Studies of the mode of action of the bisphosphonate alendronate showed that 1 d after the injection of 0.4 mg/kg [3H]alendronate to newborn rats, 72% of the osteoclastic surface, 2% of the bone forming, and 13% of all other surfaces were densely labeled. Silver grains were seen above the osteoclasts and no other cells. 6 d later the label was 600-1,000 microns away from the epiphyseal plate and buried inside the bone, indicating normal growth and matrix deposition on top of alendronate-containing bone. Osteoclasts from adult animals, infused with parathyroid hormone-related peptide (1-34) and treated with 0.4 mg/kg alendronate subcutaneously for 2 d, all lacked ruffled border but not clear zone. In vitro alendronate bound to bone particles with a Kd of approximately 1 mM and a capacity of 100 nmol/mg at pH 7. At pH 3.5 binding was reduced by 50%. Alendronate inhibited bone resorption by isolated chicken or rat osteoclasts when the amount on the bone surface was around 1.3 x 10(-3) fmol/microns 2, which would produce a concentration of 0.1-1 mM in the resorption space if 50% were released. At these concentrations membrane leakiness to calcium was observed. These findings suggest that alendronate binds to resorption surfaces, is locally released during acidification, the rise in concentration stops resorption and membrane ruffling, without destroying the osteoclasts.
M Sato, W Grasser, N Endo, R Akins, H Simmons, D D Thompson, E Golub, G A Rodan
Title and authors | Publication | Year |
---|---|---|
Alendronate for Effective Treatment of Male Osteoporosis: An Insight.
Al Lawati H, Al Busaidi S, Al Rawahi T, Al Lawati A, Kifah A, Das S |
Current pharmaceutical design | 2025 |
Unexpected chronic lymphocytic leukemia B cell activation by bisphosphonates.
Mazzarello AN, Gugiatti E, Cossu V, Bertola N, Bagnara D, Carta S, Ravera S, Salvetti C, Ibatici A, Ghiotto F, Colombo M, Cutrona G, Marini C, Sambuceti G, Fais F, Bruno S |
Cancer Immunology, Immunotherapy | 2024 |
Bisphosphonates do not affect healing of a critical-size defect in estrogen-deficient mice.
Strunz F, Gentil-Perret S, Siegrist M, Bohner M, Saulacic N, Hofstetter W |
Bone Reports | 2024 |
Development of a 99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model
Bohrmann L, Poulie CB, Rodríguez-Rodríguez C, Karagiozov S, Saatchi K, Herth MM, Häfeli UO |
PloS one | 2024 |
Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent
Jerez HE, Simioni YR, Ghosal K, Morilla MJ, Romero EL |
Beilstein Journal of Nanotechnology | 2024 |
A study of peri-implant tissue clinical parameters in patients starting anti-osteoporosis medication after existing implant function: a prospective cohort study.
Seki K, Tamagawa T, Yasuda H, Manaka S, Akita D, Kamimoto A, Hagiwara Y |
International journal of implant dentistry | 2024 |
Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration
Shariati K, Bedar M, Huang KX, Moghadam S, Mirzaie S, LaGuardia JS, Chen W, Kang Y, Ren X, Lee JC |
Advanced therapeutics | 2024 |
Pharmacological Interventions Targeting Pain in Fibrous Dysplasia/McCune–Albright Syndrome
Tucker-Bartley A, Selen DJ, Golden E, van Gool R, Ebb D, Mannstadt M, Upadhyay J |
International journal of molecular sciences | 2023 |
A variability in response of osteoclasts to zoledronic acid is mediated by smoking-associated modification in the DNA methylome.
Tan Q, Møller AMJ, Qiu C, Madsen JS, Shen H, Bechmann T, Delaisse JM, Kristensen BW, Deng HW, Karasik D, Søe K |
Clinical Epigenetics | 2023 |
Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability.
Calvo-Gallego JL, Manchado-Morales P, Pivonka P, Martínez-Reina J |
Frontiers in Bioengineering and Biotechnology | 2023 |
Pegylated Liposomal Alendronate Biodistribution, Immune Modulation, and Tumor Growth Inhibition in a Murine Melanoma Model.
Islam MR, Patel J, Back PI, Shmeeda H, Kallem RR, Shudde C, Markiewski M, Putnam WC, Gabizon AA, La-Beck NM |
Biomolecules | 2023 |
Bone Health Management in the Continuum of Prostate Cancer Disease.
Boopathi E, Birbe R, Shoyele SA, Den RB, Thangavel C |
Cancers | 2022 |
Advances in Our Understanding of the Mechanism of Action of Drugs (including Traditional Chinese Medicines) for the Intervention and Treatment of Osteoporosis
Lu J, Hu D, Ma C, Shuai B |
Frontiers in pharmacology | 2022 |
Inhibition of osteoclastogenesis after bisphosphonate therapy discontinuation: an in vitro approach.
Bradaschia-Correa V, Ribeiro-Santos GC, de Faria LP, Rezende-Teixeira P, Arana-Chavez VE |
Journal Of Molecular Histology | 2022 |
Is the Use of Bisphosphonates Putting Horses at Risk? An Osteoclast Perspective.
Vergara-Hernandez FB, Nielsen BD, Colbath AC |
2022 | |
Modeling osteoporosis to design and optimize pharmacological therapies comprising multiple drug types.
Jörg DJ, Fuertinger DH, Cherif A, Bushinsky DA, Mermelstein A, Raimann JG, Kotanko P |
eLife | 2022 |
Mechanistic PK-PD model of alendronate treatment of postmenopausal osteoporosis predicts bone site-specific response.
Calvo-Gallego JL, Pivonka P, Ruiz-Lozano R, Martínez-Reina J |
Frontiers in Bioengineering and Biotechnology | 2022 |
Reducing farnesyl diphosphate synthase levels activates Vγ9Vδ2 T cells and improves tumor suppression in murine xenograft cancer models.
Liou ML, Lahusen T, Li H, Xiao L, Pauza CD |
Frontiers in immunology | 2022 |
Duration and timing of bisphosphonate treatment as factors determining osteoblast mineralization.
Patntirapong S |
Journal of Oral Biology and Craniofacial Research | 2022 |
Practical guidance for new multiple myeloma treatment regimens: A nursing perspective.
Epstein M, Morrison C |
Seminars in Oncology | 2022 |
Bisphosphonate use is associated with a decreased joint narrowing rate in the non-arthritic hip.
Kawai T, Nishitani K, Okuzu Y, Goto K, Kuroda Y, Kuriyama S, Nakamura S, Matsuda S |
Bone & joint research | 2022 |
Bone Health and Denosumab Discontinuation in Oncology Populations.
Cheung YM, Morgans A, Hamnvik OR |
The oncologist | 2022 |
Squaric Acid Bisphposphonates for Theranostics of Bone Metastasis – the Easy DOTA-Zoledronate
Greifenstein L, Engelbogen N, Máthé D, Grus T, Rösch F, Bergmann R |
Frontiers in Nuclear Medicine | 2022 |
Exploiting bone niches: Progression of disseminated tumor cells to metastasis
Aaron M Muscarella, Sergio Aguirre, Xiaoxin Hao, Sarah M. Waldvogel, Xiang H.-F. Zhang |
Journal of Clinical Investigation | 2021 |
Osteoporosis therapies and their mechanisms of action (Review)
B Kim, Y Cho, W Lim |
Experimental and therapeutic medicine | 2021 |
Evolving cancer–niche interactions and therapeutic targets during bone metastasis
RL Satcher, XH Zhang |
Nature Reviews Cancer | 2021 |
Sequential dual-drug delivery of BMP-2 and alendronate from hydroxyapatite-collagen scaffolds for enhanced bone regeneration
D Lee, M Wufuer, I Kim, TH Choi, BJ Kim, HG Jung, B Jeon, G Lee, OH Jeon, H Chang, DS Yoon |
Scientific Reports | 2021 |
Zoledronic Acid-Loaded β-TCP Inhibits Tumor Proliferation and Osteoclast Activation: Development of a Functional Bone Substitute for an Efficient Osteosarcoma Treatment
Y Kameda, M Aizawa, T Sato, M Honda |
International journal of molecular sciences | 2021 |
Sustained release of ancillary amounts of testosterone and alendronate from PLGA coated pericard membranes and implants to improve bone healing
CJ van de Ven, NE Bakker, DP Link, EJ Geven, JA Gossen, S Mohan |
PloS one | 2021 |
Repurposing amino-bisphosphonates by liposome formulation for a new role in cancer treatment
NM La-Beck, X Liu, H Shmeeda, C Shudde, AA Gabizon |
Seminars in Cancer Biology | 2021 |
Macrophage apoptosis using alendronate in targeted nanoarchaeosomes
HE Jerez, MJ Altube, YB Gándola, L González, MC González, MJ Morilla, EL Romero |
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V | 2021 |
Geranylgeraniol prevents zoledronic acid-mediated reduction of viable mesenchymal stem cells via induction of Rho-dependent YAP activation
W Singhatanadgit, W Hankamolsiri, W Janvikul |
Royal Society Open Science | 2021 |
The Role of Bisphosphonates in Childhood Diseases
G Attina, S Mastrangelo, A Ruggiero |
2021 | |
Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative
M Li, Y Nie, Y Zeng, Y Wu, Y Liu, L Wu, J Xu, B Shen |
Frontiers in Medicine | 2021 |
New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma
KH Lu, EW Lu, CW Lin, JS Yang, SF Yang |
Pharmacology & Therapeutics | 2020 |
Molecular mechanisms of action of bisphosphonates and new insights into their effects outside the skeleton
MJ Rogers, J Mönkkönen, MA Munoz |
Bone | 2020 |
Bisphosphonates inhibit surface‐mediated osteogenesis
EM Lotz, CH Lohmann, BD Boyan, Z Schwartz |
Journal of biomedical materials research. Part A | 2020 |
Bisphosphonate-based nanocomposite hydrogels for biomedical applications
W Yuan, Z Li, X Xie, ZY Zhang, L Bian |
Bioactive Materials | 2020 |
Two new, near-infrared, fluorescent probes as potential tools for imaging bone repair
CC Lin, WH Chang, TM Cheng, LH Chiu, YH Wang, CA Lin, YS Ho, CS Zuo, YM Wang, WF Lai |
Scientific Reports | 2020 |
Evaluation of a 68Ga-Labeled DOTA-Tetrazine as a PET Alternative to 111In-SPECT Pretargeted Imaging
PE Edem, JT Jørgensen, K Nørregaard, R Rossin, A Yazdani, JF Valliant, M Robillard, MM Herth, A Kjaer |
Molecules (Basel, Switzerland) | 2020 |
Feedback-Controlled Release of Alendronate from Composite Microparticles
SS Matrali, AK Ghag |
Journal of Functional Biomaterials | 2020 |
Extensive protein expression changes induced by pamidronate in RAW 264.7 cells as determined by IP-HPLC
SS Lee, SM Kim, YS Kim, SK Lee |
PeerJ | 2020 |
Imaging with radiolabelled bisphosphonates
GJ Cook |
Bone | 2020 |
Actualización de medicamentos asociados a necrosis avascular de los maxilares. Perspectiva y revisión de literatura
DA González, JE Villasana, YJ Cruz, AU Campos |
2020 | |
Comparative Evaluation of Peri-implant Soft and Hard Tissue with and without Application of Bisphosphonate on Implant Surface and Osteotomy Site - A Clinico-radiographic, Cone-beam Computed Tomographic Study
Shabnam Jahan, Mayur Kaushik, Amit Wadhawan |
Contemporary Clinical Dentistry | 2020 |
Targeting Bortezomib to Bone Increases its Bone Anabolic Activity and Reduces Systemic Adverse Effects in Mice
H Wang, H Zhang, V Srinivasan, J Tao, W Sun, , T Wu, BF Boyce, FH Ebetino, RK Boeckman, L Xing |
Journal of Bone and Mineral Research | 2019 |
Medial Branch Block Versus Vertebroplasty for 1-Level Osteoporotic Vertebral Compression Fracture: 2-Year Retrospective Study
IS Bae, HJ Chun, KH Bak, HJ Yi, KS Choi, KD Kim |
World Neurosurgery | 2019 |
Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication)
Y Ohbayashi, F Nakai, A Iwasaki, T Ogawa, Y Yamamoto, Y Nishiyama, M Miyake |
The Japanese dental science review | 2019 |
mTOR inhibitor and bone-targeted drugs break the vicious cycle between clear-cell renal carcinoma and osteoclasts in an in vitro co-culture model
C Spadazzi, F Recine, L Mercatali, G Miserocchi, C Liverani, AD Vita, A Bongiovanni, V Fausti, T Ibrahim |
Journal of Bone Oncology | 2019 |
Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging
PE Edem, JP Sinnes, S Pektor, N Bausbacher, R Rossin, A Yazdani, M Miederer, A Kjær, JF Valliant, MS Robillard, F Rösch, MM Herth |
EJNMMI Research | 2019 |
Engineering of Bone- and CD44-Dual-Targeting Redox-Sensitive Liposomes for the Treatment of Orthotopic Osteosarcoma
S Feng, ZX Wu, Z Zhao, J Liu, K Sun, C Guo, H Wang, Z Wu |
ACS Applied Materials & Interfaces | 2019 |
Organophosphorus Chemistry: From Molecules to Applications
