik, V Olgac
Biotechnology & Biotechnological Equipment 2011
The Safety and Efficacy of Early-Stage Bi-Weekly Alendronate to Improve Bone Mineral Density and Bone Turnover in Chinese Post-Menopausal Women at Risk of Osteoporosis
L You, ZY Sheng, JY Chen, L Pan, L Chen
J INT MED RES 2011
Characterization of the Immune Response of Human Cord-Blood Derived γδ T Cells to Stimulation with Aminobisphosphonate Compounds
R Placido, G Auricchio, I Gabriele, E Galli, E Brunetti, V Colizzi, L Battistini, G Mancino
International journal of immunopathology and pharmacology 2011
Crystallization Products of Risedronate with Carbohydrates and Their Substituted Derivatives
J Kos, M Pentakova, Z Oktabec, L Krejcik, Z Mandelova, P Harokova, J Hruskova, T Pekarek, O Dammer, M Tkadlecova, J Havlicek, J Vinsova, V Kral, J Dohnal, J Jampílek
Molecules (Basel, Switzerland) 2011
Skeletal Aging and Osteoporosis
MJ Silva
2011
Teriparatide, Vitamin D, and Calcium Healed Bilateral Subtrochanteric Stress Fractures in a Postmenopausal Woman with a 13-Year History of Continuous Alendronate Therapy
SJ Gomberg, RL Wustrack, N Napoli, CD Arnaud, DM Black
The Journal of clinical endocrinology and metabolism 2011
Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo
AJ Roelofs, FP Coxon, FH Ebetino, MW Lundy, ZJ Henneman, GH Nancollas, S Sun, KM Blazewska, JL Bala, BA Kashemirov, AB Khalid, CE McKenna, MJ Rogers
Journal of Bone and Mineral Research 2010
The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation
MT Valenti, S Giannini, L Donatelli, M Zanatta, F Bertoldo, S Sella, MT Vilei, E Ossi, G Realdi, VL Cascio, LD Carbonare
Arthritis Research & Therapy 2010
Burger's Medicinal Chemistry and Drug Discovery
S Bruno, L Ronda, S Faggiano, S Bettati, A Mozzarelli
Burger's Medicinal Chemistry and Drug Discovery 2010
Osteonecrosis of the Jaw in a Patient on Denosumab
TL Aghaloo, AL Felsenfeld, S Tetradis
Journal of Oral and Maxillofacial Surgery 2010
Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78
A Streitbuerger, M Henrichs, H Ahrens, C Lanvers-Kaminzky, F Gouin, G Gosheger, J Hardes
International Orthopaedics 2010
Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro
FP Koch, C Merkel, T Ziebart, R Smeets, C Walter, B Al-Nawas
Clinical Oral Investigations 2010
Bisphosphonates treatment and orthodontic considerations
AA Ghoneima, ES Allam, SL Zunt, LJ Windsor
Orthodontics & Craniofacial Research 2010
Effects of alendronate on bone healing after tooth extraction in rats
JI Aguirre, MK Altman, SM Vanegas, SE Franz, AC Bassit, TJ Wronski
Oral Diseases 2010
Bisphosphonate-Related Osteonecrosis of the Jaw: Is pH the Missing Part in the Pathogenesis Puzzle?
S Otto, S Hafner, G Mast, T Tischer, E Volkmer, M Schieker, SR Stürzenbaum, E Tresckow, A Kolk, M Ehrenfeld, C Pautke
Journal of Oral and Maxillofacial Surgery 2010
Bisphosphonates and RANK ligand inhibitors for the treatment and prevention of metastatic bone disease
HL Neville-Webbe, RE Coleman
European Journal of Cancer 2010
Use of bisphosphonates for the treatment of osteonecrosis as a complication of therapy for childhood acute lymphoblastic leukaemia (ALL)
RS Kotecha, N Powers, SJ Lee, KJ Murray, T Carter, C Cole
Pediatric Blood & Cancer 2010
Sol-gel derived titania coating with immobilized bisphosphonate enhances screw fixation in rat tibia
P Linderbäck, S Areva, P Aspenberg, P Tengvall
Journal of Biomedical Materials Research Part A 2010
An in vitro Assay to Measure Targeted Drug Delivery to Bone Mineral
W Jahnke, C Henry
ChemMedChem 2010
Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells
TD Rachner, SK Singh, M Schoppet, P Benad, M Bornhäuser, V Ellenrieder, R Ebert, F Jakob, LC Hofbauer
Cancer Letters 2010
Osteonecrosis of the Jaws
V Vassiliou, N Tselis, D Kardamakis
Strahlentherapie und Onkologie 2010
Near-infrared fluorescent probe traces bisphosphonate delivery and retention in vivo
KM Kozloff, LI Volakis, JC Marini, MS Caird
Journal of Bone and Mineral Research 2010
Potential Anticancer Properties of Bisphosphonates
HL Neville-Webbe, M Gnant, RE Coleman
Seminars in Oncology 2010
Bone metastases: Molecular mechanisms and novel therapeutic interventions
DJ Papachristou, EK Basdra, AG Papavassiliou
Medicinal Research Reviews 2010
Bisphosphonate-modified gold nanoparticles: a useful vehicle to study the treatment of osteonecrosis of the femoral head
F Fanord, K Fairbairn, H Kim, A Garces, V Bhethanabotla, VK Gupta
Nanotechnology 2010
Inhibition of Necrotic Actions of Nitrogen-Containing Bisphosphonates (NBPs) and Their Elimination From Bone by Etidronate (a Non-NBP): A Proposal for Possible Utilization of Etidronate as a Substitution Drug for NBPs
T Oizumi, H Funayama, K Yamaguchi, M Yokoyama, H Takahashi, M Yamamoto, T Kuroishi, H Kumamoto, K Sasaki, H Kawamura, S Sugawara, Y Endo
Journal of Oral and Maxillofacial Surgery 2010
Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management
LD Carbonare, M Zanatta, A Gasparetto, MT Valenti
Drug, healthcare and patient safety 2010
Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells
SA Holstein, H Tong, RJ Hohl
Leukemia Research 2010
Bisphosphonates for Osteoporosis
MJ Favus
New England Journal of Medicine 2010
Osteonecrosis of the Jawbones in 2 Osteoporosis Patients Treated With Nitrogen-Containing Bisphosphonates: Osteonecrosis Reduction Replacing NBP With Non-NBP (Etidronate) and Rationale
K Yamaguchi, T Oizumi, H Funayama, H Kawamura, S Sugawara, Y Endo
Journal of Oral and Maxillofacial Surgery 2010
Anatomic Site Variability in Rat Skeletal Uptake and Desorption Of Fluorescently Labeled Bisphosphonate
D Wen, L Qing, G Harrison, E Golub, SO Akintoye
Oral Diseases 2010
Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells
Y Tatsuda, K Iguchi, S Usui, M Suzui, K Hirano
European Journal of Pharmacology 2010
Pamidronate inhibits antiapoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate cancer PC-3 cells
K Iguchi, Y Tatsuda, S Usui, K Hirano
European Journal of Pharmacology 2010
Osteonecrosis of the Jaw: Effect of Bisphosphonate Type, Local Concentration, and Acidic Milieu on the Pathomechanism
S Otto, C Pautke, C Opelz, I Westphal, I Drosse, J Schwager, F Bauss, M Ehrenfeld, M Schieker
Journal of Oral and Maxillofacial Surgery 2010
The Orthopaedic Implications of Diphosphonate Therapy:
MJ Weaver, MA Miller, MS Vrahas
The Journal of the American Academy of Orthopaedic Surgeons 2010
Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption - implications for osteoclast quality
AV Neutzsky-Wulff, MG Sørensen, D Kocijancic, DJ Leeming, MH Dziegiel, MA Karsdal, K Henriksen
BMC musculoskeletal disorders 2010
Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives
Z Oktabec, J Kos, Z Mandelova, L Havelkova, T Pekarek, A Rezacova, L Placek, M Tkadlecova, J Havlicek, J Dohnal, J Jampílek
Molecules (Basel, Switzerland) 2010
Osteonecrosis of the Jaws: Clinicopathologic and Radiologic Characteristics, Preventive and Therapeutic Strategies
V Vassiliou, N Tselis, D Kardamakis
Strahlentherapie und Onkologie 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Osteoimmunology
Y Choi
Osteoimmunology 2009
Osteoimmunology
Y Choi
Osteoimmunology 2009
Osteoimmunology
Y Choi
Osteoimmunology 2009
Osteoimmunology
Y Choi
Osteoimmunology 2009
Osteoimmunology
Y Choi
Osteoimmunology 2009
Osteoimmunology
Y Choi
Osteoimmunology 2009
Osteoimmunology
Y Choi
Osteoimmunology 2009
Alendronate reduces osteoclast precursors in osteoporosis
P D’Amelio, A Grimaldi, MA Cristofaro, M Ravazzoli, PA Molinatti, GP Pescarmona, GC Isaia
Osteoporosis International 2009
Bisphosphonate administration prior to tooth extraction delays initial healing of the extraction socket in rats
H Hikita, K Miyazawa, M Tabuchi, M Kimura, S Goto
Journal of Bone and Mineral Metabolism 2009
Aminobisphosphonate Stimulates Bone Regeneration and Enforces Consolidation of Titanium Implant into a New Rat Caudal Vertebrae Model
J Blazsek, CD Nagy, I Blazsek, R Varga, B Vecsei, P Fejérdy, G Varga
Pathology & Oncology Research 2009
Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro
J Räikkönen, JC Crockett, MJ Rogers, H Mönkkönen, S Auriola, J Mönkkönen
British Journal of Pharmacology 2009
Necrotic Actions of Nitrogen-Containing Bisphosphonates and Their Inhibition by Clodronate, a Non-Nitrogen-Containing Bisphosphonate in Mice: Potential for Utilization of Clodronate as a Combination Drug with a Nitrogen-Containing Bisphosphonate
T Oizumi, K Yamaguchi, H Funayama, T Kuroishi, H Kawamura, S Sugawara, Y Endo
Basic & Clinical Pharmacology & Toxicology 2009
CTX Biochemical Marker of Bone Metabolism. Is it a Reliable Predictor of Bisphosphonate-Associated Osteonecrosis of the Jaws After Surgery? Part I: Biological Concepts With a Review of the Literature
CY Lee, JB Suzuki
Implant Dentistry 2009
Influence of bisphosphonates on orthodontic tooth movement in mice
Y Fujimura, H Kitaura, M Yoshimatsu, T Eguchi, H Kohara, Y Morita, N Yoshida
The European Journal of Orthodontics 2009
Menopause
DG Weismiller
Primary Care Clinics in Office Practice 2009
Femur bone repair in ovariectomized rats under the local action of alendronate, hydroxyapatite and the association of alendronate and hydroxyapatite
AC Canettieri, CE Colombo, CM Chin, H Faig-Leite
International Journal of Experimental Pathology 2009
Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines
A Ullén, S Schwarz, L Lennartsson, KM Kälkner, P Sandström, F Costa, B Lennernäs, S Linder, S Nilsson
Scandinavian Journal of Urology and Nephrology 2009
Flare-up of hand osteoarthritis caused by zoledronic acid infusion
GR de Castro, FS Neves, SC de Magalhães Souza Fialho, IA Pereira, G Ribeiro, AF Zimmermann
Osteoporosis International 2009
Bone resorption inhibitor alendronate normalizes the reduced bone thickness of TRPV5(-/-) mice
T Nijenhuis, BC van der Eerden, JG Hoenderop, H Weinans, JP van Leeuwen, RJ Bindels
Journal of Bone and Mineral Research 2008
Alendronate Enhances Osteogenic Differentiation of Bone Marrow Stromal Cells: A Preliminary Study
HK Kim, JH Kim, AA Abbas, TR Yoon
Clinical Orthopaedics and Related Research® 2008
Hormesis and medicine
EJ Calabrese
British Journal of Clinical Pharmacology 2008
Bisphosphonat-assoziierte Osteonekrosen des Kieferknochens
MT Krauth, A Fügl, R Gruber
Wiener klinische Wochenschrift 2008
Recovery of Trabecular and Cortical Bone Turnover After Discontinuation of Risedronate and Alendronate Therapy in Ovariectomized Rats
RK Fuchs, RJ Phipps, DB Burr
Journal of Bone and Mineral Research 2008
Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
RG Russell, NB Watts, FH Ebetino, MJ Rogers
Osteoporosis International 2008
Bisphosphonate treatment and radiotherapy in metastatic breast cancer
AU Ural, F Avcu, Y Baran
Medical Oncology 2008
Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro
AI Idris, J Rojas, IR Greig, RJ Hof, SH Ralston
Calcified Tissue International 2008
Bisphosphonates induce apoptosis in CLL cells independently of MDR phenotype
KL Silva, DV Vasconcellos, ED de Castro, FC Vasconcelos, R Bigni, RC Maia
Cancer Chemotherapy and Pharmacology 2008
The effects of bisphosphonates on osteoblasts in vitro
A Naidu, PC Dechow, R Spears, JM Wright, HP Kessler, LA Opperman
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 2008
Combination Therapy Using Exercise and Pharmaceutical Agents to Optimize Bone Health
RK Fuchs, SJ Warden
Clinical Reviews in Bone and Mineral Metabolism 2008
Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs
J Baas
Acta Orthopaedica 2008
Treatment of experimental renal osteodystrophy with pamidronate
J Jokihaara, IH Pörsti, P Kööbi, PM Jolma, JT Mustonen, HH Saha, H Sievänen, P Kannus, UT Iwaniec, RT Turner, TL Järvinen
Kidney International 2008
Common Implant-Related Advanced Bone Grafting Complications: Classification, Etiology, and Management
J Li, HL Wang
Implant Dentistry 2008
Skeletal accumulation of bisphosphonates: implications for osteoporosis treatment
MR Allen
Expert Opinion on Drug Metabolism & Toxicology 2008
Effects of Bisphosphonates on Fracture Incidence and Bone Metabolism in Rheumatoid Arthritis Patients in General Practice Taking Long-Term Corticosteroid Therapy
K Katayama, T Matsuno
Clinical Drug Investigation 2008
Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth
H Mönkkönen, J Kuokkanen, I Holen, A Evans, DV Lefley, M Jauhiainen, S Auriola, J Mönkkönen
Anti-Cancer Drugs 2008
Vesicular trafficking in osteoclasts
FP Coxon, A Taylor
Seminars in Cell & Developmental Biology 2008
New research findings on zoledronic acid: Survival, pain, and anti-tumour effects
F Saad
Cancer Treatment Reviews 2008
Bone Resorption Inhibitor Alendronate Normalizes the Reduced Bone Thickness of TRPV5−/−Mice
T Nijenhuis, BC van der Eerden, JG Hoenderop, H Weinans, JP van Leeuwen, RJ Bindels
Journal of Bone and Mineral Research 2008
Comparative pharmacokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX-1
C Delguste, H Amory, J Guyonnet, D Thibaud, P Garnero, J Detilleux, OM Lepage, M Doucet
Journal of Veterinary Pharmacology and Therapeutics 2008
SAR of Carbon-Linked, 2-Substituted Purines: Synthesis and Characterization of AP23451 as a novel Bone-Targeted Inhibitor of Src Tyrosine Kinase With In Vivo Anti-Resorptive Activity
WC Shakespeare, Y Wang, R Bohacek, T Keenan, R Sundaramoorthi, C Metcalf, A Dilauro, S Roeloffzen, S Liu, J Saltmarsh, G Paramanathan, D Dalgarno, S Narula, S Pradeepan, MR van Schravendijk, J Keats, M Ram, S Liou, S Adams, S Wardwell, J Bogus, J Iuliucci, M Weigele, L Xing, B Boyce, TK Sawyer
Chemical Biology & Drug Design 2008
Long-term effects of local pretreatment with alendronate on healing of replanted rat teeth
K Komatsu, A Shimada, T Shibata, S Shimoda, S Oida, K Kawasaki, A Nifuji
Journal of Periodontal Research 2008
Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer
KG Halvorson, MA Sevcik, JR Ghilardi, LJ Sullivan, NJ Koewler, F Bauss, PW Mantyh
Journal of Pain and Symptom Management 2008
Bisphosphonate treatment in the oim mouse model alters bone modeling during growth
SH Rao, KD Evans, AM Oberbauer, RB Martin
Journal of Biomechanics 2008
An osteoclast-targeting agent for imaging and therapy of bone metastasis
W Liu, A Hajibeigi, M Lin, CL Rostollan, Z Kovacs, OK Oz, X Sun
Bioorganic & Medicinal Chemistry Letters 2008
Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells
F Journé, N Kheddoumi, C Chaboteaux, H Duvillier, G Laurent, JJ Body
Breast Cancer Research 2008
Effects of Denosumab on the Geometry of the Proximal Femur in Postmenopausal Women in Comparison with Alendronate
TJ Beck, EM Lewiecki, PD Miller, D Felsenberg, Y Liu, B Ding, C Libanati
Journal of Clinical Densitometry 2008
Exploring the anti-tumour activity of bisphosphonates in early breast cancer
MC Winter, I Holen, RE Coleman
Cancer Treatment Reviews 2008
Cancer and Orofacial Pain
DJ Fischer, GD Klasser, JB Epstein
Oral and Maxillofacial Surgery Clinics of North America 2008
Histomorphometric Evaluation of the Effects of Zoledronic Acid on Mandibular Distraction Osteogenesis in Rabbits
AA Pampu, D Dolanmaz, HH Tüz, MC Avunduk, RŞ Kisşnisşci
Journal of Oral and Maxillofacial Surgery 2008
Principles of Bone Biology
CJ Rosen, T Niu
Principles of Bone Biology 2008
Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells
FP Coxon, K Thompson, AJ Roelofs, FH Ebetino, MJ Rogers
Bone 2008
Effects of bisphosphonates on root resorption and cytokine expression during experimental tooth movement in rats
R Putranto, Y Oba, K Kaneko, A Shioyasono, K Moriyama
Orthodontic Waves 2008
Myeloma Therapy
S Lonial
2008
Chronic Prostatitis/Chronic Pelvic Pain Syndrome
DA Shoskes
2008
Effects of Bisphosphonates on Fracture Incidence and Bone Metabolism in Rheumatoid Arthritis Patients in General Practice Taking Long-Term Corticosteroid Therapy: A Retrospective Study
K Katayama, T Matsuno
Clinical Drug Investigation 2008
Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
AE Kearns, S Khosla, PJ Kostenuik
Endocrine reviews 2007
Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies
Y Abu-Amer, I Darwech, JC Clohisy
Arthritis Research & Therapy 2007
Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation
H Nassar, A Kantarci, TE van Dyke
Periodontology 2000 2007
Alendronate inhibits periprosthetic bone loss around uncemented femoral components
T Nishioka, S Yagi, T Mitsuhashi, M Miyamoto, T Tamura, T Kobayashi, T Enishi
Journal of Bone and Mineral Metabolism 2007
Long-Term Protective Effects of Zoledronic Acid on Cancellous and Cortical Bone in the Ovariectomized Rat
JA Gasser, P Ingold, A Venturiere, V Shen, JR Green
Journal of Bone and Mineral Research 2007
The Molecular Mechanisms of Action of Bisphosphonates
K Thompson, MJ Rogers
Clinical Reviews in Bone and Mineral Metabolism 2007
Pharmacological and clinical profile of once weekly alendronate for the treatment of osteoporosis (Fosamac 35 mg/Bonalon 35 mg)
S Uchida, Y Azuma, T Taniguchi, H Arizono, T Shimizu, M Okaniwa, K Nakamura, T Ohta
Folia Pharmacologica Japonica 2007
Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells
T Kubo, S Shimose, T Matsuo, A Sakai, M Ochi
Cancer Chemotherapy and Pharmacology 2007
Noninvasive Optical Detection of Bone Mineral
KM Kozloff, R Weissleder, U Mahmood
Journal of Bone and Mineral Research 2007
Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
C Ishikawa, T Matsuda, T Okudaira, M Tomita, H Kawakami, Y Tanaka, M Masuda, K Ohshiro, T Ohta, N Mori
British Journal of Haematology 2007
Effect of short-term treatment with alendronate on ulnar bone adaptation to cyclic fatigue loading in rats
JG Barrett, SJ Sample, J McCarthy, VL Kalscheur, P Muir, L Prokuski
Journal of Orthopaedic Research 2007
Bisphosphonate zur Behandlung tumorinduzierter Knochenveränderungen
P Schmid
Der Onkologe 2007
Synthesis of functionalized bisphosphonates via click chemistry
H Skarpos, SN Osipov, DV Vorob'eva, IL Odinets, E Lork, GV R?schenthaler
Organic & Biomolecular Chemistry 2007
Administration of pamidronate alters bone-titanium attachment in the presence of endotoxin-coated polyethylene particles
Z Xing, KA Hasty, RA Smith
Journal of Biomedical Materials Research Part B: Applied Biomaterials 2007
Effects of alendronate on tooth eruption and molar root formation in young growing rats
V Bradaschia-Correa, LF Massa, VE Arana-Chavez
Cell and Tissue Research 2007
A Comparison between the Effects of Hydrophobic and Hydrophilic Statins on Osteoclast Function In Vitro and Ovariectomy-Induced Bone Loss In Vivo
A Hughes, MJ Rogers, AI Idris, JC Crockett
Calcified Tissue International 2007
Effect of 17β-Estradiol and Alendronate on the Removal Torque of Osseointegrated Titanium Implants in Ovariectomized Rats
G Giro, CE Sakakura, D Gonçalves, RM Pereira, E Marcantonio, SR Orrico
Journal of Periodontology 2007
Zoledronic acid-induced IPP/ApppI production in vivo
H Mönkkönen, PD Ottewell, J Kuokkanen, J Mönkkönen, S Auriola, I Holen
Life Sciences 2007
Combination therapy for treatment of osteoporosis: A review
JA Pinkerton, AC Dalkin
American Journal of Obstetrics and Gynecology 2007
Anabolic effects of bisphosphonates on peri-implant bone stock
F Knoch, C Eckhardt, CI Alabre, E Schneider, HE Rubash, AS Shanbhag
Biomaterials 2007
Therapy Insight: the risks and benefits of bisphosphonates for the treatment of tumor-induced bone disease
CR Dunstan, D Felsenberg, MJ Seibel
Nature Clinical Practice Oncology 2007
Anti-tumor effect of bisphosphonate (YM529) on non-small cell lung cancer cell lines
R Koshimune, M Aoe, S Toyooka, F Hara, M Ouchida, M Tokumo, Y Sano, H Date, N Shimizu
BMC Cancer 2007
Osteoimmunology
M Rauner, W Sipos, P Pietschmann
International Archives of Allergy and Immunology 2007
Cytotoxic activity of the third-generation bisphosphonate zoledronic acid in acute myeloid leukemia
M Fiegl, M Juergens, W Hiddemann, J Braess
Leukemia Research 2007
Bisphosphonates and osteonecrosis of the jaws: Science and rationale
R Gutta, PJ Louis
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 2007
Bisphosphonate-associated osteonecrosis of the jaws: a therapeutic dilemma
R Diego, O D’Orto, D Pagani, A Agazzi, U Marzano, GD Troletti, W Fontanella, L Pignataro
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 2007
Comment on the American Association of Oral and Maxillofacial Surgeons Statement on Bisphosphonates
JJ Zahrowski
Journal of Oral and Maxillofacial Surgery 2007
Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals
C Magopoulos, G Karakinaris, Z Telioudis, K Vahtsevanos, I Dimitrakopoulos, K Antoniadis, S Delaroudis
American Journal of Otolaryngology 2007
Effect of local delivery of alendronate on bone formation in bioactive glass grafting in rats
S Srisubut, A Teerakapong, T Vattraphodes, S Taweechaisupapong
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 2007
Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis
Y Zheng, H Zhou, K Brennan, JM Blair, JR Modzelewski, MJ Seibel, CR Dunstan
Bone 2007
Treatment of the Postmenopausal Woman
FS Keating, JC Stevenson
Treatment of the Postmenopausal Woman 2007
Pharmacokinetic profile of bisphosphonates in the treatment of metabolic bone disorders
L Sinigaglia, M Varenna, S Casari
Clinical Cases in Mineral and Bone Metabolism 2007
Bisphosphonate treatment: An orthodontic concern calling for a proactive approach
JJ Zahrowski
American Journal of Orthodontics and Dentofacial Orthopedics 2007
Comparative effects of five bisphosphonates on apoptosis of macrophage cells in vitro
MF Moreau, C Guillet, P Massin, S Chevalier, H Gascan, MF Baslé, D Chappard
Biochemical Pharmacology 2007