V Iaroshenko |
2019 | |
Effects of pH alteration on the pathogenesis of medication-related osteonecrosis of the jaw
JW Kim, AM Alfafara, HY Kim, SY Kim, SJ Kim |
Bone | 2019 |
Inhibition of macrophage viability by bound and free bisphosphonates
S Patntirapong, P Phupunporn, D Vanichtantiphong, W Thanetchaloempong |
Acta Histochemica | 2019 |
Targeted delivery of doxorubicin for the treatment of bone metastasis from breast cancer using alendronate-functionalized graphene oxide nanosheets
TT Pham, HT Nguyen, CD Phung, S Pathak, S Regmi, DH Ha, JO Kim, CS Yong, SK Kim, JE Choi, S Yook, JB Park, JH Jeong |
Journal of Industrial and Engineering Chemistry | 2019 |
Management of Large Oroantral Fistulas Caused by Medication-Related Osteonecrosis with the Combined Sequestrectomy, Buccal Fat Pad Flap and Platelet-Rich Fibrin
A Esen, S Akkulah |
Journal of Maxillofacial and Oral Surgery | 2019 |
Humic Acid, a Polyphenolic Substance, Decreases Alveolar Bone Loss in Experimental Periodontitis in Rats
M Çalışır, A Akpınar, Ö Poyraz, F Göze, Z Çınar |
J VET DENT | 2019 |
Development of a Phosphoric Acid-Mediated Hyaluronic Acid Gel Sheet for Efficient Transdermal Delivery of Alendronate for Anti-Osteoporotic Therapy
C Naito, H Katsumi, K Yoneto, M Omura, M Nishidono, S Kamei, A Mizoguchi, A Tamba, A Tanaka, M Morishita, A Yamamoto |
Pharmaceutics | 2019 |
Improved treatment efficacy of risedronate functionalized chitosan nanoparticles in osteoporosis: formulation development, in vivo, and molecular modelling studies
S Santhosh, D Mukherjee, J Anbu, M Murahari, BV Teja |
Journal of Microencapsulation | 2019 |
Bisphosphonates and Cancer: A Relationship Beyond the Antiresorptive Effects
S Teixeira, L Branco, MH Fernandes, J Costa-Rodrigues |
Mini reviews in medicinal chemistry | 2019 |
Bisphosphonate treatment changes regional distribution of trabecular microstructure in human lumbar vertebrae
A vom Scheidt, H Hemmatian, K Püschel, M Krause, M Amling, B Busse |
Bone | 2019 |
Pharmacology of bisphosphonates in pain
TM Tzschentke |
British Journal of Pharmacology | 2019 |
Reduced Activity of GGPPS Mutant is Involved in Bisphosphonates-Induced Atypical Fractures
M Lisnyansky, N Kapelushnik, A Ben-Bassat, M Marom, A Loewenstein, D Khananshvili, M Giladi, Y Haitin |
Molecular pharmacology | 2018 |
Skeletal accumulation of fluorescently tagged zoledronate is higher in animals with early stage chronic kidney disease
EA Swallow, MW Aref, N Chen, I Byiringiro, MA Hammond, BP McCarthy, PR Territo, MM Kamocka, S Winfree, KW Dunn, SM Moe, MR Allen |
Osteoporosis International | 2018 |
Prior administration of vitamin K2 improves the therapeutic effects of zoledronic acid in ovariectomized rats by antagonizing zoledronic acid-induced inhibition of osteoblasts proliferation and mineralization
B Zhao, W Zhao, Y Wang, Z Zhao, C Zhao, S Wang, C Gao, JE Kim |
PloS one | 2018 |
Interactions between Clinically Used Bisphosphonates and Bone Mineral: from Coordination Chemistry to Biomedical Applications and Beyond
J Gałęzowska |
ChemMedChem | 2018 |
The MEK5/ERK5 mitogen-activated protein kinase cascade is an effector pathway of bone-sustaining bisphosphonates that regulates osteogenic differentiation and mineralization
C Adam, L Glück, R Ebert, M Goebeler, F Jakob, M Schmidt |
Bone | 2018 |
Influence of pH on osteoclasts treated with zoledronate and alendronate
FJ Manzano-Moreno, J Ramos-Torrecillas, E de Luna-Bertos, R Illescas-Montes, TR Arnett, C Ruiz, O García-Martínez |
Clinical Oral Investigations | 2018 |
Healing of fractures in osteoporotic bones in mice treated with bisphosphonates – A transcriptome analysis
M Hauser, M Siegrist, I Keller, W Hofstetter |
Bone | 2018 |
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis
S Savino, A Toscano, R Purgatorio, E Profilo, A Laghezza, P Tortorella, M Angelelli, S Cellamarea, R Scala, D Tricarico, CM Marobbio, F Perna, P Vitale, M Agamennone, V Dimiccoli, A Tolomeo, A Scilimati |
European Journal of Medicinal Chemistry | 2018 |
The effect of two locally administered anti-resorptive agents on bone regeneration in a rat fibula model: Alendronate and 15-deoxy-Δ 12,14 -prostaglandin J₂
JW Nam, JI Kwon, JY Hong, HJ Kim |
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery | 2018 |
Radiolabeling of zoledronic acid with 188Re as a new palliative agent radiotracer in treatment of bone tumors
M Erfani, M Tabatabaei, A Doroudi, M Shafiei |
Journal of Radioanalytical and Nuclear Chemistry | 2018 |
Importance of target-mediated drug disposition for small molecules
DA Smith, RA van Waterschoot, NJ Parrott, A Olivares-Morales, T Lavé, M Rowland |
Drug Discovery Today | 2018 |
Alteration of macrophage viability, differentiation, and function by bisphosphonates
S Patntirapong, M Poolgesorn |
Oral Diseases | 2018 |
In vitro assessment of alendronate toxic and apoptotic effects on human dental pulp stem cells
Solmaz Pourgonabadi, Ahmad Ghorbani, Zahra Tayarani Najarn, Seyed Hadi Mousavi |
Iranian Journal of Basic Medical Sciences | 2018 |
Bisphosphonates reduce biomaterial turnover in healing of critical-size rat femoral defects
M Hauser, M Siegrist, A Denzer, N Saulacic, J Grosjean, M Bohner, W Hofstetter |
Journal of Orthopaedic Surgery | 2018 |
Diosmetin inhibits osteoclast formation and differentiation and prevents LPS-induced osteolysis in mice: SHAO et al
S Shao, F Fu, Z Wang, F Song, C Li, Z Wu, J Ding, K Li, Y Xiao, Y Su, , G Yuan, J Zhao, Q Liu, J Xu |
Journal of Cellular Physiology | 2018 |
Exposure to antiresorptive therapy with bisphosphonates does not induce histological changes in human alveolar jawbone
A Bedogni, G Bettini, G Bedogni, N Abbasi, G Saia, S Blandamura |
2018 | |
BISPHOSPHONATE THERAPY AND JAW OSTEONECROSIS: AN OVERVIEW
S Krishnan, GS Babu, R T.P |
2018 | |
Macrophages and skeletal health
MN Michalski, LK McCauley |
Pharmacology & Therapeutics | 2017 |
Cochrane Database of Systematic Reviews: Reviews
JM Bell, MD Shields, J Watters, A Hamilton, T Beringer, M Elliott, R Quinlivan, S Tirupathi, B Blackwood, MD Shields |
Cochrane Database of Systematic Reviews: Reviews | 2017 |
Bisphosphonates hinder osteoblastic/osteoclastic differentiation in the maxillary sinus mucosa-derived stem cells
J Zhang, J Park, JW Lee, YD Kwon, EC Kim |
Clinical Oral Investigations | 2017 |
Effect of teriparatide (rh-PTH 1–34) versus bisphosphonate on the healing of osteoporotic vertebral compression fracture: A retrospective comparative study
A Iwata, M Kanayama, F Oha, T Hashimoto, N Iwasaki |
BMC musculoskeletal disorders | 2017 |
Osteonecrosis
AR Zorzi, JB de Miranda |
Osteonecrosis | 2017 |
Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors
M Tanaka, A Hosoya, H Mori, R Kayasuga, H Nakamura, H Ozawa |
Journal of Bone and Mineral Metabolism | 2017 |
Bone-seeking agents for the treatment of bone disorders
J Cawthray, E Wasan, K Wasan |
Drug Delivery and Translational Research | 2017 |
The influence of zoledronate and teriparatide on gamma delta T cells in mice
E Yamachika, Y Matsui, M Matsubara, T Matsumura, N Nakata, N Moritani, A Ikeda, H Tsujigiwa, N Ohara, S Iida |
Journal of Dental Sciences | 2017 |
Cytokine Mixtures Mimicking Secretomes From Mesenchymal Stem Cells Improve Medication-Related Osteonecrosis of the Jaw in a Rat Model: CYTOKINE MIXTURES IMPROVE MRONJ
K Ogata, M Matsumura, M Moriyama, W Katagiri, H Hibi, S Nakamura |
JBMR Plus | 2017 |
Efficacy of teriparatide and denosumab combination treatment in a patient with atypical femoral fracture and Behçet’s disease: a case report and review of the literature
M Uehara, Y Nakamura, J Takahashi, F Isobe, S Ikegami, T Suzuki, S Uchiyama, M Kamimura, H Kato |
Modern Rheumatology Case Reports | 2017 |
Technetium(I) Complexes of Bathophenanthrolinedisulfonic Acid
A Yazdani, N Janzen, S Czorny, JF Valliant |
Inorganic Chemistry | 2017 |
Preparation and evaluation of rhenium-188-pamidronate as a palliative treatment in bone metastasis
M Erfani, N Rahmani, A Doroudi, M Shafiei |
Nuclear Medicine and Biology | 2017 |
Preventive Effect of Phosphodiesterase Inhibitor Pentoxifylline Against Medication-Related Osteonecrosis of the Jaw: An Animal Study
GM Yalcin-Ulker, A Cumbul, G Duygu-Capar, Ü Uslu, K Sencift |
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | 2017 |
Antiresorptives: Safety Concerns—Clinical Perspective
JP Brown |
Toxicologic pathology | 2017 |
Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis
FO Özden, EE Sakallioğlu, E Demir, B Bilgici, ÖK Tunçel, F Gökosmanoğlu, A Atmaca |
Journal of Oral Science | 2017 |
Osteonecrosis of the Jaw—a Bone Site-Specific Effect of Bisphosphonates
JA Vermeer, GA Renders, V Everts |
Current Osteoporosis Reports | 2016 |
Composite Hydrogels for Bone Regeneration
G Tozzi, AD Mori, A Oliveira, M Roldo |
Materials | 2016 |
Effects of drug discontinuation after short-term daily alendronate administration on osteoblasts and osteocytes in mice
K Tsuboi, T Hasegawa, T Yamamoto, M Sasaki, H Hongo, PH de Freitas, T Shimizu, M Takahata, K Oda, T Michigami, M Li, Y Kitagawa, N Amizuka |
Histochemistry and Cell Biology | 2016 |
PLGA-linked alendronate enhances bone repair in diaphysis defect model: PLGA-linked alendronate enhances bone repair
YH Wang, E Rajalakshmanan, CK Wang, CH Chen, YC Fu, TL Tsai, JK Chang, ML Ho |
Journal of Tissue Engineering and Regenerative Medicine | 2016 |
Effect of Alendronate with β – TCP Bone Substitute in Surgical Therapy of Periodontal Intra-Osseous Defects: A Randomized Controlled Clinical Trial
R Naineni |
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH | 2016 |
Thermodynamic study of the interaction between calcium and zoledronic acid by calorimetry
MA Larbi, C Sauzet, P Piccerelle, P Cau, N Levy, P Gallice, D Berge-Lefranc |
The Journal of Chemical Thermodynamics | 2016 |
Osteoblast-like cells with different embryological origins behave differently to increasing zoledronic acid concentrations - A pilot study in pigs
P Kauffmann, W Hahn, N Sievers, M Troeltzsch, K Hohloch, P Brockmeyer, R Cordesmeyer, H Schliephake, RM Gruber |
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology | 2016 |
A Bone-Seeking trans -Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99m Tc- and 177 Lu-Labeled Tetrazines
A Yazdani, H Bilton, A Vito, AR Genady, SM Rathmann, Z Ahmad, N Janzen, S Czorny, BM Zeglis, LC Francesconi, JF Valliant |
Journal of Medicinal Chemistry | 2016 |
Low-Level Laser Action on Orthodontically Induced Root Resorption: Histological and Histomorphometric Evaluation
EC Vasconcelos, JF Henriques, MV Sousa, C Oliveira, A Consolaro, A Pinzan, FP Henriques, N Bronfman |
Journal of Lasers in Medical Sciences | 2016 |
Localization of Minodronate in Mouse Femora Through Isotope Microscopy
H Hongo, M Sasaki, S Kobayashi, T Hasegawa, T Yamamoto, K Tsuboi, E Tsuchiya, T Nagai, N Khadiza, M Abe, A Kudo, K Oda, PH de Freitas, M Li, H Yurimoto, N Amizuka |
Journal of Histochemistry & Cytochemistry | 2016 |
Solid-State Phase Transition Mechanism and Physical–Chemical Study of the Crystal Forms of Monosodium Alendronate: Trihydrate versus Anhydrate
EV Gonzaga, AL Viana, OM Viana, AC Doriguetto |
Crystal Growth & Design | 2016 |
Histochemical observation of bony reversal lines in bisphosphonate-related osteonecrosis of the jaw
SM Kim, MY Eo, YS Kim, SK Lee |
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology | 2016 |
The Effects of Low-Dose Bisphosphonate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Patients With Osteoporosis
SY Lee, KM Kim, SH Kong, TJ Oh, JH Moon, SH Choi, S Lim, HC Jang |
Annals of Geriatric Medicine and Research | 2016 |
Zoledronic acid is an effective radiosensitizer in the treatment of osteosarcoma
EH Kim, MS Kim, KH Lee, JS Koh, WG Jung, CB Kong |
Oncotarget | 2016 |
Pathophysiology of Osteonecrosis of the Jaws
T Aghaloo, R Hazboun, S Tetradis |
Oral and Maxillofacial Surgery Clinics of North America | 2015 |
Dual-therapy with αvβ3-targeted Sn2 lipase-labile fumagillin-prodrug nanoparticles and zoledronic acid in the Vx2 rabbit tumor model
AK Esser, AH Schmieder, MH Ross, J Xiang, X Su, G Cui, H Zhang, X Yang, JS Allen, T Williams, SA Wickline, D Pan, GM Lanza, KN Weilbaecher |
Nanomedicine: Nanotechnology, Biology and Medicine | 2015 |
Bone Sarcomas in Pediatrics: Progress in Our Understanding of Tumor Biology and Implications for Therapy
RK Rivera-Valentin, L Zhu, DP Hughes |
Pediatric Drugs | 2015 |
The effect of nitrogen containing bisphosphonates, zoledronate and alendronate, on the production of pro-angiogenic factors by osteoblastic cells
S Ishtiaq, S Edwards, A Sankaralingam, BA Evans, C Elford, ML Frost, I Fogelman, G Hampson |
Cytokine | 2015 |
Effects of Alendronate on Osteoclast Formation and Activity In Vitro
CA Martins, G Leyhausen, J Volk, W Geurtsen |
Journal of Endodontics | 2015 |
Effects of zoledronic acid and docetaxel on small GTP-binding proteins in prostate cancer
RM Jones, C Morgan, G Bertelli |
Tumor Biology | 2015 |
Quantitative computed tomographic assessment of bone mineral density changes associated with administration of prednisolone or prednisolone and alendronate sodium in dogs
S Park, J Oh, KY Son, KO Cho, J Choi |
American Journal of Veterinary Research | 2015 |
Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model
K Ogata, W Katagiri, M Osugi, T Kawai, Y Sugimura, H Hibi, S Nakamura, M Ueda |
Bone | 2015 |
pH-Activated Nanoparticles for Controlled Topical Delivery of Farnesol To Disrupt Oral Biofilm Virulence
B Horev, MI Klein, G Hwang, Y Li, D Kim, H Koo, DS Benoit |
ACS Nano | 2015 |
Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages
M Ueno, T Maeno, S Nishimura, F Ogata, H Masubuchi, K Hara, K Yamaguchi, F Aoki, T Suga, R Nagai, M Kurabayashi |
Nature Communications | 2015 |
Bisphosphonate-modified biomaterials for drug delivery and bone tissue engineering
DA Ossipov |
Expert Opinion on Drug Delivery | 2015 |
Histochemical evidence of zoledronate inhibiting c-src expression and interfering with CD44/OPN-mediated osteoclast adhesion in the tibiae of mice
H Liu, J Cui, J Sun, J Du, W Feng, B Sun, J Li, X Han, B Liu, Yimin, K Oda, N Amizuka, M Li |
Journal Of Molecular Histology | 2015 |
Bisphosphonate treatment of type I diabetic mice prevents early bone loss but accentuates suppression of bone formation: ALENDRONATE RESCUES DIABETIC BONE LOSS
LM Coe, SA Tekalur, Y Shu, MJ Baumann, LR McCabe |
Journal of Cellular Physiology | 2015 |
Local Application of Ibandronate/Gelatin Sponge Improves Osteotomy Healing in Rabbits
Z Yang, W Chen, Z Xia, Y Liu, S Peggrem, T Geng, Z Yang, H Li, B Xu, C Zhang, JT Triffitt, Y Zhang, J Cray |
PloS one | 2015 |
Bone Cancer
PG Fournier, P Juárez, TA Guise |
Bone Cancer | 2015 |
Hydroxyapatite nanocrystals functionalized with alendronate as bioactive components for bone implant coatings to decrease osteoclastic activity
R Bosco, M Iafisco, A Tampieri, JA Jansen, SC Leeuwenburgh, JJ van Beucken |
Applied Surface Science | 2015 |
The Effect of Local Delivery Doxycycline and Alendronate on Bone Repair
PH Limirio, FS Rocha, JD Batista, JC Guimarães-Henriques, GB de Melo, P Dechichi |
AAPS PharmSciTech | 2015 |
Removal of pamidronate from bone in rats using systemic and local chelation
RN Howie, M Bhattacharyya, ME Salama, ME Refaey, C Isales, J Borke, A Daoudi, F Medani, ME Elsalanty |
Archives of Oral Biology | 2015 |
Extracellular matrix networks in bone remodeling
AI Alford, KM Kozloff, KD Hankenson |
The International Journal of Biochemistry & Cell Biology | 2015 |
Molecular Aspects of Bone Resorption in β-Thalassemia Major
Najmaldin Saki, Saeid Abroun, Fatemeh Salari, Fakher Rahim, Mohammad Shahjahani, Mohammadi-Asl Javad |
Cell Journal (Yakhteh) | 2015 |
Medication-Related Osteonecrosis of the Jaw
MR Allen |
Oral and Maxillofacial Surgery Clinics of North America | 2015 |
Recognition of the Causative Agent of “Phossy Jaw” and “Fragile Femur” in Fumes Arising from White Phosphorus
WB Hinshaw, LD Quin |
Phosphorus, Sulfur, and Silicon and the Related Elements | 2015 |
Vγ9Vδ2 T cells and zoledronate mediate antitumor activity in an orthotopic mouse model of human chondrosarcoma
L Sun, Y Li, Z Jiang, J Zhang, H Li, B Li, Z Ye |
Tumor Biology | 2015 |
Management of Root Resorption Using Chemical Agents: A Review
Zahed Mohammadi, Zafer C. Cehreli, Sousan Shalavi, Luciano Giardino, Flavio Palazzi, Saeed Asgary |
Iranian Endodontic Journal | 2015 |
A Practical Method to Synthesize 1,2,3-Triazole-Amino-Bisphosphonate Derivatives
S Liu, W Bi, X Li, X Chen, L Qu, Y Zhao |
Phosphorus, Sulfur, and Silicon and the Related Elements | 2015 |
Ultrastructural alterations of the inferior alveolar nerve in wistar rats after alendronate administration per os: hypothesis for the generation of the "numb chin syndrome"
EM Dietrich, P Theodora, S Antonia, K Georgios, N Esthelle |
Journal of Histology and Histopathology | 2015 |
Onconephrology
KD Jhaveri, AK Salahudeen |
2015 | |
Bisphosphonate Associated Osteonecrosis of the Jaw: An Update on Pathophysiology, Risk Factors, and Treatment
L Rasmusson, J Abtahi |
International journal of dentistry | 2014 |
Influence of Alendronate and Endplate Degeneration to Single Level Posterior Lumbar Spinal Interbody Fusion
SM Kim, W Rhee, S Ha, JH Lim, IT Jang |
Korean Journal of Spine | 2014 |
The effect of dipeptidyl peptidase-IV inhibition on bone in a mouse model of type 2 diabetes: DPP-IV inhibition and bone
EJ Gallagher, H Sun, C Kornhauser, A Tobin-Hess, S Epstein, S Yakar, D LeRoith |
Diabetes/Metabolism Research and Reviews | 2014 |
Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing's sarcoma via inhibition of cell migration
G Odri, PP Kim, F Lamoureux, C Charrier, S Battaglia, J Amiaud, D Heymann, F Gouin, F Redini |
BMC Cancer | 2014 |
Histomorphologic characteristics of bisphosphonate-related osteonecrosis of the jaw
S Koerdt, S Dax, H Grimaldi, O Ristow, AC Kuebler, T Reuther |
Journal of Oral Pathology & Medicine | 2014 |
Advances in Noninvasive Functional Imaging of Bone
SM Lan, YN Wu, PC Wu, CK Sun, DB Shieh, RM Lin |
Academic Radiology | 2014 |
Alendronate-induced atypical bone fracture: evidence that the drug inhibits osteogenesis
S Patntirapong, W Singhatanadgit, S Arphavasin |
Journal of Clinical Pharmacy and Therapeutics | 2014 |
In Vitro Effect of Bisphosphonates on Oral Keratinocytes and Fibroblasts
NM McLeod, KA Moutasim, PA Brennan, G Thomas, V Jenei |
Journal of Oral and Maxillofacial Surgery | 2014 |
Periprosthetic bone loss: diagnostic and therapeutic approaches
L Cavalli, ML Brandi |
F1000Research | 2014 |
The Local Effect of Alendronate with Intra-alveolar Collagen Sponges on Post Extraction Alveolar ridge Resorption: A Clinical Trial
AD Sarkar, N Singhvi, JN Shetty, T Ramakrishna, O Shetye, M Islam, H Keerthy |
Journal of Maxillofacial and Oral Surgery | 2014 |
CSF-1 blockade impairs breast cancer osteoclastogenic potential in co-culture systems
C Liverani, L Mercatali, C Spadazzi, FL Manna, AD Vita, N Riva, S Calpona, M Ricci, A Bongiovanni, E Gunelli, M Zanoni, F Fabbri, W Zoli, D Amadori, T Ibrahim |
Bone | 2014 |
Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting
S D'Souza, H Murata, MV Jose, S Askarova, Y Yantsen, JD Andersen, CD Edington, WP Clafshenkel, RR Koepsel, AJ Russell |
Biomaterials | 2014 |
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes |
2014 | |
Bifosfonati e terapia ortodontica: implicazioni cliniche
RD Bari, C Grippaudo, R Deli |
Dental Cadmos | 2014 |
Zoledronic Acid and Leuprorelin Acetate, Alone or in Combination, Similarly Reduce Proliferation and Migration of Prostate Cancer Cells In Vitro
B Mognetti, GL Montagna, MG Perrelli, S Marino, P Pagliaro, CM Cracco, C Penna |
International Journal of Medical Biology | 2014 |
Vγ9Vδ2 T lymphocytes activation in osteoporotic patients treated with bisphosphonates
Delia Sprini, Laura Di Stefano, Giovam Battista Rini, Luisella Cianferotti, Nicola Napoli |
Clinical Cases in Mineral and Bone Metabolism | 2014 |
Effect of Bisphosphonate on Osteoclast of Bone
S Ralte, A Bhattacharyya |
Forensic Medicine and Anatomy Research | 2014 |
Implant failure caused by non-union of bisphosphonate-associated subtrochanteric femur fracture
BJ O'Neill, S O'hEireamhoin, DI Morrissey, P Keogh |
BMJ case reports | 2014 |
Knochenmetastasen
A Stenzl, T Fehm, LC Hofbauer, F Jakob |
2014 | |
Kidney Transplantation
MR Weir, EV Lerma |
Kidney Transplantation | 2014 |
Medication-Related Osteonecrosis of the Jaws
S Otto |
2014 | |
Medicines For Women
M Harrison-Woolrych |
2014 | |
Population pharmacokinetic and pharmacodynamic modeling for assessing risk of bisphosphonate-related osteonecrosis of the jaw
PP Sedghizadeh, AC Jones, C LaVallee, RW Jelliffe, AD Le, P Lee, A Kiss, M Neely |
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology | 2013 |
Immobilization of pamidronic acids on the nanotube surface of titanium discs and their interaction with bone cells
TH Koo, JS Borah, ZC Xing, SM Moon, Y Jeong, IK Kang |
Nanoscale Research Letters | 2013 |
In Vitro and In Vivo Responses to High and Low Doses of Nitrogen-Containing Bisphosphonates Suggest Engagement of Different Mechanisms for Inhibition of Osteoclastic Bone Resorption
JE Fisher, E Rosenberg, AC Santora, AA Reszka |
Calcified Tissue International | 2013 |
Biomedical applications of bisphosphonates
EV Giger, B Castagner, JC Leroux |
Journal of Controlled Release | 2013 |
1% Alendronate Gel as Local Drug Delivery in the Treatment of Class II Furcation Defects: A Randomized Controlled Clinical Trial
AR Pradeep, M Kumari, NS Rao, SB Naik |
Journal of Periodontology | 2013 |
Oral Health Risk Factors for Bisphosphonate-Associated Jaw Osteonecrosis
C Tsao, I Darby, PR Ebeling, K Walsh, N O'Brien-Simpson, E Reynolds, G Borromeo |
Journal of Oral and Maxillofacial Surgery | 2013 |
Simple, efficient one-pot method for synthesis of novel N-attached 1,2,3-triazole containing bisphosphonates
X Chen, X Li, J Yuan, L Qu, S Wang, H Shi, Y Tang, L Duan |
Tetrahedron | 2013 |
Improved dosage form of the combined alendronate and calcitriol (Maxmarvil®) on the absorption of alendronate in Korean postmenopausal women
YS Chung, YJ Choi, SH Kim |
Archives of Pharmacal Research | 2013 |
Proline modulates the effect of bisphosphonate on calcium levels and adenosine triphosphate production in cell lines derived from bovine Echinococcus granulosus protoscoleces
AG Fuchs, CI Echeverría, FG Rojo, EA González, EJ Roldán |
Journal of Helminthology | 2013 |
Bisphosphonatassoziierte Kiefernekrose: Pathogenese und Prävention
S Otto, T Ziebart |
Der MKG-Chirurg | 2013 |
Preparation, characterization, release kinetics, and in vitro cytotoxicity of calcium silicate cement as a risedronate delivery system: Calcium Silicate Cement as Risedronate Delivery System
T Gong, Z Wang, Y Zhang, C Sun, Q Yang, T Troczynski, UO Häfeli |
Journal of Biomedical Materials Research Part A | 2013 |
Basic research and clinical applications of bisphosphonates in bone disease: what have we learned over the last 40 years?