Osteonecrosis of the jaw and bisphosphonates: A comparison with white phosphorus, radium, and osteopetrosis
MA Vance
Clinical Toxicology 2007
Comprehensive Medicinal Chemistry II
E Littler, XX Zhou
Comprehensive Medicinal Chemistry II 2007
The in vitro anti-tumour activity of zoledronic acid and docetaxel at clinically achievable concentrations in prostate cancer
C Morgan, PD Lewis, RM Jones, G Bertelli, GA Thomas, RC Leonard
Acta Oncologica 2007
Bisphosphonate induced osteonecrosis of the jaws: Unravelling uncertainty in disease causality
FC Kelleher, M McKenna, C Collins, G Brady, I Collins, J Crown
Acta Oncologica 2007
Mechanism of Action, Pharmacokinetic and Pharmacodynamic Profile, and Clinical Applications of Nitrogen-containing Bisphosphonates
DB Kimmel
Journal of dental research 2007
Potential Applications of Biphosphonates in Dental Surgical Implants
D Berardi, T Carlesi, F Rossi, M Calderini, R Volpi, G Perfetti
International journal of immunopathology and pharmacology 2007
Emergencies in Urology
M Hohenfellner, RA Santucci
2007
Synthesis and Biological Evaluation of α-Halogenated Bisphosphonate and Phosphonocarboxylate Analogues of Risedronate
MS Marma, Z Xia, C Stewart, F Coxon, JE Dunford, R Baron, BA Kashemirov, FH Ebetino, JT Triffitt, RG Russell, CE McKenna
Journal of Medicinal Chemistry 2007
Einführung in die Bisphosphonate: Geschichte und Wirkungsmechanismen
H Fleisch
Der Orthopäde 2007
Oncologic Emergencies
Jacobsen NE, Beck SD, Foster RS
2007
Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis
K Thompson, MJ Rogers, FP Coxon, JC Crockett
Molecular pharmacology 2006
A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo
K Sato, T Yuasa, M Nogawa, S Kimura, H Segawa, A Yokota, T Maekawa
British Journal of Cancer 2006
The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis
N Horie, H Murata, Y Nishigaki, T Matsui, H Segawa, M Nogawa, T Yuasa, S Kimura, T Maekawa, S Fushiki, T Kubo
Cancer Letters 2006
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
H Mönkkönen, S Auriola, P Lehenkari, M Kellinsalmi, IE Hassinen, J Vepsäläinen, J Mönkkönen
British Journal of Pharmacology 2006
Ibandronate treatment for osteoporosis: Rationale, preclinical and clinical development of extended dosing regimens
S Epstein
Current Osteoporosis Reports 2006
Sequence- and concentration-dependent effects of acute and long-term exposure to the bisphosphonate ibandronate in combination with single and multiple fractions of ionising radiation doses in human breast cancer cell lines
F Journé, N Magné, C Chaboteaux, E Kinnaert, F Bauss, JJ Body
Clinical & Experimental Metastasis 2006
Neuropathy-induced osteopenia in rats is not due to a reduction in weight born on the affected limb
GT Whiteside, JM Boulet, R Sellers, TE Bunton, K Walker
Bone 2006
Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy
CT Leu, E Luegmayr, LP Freedman, GA Rodan, AA Reszka
Bone 2006
Bisphosphonate actions: Physical chemistry revisited
SE Papapoulos
Bone 2006
Synergistic antimyeloma effects of zoledronate and simvastatin
R Schmidmaier, M Simsek, P Baumann, B Emmerich, G Meinhardt
Anti-Cancer Drugs 2006
Bone regeneration in limb lengthening
JL Walker, S Battibugli
Current Opinion in Orthopaedics 2006
Anticancer effects of zoledronic acid against human osteosarcoma cells
B Kubista, K Trieb, F Sevelda, C Toma, F Arrich, P Heffeter, L Elbling, H Sutterlüty, K Scotlandi, R Kotz, M Micksche, W Berger
Journal of Orthopaedic Research 2006
Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells
T Kubo, S Shimose, T Matsuo, K Tanaka, Y Yasunaga, A Sakai, M Ochi
Journal of Orthopaedic Research 2006
Biphosphonates in Advanced Prostate and Renal Cell Cancer – Current Status and Potential Applications
CE Hoesl, JE Altwein
Urologia Internationalis 2006
Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate
X Deng, Z Yu, H Funayama, N Shoji, T Sasano, Y Iwakura, S Sugawara, Y Endo
Toxicology and Applied Pharmacology 2006
Effects of a combined alendronate and calcitriol agent (Maxmarvil®) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study
Y Rhee, M Kang, Y Min, D Byun, Y Chung, C Ahn, K Baek, J Mok, D Kim*, D Kim**, H Kim, Y Kim, S Myoung, D Kim***, SK Lim
Osteoporosis International 2006
Cytotoxicity evaluation of sodium alendronate on cultured human periodontal ligament fibroblasts
VF Correia, CL Caldeira, MM Marques
Dental Traumatology 2006
Bioequivalence and pharmacokinetics of 70 mg alendronate sodium tablets by measuring alendronate in plasma
MH Yun, JS Woo, KI Kwon
Archives of Pharmacal Research 2006
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts
JT Woo, M Kawatani, M Kato, T Shinki, T Yonezawa, N Kanoh, H Nakagawa, M Takami, KH Lee, PH Stern, K Nagai, H Osada
Proceedings of the National Academy of Sciences 2006
Les bisphosphonates oraux dans le traitement de l'ostéoporose postménopausique
T Thomas, V Breuil, K Briot
Revue du Rhumatisme 2006
Emerging Issues With Bisphosphonates
IR Reid
Rheumatic Disease Clinics of North America 2006
Is it feasible to adjust bisphosphonate dose according to bone mineral density value in postmenopausal breast cancer patients with bone metastases?
T Delibasi, NI Akkus, O Altundag, T Pinar, K Altundag
Medical Hypotheses 2006
Bisphosphonate-induced avascular osteonecrosis of the jaws: a clinical report of 11 cases
I Dimitrakopoulos, C Magopoulos, D Karakasis
International Journal of Oral and Maxillofacial Surgery 2006
Use of Bisphosphonates to Improve the Durability of Total Joint Replacements:
AS Shanbhag
The Journal of the American Academy of Orthopaedic Surgeons 2006
Additive/synergistic anti-tumoral effects of the combination of docetaxel and zoledronic acid on prostate cancer cells: Possible mechanisms?
AU Ural, F Avcu
Acta Oncologica 2006
Increased excretion of collagen crosslinks in irradiated patients indicates destruction of collagen
P Niehoff, J Wiltfang, IN Springer, N Weppner, B Kimmig, Y Acil
International Journal of Radiation Biology 2006
In vitrosynergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells
AU Ural, F Avcu, M Candir, M Guden, MA Ozcan
Breast Cancer Research 2006
In Vitro Effects of Aminobisphosphonates on Vγ9Vδ2 T Cell Activation and Differentiation
V Ferlazzo, C Sferrazza, N Caccamo, GD Fede, GD Lorenzo, M D'Asaro, S Meraviglia, F Dieli, G Rini, A Salerno
International journal of immunopathology and pharmacology 2006
Immunocytochemical Study of Amelogenin Deposition during the Early Odontogenesis of Molars in Alendronate-treated Newborn Rats
LF Massa, V Bradaschia-Correa, VE Arana-Chavez
Journal of Histochemistry & Cytochemistry 2006
Bisphosphonates: From Bench to Bedside
RG Russell
Annals of the New York Academy of Sciences 2006
The Effect of Anti-TNF- Therapy on Spinal Bone Mineral Density in Patients with Crohn's Disease
M Pazianas
Annals of the New York Academy of Sciences 2006
Current Topics in Pharmacological Research on Bone Metabolism: Inhibitory Effects of Bisphosphonates on the Differentiation and Activity of Osteoclasts
K Suzuki, S Takeyama, Y Sakai, S Yamada, H Shinoda
Journal of Pharmacological Sciences 2006
Effects of a combined alendronate and calcitriol agent (Maxmarvil®) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study
Y Rhee, M Kang, Y Min, D Byun, Y Chung, C Ahn, K Baek, J Mok, D Kim, D Kim, H Kim, Y Kim, S Myoung, D Kim, SK Lim
Osteoporosis International 2006
Bisphosphonates decrease telomerase activity and hTERT expression in MCF-7 breast cancer cells
LD Carbonare, MT Valenti, G Azzarello, E Balducci, G Crepaldi, G Realdi, O Vinante, S Giannini
Molecular and Cellular Endocrinology 2005
Comparison of Fc-osteoprotegerin and zoledronic acid activities suggests that zoledronic acid inhibits prostate cancer in bone by indirect mechanisms
JE Quinn, LG Brown, J Zhang, ET Keller, RL Vessella, E Corey
Prostate Cancer and Prostatic Diseases 2005
Evolving therapeutic role of bisphosphonates in multiple myeloma
AU Ural, F Avcu
British Journal of Cancer 2005
Neridronate and human osteoblasts in normal, osteoporotic and osteoarthritic subjects
A Corrado, FP Cantatore, M Grano, S Colucci
Clinical Rheumatology 2005
Zoledronate synergises with imatinib mesylate to inhibit Ph+ primary leukaemic cell growth
H Segawa, S Kimura, J Kuroda, K Sato, A Yokota, E Kawata, Y Kamitsuji, E Ashihara, T Yuasa, Y Fujiyama, OG Ottmann, T Maekawa
British Journal of Haematology 2005
Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models
M Nogawa, T Yuasa, S Kimura, J Kuroda, K Sato, H Segawa, A Yokota, T Maekawa
Cancer Letters 2005
Microdamage accumulation in the monkey vertebra does not occur when bone turnover is suppressed by 50% or less with estrogen or raloxifene
J Li, M Sato, C Jerome, CH Turner, Z Fan, DB Burr
Journal of Bone and Mineral Metabolism 2005
The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats
H Kajiwara, T Yamaza, M Yoshinari, T Goto, S Iyama, I Atsuta, MA Kido, T Tanaka
Biomaterials 2005
Nitrogen-Containing Biphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
SP Luckman, DE Hughes, FP Coxon, RG Russell, MJ Rogers
Journal of Bone and Mineral Research 2005
Effects of alendronate on the markers of bone metabolic activity in postmenopausal women with osteoporosis
J Ilic, B Kovacev, LB J., N Curic, J Radosavljevic
Medicinski pregled 2005
The Cochrane Database of Systematic Reviews (Protocol)
VG da Silva, GA Romito, JM Aldrighi, A Cranney, GH Gomes, A Tirlone, FE Pustiglioni, VG da Silva
The Cochrane Database of Systematic Reviews (Protocol) 2005
Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo
FP Coxon, FH Ebetino, EH Mules, MC Seabra, CE McKenna, MJ Rogers
Bone 2005
Inhibition of Inflammatory and Bone-Resorption–Inhibitory Effects of Alendronate by Etidronate
H Funayama, M Ohsako, Y Monma, H Mayanagi, S Sugawara, Y Endo
Calcified Tissue International 2005
Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone
CA Migliorati, MM Schubert, DE Peterson, LM Seneda
Cancer 2005
Histological comparison of alendronate, calcium hydroxide and formocresol in amputated rat molar
SB Cengiz, Y Batirbaygil, MA Onur, P Atilla, E Asan, N Altay, ZC Cehreli
Dental Traumatology 2005
Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells
C Chuah, DJ Barnes, M Kwok, A Corbin, MW Deininger, BJ Druker, JV Melo
Leukemia 2005
Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro
JK Woodward, HL Neville-Webbe, RE Coleman, I Holen
Anti-Cancer Drugs 2005
Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice
B Ory, MF Heymann, A Kamijo, F Gouin, D Heymann, F Redini
Cancer 2005
Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cells from dogs
JA Ashton, JP Farese, RJ Milner, LM Lee-Ambrose, JM van Gilder
American Journal of Veterinary Research 2005
Skeletal Retention of Bisphosphonate (Pamidronate) and Its Relation to the Rate of Bone Resorption in Patients With Breast Cancer and Bone Metastases