XL Xu, WL Gou, AY Wang, Y Wang, QY Guo, Q Lu, SB Lu, J Peng |
Journal of Translational Medicine | 2013 |
Role of osteoclasts in regulating hematopoietic stem and progenitor cells
T Miyamoto |
World Journal of Orthopedics | 2013 |
Periapical disease and bisphosphonates induce osteonecrosis of the jaws in mice
B Kang, S Cheong, T Chaichanasakul, O Bezouglaia, E Atti, SM Dry, FQ Pirih, TL Aghaloo, S Tetradis |
Journal of Bone and Mineral Research | 2013 |
Pathologic fractures in bisphosphonate-related osteonecrosis of the jaw-review of the literature and review of our own cases
S Otto, C Pautke, S Hafner, R Hesse, LF Reichardt, G Mast, M Ehrenfeld, CP Cornelius |
Craniomaxillofacial Trauma & Reconstruction | 2013 |
The osteoblast and osteoclast responses to phosphonic acid containing poly(ε-caprolactone) electrospun scaffolds
AK Ghag, JE Gough, S Downes |
Biomaterials Science | 2013 |
Alendronate promotes bone formation by inhibiting protein prenylation in osteoblasts in rat tooth replantation model
K Komatsu, A Shimada, T Shibata, S Wada, H Ideno, K Nakashima, N Amizuka, M Noda, A Nifuji |
Journal of Endocrinology | 2013 |
Differential impact of the Bisphosphonate Alendronate on undifferentiated and terminally differentiated human myogenic cells: Impact of Alendronate on human myogenic cell
K Shiomi, Y Nagata, T Kiyono, A Harada, N Hashimoto |
Journal of Pharmacy and Pharmacology | 2013 |
Low concentrations of zoledronic acid are better at regulating bone formation and repair
Yang |
Intractable & Rare Diseases Research | 2013 |
Anti-Aging Efficacy of a New Alendronate-Pravastatin Cosmetic Combination: A Randomized Double Blind Comparative Study
B Cantecor, MP Savelli, MP Savelli, P Piccerelle, N Lévy, V Bonniol, P Cau |
Journal of Cosmetics, Dermatological Sciences and Applications | 2013 |
Are Bisphosphonates Effective in the Treatment of Osteoarthritis Pain? A Meta-Analysis and Systematic Review
AJ Davis, TO Smith, CB Hing, N Sofat, S Eldabe |
PloS one | 2013 |
Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages
D Muratsu, D Yoshiga, T Taketomi, T Onimura, Y Seki, A Matsumoto, S Nakamura, Ö Yilmaz |
PloS one | 2013 |
The effect of alendronate on the expression of important cell factors in osteoclasts
Q Zhang, M Liu, YI ZHOU, W Liu, J Shen, Y Shen, LI LIU |
Molecular medicine reports | 2013 |
Periprosthetic bone loss: diagnostic and therapeutic approaches
L Cavalli, ML Brandi |
F1000Research | 2013 |
Pathologic Fractures in Bisphosphonate-Related Osteonecrosis of the Jaw—Review of the Literature and Review of Our Own Cases
S Otto, C Pautke, S Hafner, R Hesse, LF Reichardt, G Mast, M Ehrenfeld, CP Cornelius |
Craniomaxillofacial Trauma & Reconstruction | 2013 |
Bisphosphonates: effects on osteoblast
N Maruotti, A Corrado, A Neve, FP Cantatore |
European Journal of Clinical Pharmacology | 2012 |
The role of the bone microenvironment in skeletal metastasis
Y Zheng, H Zhou, CR Dunstan, RL Sutherland, MJ Seibel |
Journal of Bone Oncology | 2012 |
Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter
SL Chinault, JL Prior, KM Kaltenbronn, A Penly, KN Weilbaecher, D Piwnica-Worms, KJ Blumer |
Clinical cancer research | 2012 |
Role of connexin 43 in the mechanism of action of alendronate: dissociation of anti-apoptotic and proliferative signaling pathways
V Lezcano, T Bellido, LI Plotkin, R Boland, S Morelli |
Archives of Biochemistry and Biophysics | 2012 |
Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits
J Turek, FH Ebetino, MW Lundy, S Sun, BA Kashemirov, CE McKenna, MA Gallant, LI Plotkin, T Bellido, X Duan, JT Triffitt, RG Russell, DB Burr, MR Allen |
Calcified Tissue International | 2012 |
Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
JP Cattalini, AR Boccaccini, S Lucangioli, V Mouriño |
Tissue Engineering Part B Reviews | 2012 |
Effects of alendronate on human osteoblast-like MG63 cells and matrix metalloproteinases
J Sun, F Song, W Zhang, BE Sexton, LJ Windsor |
Archives of Oral Biology | 2012 |
Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo
AJ Roelofs, CA Stewart, S Sun, KM Błażewska, BA Kashemirov, CE McKenna, RG Russell, MJ Rogers, MW Lundy, FH Ebetino, FP Coxon |
Journal of Bone and Mineral Research | 2012 |
Zoledronic Acid Produces Antitumor Effects on Mesothelioma Through Apoptosis and S-Phase Arrest in p53-Independent and Ras prenylation-Independent Manners :
S Okamoto, K Kawamura, Q Li, M Yamanaka, S Yang, T Fukamachi, Y Tada, K Tatsumi, H Shimada, K Hiroshima, H Kobayashi, M Tagawa |
Journal of Thoracic Oncology | 2012 |
Zoledronic acid suppresses mineralization through direct cytotoxicity and osteoblast differentiation inhibition : Effects of zoledronate on mineralization
S Patntirapong, W Singhatanadgit, C Chanruangvanit, K Lavanrattanakul, Y Satravaha |
Journal of Oral Pathology and Medicine | 2012 |
Cochrane Database of Systematic Reviews: Protocols
JJ Ho, AS Adnan, Z Darus, NZ Ismail, HV Rostenberghe, JJ Ho |
Cochrane Database of Systematic Reviews: Protocols | 2012 |
Efficacy of glucosamine alendronate alone & in combination with dihydroquercetin for treatment of osteoporosis in animal model
NA Muraleva, EN Ofitserov, VP Tikhonov, NG Kolosova |
The Indian journal of medical research | 2012 |
Management of bone metastases: recent advances and current status
K Dennis, V Vassiliou, T Balboni, E Chow |
Journal of Radiation Oncology | 2012 |
Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid
I Sirisoontorn, H Hotokezaka, M Hashimoto, C Gonzales, S Luppanapornlarp, MA Darendeliler, N Yoshida |
American Journal of Orthodontics and Dentofacial Orthopedics | 2012 |
Alendronate promotes plasmin-mediated MMP-9 inactivation by exposing cryptic plasmin degradation sites within the MMP-9 catalytic domain
AR Farina, L Cappabianca, ND Ianni, P Ruggeri, M Ragone, S Merolle, A Gulino, AR Mackay |
FEBS Letters | 2012 |
Quantification by energy dispersive x-ray spectroscopy of alendronate in the diseased jaw bone of patients with bisphosphonate-related jaw osteonecrosis
C Schaudinn, A Gorur, P Webster, AC Jones, M Neely, RW Jelliffe, AD Le, PP Sedghizadeh |
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology | 2012 |
Incidence and Risk Factors of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients Having Undergone Autologous Stem Cell Transplantation
C Then, N Hörauf, S Otto, C Pautke, E Tresckow, T Röhnisch, P Baumann, R Schmidmaier, I Bumeder, FS Oduncu |
Onkologie | 2012 |
Safety of Bisphosphonates
C Orozco, NM Maalouf |
Rheumatic Disease Clinics of North America | 2012 |
Inhibition of breast cancer cell proliferation in repeated and non-repeated treatment with zoledronic acid
T Ibrahim, L Mercatali, E Sacanna, A Tesei, S Carloni, P Ulivi, C Liverani, F Fabbri, M Zanoni, W Zoli, D Amadori |
Cancer Cell International | 2012 |
Clinical role of bisphosphonate therapy
G Hampson, I Fogelman |
International journal of women's health | 2012 |
Zoledronate and pamidronate depress neutrophil functions and survival in mice
JW Kuiper, C Forster, C Sun, S Peel, M Glogauer |
British Journal of Pharmacology | 2012 |
Pathophysiology of Bone Remodelling and Current Therapeutic Approaches
I Juhasz-Böss, T Fehm, J Ney, E Solomayer |
Geburtshilfe und Frauenheilkunde | 2012 |
Tissue Engineering and Regenerative Medicine: A Nano Approach
J Lai, A Ramasubramanian, S Jeeawoody, F Yang |
Tissue Engineering and Regenerative Medicine: A Nano Approach | 2012 |
Simulated resistance training, but not alendronate, increases cortical bone formation and suppresses sclerostin during disuse
BR Macias, JM Swift, MI Nilsson, HA Hogan, SD Bouse, SA Bloomfield |
Journal of applied physiology | 2012 |
Zoledronic acid inhibits macrophage SOCS3 expression and enhances cytokine production
EL Scheller, KD Hankenson, JS Reuben, PH Krebsbach |
Journal of Cellular Biochemistry | 2011 |
Direct antitumour activity of zoledronic acid: preclinical and clinical data.
Bosch-Barrera J, Merajver SD, Menéndez JA, Van Poznak C |
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico | 2011 |
Bisphosphonates: The first 40years
RG Russell |
Bone | 2011 |
Short-term effects of zoledronate on the histomorphology of osteoclast in young albino rats
S Ralte, K Khatri, M Nagar |
Annals of Anatomy - Anatomischer Anzeiger | 2011 |
Bisphosphonate treatment delays stress fracture remodeling in the rat ulna
LJ Kidd, NR Cowling, AC Wu, WL Kelly, MR Forwood |
Journal of Orthopaedic Research | 2011 |
Denosumab and bisphosphonates: Different mechanisms of action and effects
R Baron, S Ferrari, RG Russell |
Bone | 2011 |
Biochemical and molecular mechanisms of action of bisphosphonates
MJ Rogers, JC Crockett, FP Coxon, J Mönkkönen |
Bone | 2011 |
Effect of bisphosphonates on human gingival fibroblast production of mediators of osteoclastogenesis: RANKL, osteoprotegerin and interleukin-6
DA Tipton, BA Seshul, MK Dabbous |
Journal of Periodontal Research | 2011 |
Effect of Bisphosphonates on the Progression of Degenerative Aortic Stenosis
AL Innasimuthu, WE Katz |
Echocardiography | 2011 |
Bisphosphonates, specific inhibitors of osteoclast function and a class of drugs for osteoporosis therapy
B Li, JF Chau, X Wang, WF Leong |
Journal of Cellular Biochemistry | 2011 |
Direct antitumour activity of zoledronic acid: preclinical and clinical data
J Bosch-Barrera, SD Merajver, JA Menéndez, C Poznak |
Clinical and Translational Oncology | 2011 |
The Role of Jak/STAT Pathways in Osteoclast Differentiation
YK Lee, HH Kim |
Biomolecules and Therapeutics | 2011 |
Effects of Zoledronic Acid on Healing of Mandibular Fractures: An Experimental Study in Rabbits
U Tatlı, Y Üstün, M Kürkçü, Ö Erdoğan, CC Gürbüz, H Özgür, S Polat |
Journal of Oral and Maxillofacial Surgery | 2011 |
Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates
S Thiele, M Rauner, C Goettsch, TD Rachner, P Benad, S Fuessel, K Erdmann, C Hamann, GB Baretton, MP Wirth, F Jakob, LC Hofbauer |
Journal of Cellular Biochemistry | 2011 |
Bisphosphonate related osteonecrosis of the jaw – Manifestation in a microvascular iliac bone flap
C Pautke, S Otto, S Reu, A Kolk, M Ehrenfeld, S Stürzenbaum, KD Wolff |
Oral Oncology | 2011 |
Bisphosphonate-related osteonecrosis of the jaws – Characteristics, risk factors, clinical features, localization and impact on oncological treatment
S Otto, C Schreyer, S Hafner, G Mast, M Ehrenfeld, S Stürzenbaum, C Pautke |
Journal of Cranio-Maxillofacial Surgery | 2011 |
Pharmacology of bisphosphonates
S Cremers, S Papapoulos |
Bone | 2011 |
The relationship between the chemistry and biological activity of the bisphosphonates
FH Ebetino, AM Hogan, S Sun, MK Tsoumpra, X Duan, JT Triffitt, AA Kwaasi, JE Dunford, BL Barnett, U Oppermann, MW Lundy, A Boyde, BA Kashemirov, CE McKenna, RG Russell |
Bone | 2011 |
Consensus on the utility of bone markers in the malignant bone disease setting
R Coleman, L Costa, F Saad, R Cook, P Hadji, E Terpos, P Garnero, J Brown, JJ Body, M Smith, KA Lee, P Major, M Dimopoulos, A Lipton |
Critical Reviews in Oncology/Hematology | 2011 |
Does alendronate disturb the healing process of posterior lumbar interbody fusion? A prospective randomized trial
K Nagahama, M Kanayama, D Togawa, T Hashimoto, A Minami |
Journal of Neurosurgery: Spine | 2011 |
Bisphosphonates modulate the expression of OPG and M-CSF in hMSC-derived osteoblasts
JY Ohe, YD Kwon, HW Lee |
Clinical Oral Investigations | 2011 |
Cancellous bone formation response to simulated resistance training during disuse is blunted by concurrent alendronate treatment
JM Swift, SN Swift, MI Nilsson, HA Hogan, SD Bouse, SA Bloomfield |
Journal of Bone and Mineral Research | 2011 |
Alendronate and raloxifene affect the osteoprotegerin/RANKL system in human osteoblast primary cultures from patients with osteoporosis and osteoarthritis
M Giner, MJ Rios, MJ Montoya, MA Vázquez, C Miranda, R Pérez-Cano |
European Journal of Pharmacology | 2011 |
Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices — A simple method for identifying polarized osteoclasts