SC Cremers, SE Papapoulos, H Gelderblom, C Seynaeve, J Hartigh, P Vermeij, CC van derRijt, L Zuylen
Journal of Bone and Mineral Research 2005
Bisphosphonate Modulates Cementoblast Behavior In Vitro
YH Chun, BL Foster, PA Lukasavage, JE Berry, M Zhao, HC Tenenbaum, MJ Somerman
Journal of Periodontology 2005
Systemic Low-Dose Doxycycline and Alendronate Administration and Serum Interleukin-1Beta, Osteocalcin, and C-Reactive Protein Levels in Rats
E Buduneli, N Buduneli, S Vardar-Şengül, L Kardeşler, G Atilla, D Lappin, DF Kinane
Journal of Periodontology 2005
The decrease of particle-induced osteolysis after a single dose of bisphosphonate
M Knoch, C Wedemeyer, A Pingsmann, F Knoch, G Hilken, C Sprecher, F Henschke, B Barden, F Löer
Biomaterials 2005
Osteolytic bone diseases: physiological analogues of bone resorption effectors as alternative therapeutic tools
D Heymann, Y Fortun, F Rédini, M Padrines
Drug Discovery Today 2005
The anti-leukemic efficacy of the third generation bisphosphonate ONO5920/YM529
H Segawa, S Kimura, J Kuroda, K Sato, M Nogawa, T Yuasa, A Yokota, K Hodohara, Y Fujiyama, T Maekawa
Leukemia Research 2005
Zoledronic acid: pharmacologic profile of a potent bisphosphonate
JR Green
Journal of Organometallic Chemistry 2005
Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines
E Algur, RM Macklis, UO Häfeli
International journal of radiation oncology, biology, physics 2005
Zoledronic acid sensitizes tumor cells to radiation: In response to Algur et al. (Int J Radiat Oncol Biol Phys 2005;61:535–542)
AU Ural, F Avcu
International journal of radiation oncology, biology, physics 2005
The influence of alendronate on bone formation after autogenous free bone grafting in rats
H Altundal, B Gursoy
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology 2005
Osteoclast responses to lipopolysaccharide, parathyroid hormone and bisphosphonates in neonatal murine calvaria analyzed by laser scanning confocal microscopy
K Suzuki, S Takeyama, T Kikuchi, S Yamada, J Sodek, H Shinoda
Journal of Histochemistry & Cytochemistry 2005
Effects of alendronate on bone mineral density and bone metabolic markers in postmenopausal asthmatic women treated with inhaled corticosteroids
S Kasayama, M Fujita, K Goya, H Yamamoto, K Fujita, Y Morimoto, I Kawase, A Miyatake
Metabolism 2005
Osteoclast Responses to Lipopolysaccharide, Parathyroid Hormone and Bisphosphonates in Neonatal Murine Calvaria Analyzed by Laser Scanning Confocal Microscopy
K Suzuki, S Takeyama, T Kikuchi, S Yamada, J Sodek, H Shinoda
Journal of Histochemistry & Cytochemistry 2005
Managing the care of patients with bisphosphonate-associated osteonecrosis
CA Migliorati, J Casiglia, J Epstein, PL Jacobsen, MA Siegel, SB Woo
The Journal of the American Dental Association 2005
Additive/synergistic antitumoral effects on prostate cancer cells in vitro following treatment with a combination of docetaxel and zoledronic acid
A Ullén, L Lennartsson, U Harmenberg, M Hjelm-Eriksson, KM Kälkner, B Lennernäs, S Nilsson
Acta Oncologica 2005
Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines
F Journe, C Chaboteaux, N Magne, H Duvillier, G Laurent, JJ Body
Breast Cancer Research 2005
ROL' I MESTO BISFOSFONATOV V PROFILAKTIKE I LEChENII OSTEOPOROZA. 10-LETNIY OPYT PRIMENENIYa ALENDRONATA (FOSAMAKSA)Obzor literatury
II Dedov, LY Rozhinskaya, ZE Belaya
Osteoporosis and osteopathy 2005
Discovery, Clinical Development, and Therapeutic Uses of Bisphosphonates
AA Licata
The Annals of pharmacotherapy 2005
Pharmacokinetics/Pharmacodynamics of Bisphosphonates: Use for Optimisation of Intermittent Therapy for Osteoporosis
SC Cremers, GC Pillai, SE Papapoulos
Clinical Pharmacokinetics 2005
Pharmacokinetic Considerations in Determining the Terminal Elimination Half-Lives of Bisphosphonates:
KC Lasseter, AG Porras, A Denker, A Santhanagopal, A Daifotis
Clinical Drug Investigation 2005
Alendronate Prevents Alveolar Bone Loss in Experimental Rat Periodontitis
H Seto, C Wada, M Horibe, T Nagata
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) 2005
The Inhibition of RANKL Causes Greater Suppression of Bone Resorption and Hypercalcemia Compared with Bisphosphonates in Two Models of Humoral Hypercalcemia of Malignancy
S Morony, K Warmington, S Adamu, F Asuncion, Z Geng, M Grisanti, HL Tan, C Capparelli, C Starnes, B Weimann, CR Dunstan, PJ Kostenuik
Endocrinology 2005
p53‐independent anti‐tumor effects of the nitrogen‐containing bisphosphonate zoledronic acid
Kuroda J, Kimura S, Segawa H, Sato K, Matsumoto S, Nogawa M, Yuasa T, Kobayashi Y, Yoshikawa T, Ottmann OG, Maekawa T
Cancer Science 2005
Functional foods, ageing and degenerative disease
L Ovesen
Functional foods, ageing and degenerative disease 2004
Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells
F Journe, C Chaboteaux, JC Dumon, G Leclercq, G Laurent, JJ Body
British Journal of Cancer 2004
A theoretical analysis of long-term bisphosphonate effects on trabecular bone volume and microdamage
JS Nyman, OC Yeh, SJ Hazelwood, RB Martin
Bone 2004
Preventing osteoporotic fractures with antiresorptive therapy: implications of microarchitectural changes
S Boonen, P Haentjens, L Vandenput, D Vanderschueren
Journal of Internal Medicine 2004
Bone safety of long-term bisphosphonate treatment
G Rodan, A Reszka, E Golub, R Rizzoli
Current Medical Research and Opinion 2004
Osteoblast proliferation and maturation by bisphosphonates
GI Im, SA Qureshi, J Kenney, HE Rubash, AS Shanbhag
Biomaterials 2004
The Nitrogen-Containing Bisphosphonate, Zoledronic Acid, Influences RANKL Expression in Human Osteoblast-Like Cells by Activating TNF-α Converting Enzyme (TACE)
B Pan, AN Farrugia, LB To, DM Findlay, J Green, K Lynch, AC Zannettino
Journal of Bone and Mineral Research 2004
From Molds and Macrophages to Mevalonate: A Decade of Progress in Understanding the Molecular Mode of Action of Bisphosphonates
MJ Rogers
Calcified Tissue International 2004
Cytostatic and Apoptotic Effects of Bisphosphonates on Prostate Cancer Cells
JC Dumon, F Journé, N Kheddoumi, L Lagneaux, JJ Body
European Urology 2004
Antiproliferative Efficacy of the Third-Generation Bisphosphonate, Zoledronic Acid, Combined with Other Anticancer Drugs in Leukemic Cell Lines
S Kimura, J Kuroda, H Segawa, K Sato, M Nogawa, T Yuasa, OG Ottmann, T Maekawa
International Journal of Hematology 2004
Topical, single dose bisphosphonate treatment reduced bone resorption in a rat model for prosthetic loosening
J Åstrand, P Aspenberg
Journal of Orthopaedic Research 2004
Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation
JP Coxon, GM Oades, RS Kirby, KW Colston
BJU International 2004
THE EFFECT OF THE BISPHOSPHONATE ALENDRONATE ON VIABILITY OF CANINE OSTEOSARCOMA CELLS IN VITRO
JP Farese, J Ashton, R Milner, LL Ambrose, JV Gilder
In Vitro Cellular & Developmental Biology - Animal 2004
p53-independent anti-tumor effects of the nitrogen-containing bisphosphonate zoledronic acid
J Kuroda, S Kimura, H Segawa, K Sato, S Matsumoto, M Nogawa, T Yuasa, Y Kobayashi, T Yoshikawa, OG Ottmann, T Maekawa
Cancer Science 2004
Bisphosphonates: new therapeutic agents for the treatment of bone tumors
D Heymann, B Ory, F Gouin, JR Green, F Rédini
Trends in Molecular Medicine 2004
Differential Inhibition of Invasion and Proliferation by Bisphosphonates: Anti-Metastatic Potential of Zoledronic Acid in Prostate Cancer
R Montague, CA Hart, NJ George, VA Ramani, MD Brown, NW Clarke
European Urology 2004
Long-term effects of neridronate on human osteoblastic cell cultures
B Frediani, A Spreafico, C Capperucci, F Chellini, D Gambera, P Ferrata, F Baldi, P Falsetti, A Santucci, L Bocchi, R Marcolongo
Bone 2004
Preclinical Investigations of Drug and Radionuclide Conjugates of Bisphosphonates for the Treatment of Metastatic Bone Cancer
A El-Mabhouh, C Angelov, A McEwan, G Jia, J Mercer
Cancer Biotherapy & Radiopharmaceuticals 2004
The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro
B Pan, LB To, AN Farrugia, DM Findlay, J Green, S Gronthos, A Evdokiou, K Lynch, GJ Atkins, AC Zannettino
Bone 2004
Effects of vitamin K2 (menatetrenone) and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet
M Kobayashi, K Hara, Y Akiyama
Bone 2004
Effects of Combined Systemic Administration of Low-Dose Doxycycline and Alendronate on Endotoxin-Induced Periodontitis in Rats
E Buduneli, S Vardar, N Buduneli, AH Berdeli, O Türkoǧlu, A Başkesen, G Atilla
Journal of Periodontology 2004
Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition
M Chaplet, C Detry, C Deroanne, LW Fisher, V Castronovo, A Bellahcéne
Biochemical Journal 2004
The effect of alendronate sodium on spinal fusion: a rabbit model
RA Lehman, TR Kuklo, BA Freedman, JR Cowart, MG Mense, KD Riew
The Spine Journal 2004
Particle bioreactivity and wear-mediated osteolysis
ML Wang, PF Sharkey, RS Tuan
The Journal of Arthroplasty 2004
In vitro toxicity of bisphosphonates on human neuroblastoma cell lines:
M Vorotnjak, J Boos, C Lanvers-Kaminsky
Anti-Cancer Drugs 2004
Advances in the use of bisphosphonates in the prostate cancer setting
JP Coxon, GM Oades, KW Colston, RS Kirby
Prostate Cancer and Prostatic Diseases 2004
High-dose Alendronate Uncouples Osteoclast and Osteoblast Function: A Study in a Rat Spine Pseudarthrosis Model
AA Sama, SN Khan, ER Myers, RC Huang, FP Cammisa, HS Sandhu, JM Lane
Clinical Orthopaedics and Related Research® 2004
The Role of Bisphosphonates in the Treatment of Skeletal Complications of Breast Cancer:
BF El-Rayes, PM LoRusso
American Journal of Cancer 2004
Bone Metastasis and Molecular Mechanisms
G Singh, W Orr
2004
Applications of Pharmacokinetic Principles in Drug Development
R Krishna
2004
The Biology of Skeletal Metastases
ET Keller, LW Chung
2004
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate
S Kimura, J Kuroda, T Maekawa
Ensho Saisei 2004
Bisphosphonates: Preclinical Review
JR Green
The oncologist 2004
THE EFFECT OF THE BISPHOSPHONATE ALENDRONATE ON VIABILITY OF CANINE OSTEOSARCOMA CELLS IN VITRO
JP Farese, J Ashton, R Milner, LL Ambrose, JV Gilder
In vitro cellular & developmental biology. Animal 2004
Antitumor effects of bisphosphonates
JR Green
Cancer 2003
The role of bisphosphonates in diseases of childhood
T Srivastava, US Alon
European Journal of Pediatrics 2003
A Histopathological Investigation on the Effect of Systemic Administration of the Bisphosphonate Alendronate on Resorptive Phase Following Mucoperiosteal Flap Surgery in the Rat Mandible
D Kaynak, R Meffert, H Bostancı, Ö Günhan, ÖG Özkaya
Journal of Periodontology 2003
The Bisphosphonate Zoledronic Acid Induces Cytotoxicity in Human Myeloma Cell Lines with Enhancing Effects of Dexamethasone and Thalidomide
AU Ural, MI Yilmaz, F Avcu, A Pekel, M Zerman, O Nevruz, A Sengul, A Yalcin
International Journal of Hematology 2003
Bisphosphonate mechanism of action
AA Reszka, GA Rodan
Current Rheumatology Reports 2003
Mechanism of action of bisphosphonates
AA Reszka, GA Rodan
Current Osteoporosis Reports 2003
Antagonistic Effects of Different Classes of Bisphosphonates in Osteoclasts and Macrophages In Vitro
JC Frith, MJ Rogers
Journal of Bone and Mineral Research 2003
Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis
A Evdokiou, A Labrinidis, S Bouralexis, S Hay, DM Findlay
Bone 2003
Nitrogen Containing Bisphosphonates Induce Apoptosis and Inhibit the Mevalonate Pathway, Impairing Ras Membrane Localization in Prostate Cancer Cells
GM Oades, SG Senaratne, IA Clarke, RS Kirby, KW Colston
The Journal of Urology 2003
The bisphosphonates alendronate and zoledronate are inhibitors of canine and human osteosarcoma cell growth in vitro
VJ Poirier, MK Huelsmeyer, ID Kurzman, DH Thamm, DM Vail
Veterinary and Comparative Oncology 2003
The development and function of the skeleton and bone metastases
GA Rodan
Cancer 2003
Combined Local Application of Tetracycline and Bisphosphonate Reduces Alveolar Bone Resorption in Rats
A Yaffe, A Herman, H Bahar, I Binderman
Journal of Periodontology 2003
The Influence of Alendronate on Bone Formation and Resorption in a Rat Ectopic Bone Development Model
A Yaffe, R Kollerman, H Bahar, I Binderman
Journal of Periodontology 2003
Periodontal Host Modulation with Antiproteinase, Anti-Inflammatory, and Bone-Sparing Agents.A Systematic Review
MS Reddy, NC Geurs, JC Gunsolley
Annals of Periodontology 2003
Review of ibandronate in the treatment of osteoporosis
RD Chapurlat, PD Delmas
Expert Opinion on Pharmacotherapy 2003
Preventive effects of sequential treatment with alendronate and 1α-hydroxyvitamin D3 on bone mass and strength in ovariectomized rats
M Ito, Y Azuma, H Takagi, T Kamimura, K Komoriya, T Ohta, H Kawaguchi
Bone 2003
Involvement of vacuolar H+-ATPase in incorporation of risedronate into osteoclasts
M Takami, K Suda, T Sahara, K Itoh, K Nagai, T Sasaki, N Udagawa, N Takahashi
Bone 2003
Bisphosphonates antagonise bone growth factors' effects on human breast cancer cells survival
O Fromigue, N Kheddoumi, JJ Body
British Journal of Cancer 2003
New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects
C Denoyelle, L Hong, JP Vannier, J Soria, C Soria
British Journal of Cancer 2003
Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates
H Valleala, R Hanemaaijer, J Mandelin, A Salminen, O Teronen, J Mönkkönen, YT Konttinen
Life Sciences 2003
Management of glucocorticoid induced osteoporosis in premenopausal women with autoimmune disease
Nathalie Franchimont, Ernesto Canalis
Autoimmunity Reviews 2003
Intracellular membrane trafficking in bone resorbing osteoclasts: Membrane Trafficking in Osteoclasts
M Mulari, J Vääräniemi, HK Väänänen
Microscopy Research and Technique 2003
A Simulation Model at Trabecular Level to Predict Effects of Antiresorptive Treatment after Menopause
JC van der Linden, JA Verhaar, HA Pols, H Weinans
Calcified Tissue International 2003
Mandible and Maxilla Bone Mineral Density and Threshold Analysis Studies by pQCT in Two Edentulous Women Receiving Pamidronate
VE Montangero, R Capiglioni, EJ Roldán
CRANIO 2003
OSTEOPOROSIS AND BISPHOSPHONATES☆:
GA Rodan, AA Reszka
The Journal of Bone and Joint Surgery. American volume. 2003
New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects
C Denoyelle, L Hong, JP Vannier, J Soria, C Soria
British Journal of Cancer 2003
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro
P Tassone, P Tagliaferri, C Viscomi, C Palmieri, M Caraglia, A D'Alessandro, E Galea, A Goel, A Abbruzzese, CR Boland, S Venuta
British Journal of Cancer 2003
Cellular mechanism of inhibition of osteoclastic resorption of bone and calcified cartilage by long-term pamidronate administration in ovariectomized mature rats
M Mayahara, T Sasaki
The Anatomical Record 2003
The effect of sintered dicalcium pyrophosphate on osteoclast metabolism: An ultrastructural study
JS Sun, YC Huang, FH Lin, LT Chen
Journal of Biomedical Materials Research 2003
Bone as an Effect Compartment: Models for Uptake and Release of Drugs
D Stepensky, L Kleinberg, A Hoffman
Clinical Pharmacokinetics 2003
New Bone Formation with Teriparatide [Human Parathyroid Hormone-(1–34)] Is Not Retarded by Long-Term Pretreatment with Alendronate, Estrogen, or Raloxifene in Ovariectomized Rats
YL Ma, HU Bryant, Q Zeng, A Schmidt, J Hoover, HW Cole, W Yao, WS Jee, M Sato
Endocrinology 2003
Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
S Yaccoby, RN Pearse, CL Johnson, B Barlogie, Y Choi, J Epstein
British Journal of Haematology 2002
Dissociation of Angiogenesis and Osteoclastogenesis During Endochondral Bone Formation in Neonatal Mice
MM Deckers, ER van Beek, GV der Pluijm, A Wetterwald, LV der Wee-Pals, MG Cecchini, SE Papapoulos, CW Löwik
Journal of Bone and Mineral Research 2002
Drugs in development: bisphosphonates and metalloproteinase inhibitors
JB Catterall, TE Cawston
Arthritis Research & Therapy 2002
Synergistic Growth Inhibition of YM529 with Biologic Response Modifiers (BRMs) in Myeloma Cells
K Yata, T Otsuki, O Yamada, H Wada, Y Yawata, T Sugihara
International Journal of Hematology 2002
Pharmacological and clinical properties of alendronate sodium hydrate
T OHTA, S KOMATSU, N TOKUTAKE
Folia Pharmacologica Japonica 2002
Bisphosphonates and Periodontics: Potential Applications for Regulation of Bone Mass in the Periodontium and Other Therapeutic/ Diagnostic Uses
HC Tenenbaum, A Shelemay, B Girard, R Zohar, PC Fritz
Journal of Periodontology 2002
A Cysteine Protease Inhibitor Prevents Suspension-Induced Declines in Bone Weight and Strength in Rats
T Nikawa, M Ikemoto, C Watanabe, T Kitano, M Kano, M Yoshimoto, T Towatari, N Katunuma, F Shizuka, K Kishi
Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science 2002
Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines
P Heikkilä, O Teronen, M Moilanen, YT Konttinen, R Hanemaaijer, M Laitinen, P Maisi, G der Pluijm, JD Bartlett, T Salo, T Sorsa
Anti-Cancer Drugs 2002
Curative Effect of Combined Treatment With Alendronate and 1α-Hydroxyvitamin D3 on Bone Loss by Ovariectomy in Aged Rats
M Ito, Y Azuma, H Takagi, K Komoriya, T Ohta, H Kawaguchi
The Japanese Journal of Pharmacology 2002
Mechanisms of Bisphosphonate Effects on Osteoclasts, Tumor Cell Growth, and Metastasis
JR Green, P Clézardin
American Journal of Clinical Oncology 2002
Future Directions in the Treatment and Prevention of Bone Metastases
RE Coleman
American Journal of Clinical Oncology 2002
Bisphosphonates in cancer therapy
JR Green
Current Opinion in Oncology 2002
Pharmacologic profile of zoledronic acid: A highly potent inhibitor of bone resorption
JR Green, MJ Rogers
Drug Development Research 2002
Intravenous Zoledronic Acid in Postmenopausal Women with Low Bone Mineral Density
IR Reid, JP Brown, P Burckhardt, Z Horowitz, P Richardson, U Trechsel, A Widmer, JP Devogelaer, JM Kaufman, P Jaeger, JJ Body, ML Brandi, J Broell, RD Micco, AR Genazzani, D Felsenberg, J Happ, MJ Hooper, J Ittner, G Leb, H Mallmin, T Murray, S Ortolani, A Rubinacci, M Sääf, G Samsioe, L Verbruggen, PJ Meunier
New England Journal of Medicine 2002
Advances in Cell Aging and Gerontology
T Fülöp, K Hirokawa, G Dupuis, A Larbi, G Pawelec
Advances in Cell Aging and Gerontology 2002
Bisphosphonates influence the proliferation and the maturation of normal human osteoblasts
O Fromigué, JJ Body
Journal of Endocrinological Investigation 2002
Treatment of rheumatic diseases in children: special considerations
DS Milojevic, NT Ilowite
Rheumatic Disease Clinics of North America 2002
Generation and activity of equine osteoclasts in vitro: effects of the bisphosphonate pamidronate (APD)
AW Gray, ME Davies, LB Jeffcott
Research in Veterinary Science 2002
Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model:
PJ Millett, MJ Allen, MP Bostrom
The Journal of Bone and Joint Surgery. American volume. 2002
Alendronate Does Not Inhibit Early Bone Apposition to Hydroxyapatite-Coated Total Joint Implants: A Preliminary Study
Y Mochida, TW Bauer, T Akisue, PR Brown
The Journal of Bone and Joint Surgery. American volume. 2002
Transport of inorganic phosphate in primary cultures of chondrocytes isolated from the tibial growth plate of normal adolescent chickens
LN Wu, Y Guo, BR Genge, Y Ishikawa, RE Wuthier
Journal of Cellular Biochemistry 2002
Localization of Osteoprotegerin (OPG) on Bone Surfaces and Cement Lines in Rat Tibia
H Nakamura, T Tsuji, A Hirata, T Yamamoto
Journal of Histochemistry & Cytochemistry 2002
Synergism of Aminobisphosphonates and Farnesyl Transferase Inhibitors on Tumor Metastasis:
VB Andela, JD Rosenblatt, EM Schwarz, EJ Puzas, RJ OKeefe, RN Rosier
Clinical Orthopaedics and Related Research® 2002
Peptides for the New Millennium
GB Fields, JP Tam, G Barany
2002
Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite
PP Lehenkari, M Kellinsalmi, JP Näpänkangas, KV Ylitalo, J Mönkkönen, MJ Rogers, A Azhayev, HK Väänänen, IE Hassinen
Molecular pharmacology 2002
Osteoporose
A Hedtmann, S Götte
2002
Sequential Treatment with Basic Fibroblast Growth Factor and PTH Is More Efficacious than Treatment with PTH Alone for Increasing Vertebral Bone Mass and Strength in Osteopenic Ovariectomized Rats
UT Iwaniec, L Mosekilde, NG Mitova-Caneva, JS Thomsen, TJ Wronski
Endocrinology 2002
Inhibition of Particulate Debris-Induced Osteolysis by Alendronate in a Rat Model
PJ Thadani, B Waxman, E Sladek, R Barmada, MH Gonzalez
Orthopedics 2002
Sintered dicalcium pyrophosphate increases bone mass in ovariectomized rats
JS Sun, YC Huang, YH Tsuang, LT Chen, FH Lin
Journal of Biomedical Materials Research 2001
The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis
JC Frith, J Mönkkönen, S Auriola, H Mönkkönen, MJ Rogers
Arthritis & Rheumatism 2001
Maintenance of cortical bone in human parathyroid hormone(1-84)-treated ovariectomized rats
E Samnegård, UT Iwaniec, DM Cullen, DB Kimmel, RR Recker
Bone 2001
Maintenance of vertebral body bone mass and strength created by human parathyroid hormone treatment in ovariectomized rats
E Samnegård, MP Akhter, RR Recker
Bone 2001
Molekulare Wirkmechanismen der Bisphosphonate: Osteoklasten im Fadenkreuz
HA Fleisch
Pharmazie in unserer Zeit 2001
Long-Term Effects of Withdrawal of Bisphosphonate Incadronate Disodium (YM175) on Bone Mineral Density, Mass, Structure, and Turnover in the Lumbar Vertebrae of Ovariectomized Rats
Y Tamura, N Miyakoshi, E Itoi, T Abe, T Kudo, T Tsuchida, Y Kasukawa, K Sato
Journal of Bone and Mineral Research 2001
Bisphosphonate acts on osteoclasts independent of ruffled borders in osteosclerotic (oc/oc) mice
M Ito, N Amizuka, T Nakajima, H Ozawa
Bone 2001
Alendronate Therapy of Primary Hyperparathyroidism