T Nakayama, T Mizoguchi, S Uehara, T Yamashita, I Kawahara, Y Kobayashi, Y Moriyama, S Kurihara, N Sahara, H Ozawa, N Udagawa, N Takahashi |
Bone | 2011 |
Novel mineral contrast agent for magnetic resonance studies of bone implants grown on a chick chorioallantoic membrane
IE Chesnick, CB Fowler, JT Mason, K Potter |
Magnetic Resonance Imaging | 2011 |
Up-regulation of inhibitors of DNA binding/differentiation gene during alendronate-induced osteoblast differentiation
AR Kang, YR Oh, HY Kim, MJ Park, BS Joo, WJ Choi, JY Lee, MH Jung, YI Ji, JS Choi |
Archives of Gynecology and Obstetrics | 2011 |
Impact of oncopediatric dosing regimen of zoledronic acid on bone growth: Preclinical studies and case report of an osteosarcoma pediatric patient
S Battaglia, S Dumoucel, J Chesneau, MF Heymann, G Picarda, F Gouin, N Corradini, D Heymann, F Redini |
Journal of Bone and Mineral Research | 2011 |
Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: Role of the akt pathway and the ERK/Bim axis
T Matsumoto, Y Nagase, M Iwasawa, T Yasui, H Masuda, Y Kadono, K Nakamura, S Tanaka |
Arthritis & Rheumatism | 2011 |
Preventive Effects of Zoledronic Acid on Bone Metastasis in Mice Injected with Human Breast Cancer Cells
J Jeong, KS Lee, YK Choi, YJ Oh, HD Lee |
Journal of Korean Medical Science | 2011 |
Annual Reports in Medicinal Chemistry
JJ Liu, TW Lee |
Annual Reports in Medicinal Chemistry Volume 46 | 2011 |
Antiangiogenic effects of zoledronate on cancer neovasculature
S Metcalf, HS Pandha, R Morgan |
Future Oncology | 2011 |
Small interfering RNA knocks down the molecular target of alendronate, farnesyl pyrophosphate synthase, in osteoclast and osteoblast cultures
Y Wang, A Panasiuk, DW Grainger |
Molecular Pharmaceutics | 2011 |
The Role of Bisphosphonates in Multiple Myeloma: Mechanisms, Side Effects, and the Future
S Pozzi, N Raje |
The oncologist | 2011 |
Zoledronic acid induces S-phase arrest via a DNA damage response in normal human oral keratinocytes
H Ohnuki, K Izumi, M Terada, T Saito, H Kato, A Suzuki, Y Kawano, K Nozawa-Inoue, R Takagi, T Maeda |
Archives of Oral Biology | 2011 |
Osteoclasts derived from patients with neurofibromatosis 1 (NF1) display insensitivity to bisphosphonates in vitro
E Heervä, S Peltonen, E Svedström, HT Aro, K Väänänen, J Peltonen |
Bone | 2011 |
DC-like cell-dependent activation of human natural killer cells by the bisphosphonate zoledronic acid is regulated by γδ T lymphocytes
O Nussbaumer, G Gruenbacher, H Gander, M Thurnher |
Blood | 2011 |
Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study
F Öztürk, H Babacan, S İnan, C Gümüş |
American Journal of Orthodontics and Dentofacial Orthopedics | 2011 |
The Influence of Alendronate on Spine Fusion in an Osteoporotic Animal Model:
S Nakao, A Minamide, M Kawakami, SD Boden, M Yoshida |
Spine | 2011 |
Comparison of the Effects of Local Application of Hydroxyapatite Graft Soaked with Alendronate Solution and Pure Hydroxyapatite Graft in the Mandible of Ovariectomized Rats
A Arslan, H Altundal, O Cevik, V Olgac |
Biotechnology & Biotechnological Equipment | 2011 |
The Safety and Efficacy of Early-Stage Bi-Weekly Alendronate to Improve Bone Mineral Density and Bone Turnover in Chinese Post-Menopausal Women at Risk of Osteoporosis
L You, ZY Sheng, JY Chen, L Pan, L Chen |
J INT MED RES | 2011 |
Characterization of the Immune Response of Human Cord-Blood Derived γδ T Cells to Stimulation with Aminobisphosphonate Compounds
R Placido, G Auricchio, I Gabriele, E Galli, E Brunetti, V Colizzi, L Battistini, G Mancino |
International journal of immunopathology and pharmacology | 2011 |
Crystallization Products of Risedronate with Carbohydrates and Their Substituted Derivatives
J Kos, M Pentakova, Z Oktabec, L Krejcik, Z Mandelova, P Harokova, J Hruskova, T Pekarek, O Dammer, M Tkadlecova, J Havlicek, J Vinsova, V Kral, J Dohnal, J Jampílek |
Molecules (Basel, Switzerland) | 2011 |
Skeletal Aging and Osteoporosis
MJ Silva |
2011 | |
Teriparatide, Vitamin D, and Calcium Healed Bilateral Subtrochanteric Stress Fractures in a Postmenopausal Woman with a 13-Year History of Continuous Alendronate Therapy
SJ Gomberg, RL Wustrack, N Napoli, CD Arnaud, DM Black |
The Journal of clinical endocrinology and metabolism | 2011 |
Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo
AJ Roelofs, FP Coxon, FH Ebetino, MW Lundy, ZJ Henneman, GH Nancollas, S Sun, KM Blazewska, JL Bala, BA Kashemirov, AB Khalid, CE McKenna, MJ Rogers |
Journal of Bone and Mineral Research | 2010 |
The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation
MT Valenti, S Giannini, L Donatelli, M Zanatta, F Bertoldo, S Sella, MT Vilei, E Ossi, G Realdi, VL Cascio, LD Carbonare |
Arthritis Research & Therapy | 2010 |
Burger's Medicinal Chemistry and Drug Discovery
S Bruno, L Ronda, S Faggiano, S Bettati, A Mozzarelli |
Burger's Medicinal Chemistry and Drug Discovery | 2010 |
Osteonecrosis of the Jaw in a Patient on Denosumab
TL Aghaloo, AL Felsenfeld, S Tetradis |
Journal of Oral and Maxillofacial Surgery | 2010 |
Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78
A Streitbuerger, M Henrichs, H Ahrens, C Lanvers-Kaminzky, F Gouin, G Gosheger, J Hardes |
International Orthopaedics | 2010 |
Influence of bisphosphonates on the osteoblast RANKL and OPG gene expression in vitro
FP Koch, C Merkel, T Ziebart, R Smeets, C Walter, B Al-Nawas |
Clinical Oral Investigations | 2010 |
Bisphosphonates treatment and orthodontic considerations
AA Ghoneima, ES Allam, SL Zunt, LJ Windsor |
Orthodontics & Craniofacial Research | 2010 |
Effects of alendronate on bone healing after tooth extraction in rats
JI Aguirre, MK Altman, SM Vanegas, SE Franz, AC Bassit, TJ Wronski |
Oral Diseases | 2010 |
Bisphosphonate-Related Osteonecrosis of the Jaw: Is pH the Missing Part in the Pathogenesis Puzzle?
S Otto, S Hafner, G Mast, T Tischer, E Volkmer, M Schieker, SR Stürzenbaum, E Tresckow, A Kolk, M Ehrenfeld, C Pautke |
Journal of Oral and Maxillofacial Surgery | 2010 |
Bisphosphonates and RANK ligand inhibitors for the treatment and prevention of metastatic bone disease
HL Neville-Webbe, RE Coleman |
European Journal of Cancer | 2010 |
Use of bisphosphonates for the treatment of osteonecrosis as a complication of therapy for childhood acute lymphoblastic leukaemia (ALL)
RS Kotecha, N Powers, SJ Lee, KJ Murray, T Carter, C Cole |
Pediatric Blood & Cancer | 2010 |
Sol-gel derived titania coating with immobilized bisphosphonate enhances screw fixation in rat tibia
P Linderbäck, S Areva, P Aspenberg, P Tengvall |
Journal of Biomedical Materials Research Part A | 2010 |
An in vitro Assay to Measure Targeted Drug Delivery to Bone Mineral
W Jahnke, C Henry |
ChemMedChem | 2010 |
Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells
TD Rachner, SK Singh, M Schoppet, P Benad, M Bornhäuser, V Ellenrieder, R Ebert, F Jakob, LC Hofbauer |
Cancer Letters | 2010 |
Osteonecrosis of the Jaws
V Vassiliou, N Tselis, D Kardamakis |
Strahlentherapie und Onkologie | 2010 |
Near-infrared fluorescent probe traces bisphosphonate delivery and retention in vivo
KM Kozloff, LI Volakis, JC Marini, MS Caird |
Journal of Bone and Mineral Research | 2010 |
Potential Anticancer Properties of Bisphosphonates
HL Neville-Webbe, M Gnant, RE Coleman |
Seminars in Oncology | 2010 |
Bone metastases: Molecular mechanisms and novel therapeutic interventions
DJ Papachristou, EK Basdra, AG Papavassiliou |
Medicinal Research Reviews | 2010 |
Bisphosphonate-modified gold nanoparticles: a useful vehicle to study the treatment of osteonecrosis of the femoral head
F Fanord, K Fairbairn, H Kim, A Garces, V Bhethanabotla, VK Gupta |
Nanotechnology | 2010 |
Inhibition of Necrotic Actions of Nitrogen-Containing Bisphosphonates (NBPs) and Their Elimination From Bone by Etidronate (a Non-NBP): A Proposal for Possible Utilization of Etidronate as a Substitution Drug for NBPs
T Oizumi, H Funayama, K Yamaguchi, M Yokoyama, H Takahashi, M Yamamoto, T Kuroishi, H Kumamoto, K Sasaki, H Kawamura, S Sugawara, Y Endo |
Journal of Oral and Maxillofacial Surgery | 2010 |
Safety and tolerability of zoledronic acid and other bisphosphonates in osteoporosis management
LD Carbonare, M Zanatta, A Gasparetto, MT Valenti |
Drug, healthcare and patient safety | 2010 |
Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells
SA Holstein, H Tong, RJ Hohl |
Leukemia Research | 2010 |
Bisphosphonates for Osteoporosis
MJ Favus |
New England Journal of Medicine | 2010 |
Osteonecrosis of the Jawbones in 2 Osteoporosis Patients Treated With Nitrogen-Containing Bisphosphonates: Osteonecrosis Reduction Replacing NBP With Non-NBP (Etidronate) and Rationale
K Yamaguchi, T Oizumi, H Funayama, H Kawamura, S Sugawara, Y Endo |
Journal of Oral and Maxillofacial Surgery | 2010 |
Anatomic Site Variability in Rat Skeletal Uptake and Desorption Of Fluorescently Labeled Bisphosphonate
D Wen, L Qing, G Harrison, E Golub, SO Akintoye |
Oral Diseases | 2010 |
Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells
Y Tatsuda, K Iguchi, S Usui, M Suzui, K Hirano |
European Journal of Pharmacology | 2010 |
Pamidronate inhibits antiapoptotic bcl-2 expression through inhibition of the mevalonate pathway in prostate cancer PC-3 cells
K Iguchi, Y Tatsuda, S Usui, K Hirano |
European Journal of Pharmacology | 2010 |
Osteonecrosis of the Jaw: Effect of Bisphosphonate Type, Local Concentration, and Acidic Milieu on the Pathomechanism
S Otto, C Pautke, C Opelz, I Westphal, I Drosse, J Schwager, F Bauss, M Ehrenfeld, M Schieker |
Journal of Oral and Maxillofacial Surgery | 2010 |
The Orthopaedic Implications of Diphosphonate Therapy:
MJ Weaver, MA Miller, MS Vrahas |
The Journal of the American Academy of Orthopaedic Surgeons | 2010 |
Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption - implications for osteoclast quality
AV Neutzsky-Wulff, MG Sørensen, D Kocijancic, DJ Leeming, MH Dziegiel, MA Karsdal, K Henriksen |
BMC musculoskeletal disorders | 2010 |
Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives
Z Oktabec, J Kos, Z Mandelova, L Havelkova, T Pekarek, A Rezacova, L Placek, M Tkadlecova, J Havlicek, J Dohnal, J Jampílek |
Molecules (Basel, Switzerland) | 2010 |
Osteonecrosis of the Jaws: Clinicopathologic and Radiologic Characteristics, Preventive and Therapeutic Strategies
V Vassiliou, N Tselis, D Kardamakis |
Strahlentherapie und Onkologie | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Osteoimmunology
Y Choi |
Osteoimmunology | 2009 |
Osteoimmunology
Y Choi |
Osteoimmunology | 2009 |
Osteoimmunology
Y Choi |
Osteoimmunology | 2009 |
Osteoimmunology
Y Choi |
Osteoimmunology | 2009 |
Osteoimmunology
Y Choi |
Osteoimmunology | 2009 |
Osteoimmunology
Y Choi |
Osteoimmunology | 2009 |
Osteoimmunology
Y Choi |
Osteoimmunology | 2009 |
Alendronate reduces osteoclast precursors in osteoporosis
P D’Amelio, A Grimaldi, MA Cristofaro, M Ravazzoli, PA Molinatti, GP Pescarmona, GC Isaia |
Osteoporosis International | 2009 |
Bisphosphonate administration prior to tooth extraction delays initial healing of the extraction socket in rats
H Hikita, K Miyazawa, M Tabuchi, M Kimura, S Goto |
Journal of Bone and Mineral Metabolism | 2009 |
Aminobisphosphonate Stimulates Bone Regeneration and Enforces Consolidation of Titanium Implant into a New Rat Caudal Vertebrae Model
J Blazsek, CD Nagy, I Blazsek, R Varga, B Vecsei, P Fejérdy, G Varga |
Pathology & Oncology Research | 2009 |
Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro
J Räikkönen, JC Crockett, MJ Rogers, H Mönkkönen, S Auriola, J Mönkkönen |
British Journal of Pharmacology | 2009 |
Necrotic Actions of Nitrogen-Containing Bisphosphonates and Their Inhibition by Clodronate, a Non-Nitrogen-Containing Bisphosphonate in Mice: Potential for Utilization of Clodronate as a Combination Drug with a Nitrogen-Containing Bisphosphonate
T Oizumi, K Yamaguchi, H Funayama, T Kuroishi, H Kawamura, S Sugawara, Y Endo |
Basic & Clinical Pharmacology & Toxicology | 2009 |
CTX Biochemical Marker of Bone Metabolism. Is it a Reliable Predictor of Bisphosphonate-Associated Osteonecrosis of the Jaws After Surgery? Part I: Biological Concepts With a Review of the Literature