S Hassani, GD Braunstein, MJ Seibel, AS Brickman, F Geola, AE Pekary, JM Hershman
The Endocrinologist 2001
Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro
HL Benford, NW McGowan, MH Helfrich, ME Nuttall, MJ Rogers
Bone 2001
Bisphosphonates in renal osteodystrophy
SL Fan, J Cunningham
Current Opinion in Nephrology and Hypertension 2001
Effect of topical alendronate on root resorption of dried replanted dog teeth
L Levin, EC Bryson, D Caplan, M Trope
Dental Traumatology 2001
Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice
DR Clohisy, PF O'Keefe, ML Ramnaraine
Journal of Orthopaedic Research 2001
Bisphosphonates and in vivo models of multiple myeloma
M Salomo, P Gimsing
British Journal of Haematology 2001
Reply to salomo and gimsing
CM Shipman, PI Croucher, K Vanderkerken
British Journal of Haematology 2001
Statins and their potential for osteoporosis
GR Mundy
Bone 2001
Novel therapeutic approaches to cancer patients with bone metastasis
R Maisano, S Pergolizzi, S Cascinu
Critical Reviews in Oncology/Hematology 2001
Bisphosphonates: mechanisms of action
H Fleisch
Expert Opinion on Therapeutic Patents 2001
Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption
SM Violette, W Guan, C Bartlett, JA Smith, C Bardelay, E Antoine, RJ Rickles, E Mandine, MR Schravendijk, SE Adams, BA Lynch, WC Shakespeare, M Yang, VA Jacobsen, CS Takeuchi, KJ Macek, RS Bohacek, DC Dalgarno, M Weigele, D Lesuisse, TK Sawyer, R Baron
Bone 2001
Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis
JM Halasy-Nagy, GA Rodan, AA Reszka
Bone 2001
The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel
SP Jagdev, RE Coleman, CM Shipman, A Rostami-H, PI Croucher
British Journal of Cancer 2001
Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line
PS Mackie, JL Fisher, H Zhou, PF Choong
British Journal of Cancer 2001
A newly developed bisphosphonate, YM529, is a potent apoptosis inducer of human myeloma cells
R Takahashi, C Shimazaki, T Inaba, A Okano, M Hatsuse, A Okamoto, H Hirai, E Ashihara, M Nakagawa
Leukemia Research 2001
Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption
PA Price, SA Faus, MK Williamson
Arteriosclerosis, thrombosis, and vascular biology 2001
Treatment of Osteoporosis with Bisphosphonates
NB Watts
Rheumatic Disease Clinics of North America 2001
Novel Drug Delivery System to Bone Using Acidic Oligopeptide: Pharmacokinetic Characteristics and Pharmacological Potential
T Sekido, N Sakura, Y Higashi, K Miya, Y Nitta, M Nomura, H Sawanishi, K Morito, Y Masamune, S Kasugai, K Yokogawa, KI Miyamoto
Journal of Drug Targeting 2001
Effect of 17ß-estradiol or alendronate on the bone densitometry, bone histomorphometry and bone metabolism of ovariectomized rats
LH Paz, V Falco, NC Teng, LM Reis, RM Pereira, V Jorgetti
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 2001
The role of bisphosphonates in breast cancer: Direct effects of bisphosphonates on breast cancer cells
SG Senaratne, KW Colston
Breast Cancer Research 2001
Osteoprotegerin Inhibits Artery Calcification Induced by Warfarin and by Vitamin D
PA Price, HH June, JR Buckley, MK Williamson
Arteriosclerosis, thrombosis, and vascular biology 2001
Alendronate: An Update of its Use in Osteoporosis
M Sharpe, S Noble, CM Spencer
Drugs 2001
Vγ2Vδ2 T-cell receptor–mediated recognition of aminobisphosphonates
H Das, L Wang, A Kamath, JF Bukowski
Blood 2001
The cellular uptake and metabolism of clodronate in RAW 264 macrophages
H Mönkkönen, M J Rogers, N Makkonen, S Niva, S Auriola, J Mönkkönen
Pharmaceutical Research 2001
Cellular and molecular mechanisms of action of bisphosphonates
MJ Rogers, S Gordon, HL Benford, FP Coxon, SP Luckman, J Monkkonen, JC Frith
Cancer 2000
Effects of Bisphosphonate on Matrix Metalloproteinase Enzymes in Human Periodontal Ligament Cells
H Nakaya, G Osawa, N Iwasaki, DL Cochran, K Kamoi, TW Oates
Journal of Periodontology 2000
Bisphosphonates Induce Breast Cancer Cell Death In Vitro
O Fromigue, L Lagneaux, JJ Body
Journal of Bone and Mineral Research 2000
Concentration of Bisphosphonate (Incadronate) in Callus Area and Its Effects on Fracture Healing in Rats
J Li, S Mori, Y Kaji, J Kawanishi, T Akiyama, H Norimatsu
Journal of Bone and Mineral Research 2000
Alendronate Stimulates Collagenase 3 Expression in Osteoblasts by Posttranscriptional Mechanisms
S Varghese, E Canalis
Journal of Bone and Mineral Research 2000
Bisphosphonate administration alters subcellular localization of vacuolar-type H+-ATPase and cathepsin K in osteoclasts during experimental movement of rat molars
Y Sato, H Sakai, Y Kobayashi, Y Shibasaki, T Sasaki
The Anatomical Record 2000
Effectiveness of Local Delivery of Alendronate in Reducing Alveolar Bone Loss Following Periodontal Surgery in Rats
I Binderman, M Adut, A Yaffe
Journal of Periodontology 2000
Chronic Intravenous Aminobisphosphonate Therapy Increases High-Density Lipoprotein Cholesterol and Decreases Low-Density Lipoprotein Cholesterol
S Adami, V Braga, G Guidi, D Gatti, D Gerardi, E Fracassi
Journal of Bone and Mineral Research 2000
Alendronate Administration and Skeletal Response During Chronic Alcohol Intake in the Adolescent Male Rat
FH Wezeman, MA Emanuele, SF Moskal, J Steiner, N Lapaglia
Journal of Bone and Mineral Research 2000
Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma
T Yoneda, T Michigami, B Yi, PJ Williams, M Niewolna, T Hiraga
Cancer 2000
The Effect of Topical Delivery of Novel Bisacylphosphonates in Reducing Alveolar Bone Loss in the Rat Model
A Yaffe, G Golomb, E Breuer, I Binderman
Journal of Periodontology 2000
Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI-298
FP Coxon, MH Helfrich, RV Hof, S Sebti, SH Ralston, A Hamilton, MJ Rogers
Journal of Bone and Mineral Research 2000
Bisphosphonates induce apoptosis in human breast cancer cell lines
SG Senaratne, G Pirianov, JL Mansi, TR Arnett, KW Colston
British Journal of Cancer 2000
Bisphosphonates in Bone Disease
H Fleisch
Bisphosphonates in Bone Disease 2000
Alendronate Is a Specific, Nanomolar Inhibitor of Farnesyl Diphosphate Synthase
JD Bergstrom, RG Bostedor, PJ Masarachia, AA Reszka, G Rodan
Archives of Biochemistry and Biophysics 2000
Mécanismes d'action des bisphosphonates sur les cellules tumorales et perspectives d'utilisation dans le traitement de l'ostéolyse maligne
P Clézardin, J Gligorov, P Delmas
Revue du Rhumatisme 2000
Bisphosphonates and atherosclerosis
R Ylitalo
General Pharmacology: The Vascular System 2000
Bisphosphonates - Mechanisms of Action in Multiple Myeloma
CM Karin
Acta Oncologica 2000
Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines
P Tassone, S Forciniti, E Galea, G Morrone, MC Turco, V Martinelli, P Tagliaferri, S Venuta
Leukemia 2000
Management of Fractures in Severely Osteoporotic Bone
K Obrant
2000
Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma
V Kunzmann, E Bauer, J Feurle, HP Weißinger, M Wilhelm
Blood 2000
Phosphate depletion in the rat: Effect of bisphosphonates and the calcemic response to PTH
A Jara, E Lee, D Stauber, F Moatamed, AJ Felsenfeld, CR Kleeman
Kidney International 1999
Bisphosphonates: from the laboratory to the clinic and back again
RG Russell, MJ Rogers
Bone 1999
The Role of Geranylgeranylation in Bone Resorption and Its Suppression by Bisphosphonates in Fetal Bone Explants In Vitro: A Clue to the Mechanism of Action of Nitrogen-Containing Bisphosphonates
EV Beek, C Löwik, GV der Pluijm, S Papapoulos
Journal of Bone and Mineral Research 1999
Relationship between bisphosphonate concentration and osteoclast activity and viability
DJ Rowe, LA Etre, MJ Lovdahl, DJ Pietrzyk
In Vitro Cellular & Developmental Biology - Animal 1999
Effect of Prostaglandin and Bisphosphonate on Cancellous Bone Volume and Structure in the Ovariectomized Rat Studied by Quantitative Three-Dimensional Nuclear Magnetic Resonance Microscopy
M Takahashi, FW Wehrli, SL Wehrli, SN Hwang, MW Lundy, J Hartke, B Borah
Journal of Bone and Mineral Research 1999
Molecular mechanisms of action of bisphosphonates
MJ Rogers, JC Frith, SP Luckman, FP Coxon, HL Benford, J M̈onkk̈onen, S Auriola, KM Chilton, RG Russell
Bone 1999
Bisphosphonates as anticancer drugs
GR Mundy
Expert Opinion on Investigational Drugs 1999
The Effects of Nitrogen-Containing Bisphosphonates on Human Epithelial (Caco-2) Cells, an In Vitro Model for Intestinal Epithelium
IM Twiss, O Pas, W Ramp-Koopmanschap, JD Hartigh, P Vermeij
Journal of Bone and Mineral Research 1999
Short-term effects of bisphosphonates on the biomechanical properties of canine bone
X Wang, AS Shanbhag, HE Rubash, CM Agrawal
Journal of Biomedical Materials Research 1999
Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats
N Patlas, G Golomb, P Yaffe, T Pinto, E Breuer, A Ornoy
Teratology 1999
Zoledronate Is a Potent Inhibitor of Myeloma Cell Growth and Secretion of IL-6 and MMP-1 by the Tumoral Environment
S Derenne, M Amiot, S Barillé, M Collette, N Robillard, P Berthaud, JL Harousseau, R Bataille
Journal of Bone and Mineral Research 1999
Intermittent and Continuous Administration of the Bisphosphonate Ibandronate in Ovariohysterectomized Beagle Dogs: Effects on Bone Morphometry and Mineral Properties
MC Monier-Faugere, Z Geng, EP Paschalis, Q Qi, I Arnala, F Bauss, AL Boskey, HH Malluche
Journal of Bone and Mineral Research 1999
Qualitative Analysis of Peripheral Peri-Implant Bone and Influence of Alendronate Sodium on Early Bone Regeneration
SJ Meraw, CM Reeve
Journal of Periodontology 1999
Disposition of Alendronate Following Local Delivery in a Rat Jaw
A Yaffe, I Binderman, E Breuer, T Pinto, G Golomb
Journal of Periodontology 1999
Use of bisphosphonates for the treatment of bone metastasis in experimental animal models
T Yoneda, T Michigami, B Yi, PJ Williams, M Niewolna, T Hiraga
Cancer Treatment Reviews 1999
Ultrastructural and cytochemical studies on cell death of osteoclasts induced by bisphosphonate treatment
M Ito, N Amizuka, T Nakajima, H Ozawa
Bone 1999
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
JE Fisher, MJ Rogers, JM Halasy, SP Luckman, DE Hughes, PJ Masarachia, G Wesolowski, RG Russell, GA Rodan, AA Reszka
Proceedings of the National Academy of Sciences 1999
The pharmacology of bisphosphonates and new insights into their mechanisms of action
RG Russell, MJ Rogers, JC Frith, SP Luckman, FP Coxon, HL Benford, PI Croucher, C Shipman, HA Fleisch
Journal of Bone and Mineral Research 1999
The Bisphosphonate Odyssey. A Journey from Chemistry to the Clinic
R Graham, G Russell
Phosphorus Sulfur and Silicon and the Related Elements 1999
Amino-Substituted <i>GEM</i>-Bisphosphonates
L Widler, KA Jaeggi, JR Green
Phosphorus Sulfur and Silicon and the Related Elements 1999
The Aging Skeleton
AB Hodsman, LJ Fraher, PH Watson
The Aging Skeleton 1999
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