CY Lee, JB Suzuki |
Implant Dentistry | 2009 |
Influence of bisphosphonates on orthodontic tooth movement in mice
Y Fujimura, H Kitaura, M Yoshimatsu, T Eguchi, H Kohara, Y Morita, N Yoshida |
The European Journal of Orthodontics | 2009 |
Menopause
DG Weismiller |
Primary Care Clinics in Office Practice | 2009 |
Femur bone repair in ovariectomized rats under the local action of alendronate, hydroxyapatite and the association of alendronate and hydroxyapatite
AC Canettieri, CE Colombo, CM Chin, H Faig-Leite |
International Journal of Experimental Pathology | 2009 |
Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines
A Ullén, S Schwarz, L Lennartsson, KM Kälkner, P Sandström, F Costa, B Lennernäs, S Linder, S Nilsson |
Scandinavian Journal of Urology and Nephrology | 2009 |
Flare-up of hand osteoarthritis caused by zoledronic acid infusion
GR de Castro, FS Neves, SC de Magalhães Souza Fialho, IA Pereira, G Ribeiro, AF Zimmermann |
Osteoporosis International | 2009 |
Bone resorption inhibitor alendronate normalizes the reduced bone thickness of TRPV5(-/-) mice
T Nijenhuis, BC van der Eerden, JG Hoenderop, H Weinans, JP van Leeuwen, RJ Bindels |
Journal of Bone and Mineral Research | 2008 |
Alendronate Enhances Osteogenic Differentiation of Bone Marrow Stromal Cells: A Preliminary Study
HK Kim, JH Kim, AA Abbas, TR Yoon |
Clinical Orthopaedics and Related Research® | 2008 |
Hormesis and medicine
EJ Calabrese |
British Journal of Clinical Pharmacology | 2008 |
Bisphosphonat-assoziierte Osteonekrosen des Kieferknochens
MT Krauth, A Fügl, R Gruber |
Wiener klinische Wochenschrift | 2008 |
Recovery of Trabecular and Cortical Bone Turnover After Discontinuation of Risedronate and Alendronate Therapy in Ovariectomized Rats
RK Fuchs, RJ Phipps, DB Burr |
Journal of Bone and Mineral Research | 2008 |
Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy
RG Russell, NB Watts, FH Ebetino, MJ Rogers |
Osteoporosis International | 2008 |
Bisphosphonate treatment and radiotherapy in metastatic breast cancer
AU Ural, F Avcu, Y Baran |
Medical Oncology | 2008 |
Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro
AI Idris, J Rojas, IR Greig, RJ Hof, SH Ralston |
Calcified Tissue International | 2008 |
Bisphosphonates induce apoptosis in CLL cells independently of MDR phenotype
KL Silva, DV Vasconcellos, ED de Castro, FC Vasconcelos, R Bigni, RC Maia |
Cancer Chemotherapy and Pharmacology | 2008 |
The effects of bisphosphonates on osteoblasts in vitro
A Naidu, PC Dechow, R Spears, JM Wright, HP Kessler, LA Opperman |
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology | 2008 |
Combination Therapy Using Exercise and Pharmaceutical Agents to Optimize Bone Health
RK Fuchs, SJ Warden |
Clinical Reviews in Bone and Mineral Metabolism | 2008 |
Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs
J Baas |
Acta Orthopaedica | 2008 |
Treatment of experimental renal osteodystrophy with pamidronate
J Jokihaara, IH Pörsti, P Kööbi, PM Jolma, JT Mustonen, HH Saha, H Sievänen, P Kannus, UT Iwaniec, RT Turner, TL Järvinen |
Kidney International | 2008 |
Common Implant-Related Advanced Bone Grafting Complications: Classification, Etiology, and Management
J Li, HL Wang |
Implant Dentistry | 2008 |
Skeletal accumulation of bisphosphonates: implications for osteoporosis treatment
MR Allen |
Expert Opinion on Drug Metabolism & Toxicology | 2008 |
Effects of Bisphosphonates on Fracture Incidence and Bone Metabolism in Rheumatoid Arthritis Patients in General Practice Taking Long-Term Corticosteroid Therapy
K Katayama, T Matsuno |
Clinical Drug Investigation | 2008 |
Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth
H Mönkkönen, J Kuokkanen, I Holen, A Evans, DV Lefley, M Jauhiainen, S Auriola, J Mönkkönen |
Anti-Cancer Drugs | 2008 |
Vesicular trafficking in osteoclasts
FP Coxon, A Taylor |
Seminars in Cell & Developmental Biology | 2008 |
New research findings on zoledronic acid: Survival, pain, and anti-tumour effects
F Saad |
Cancer Treatment Reviews | 2008 |
Bone Resorption Inhibitor Alendronate Normalizes the Reduced Bone Thickness of TRPV5−/−Mice
T Nijenhuis, BC van der Eerden, JG Hoenderop, H Weinans, JP van Leeuwen, RJ Bindels |
Journal of Bone and Mineral Research | 2008 |
Comparative pharmacokinetics of two intravenous administration regimens of tiludronate in healthy adult horses and effects on the bone resorption marker CTX-1
C Delguste, H Amory, J Guyonnet, D Thibaud, P Garnero, J Detilleux, OM Lepage, M Doucet |
Journal of Veterinary Pharmacology and Therapeutics | 2008 |
SAR of Carbon-Linked, 2-Substituted Purines: Synthesis and Characterization of AP23451 as a novel Bone-Targeted Inhibitor of Src Tyrosine Kinase With In Vivo Anti-Resorptive Activity
WC Shakespeare, Y Wang, R Bohacek, T Keenan, R Sundaramoorthi, C Metcalf, A Dilauro, S Roeloffzen, S Liu, J Saltmarsh, G Paramanathan, D Dalgarno, S Narula, S Pradeepan, MR van Schravendijk, J Keats, M Ram, S Liou, S Adams, S Wardwell, J Bogus, J Iuliucci, M Weigele, L Xing, B Boyce, TK Sawyer |
Chemical Biology & Drug Design | 2008 |
Long-term effects of local pretreatment with alendronate on healing of replanted rat teeth
K Komatsu, A Shimada, T Shibata, S Shimoda, S Oida, K Kawasaki, A Nifuji |
Journal of Periodontal Research | 2008 |
Intravenous ibandronate rapidly reduces pain, neurochemical indices of central sensitization, tumor burden, and skeletal destruction in a mouse model of bone cancer
KG Halvorson, MA Sevcik, JR Ghilardi, LJ Sullivan, NJ Koewler, F Bauss, PW Mantyh |
Journal of Pain and Symptom Management | 2008 |
Bisphosphonate treatment in the oim mouse model alters bone modeling during growth
SH Rao, KD Evans, AM Oberbauer, RB Martin |
Journal of Biomechanics | 2008 |
An osteoclast-targeting agent for imaging and therapy of bone metastasis
W Liu, A Hajibeigi, M Lin, CL Rostollan, Z Kovacs, OK Oz, X Sun |
Bioorganic & Medicinal Chemistry Letters | 2008 |
Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells
F Journé, N Kheddoumi, C Chaboteaux, H Duvillier, G Laurent, JJ Body |
Breast Cancer Research | 2008 |
Effects of Denosumab on the Geometry of the Proximal Femur in Postmenopausal Women in Comparison with Alendronate
TJ Beck, EM Lewiecki, PD Miller, D Felsenberg, Y Liu, B Ding, C Libanati |
Journal of Clinical Densitometry | 2008 |
Exploring the anti-tumour activity of bisphosphonates in early breast cancer
MC Winter, I Holen, RE Coleman |
Cancer Treatment Reviews | 2008 |
Cancer and Orofacial Pain
DJ Fischer, GD Klasser, JB Epstein |
Oral and Maxillofacial Surgery Clinics of North America | 2008 |
Histomorphometric Evaluation of the Effects of Zoledronic Acid on Mandibular Distraction Osteogenesis in Rabbits
AA Pampu, D Dolanmaz, HH Tüz, MC Avunduk, RŞ Kisşnisşci |
Journal of Oral and Maxillofacial Surgery | 2008 |
Principles of Bone Biology
CJ Rosen, T Niu |
Principles of Bone Biology | 2008 |
Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells
FP Coxon, K Thompson, AJ Roelofs, FH Ebetino, MJ Rogers |
Bone | 2008 |
Effects of bisphosphonates on root resorption and cytokine expression during experimental tooth movement in rats
R Putranto, Y Oba, K Kaneko, A Shioyasono, K Moriyama |
Orthodontic Waves | 2008 |
Myeloma Therapy
S Lonial |
2008 | |
Chronic Prostatitis/Chronic Pelvic Pain Syndrome
DA Shoskes |
2008 | |
Effects of Bisphosphonates on Fracture Incidence and Bone Metabolism in Rheumatoid Arthritis Patients in General Practice Taking Long-Term Corticosteroid Therapy: A Retrospective Study
K Katayama, T Matsuno |
Clinical Drug Investigation | 2008 |
Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
AE Kearns, S Khosla, PJ Kostenuik |
Endocrine reviews | 2007 |
Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies
Y Abu-Amer, I Darwech, JC Clohisy |
Arthritis Research & Therapy | 2007 |
Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation
H Nassar, A Kantarci, TE van Dyke |
Periodontology 2000 | 2007 |
Alendronate inhibits periprosthetic bone loss around uncemented femoral components
T Nishioka, S Yagi, T Mitsuhashi, M Miyamoto, T Tamura, T Kobayashi, T Enishi |
Journal of Bone and Mineral Metabolism | 2007 |
Long-Term Protective Effects of Zoledronic Acid on Cancellous and Cortical Bone in the Ovariectomized Rat
JA Gasser, P Ingold, A Venturiere, V Shen, JR Green |
Journal of Bone and Mineral Research | 2007 |
The Molecular Mechanisms of Action of Bisphosphonates
K Thompson, MJ Rogers |
Clinical Reviews in Bone and Mineral Metabolism | 2007 |
Pharmacological and clinical profile of once weekly alendronate for the treatment of osteoporosis (Fosamac 35 mg/Bonalon 35 mg)
S Uchida, Y Azuma, T Taniguchi, H Arizono, T Shimizu, M Okaniwa, K Nakamura, T Ohta |
Folia Pharmacologica Japonica | 2007 |
Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells
T Kubo, S Shimose, T Matsuo, A Sakai, M Ochi |
Cancer Chemotherapy and Pharmacology | 2007 |
Noninvasive Optical Detection of Bone Mineral
KM Kozloff, R Weissleder, U Mahmood |
Journal of Bone and Mineral Research | 2007 |
Bisphosphonate incadronate inhibits growth of human T-cell leukaemia virus type I-infected T-cell lines and primary adult T-cell leukaemia cells by interfering with the mevalonate pathway
C Ishikawa, T Matsuda, T Okudaira, M Tomita, H Kawakami, Y Tanaka, M Masuda, K Ohshiro, T Ohta, N Mori |
British Journal of Haematology | 2007 |
Effect of short-term treatment with alendronate on ulnar bone adaptation to cyclic fatigue loading in rats
JG Barrett, SJ Sample, J McCarthy, VL Kalscheur, P Muir, L Prokuski |
Journal of Orthopaedic Research | 2007 |
Bisphosphonate zur Behandlung tumorinduzierter Knochenveränderungen
P Schmid |
Der Onkologe | 2007 |
Synthesis of functionalized bisphosphonates via click chemistry
H Skarpos, SN Osipov, DV Vorob'eva, IL Odinets, E Lork, GV R?schenthaler |
Organic & Biomolecular Chemistry | 2007 |
Administration of pamidronate alters bone-titanium attachment in the presence of endotoxin-coated polyethylene particles
Z Xing, KA Hasty, RA Smith |
Journal of Biomedical Materials Research Part B: Applied Biomaterials | 2007 |
Effects of alendronate on tooth eruption and molar root formation in young growing rats
V Bradaschia-Correa, LF Massa, VE Arana-Chavez |
Cell and Tissue Research | 2007 |
A Comparison between the Effects of Hydrophobic and Hydrophilic Statins on Osteoclast Function In Vitro and Ovariectomy-Induced Bone Loss In Vivo
A Hughes, MJ Rogers, AI Idris, JC Crockett |
Calcified Tissue International | 2007 |
Effect of 17β-Estradiol and Alendronate on the Removal Torque of Osseointegrated Titanium Implants in Ovariectomized Rats
G Giro, CE Sakakura, D Gonçalves, RM Pereira, E Marcantonio, SR Orrico |
Journal of Periodontology | 2007 |
Zoledronic acid-induced IPP/ApppI production in vivo
H Mönkkönen, PD Ottewell, J Kuokkanen, J Mönkkönen, S Auriola, I Holen |
Life Sciences | 2007 |
Combination therapy for treatment of osteoporosis: A review
JA Pinkerton, AC Dalkin |
American Journal of Obstetrics and Gynecology | 2007 |
Anabolic effects of bisphosphonates on peri-implant bone stock
F Knoch, C Eckhardt, CI Alabre, E Schneider, HE Rubash, AS Shanbhag |
Biomaterials | 2007 |
Therapy Insight: the risks and benefits of bisphosphonates for the treatment of tumor-induced bone disease
CR Dunstan, D Felsenberg, MJ Seibel |
Nature Clinical Practice Oncology | 2007 |
Anti-tumor effect of bisphosphonate (YM529) on non-small cell lung cancer cell lines
R Koshimune, M Aoe, S Toyooka, F Hara, M Ouchida, M Tokumo, Y Sano, H Date, N Shimizu |
BMC Cancer | 2007 |
Osteoimmunology
M Rauner, W Sipos, P Pietschmann |
International Archives of Allergy and Immunology | 2007 |
Cytotoxic activity of the third-generation bisphosphonate zoledronic acid in acute myeloid leukemia
M Fiegl, M Juergens, W Hiddemann, J Braess |
Leukemia Research | 2007 |
Bisphosphonates and osteonecrosis of the jaws: Science and rationale
R Gutta, PJ Louis |
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2007 |
Bisphosphonate-associated osteonecrosis of the jaws: a therapeutic dilemma