HL Benford, JC Frith, S Auriola, J Mönkkönen, MJ Rogers
Molecular pharmacology 1999
An ultrastructural study of the effects of bisphosphonate administration on osteoclastic bone resorption during relapse of experimentally moved rat molars
TW Kim, Y Yoshida, K Yokoya, T Sasaki
American Journal of Orthodontics and Dentofacial Orthopedics 1999
Disposition of tiludronate (Skelid) in animals
H Davi, C Tronquet, J Caix, J Simiand, C Briot, Y Berger, JF Thiercelin
Xenobiotica 1999
Bisphosphonates: From Grandparents to Grandchildren
T Srivastava, US Alon
Clinical Pediatrics 1999
Pharmacokinetics of Bisphosphonates in Rabbits
S Luurila, S Kautiainen, P Ylitalo, R Ylitalo
Pharmacology and Toxicology 1999
Selective inhibition of β-1,4- and α-1,3-galactosyltransferases: donor sugar-nucleotide based approach
S Takayama, SJ Chung, Y Igarashi, Y Ichikawa, A Sepp, RI Lechler, J Wu, T Hayashi, G Siuzdak, CH Wong
Bioorganic & Medicinal Chemistry 1999
Bisphosphonates Act Directly on the Osteoclast to Induce Caspase Cleavage of Mst1 Kinase during Apoptosis: A LINK BETWEEN INHIBITION OF THE MEVALONATE PATHWAY AND REGULATION OF AN APOPTOSIS-PROMOTING KINASE
AA Reszka, JM Halasy-Nagy, PJ Masarachia, GA Rodan
The Journal of biological chemistry 1999
Inorganic Polyphosphates
HC Schröder, WE Müller
1999
New Bisphosphonates in the Treatment of Bone Diseases:
D Gatti, S Adami
Drugs & Aging 1999
Relationship between bisphosphonate concentration and osteoclast activity and viability
DJ Rowe, LA Etre, MJ Lovdahl, DJ Pietrzyk
In vitro cellular & developmental biology. Animal 1999
Pharmacokinetics of Alendronate:
AG Porras, SD Holland, BJ Gertz
Clinical Pharmacokinetics 1999
Heterocycle-Containing Bisphosphonates Cause Apoptosis and Inhibit Bone Resorption by Preventing Protein Prenylation: Evidence from Structure-Activity Relationships in J774 Macrophages
SP Luckman, FP Coxon, FH Ebetino, RG Russell, MJ Rogers
Journal of Bone and Mineral Research 1998
Bisphosphonates
JJ Body
European Journal of Cancer 1998
MECHANISMS OF ACTION OF BISPHOSPHONATES
GA Rodan
Annual Review of Pharmacology and Toxicology 1998
Human Osteoclast Formation and Activity In Vitro: Effects of Alendronate
V Breuil, F Cosman, L Stein, W Horbert, J Nieves, V Shen, R Lindsay, DW Dempster
Journal of Bone and Mineral Research 1998
A Third-Generation Bisphosphonate, YM175, Inhibits Osteoclast Formation in Murine Cocultures by Inhibiting Proliferation of Precursor Cells via Supporting Cell-Dependent Mechanisms
M Nishikawa, M Yamamoto, T Murakami, T Akatsu, N Kugai, N Nagata
Journal of Bone and Mineral Research 1998
Effect of a newly developed bisphosphonate, YH529, on osteolytic bone metastases in nude mice
A Sasaki, K Kitamura, RE Alcalde, T Tanaka, A Suzuki, Y Etoh, T Matsumura
International Journal of Cancer 1998
Effect of alendronate on cultured normal human osteoblasts
C García-Moreno, S Serrano, M Nacher, M Farré, A Díez, ML Mariñoso, J Carbonell, L Mellibovsky, X Nogués, J Ballester, J Aubía
Bone 1998
Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
SP Luckman, DE Hughes, FP Coxon, RG Russell, MJ Rogers
Journal of Bone and Mineral Research 1998
Preadministration of incadronate disodium can prevent bone loss in rat proximal tibial metaphysis when induced by hindlimb immobilization by bandage
J Li, S Mori, T Mashiba, Y Kaji, M Taki, S Komatsubara, J Kawanishi, H Norimatsu
Bone 1998
Bisphosphonates Stimulate Formation of Osteoblast Precursors and Mineralized Nodules in Murine and Human Bone Marrow Cultures In Vitro and Promote Early Osteoblastogenesis in Young and Aged Mice In Vivo
N Giuliani, M Pedrazzoni, G Negri, G Passeri, M Impicciatore, G Girasole
Bone 1998
The interpretation of preclinical data in predicting bisphosphonate response in the treatment of osteoporosis
JD Ringe
Clinical Therapeutics 1998
The Morbidity of Bone Disease in Thalassemia
EP Vichinsky
Annals of the New York Academy of Sciences 1998
Alendronate/Interleukin-1β Cotreatment Increases Interleukin-6 in Bone and UMR-106 Cells: Dose Dependence and Relationship to the Antiresorptive Effect of Alendronate
JL Sanders, G Tarjan, SA Foster, PH Stern
Journal of Bone and Mineral Research 1998
Structurally different bisphosphonates exert opposing effects on alkaline phosphatase and mineralization in marrow osteoprogenitors
BY Klein, H Ben-Bassat, E Breuer, V Solomon, G Golomb
Journal of Cellular Biochemistry 1998
Alendronate and osteoporosis
AJ Yates, GA Rodan
Drug Discovery Today 1998
Accumulation of Bisphosphonates in Human Artery and their Effects on Human and Rat Arterial Functionin vitro
R Ylitalo, J Kalliovalkama, X Wu, H Kankaanranta, JP Salenius, T Sisto, T Lähteenmäki, P Ylitalo, I Pörsti
Pharmacology & Toxicology 1998
Acute Lymphoblastic Leukemia Accompanied by Severe Hypercalcemia: Successful Treatment Including Aminohydroxypropylidene Bisphosphonate (Pamidronate Disodium)
M Takagi, K Takahiashi, T Maruyama, K Kaneko, K Obinata, R Tadokoro, K Kastumata, Y Miura, H Fujita, A Tokita, K Ishimoto, K Yabuta
Pediatric Hematology-Oncology 1998
Withdrawal of Parathyroid Hormone Treatment Causes Rapid Resorption of Newly Formed Vertebral Cancellous and Endocortical Bone in Old Rats
C Ejersted, H Oxlund, EF Eriksen, TT Andreassen
Bone 1998
Advances in Organ Biology
AJ Liedtke
Advances in Organ Biology 1998
Metabolic Bone Disease and Clinically Related Disorders
FR Singer, SM Krane
Metabolic Bone Disease and Clinically Related Disorders 1998
TREATMENT OF OSTEOPOROSIS WITH BISPHOSPHONATES
NB Watts
Endocrinology and metabolism clinics of North America 1998
Effects of alendronate sodium on severe osteodystrophy in postmenopausal patients with primary biliary cirrhosis: a pilot study
A Floreani, L Tizian, G Luisetto, A Buda, A Mega, R Naccarato
Current Therapeutic Research 1998
Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro
J Mönkkönen, J Similä, MJ Rogers
Life Sciences 1998
Bisphosphonates: a potential role in the prevention of osteoporosis in laying hens
S Wilson, SE Solomon, BH Thorp
Research in Veterinary Science 1998
Histomorphometric Evidence for Echistatin Inhibition of Bone Resorption in Mice with Secondary Hyperparathyroidism
P Masarachia, M Yamamoto, CT Leu, G Rodan, L Duong
Endocrinology 1998
Non HRT Options for the Treatment of Osteoporosis
M Davies
1998
Macrophage Activation Results in Bone Resorption:
J Lassus, J Salo, WA Jiranek, S Santavirta, J Nevalainen, M Matucci-Cerinic, P Hork, Y Konttinen
Clinical Orthopaedics and Related Research® 1998
Bisphosphonates: Mechanisms of Action
H Fleisch
Endocrine reviews 1998
Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis
PM Chavassieux, ME Arlot, C Reda, L Wei, AJ Yates, PJ Meunier
Journal of Clinical Investigation 1997
Osteoporosis
DL Glaser, FS Kaplan
Spine 1997
Bisphosphonates: Preclinical Aspects and Use in Osteoporosis
HA Fleisch
Annals of Medicine 1997
Clodronate and Liposome-Encapsulated Clodronate Are Metabolized to a Toxic ATP Analog, Adenosine 5′-(β,γ-Dichloromethylene) Triphosphate, by Mammalian Cells In Vitro
JC Frith, J Mönkkönen, GM Blackburn, RG Russell, MJ Rogers
Journal of Bone and Mineral Research 1997
Overview of bisphosphonates
MJ Rogers, DJ Watts, RG Russell
Cancer 1997
Osteoclast activation: Potent inhibition by the bisphosphonate alendronate through a nonresorptive mechanism
JM Owens, K Fuller, TJ Chambers
Journal of Cellular Physiology 1997
Bisphosphonate Therapy
AA Licata
The American Journal of the Medical Sciences 1997
Alendronate prevents cyclosporin A-induced osteopenia in the rat
DA Sass, AR Bowman, Z Yuan, Y Ma, WS Jee, S Epstein
Bone 1997
Pamidronate content and turnover in sternum, vertebral body, and iliac bones of dogs
LE King, MD Grynpas, G Tomlinson, R Vieth
Bone 1997
Cell death in oral tissues and diseases
T Kaku, Y Abiko
Oral Medicine & Pathology 1997
Elimination and Biochemical Responses to Intravenous Alendronate in Postmenopausal Osteoporosis
SA Khan, JA Kanis, S Vasikaran, WF Kline, BK Matuszewski, EV McCloskey, MN Beneton, BJ Gertz, DG Sciberras, SD Holland, J Orgee, GM Coombes, SR Rogers, AG Porras
Journal of Bone and Mineral Research 1997
Short-Term Intravenous Bisphosphonates in Prevention of Postmenopausal Bone Loss
JE Heikkinen, KS Selander, K Laitinen, I Arnala, HK Väänänen
Journal of Bone and Mineral Research 1997
Pamidronate and biochemical markers of bone turnover
ME Martínez, MT Campo, MA Plaza, A Torrijos, J Gijón
Scandinavian Journal of Clinical & Laboratory Investigation 1997
Inhibition of Bone Resorption by Pamidronate Cannot Restore Normal Gain in Cortical Bone Mass and Strength in Tail-Suspended Rapidly Growing Rats
Y Kodama, K Nakayama, H Fuse, S Fukumoto, H Kawahara, H Takahashi, T Kurokawa, C Sekiguchi, T Nakamura, T Matsumoto
Journal of Bone and Mineral Research 1997
Mineralization of cancellous bone after alendronate and sodium fluoride treatment: A quantitative backscattered electron imaging study on minipig ribs
P Roschger, P Fratzl, K Klaushofer, G Rodan
Bone 1997
Decrease in canine proximal femoral ultimate strength and stiffness due to fatigue damage
SJ Hoshaw, DD Cody, AM Saad, DP Fyhrie
Journal of Biomechanics 1997
Effects of bisphosphonates on alkaline phosphatase activity, mineralization, and prostaglandin E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1
K Igarashi, M Hirafuji, H Adachi, H Shinoda, H Mitani
Prostaglandins, Leukotrienes and Essential Fatty Acids 1997
Local Delivery of an Amino Bisphosphonate Prevents the Resorptive Phase of Alveolar Bone Following Mucoperiosteal Flap Surgery in Rats
A Yaffe, M Iztkovich, Y Earon, I Alt, R Lilov, I Binderman
Journal of Periodontology 1997
EFFECTS OF LIPOSOME-ENCAPSULATED BISPHOSPHONATES ON ACETYLATED LDL METABOLISM, LIPID ACCUMULATION AND VIABILITY OF PHAGOCYTING CELLS
R Ylitalo, J Monkkonen, S Ylä-Herttuala
Life Sciences 1997
Alendronate inhibition of protein-tyrosine-phosphatase-meg1
EE Opas, SJ Rutledge, E Golub, A Stern, Z Zimoio, GA Rodan, A Schmidt
Biochemical Pharmacology 1997
Increments in bone mineral density of the lumbar spine and hip and suppression of bone turnover are maintained after discontinuation of alendronate in postmenopausal women
J L Stock, N H Bell, C H Chesnut 3rd, K E Ensrud, H K Genant, S T Harris, M R McClung, F R Singer, R A Yood, S Pryor-Tillotson, L Wei, A C Santora 2nd
The American Journal of Medicine 1997
Drug disposition of incadronate, a new bisphosphonate, in rats with bone metastases
T USUI, S TANAKA, T SONODA, Y OZAWA, K TERAMURA, E NAKAMURA, T WATANABE, S HIGUCHI
Xenobiotica 1997
Human Neutrophil Collagenase MMP-8 in Peri-implant Sulcus Fluid and its Inhibition by Clodronate
O Teronen, YT Konttinen, C Lindqvist, T Salo, T Ingman, A Lauhio, Y Ding, S Santavirta, T Sorsa
Journal of dental research 1997
How Does Alendronate Inhibit Protein-tyrosine Phosphatases?