R Diego, O D’Orto, D Pagani, A Agazzi, U Marzano, GD Troletti, W Fontanella, L Pignataro |
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2007 |
Comment on the American Association of Oral and Maxillofacial Surgeons Statement on Bisphosphonates
JJ Zahrowski |
Journal of Oral and Maxillofacial Surgery | 2007 |
Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals
C Magopoulos, G Karakinaris, Z Telioudis, K Vahtsevanos, I Dimitrakopoulos, K Antoniadis, S Delaroudis |
American Journal of Otolaryngology | 2007 |
Effect of local delivery of alendronate on bone formation in bioactive glass grafting in rats
S Srisubut, A Teerakapong, T Vattraphodes, S Taweechaisupapong |
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2007 |
Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis
Y Zheng, H Zhou, K Brennan, JM Blair, JR Modzelewski, MJ Seibel, CR Dunstan |
Bone | 2007 |
Treatment of the Postmenopausal Woman
FS Keating, JC Stevenson |
Treatment of the Postmenopausal Woman | 2007 |
Pharmacokinetic profile of bisphosphonates in the treatment of metabolic bone disorders
L Sinigaglia, M Varenna, S Casari |
Clinical Cases in Mineral and Bone Metabolism | 2007 |
Bisphosphonate treatment: An orthodontic concern calling for a proactive approach
JJ Zahrowski |
American Journal of Orthodontics and Dentofacial Orthopedics | 2007 |
Comparative effects of five bisphosphonates on apoptosis of macrophage cells in vitro
MF Moreau, C Guillet, P Massin, S Chevalier, H Gascan, MF Baslé, D Chappard |
Biochemical Pharmacology | 2007 |
Osteonecrosis of the jaw and bisphosphonates: A comparison with white phosphorus, radium, and osteopetrosis
MA Vance |
Clinical Toxicology | 2007 |
Comprehensive Medicinal Chemistry II
E Littler, XX Zhou |
Comprehensive Medicinal Chemistry II | 2007 |
The in vitro anti-tumour activity of zoledronic acid and docetaxel at clinically achievable concentrations in prostate cancer
C Morgan, PD Lewis, RM Jones, G Bertelli, GA Thomas, RC Leonard |
Acta Oncologica | 2007 |
Bisphosphonate induced osteonecrosis of the jaws: Unravelling uncertainty in disease causality
FC Kelleher, M McKenna, C Collins, G Brady, I Collins, J Crown |
Acta Oncologica | 2007 |
Mechanism of Action, Pharmacokinetic and Pharmacodynamic Profile, and Clinical Applications of Nitrogen-containing Bisphosphonates
DB Kimmel |
Journal of dental research | 2007 |
Potential Applications of Biphosphonates in Dental Surgical Implants
D Berardi, T Carlesi, F Rossi, M Calderini, R Volpi, G Perfetti |
International journal of immunopathology and pharmacology | 2007 |
Emergencies in Urology
M Hohenfellner, RA Santucci |
2007 | |
Synthesis and Biological Evaluation of α-Halogenated Bisphosphonate and Phosphonocarboxylate Analogues of Risedronate
MS Marma, Z Xia, C Stewart, F Coxon, JE Dunford, R Baron, BA Kashemirov, FH Ebetino, JT Triffitt, RG Russell, CE McKenna |
Journal of Medicinal Chemistry | 2007 |
Einführung in die Bisphosphonate: Geschichte und Wirkungsmechanismen
H Fleisch |
Der Orthopäde | 2007 |
Oncologic Emergencies
Jacobsen NE, Beck SD, Foster RS |
2007 | |
Cytosolic entry of bisphosphonate drugs requires acidification of vesicles after fluid-phase endocytosis
K Thompson, MJ Rogers, FP Coxon, JC Crockett |
Molecular pharmacology | 2006 |
A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo
K Sato, T Yuasa, M Nogawa, S Kimura, H Segawa, A Yokota, T Maekawa |
British Journal of Cancer | 2006 |
The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis
N Horie, H Murata, Y Nishigaki, T Matsui, H Segawa, M Nogawa, T Yuasa, S Kimura, T Maekawa, S Fushiki, T Kubo |
Cancer Letters | 2006 |
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
H Mönkkönen, S Auriola, P Lehenkari, M Kellinsalmi, IE Hassinen, J Vepsäläinen, J Mönkkönen |
British Journal of Pharmacology | 2006 |
Ibandronate treatment for osteoporosis: Rationale, preclinical and clinical development of extended dosing regimens
S Epstein |
Current Osteoporosis Reports | 2006 |
Sequence- and concentration-dependent effects of acute and long-term exposure to the bisphosphonate ibandronate in combination with single and multiple fractions of ionising radiation doses in human breast cancer cell lines
F Journé, N Magné, C Chaboteaux, E Kinnaert, F Bauss, JJ Body |
Clinical & Experimental Metastasis | 2006 |
Neuropathy-induced osteopenia in rats is not due to a reduction in weight born on the affected limb
GT Whiteside, JM Boulet, R Sellers, TE Bunton, K Walker |
Bone | 2006 |
Relative binding affinities of bisphosphonates for human bone and relationship to antiresorptive efficacy
CT Leu, E Luegmayr, LP Freedman, GA Rodan, AA Reszka |
Bone | 2006 |
Bisphosphonate actions: Physical chemistry revisited
SE Papapoulos |
Bone | 2006 |
Synergistic antimyeloma effects of zoledronate and simvastatin
R Schmidmaier, M Simsek, P Baumann, B Emmerich, G Meinhardt |
Anti-Cancer Drugs | 2006 |
Bone regeneration in limb lengthening
JL Walker, S Battibugli |
Current Opinion in Orthopaedics | 2006 |
Anticancer effects of zoledronic acid against human osteosarcoma cells
B Kubista, K Trieb, F Sevelda, C Toma, F Arrich, P Heffeter, L Elbling, H Sutterlüty, K Scotlandi, R Kotz, M Micksche, W Berger |
Journal of Orthopaedic Research | 2006 |
Inhibitory effects of a new bisphosphonate, minodronate, on proliferation and invasion of a variety of malignant bone tumor cells
T Kubo, S Shimose, T Matsuo, K Tanaka, Y Yasunaga, A Sakai, M Ochi |
Journal of Orthopaedic Research | 2006 |
Biphosphonates in Advanced Prostate and Renal Cell Cancer – Current Status and Potential Applications
CE Hoesl, JE Altwein |
Urologia Internationalis | 2006 |
Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate
X Deng, Z Yu, H Funayama, N Shoji, T Sasano, Y Iwakura, S Sugawara, Y Endo |
Toxicology and Applied Pharmacology | 2006 |
Effects of a combined alendronate and calcitriol agent (Maxmarvil®) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study
Y Rhee, M Kang, Y Min, D Byun, Y Chung, C Ahn, K Baek, J Mok, D Kim*, D Kim**, H Kim, Y Kim, S Myoung, D Kim***, SK Lim |
Osteoporosis International | 2006 |
Cytotoxicity evaluation of sodium alendronate on cultured human periodontal ligament fibroblasts
VF Correia, CL Caldeira, MM Marques |
Dental Traumatology | 2006 |
Bioequivalence and pharmacokinetics of 70 mg alendronate sodium tablets by measuring alendronate in plasma
MH Yun, JS Woo, KI Kwon |
Archives of Pharmacal Research | 2006 |
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts
JT Woo, M Kawatani, M Kato, T Shinki, T Yonezawa, N Kanoh, H Nakagawa, M Takami, KH Lee, PH Stern, K Nagai, H Osada |
Proceedings of the National Academy of Sciences | 2006 |
Les bisphosphonates oraux dans le traitement de l'ostéoporose postménopausique
T Thomas, V Breuil, K Briot |
Revue du Rhumatisme | 2006 |
Emerging Issues With Bisphosphonates
IR Reid |
Rheumatic Disease Clinics of North America | 2006 |
Is it feasible to adjust bisphosphonate dose according to bone mineral density value in postmenopausal breast cancer patients with bone metastases?
T Delibasi, NI Akkus, O Altundag, T Pinar, K Altundag |
Medical Hypotheses | 2006 |
Bisphosphonate-induced avascular osteonecrosis of the jaws: a clinical report of 11 cases
I Dimitrakopoulos, C Magopoulos, D Karakasis |
International Journal of Oral and Maxillofacial Surgery | 2006 |
Use of Bisphosphonates to Improve the Durability of Total Joint Replacements:
AS Shanbhag |
The Journal of the American Academy of Orthopaedic Surgeons | 2006 |
Additive/synergistic anti-tumoral effects of the combination of docetaxel and zoledronic acid on prostate cancer cells: Possible mechanisms?
AU Ural, F Avcu |
Acta Oncologica | 2006 |
Increased excretion of collagen crosslinks in irradiated patients indicates destruction of collagen
P Niehoff, J Wiltfang, IN Springer, N Weppner, B Kimmig, Y Acil |
International Journal of Radiation Biology | 2006 |
In vitrosynergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells
AU Ural, F Avcu, M Candir, M Guden, MA Ozcan |
Breast Cancer Research | 2006 |
In Vitro Effects of Aminobisphosphonates on Vγ9Vδ2 T Cell Activation and Differentiation
V Ferlazzo, C Sferrazza, N Caccamo, GD Fede, GD Lorenzo, M D'Asaro, S Meraviglia, F Dieli, G Rini, A Salerno |
International journal of immunopathology and pharmacology | 2006 |
Immunocytochemical Study of Amelogenin Deposition during the Early Odontogenesis of Molars in Alendronate-treated Newborn Rats
LF Massa, V Bradaschia-Correa, VE Arana-Chavez |
Journal of Histochemistry & Cytochemistry | 2006 |
Bisphosphonates: From Bench to Bedside
RG Russell |
Annals of the New York Academy of Sciences | 2006 |
The Effect of Anti-TNF- Therapy on Spinal Bone Mineral Density in Patients with Crohn's Disease
M Pazianas |
Annals of the New York Academy of Sciences | 2006 |
Current Topics in Pharmacological Research on Bone Metabolism: Inhibitory Effects of Bisphosphonates on the Differentiation and Activity of Osteoclasts
K Suzuki, S Takeyama, Y Sakai, S Yamada, H Shinoda |
Journal of Pharmacological Sciences | 2006 |
Effects of a combined alendronate and calcitriol agent (Maxmarvil®) on bone metabolism in Korean postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study
Y Rhee, M Kang, Y Min, D Byun, Y Chung, C Ahn, K Baek, J Mok, D Kim, D Kim, H Kim, Y Kim, S Myoung, D Kim, SK Lim |
Osteoporosis International | 2006 |
Bisphosphonates decrease telomerase activity and hTERT expression in MCF-7 breast cancer cells
LD Carbonare, MT Valenti, G Azzarello, E Balducci, G Crepaldi, G Realdi, O Vinante, S Giannini |
Molecular and Cellular Endocrinology | 2005 |
Comparison of Fc-osteoprotegerin and zoledronic acid activities suggests that zoledronic acid inhibits prostate cancer in bone by indirect mechanisms
JE Quinn, LG Brown, J Zhang, ET Keller, RL Vessella, E Corey |
Prostate Cancer and Prostatic Diseases | 2005 |
Evolving therapeutic role of bisphosphonates in multiple myeloma
AU Ural, F Avcu |
British Journal of Cancer | 2005 |
Neridronate and human osteoblasts in normal, osteoporotic and osteoarthritic subjects
A Corrado, FP Cantatore, M Grano, S Colucci |
Clinical Rheumatology | 2005 |
Zoledronate synergises with imatinib mesylate to inhibit Ph+ primary leukaemic cell growth
H Segawa, S Kimura, J Kuroda, K Sato, A Yokota, E Kawata, Y Kamitsuji, E Ashihara, T Yuasa, Y Fujiyama, OG Ottmann, T Maekawa |
British Journal of Haematology | 2005 |
Monitoring luciferase-labeled cancer cell growth and metastasis in different in vivo models
M Nogawa, T Yuasa, S Kimura, J Kuroda, K Sato, H Segawa, A Yokota, T Maekawa |
Cancer Letters | 2005 |
Microdamage accumulation in the monkey vertebra does not occur when bone turnover is suppressed by 50% or less with estrogen or raloxifene
J Li, M Sato, C Jerome, CH Turner, Z Fan, DB Burr |
Journal of Bone and Mineral Metabolism | 2005 |
The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats
H Kajiwara, T Yamaza, M Yoshinari, T Goto, S Iyama, I Atsuta, MA Kido, T Tanaka |
Biomaterials | 2005 |
Nitrogen-Containing Biphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
SP Luckman, DE Hughes, FP Coxon, RG Russell, MJ Rogers |
Journal of Bone and Mineral Research | 2005 |
Effects of alendronate on the markers of bone metabolic activity in postmenopausal women with osteoporosis
J Ilic, B Kovacev, LB J., N Curic, J Radosavljevic |
Medicinski pregled | 2005 |
The Cochrane Database of Systematic Reviews (Protocol)
VG da Silva, GA Romito, JM Aldrighi, A Cranney, GH Gomes, A Tirlone, FE Pustiglioni, VG da Silva |
The Cochrane Database of Systematic Reviews (Protocol) | 2005 |
Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo
FP Coxon, FH Ebetino, EH Mules, MC Seabra, CE McKenna, MJ Rogers |
Bone | 2005 |
Inhibition of Inflammatory and Bone-Resorption–Inhibitory Effects of Alendronate by Etidronate
H Funayama, M Ohsako, Y Monma, H Mayanagi, S Sugawara, Y Endo |
Calcified Tissue International | 2005 |
Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone
CA Migliorati, MM Schubert, DE Peterson, LM Seneda |