K Skorey, HD Ly, J Kelly, M Hammond, C Ramachandran, Z Huang, MJ Gresser, Q Wang
The Journal of biological chemistry 1997
Inhibition of Wear Debris Mediated Osteolysis in a Canine Total Hip Arthroplasty Model:
AS Shanbhag, CT Hasselman, HE Rubash
Clinical Orthopaedics and Related Research® 1997
Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake
M J Rogers, X Xiong, X Ji, J Mönkkönen, R G Russell, M P Williamson, F H Ebetino, D J Watts
Pharmaceutical Research 1997
Alendronate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Postmenopausal Osteoporosis
W Jeal, LB Barradell, D McTavish
Drugs 1997
Bisphosphonates: mechanisms of action
GA Rodan, HA Fleisch
Journal of Clinical Investigation 1996
Inhibitory effects of bisphosphonate (YM175) on bone resorption induced by a metastatic bone tumor
T Hiraga, S Tanaka, M Yamamoto, T Nakajima, H Ozawa
Bone 1996
Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
MJ Rogers, KM Chilton, FP Coxon, J Lawry, MO Smith, S Suri, RG Russel
Journal of Bone and Mineral Research 1996
Use of bisphosphonates in cancer patients
JJ Body, RE Coleman, M Piccart
Cancer Treatment Reviews 1996
Comparison of the distribution of 3H-alendronate and 3H-Etidronate in rat and mouse bones
P Masarachia, M Weinreb, R Balena, GA Rodan
Bone 1996
Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures
M Nishikawa, T Akatsu, Y Katayama, Y Yasutomo, S Kado, N Kugai, M Yamamoto, N Nagata
Bone 1996
Theoretical perspective: A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates
AM Parfitt, GR Mundy, GD Roodman, DE Hughes, BF Boyce
Journal of Bone and Mineral Research 1996
The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H+-ATPase
PE David, H Nguyen, A Barbier, R Baron
Journal of Bone and Mineral Research 1996
Effect of alendronate on fracture healing and bone remodeling in dogs
CP Peter, WO Cook, DM Nunamaker, MT Provost, JG Seedor, GA Rodan
Journal of Orthopaedic Research 1996
Treatment of osteoporosis: bisphosphonates as an alternative to hormone replacement therapy
C Parker, D Hosking
Current Obstetrics & Gynaecology 1996
Interaction between effects of parathyroid hormone and bisphosphonate on regulation of osteoclast activity by the osteoblast-like cell line UMR-106
X Yu, J Schøller, NT Foged
Bone 1996
Human protein tyrosine phosphatase-σ: Alternative splicing and inhibition by bisphosphonates
N Endo, SJ Rutledge, EE Opas, R Vogel, GA Rodan, A Schmidt
Journal of Bone and Mineral Research 1996
Effects of sodium fluoride and alendronate on the bone mineral in minipigs: A small-angle X-ray scattering and backscattered electron imaging study
P Fratzl, S Schreiber, P Roschger, MH Lafage, G Rodan, K Klaushofer
Journal of Bone and Mineral Research 1996
Bisphosphonates: A review of their pharmacokinetic properties
JH Lin
Bone 1996
Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate
A Schmidt, SJ Rutledge, N Endo, EE Opas, H Tanaka, G Wesolowski, CT Leu, Z Huang, C Ramachandaran, SB Rodan, GA Rodan
Proceedings of the National Academy of Sciences 1996
Effects of alendronate on bone loss in pre- and postmenopausal hyperthyroid women treated with methimazole
G Lupoli, V Nuzzo, CD Carlo, P Affmito, M Vollery, G Vitale, E Cascone, F Arlotta, C Nappi
Gynecological Endocrinology 1996
Drug Evaluation Oncologic, Endocrine & Metabolic: Alendronate (Fosamax®): clinical utility in metabolic bone disease
J Hayes, P Sambrook
Expert Opinion on Investigational Drugs 1996
Inhibitory Effect of the Topical Administration of a Bisphosphonate (Risedronate) on Root Resorption Incident to Orthodontic Tooth Movement in Rats
K Igar, H Adachi, H Mitani, H Shinoda
Journal of dental research 1996
Development of Alendronate (Preclinical Studies)
GA Rodan
Proceedings (Baylor University. Medical Center) 1996
Oral Alendronate in the Treatment of Postmenopausal Osteoporosis
A Lombardi, D Freedholm, AJ Yates
Proceedings (Baylor University. Medical Center) 1996
Alendronate treatment for osteoporosis: A review of the clinical evidence
P Selby
Osteoporosis International 1996
Prevention of Bone Loss by Bisphosphonate YM175 in Ovariectomized Dogs with Dietary Calcium Restriction
H Motoie, H Kanoh, S Ogata, K Kawamuki, H Shikama, T Fujikura
The Japanese Journal of Pharmacology 1996
The Molecular Biology of Paget’s Disease
PT Sharpe
1996
α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase
DR Magnin, SA Biller, Y Chen, JK Dickson, OM Fryszman, RM Lawrence, JV Logan, ES Sieber-McMaster, RB Sulsky, SC Traeger, DC Hsieh, SJ Lan, JK Rinehart, TW Harrity, KG Jolibois, LK Kunselman, LC Rich, DA Slusarchyk, CP Ciosek
Journal of Medicinal Chemistry 1996
Adverse Effects of Bisphosphonates: A Comparative Review
S Adami, N Zamberlan
Drug Safety 1996
Comparative Clinical Pharmacology and Therapeutic Use of Bisphosphonates in Metabolic Bone Diseases:
CJ Rosen, CR Kessenich
Drugs 1996
Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study
MH Lafage, R Balena, MA Battle, M Shea, JG Seedor, H Klein, WC Hayes, GA Rodan
Journal of Clinical Investigation 1995
Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin
Z Zimolo, G Wesolowski, GA Rodan
Journal of Clinical Investigation 1995
Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate
LA Ruml, SK Dubois, ML Roberts, CY Pak
Journal of Bone and Mineral Research 1995
Rationale for the use of alendronate in osteoporosis
JA Kanis, BJ Gertz, F Singer, S Ortolani
Osteoporosis International 1995
Studies of the oral bioavailability of alendronate*
BJ Gertz, SD Holland, WF Kline, BK Matuszewski, A Freeman, H Quan, KC Lasseter, JC Mucklow, AG Porras
Clinical Pharmacology & Therapeutics 1995
Effects of the bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovariectomized beagles on concomitant dietary calcium restriction
H Motoie, T Nakamura, N O'Uchi, H Nishikawa, H Kanoh, T Abe, H Kawashima
Journal of Bone and Mineral Research 1995
Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models
Y Azuma, H Sato, Y Oue, K Okabe, T Ohta, M Tsuchimoto, M Kiyoki
Bone 1995
A possible mechanism of the specific action of bisphosphonates on osteoclasts: Tiludronate preferentially affects polarized osteoclasts having ruffled borders
H Murakami, N Takahashi, T Sasaki, N Udagawa, S Tanaka, I Nakamura, D Zhang, A Barbier, T Suda
Bone 1995
Inhibition of antigen-presenting cell function by alendronate in vitro
P Sansoni, G Passeri, F Fagnoni, N Mohagheghpour, G Snelli, V Brianti, EG Engleman
Journal of Bone and Mineral Research 1995
17β-hydroxywortmannin: A potent inhibitor of bone resorption and phosphatidylinositol-3-kinase
JA Dodge, HU Bryant, J Kim, WF Matter, BH Norman, U Srinivasan, CJ Vlahos, M Sato
Bioorganic & Medicinal Chemistry Letters 1995
Different effects of bisphosphonate and estrogen therapy on free and peptide-bound bone cross-links excretion
P Garnero, E Gineyts, P Arbault, C Christiansen, PD Delmas
Journal of Bone and Mineral Research 1995
Stimulation of bone formation by dynamic mechanical loading of rat caudal vertebrae is not suppressed by 3-amino-1-hydroxypropylidene-1-bisphosphonate (AHPrBP)
CJ Jagger, TJ Chambers, JW Chow
Bone 1995
Effects of oral alendronate and intranasal salmon calcitonin on bone mass and biochemical markers of bone turnover in postmenopausal women with osteoporosis
S Adami, M Passeri, S Ortolani, M Broggini, L Carratelli, I Caruso, G Gandolini, L Gnessi, M Laurenzi, A Lombardi, G Norbiato, S Pryor-Tillotson, C Reda, L Romanini, D Subrizi, L Wei, AJ Yates
Bone 1995
Influence of disodium (1-hydroxythylidene) diphosphonate on bone ingrowth into porous, titanium fiber-mesh implants
T Kitsugi, T Yamamuro, T Nakamura, M Oka
The Journal of Arthroplasty 1995
Alendronate Treatment of Naturally-Occurring Periodontitis in Beagle Dogs*
MS Reddy, TW Weatherford, CA Smith, BD West, MK Jeffcoat, TM Jacks
Journal of Periodontology 1995
Osteotropic Drug Delivery System (ODDS) Based on Bisphosphonic Prodrug. I: Synthesis and in Vivo Characterization of Osteotropic Carboxyfluorescein
J Fujisaki, Y Tokunaga, T Takahashi, T Hirose, F Shimojo, A Kagayama, T Hata
Journal of Drug Targeting 1995
Section Review: Oncologic, Endocrine & Metabolic: The vacuolar H + -ATPase: A potential target for drug development in bone diseases
PE David, R Baron
Expert Opinion on Investigational Drugs 1995
Inhibitory effect of a bisphosphonate (risedronate) on experimental periodontities in rats
K Shoji, H Horiuchi, H Shinoda
Journal of Periodontal Research 1995
Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones
L Blavier, JM Delaisse
Journal of cell science 1995
Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro
N Pennanen, S Lapinjoki, A Urtti, J Mönkkönen
Pharmaceutical Research 1995
Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold dictyostelium discoideum
MJ Rogers, DJ Watts, RG Russell, X Ji, X Xiong, GM Blackburn, AV Bayless, FH Ebetino
Journal of Bone and Mineral Research 1994
Effects of two different bisphosphonates on Paget's disease of bone: ICTP assessed
P Filipponi, M Pedetti, F Beghe, B Giovagnini, M Miam, S Cristallini
Bone 1994
Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage
DD Bikle, ER Morey-Holton, SB Doty, PA Currier, SJ Tanner, BP Halloran
Journal of Bone and Mineral Research 1994
Structural requirements for bisphosphonate actions in vitro
E Beek, M Hoekstra, MD de Ruit, C Löwik, S Papapoulos
Journal of Bone and Mineral Research 1994
Dual-energy X-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats
M Sato, C McClintock, J Kim, CH Turner, HU Bryant, D Magee, CW Slemenda
Journal of Bone and Mineral Research 1994
Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis
M Rossini, D Gatti, N Zamberlan, V Braga, R Dorizzi, S Adami
Journal of Bone and Mineral Research 1994
Use of a rat model for the simultaneous assessment of pharmacokinetic and pharmacodynamic aspects of bisphosphonate treatment: Application to the study of intravenous 14C-labeled 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate
SJ Koopmans, LV der Wee-Pals, CW Löwik, SE Papapoulos
Journal of Bone and Mineral Research 1994
Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum
MJ Rogers, X Ji, RG Russell, GM Blackburn, MP Williamson, AV Bayless, FH Ebetino, DJ Watts
Biochemical Journal 1994
The effect of alendronate on renal tubular reabsorption of phosphate
SD Vasikaran, DP O’Doherty, EV McCloskey, B Gertz, S Kahn, JA Kanis
Bone and Mineral 1994
Renal and Nonrenal Clearance of Clodronate in Patients with Malignancy and Renal Impairment
NP O’Rourke, EV McCloskey, G Neugebauer, JA Kanis
Drug Investigation 1994
Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movements in rats
K Igarashi, H Mitani, H Adachi, H Shinoda
American Journal of Orthodontics and Dentofacial Orthopedics 1994
Duration of the effects of intravenous alendronate in postmenopausal women and in patients with primary hyperparathyroidism and Paget's disease of bone
S Adami, N Zamberlan, M Mian, R Dorizzi, M Rossini, B Braga, D Gatti, F Bertoldo, V Locascio
Bone and Mineral 1994
Effects of Topical Administration of a Bisphosphonate (Risedronate) on Orthodontic Tooth Movements in Rats
H Adachi, K Igarashi, H Mitani, H Shinoda
Journal of dental research 1994
The effects of bisphosphonates on the resorption cycle of isolated osteoclasts
K Selander, P Lehenkari, HK Vnnen
Calcified Tissue International 1994
Osteolytic bone metastasis in breast cancer
T Yoneda, A Sasaki, GR Mundy
Breast Cancer Research and Treatment 1994
Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys
M Weinreb, H Quartuccio, JG Seedor, TB Aufdemorte, M Brunsvold, E Chaves, KS Kornman, GA Rodan
Journal of Periodontal Research 1994
Alendronate Modulates Osteogenesis of Human Osteoblastic Cells In Vitro
M Tsuchimoto, Y Azuma, O Higuchi, I Sugimoto, N Hiraia, M Kiyoki, I Yamamoto
The Japanese Journal of Pharmacology 1994
Bisphosphonates act on rat bone resorption through the mediation of osteoblasts
M Sahni, HL Guenther, H Fleisch, P Collin, TJ Martin
Journal of Clinical Investigation 1993
New bisphosphonates in osteoporosis
H Fleisch
Osteoporosis International 1993
A new bisphosphonate, BM 21.0955, prevents bone loss associated with cessation of ovarian function in experimental dogs
MC Monier-Faugere, RM Friedler, F Bauss, HH Malluche
Journal of Bone and Mineral Research 1993
Clinical effects of bisphosphonates in involutional osteoporosis
SM Ott
Journal of Bone and Mineral Research 1993
Skeletal effects of withdrawal of estrogen and diphosphonate treatment in ovariectomized rats
TJ Wronski, LM Dann, H Qi, CF Yen
Calcified Tissue International 1993
Prevention and treatment of osteoporosis
R Lindsay
The Lancet 1993
Bisphosphonates in osteoporosis: An introduction
H Fleisch
Osteoporosis International 1993
Bisphosphonates in the Treatment of Metabolic Bone Diseases
GA Rodan, R Balena
Annals of Medicine 1993
A New Schedule for Clodronate Treatment in Patients with Breast Cancer and Bone Metastases
F Beghé, M Luzzani
Annals of the New York Academy of Sciences 1993
New bisphosphonates in the treatment of bone metastases
SD Averbuch
Cancer 1993
Alternatives to HRT in prevention and treatment
MS Marsh, JC Stevenson
Baillière's Clinical Rheumatology 1993
The role of bisphosphonates in the prevention and treatment of osteoporosis
SE Papapoulos
The American Journal of Medicine 1993
Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increase macrophages, granulocytes, and osteoclasts in vivo
Y Endo, M Nakamura, T Kikuchi, H Shinoda, Y Takeda, Y Nitta, K Kumagai
Calcified Tissue International 1993
Characterization of the bisphosphonate recognition site on hydroxyapatite using radioligand binding techniques with [14C]citric acid
MF Jarvis, CJ Burns, HW Pauls, A Assal, JS Kim, DL Cheney, RD Youssefyeh
Calcified Tissue International 1993
Physiology and Pharmacology of Bone
GR Mundy, TJ Martin
1993
Treatment of postmenopausal osteoporosis with continuous daily oral alendronate in comparison with either placebo or intranasal salmon calcitonin
S Adami, MC Baroni, M Broggini, L Carratelli, I Caruso, L Gnessi, M Laurenzi, A Lombardi, G Norbiato, S Ortolani, E Ricerca, L Romanini, S Subrizi, J Weinberg, AJ Yates
Osteoporosis International 1993
Clinical pharmacology of alendronate sodium
BJ Gertz, SD Holland, WF Kline, BK Matuszewski, AG Porras
Osteoporosis International 1993
Preclinical pharmacology of alendronate
GA Rodan, JG Seedor, R Balena
Osteoporosis International 1993
Drugs Used in the Treatment of Metabolic Bone Disease: Clinical Pharmacology and Therapeutic Use
S Patel, AR Lyons, DJ Hosking
Drugs 1993
Skeletal effects of withdrawal of estrogen and diphosphonate treatment in ovariectomized rats
TJ Wronski, LM Dann, H Qi,
Calcified Tissue International 1993
The Prevention and Treatment of Osteoporosis
AJ Wood, BL Riggs, LJ Melton
New England Journal of Medicine 1992

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