Cancer | 2005 |
Histological comparison of alendronate, calcium hydroxide and formocresol in amputated rat molar
SB Cengiz, Y Batirbaygil, MA Onur, P Atilla, E Asan, N Altay, ZC Cehreli |
Dental Traumatology | 2005 |
Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells
C Chuah, DJ Barnes, M Kwok, A Corbin, MW Deininger, BJ Druker, JV Melo |
Leukemia | 2005 |
Combined effects of zoledronic acid and doxorubicin on breast cancer cell invasion in vitro
JK Woodward, HL Neville-Webbe, RE Coleman, I Holen |
Anti-Cancer Drugs | 2005 |
Zoledronic acid suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing mice
B Ory, MF Heymann, A Kamijo, F Gouin, D Heymann, F Redini |
Cancer | 2005 |
Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cells from dogs
JA Ashton, JP Farese, RJ Milner, LM Lee-Ambrose, JM van Gilder |
American Journal of Veterinary Research | 2005 |
Skeletal Retention of Bisphosphonate (Pamidronate) and Its Relation to the Rate of Bone Resorption in Patients With Breast Cancer and Bone Metastases
SC Cremers, SE Papapoulos, H Gelderblom, C Seynaeve, J Hartigh, P Vermeij, CC van derRijt, L Zuylen |
Journal of Bone and Mineral Research | 2005 |
Bisphosphonate Modulates Cementoblast Behavior In Vitro
YH Chun, BL Foster, PA Lukasavage, JE Berry, M Zhao, HC Tenenbaum, MJ Somerman |
Journal of Periodontology | 2005 |
Systemic Low-Dose Doxycycline and Alendronate Administration and Serum Interleukin-1Beta, Osteocalcin, and C-Reactive Protein Levels in Rats
E Buduneli, N Buduneli, S Vardar-Şengül, L Kardeşler, G Atilla, D Lappin, DF Kinane |
Journal of Periodontology | 2005 |
The decrease of particle-induced osteolysis after a single dose of bisphosphonate
M Knoch, C Wedemeyer, A Pingsmann, F Knoch, G Hilken, C Sprecher, F Henschke, B Barden, F Löer |
Biomaterials | 2005 |
Osteolytic bone diseases: physiological analogues of bone resorption effectors as alternative therapeutic tools
D Heymann, Y Fortun, F Rédini, M Padrines |
Drug Discovery Today | 2005 |
The anti-leukemic efficacy of the third generation bisphosphonate ONO5920/YM529
H Segawa, S Kimura, J Kuroda, K Sato, M Nogawa, T Yuasa, A Yokota, K Hodohara, Y Fujiyama, T Maekawa |
Leukemia Research | 2005 |
Zoledronic acid: pharmacologic profile of a potent bisphosphonate
JR Green |
Journal of Organometallic Chemistry | 2005 |
Synergistic cytotoxic effects of zoledronic acid and radiation in human prostate cancer and myeloma cell lines
E Algur, RM Macklis, UO Häfeli |
International journal of radiation oncology, biology, physics | 2005 |
Zoledronic acid sensitizes tumor cells to radiation: In response to Algur et al. (Int J Radiat Oncol Biol Phys 2005;61:535–542)
AU Ural, F Avcu |
International journal of radiation oncology, biology, physics | 2005 |
The influence of alendronate on bone formation after autogenous free bone grafting in rats
H Altundal, B Gursoy |
Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2005 |
Osteoclast responses to lipopolysaccharide, parathyroid hormone and bisphosphonates in neonatal murine calvaria analyzed by laser scanning confocal microscopy
K Suzuki, S Takeyama, T Kikuchi, S Yamada, J Sodek, H Shinoda |
Journal of Histochemistry & Cytochemistry | 2005 |
Effects of alendronate on bone mineral density and bone metabolic markers in postmenopausal asthmatic women treated with inhaled corticosteroids
S Kasayama, M Fujita, K Goya, H Yamamoto, K Fujita, Y Morimoto, I Kawase, A Miyatake |
Metabolism | 2005 |
Osteoclast Responses to Lipopolysaccharide, Parathyroid Hormone and Bisphosphonates in Neonatal Murine Calvaria Analyzed by Laser Scanning Confocal Microscopy
K Suzuki, S Takeyama, T Kikuchi, S Yamada, J Sodek, H Shinoda |
Journal of Histochemistry & Cytochemistry | 2005 |
Managing the care of patients with bisphosphonate-associated osteonecrosis
CA Migliorati, J Casiglia, J Epstein, PL Jacobsen, MA Siegel, SB Woo |
The Journal of the American Dental Association | 2005 |
Additive/synergistic antitumoral effects on prostate cancer cells in vitro following treatment with a combination of docetaxel and zoledronic acid
A Ullén, L Lennartsson, U Harmenberg, M Hjelm-Eriksson, KM Kälkner, B Lennernäs, S Nilsson |
Acta Oncologica | 2005 |
Additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell lines
F Journe, C Chaboteaux, N Magne, H Duvillier, G Laurent, JJ Body |
Breast Cancer Research | 2005 |
ROL' I MESTO BISFOSFONATOV V PROFILAKTIKE I LEChENII OSTEOPOROZA. 10-LETNIY OPYT PRIMENENIYa ALENDRONATA (FOSAMAKSA)Obzor literatury
II Dedov, LY Rozhinskaya, ZE Belaya |
Osteoporosis and osteopathy | 2005 |
Discovery, Clinical Development, and Therapeutic Uses of Bisphosphonates
AA Licata |
The Annals of pharmacotherapy | 2005 |
Pharmacokinetics/Pharmacodynamics of Bisphosphonates: Use for Optimisation of Intermittent Therapy for Osteoporosis
SC Cremers, GC Pillai, SE Papapoulos |
Clinical Pharmacokinetics | 2005 |
Pharmacokinetic Considerations in Determining the Terminal Elimination Half-Lives of Bisphosphonates:
KC Lasseter, AG Porras, A Denker, A Santhanagopal, A Daifotis |
Clinical Drug Investigation | 2005 |
Alendronate Prevents Alveolar Bone Loss in Experimental Rat Periodontitis
H Seto, C Wada, M Horibe, T Nagata |
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) | 2005 |
The Inhibition of RANKL Causes Greater Suppression of Bone Resorption and Hypercalcemia Compared with Bisphosphonates in Two Models of Humoral Hypercalcemia of Malignancy
S Morony, K Warmington, S Adamu, F Asuncion, Z Geng, M Grisanti, HL Tan, C Capparelli, C Starnes, B Weimann, CR Dunstan, PJ Kostenuik |
Endocrinology | 2005 |
p53‐independent anti‐tumor effects of the nitrogen‐containing bisphosphonate zoledronic acid
Kuroda J, Kimura S, Segawa H, Sato K, Matsumoto S, Nogawa M, Yuasa T, Kobayashi Y, Yoshikawa T, Ottmann OG, Maekawa T |
Cancer Science | 2005 |
Functional foods, ageing and degenerative disease
L Ovesen |
Functional foods, ageing and degenerative disease | 2004 |
Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodronate on breast cancer cells
F Journe, C Chaboteaux, JC Dumon, G Leclercq, G Laurent, JJ Body |
British Journal of Cancer | 2004 |
A theoretical analysis of long-term bisphosphonate effects on trabecular bone volume and microdamage
JS Nyman, OC Yeh, SJ Hazelwood, RB Martin |
Bone | 2004 |
Preventing osteoporotic fractures with antiresorptive therapy: implications of microarchitectural changes
S Boonen, P Haentjens, L Vandenput, D Vanderschueren |
Journal of Internal Medicine | 2004 |
Bone safety of long-term bisphosphonate treatment
G Rodan, A Reszka, E Golub, R Rizzoli |
Current Medical Research and Opinion | 2004 |
Osteoblast proliferation and maturation by bisphosphonates
GI Im, SA Qureshi, J Kenney, HE Rubash, AS Shanbhag |
Biomaterials | 2004 |
The Nitrogen-Containing Bisphosphonate, Zoledronic Acid, Influences RANKL Expression in Human Osteoblast-Like Cells by Activating TNF-α Converting Enzyme (TACE)
B Pan, AN Farrugia, LB To, DM Findlay, J Green, K Lynch, AC Zannettino |
Journal of Bone and Mineral Research | 2004 |
From Molds and Macrophages to Mevalonate: A Decade of Progress in Understanding the Molecular Mode of Action of Bisphosphonates
MJ Rogers |
Calcified Tissue International | 2004 |
Cytostatic and Apoptotic Effects of Bisphosphonates on Prostate Cancer Cells
JC Dumon, F Journé, N Kheddoumi, L Lagneaux, JJ Body |
European Urology | 2004 |
Antiproliferative Efficacy of the Third-Generation Bisphosphonate, Zoledronic Acid, Combined with Other Anticancer Drugs in Leukemic Cell Lines
S Kimura, J Kuroda, H Segawa, K Sato, M Nogawa, T Yuasa, OG Ottmann, T Maekawa |
International Journal of Hematology | 2004 |
Topical, single dose bisphosphonate treatment reduced bone resorption in a rat model for prosthetic loosening
J Åstrand, P Aspenberg |
Journal of Orthopaedic Research | 2004 |
Zoledronic acid induces apoptosis and inhibits adhesion to mineralized matrix in prostate cancer cells via inhibition of protein prenylation
JP Coxon, GM Oades, RS Kirby, KW Colston |
BJU International | 2004 |
THE EFFECT OF THE BISPHOSPHONATE ALENDRONATE ON VIABILITY OF CANINE OSTEOSARCOMA CELLS IN VITRO
JP Farese, J Ashton, R Milner, LL Ambrose, JV Gilder |
In Vitro Cellular & Developmental Biology - Animal | 2004 |
p53-independent anti-tumor effects of the nitrogen-containing bisphosphonate zoledronic acid
J Kuroda, S Kimura, H Segawa, K Sato, S Matsumoto, M Nogawa, T Yuasa, Y Kobayashi, T Yoshikawa, OG Ottmann, T Maekawa |
Cancer Science | 2004 |
Bisphosphonates: new therapeutic agents for the treatment of bone tumors
D Heymann, B Ory, F Gouin, JR Green, F Rédini |
Trends in Molecular Medicine | 2004 |
Differential Inhibition of Invasion and Proliferation by Bisphosphonates: Anti-Metastatic Potential of Zoledronic Acid in Prostate Cancer
R Montague, CA Hart, NJ George, VA Ramani, MD Brown, NW Clarke |
European Urology | 2004 |
Long-term effects of neridronate on human osteoblastic cell cultures
B Frediani, A Spreafico, C Capperucci, F Chellini, D Gambera, P Ferrata, F Baldi, P Falsetti, A Santucci, L Bocchi, R Marcolongo |
Bone | 2004 |
Preclinical Investigations of Drug and Radionuclide Conjugates of Bisphosphonates for the Treatment of Metastatic Bone Cancer
A El-Mabhouh, C Angelov, A McEwan, G Jia, J Mercer |
Cancer Biotherapy & Radiopharmaceuticals | 2004 |
The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro
B Pan, LB To, AN Farrugia, DM Findlay, J Green, S Gronthos, A Evdokiou, K Lynch, GJ Atkins, AC Zannettino |
Bone | 2004 |
Effects of vitamin K2 (menatetrenone) and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet
M Kobayashi, K Hara, Y Akiyama |
Bone | 2004 |
Effects of Combined Systemic Administration of Low-Dose Doxycycline and Alendronate on Endotoxin-Induced Periodontitis in Rats
E Buduneli, S Vardar, N Buduneli, AH Berdeli, O Türkoǧlu, A Başkesen, G Atilla |
Journal of Periodontology | 2004 |
Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition
M Chaplet, C Detry, C Deroanne, LW Fisher, V Castronovo, A Bellahcéne |
Biochemical Journal | 2004 |
The effect of alendronate sodium on spinal fusion: a rabbit model
RA Lehman, TR Kuklo, BA Freedman, JR Cowart, MG Mense, KD Riew |
The Spine Journal | 2004 |
Particle bioreactivity and wear-mediated osteolysis
ML Wang, PF Sharkey, RS Tuan |
The Journal of Arthroplasty | 2004 |
In vitro toxicity of bisphosphonates on human neuroblastoma cell lines:
M Vorotnjak, J Boos, C Lanvers-Kaminsky |
Anti-Cancer Drugs | 2004 |
Advances in the use of bisphosphonates in the prostate cancer setting
JP Coxon, GM Oades, KW Colston, RS Kirby |
Prostate Cancer and Prostatic Diseases | 2004 |
High-dose Alendronate Uncouples Osteoclast and Osteoblast Function: A Study in a Rat Spine Pseudarthrosis Model
AA Sama, SN Khan, ER Myers, RC Huang, FP Cammisa, HS Sandhu, JM Lane |
Clinical Orthopaedics and Related Research® | 2004 |
The Role of Bisphosphonates in the Treatment of Skeletal Complications of Breast Cancer:
BF El-Rayes, PM LoRusso |
American Journal of Cancer | 2004 |
Bone Metastasis and Molecular Mechanisms
G Singh, W Orr |
2004 | |
Applications of Pharmacokinetic Principles in Drug Development
R Krishna |
2004 | |
The Biology of Skeletal Metastases
ET Keller, LW Chung |
2004 | |
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate
S Kimura, J Kuroda, T Maekawa |
Ensho Saisei | 2004 |
Bisphosphonates: Preclinical Review
JR Green |
The oncologist | 2004 |
THE EFFECT OF THE BISPHOSPHONATE ALENDRONATE ON VIABILITY OF CANINE OSTEOSARCOMA CELLS IN VITRO
JP Farese, J Ashton, R Milner, LL Ambrose, JV Gilder |
In vitro cellular & developmental biology. Animal | 2004 |
Antitumor effects of bisphosphonates
JR Green |
Cancer | 2003 |
The role of bisphosphonates in diseases of childhood
T Srivastava, US Alon |
European Journal of Pediatrics | 2003 |
A Histopathological Investigation on the Effect of Systemic Administration of the Bisphosphonate Alendronate on Resorptive Phase Following Mucoperiosteal Flap Surgery in the Rat Mandible
D Kaynak, R Meffert, H Bostancı, Ö Günhan, ÖG Özkaya |
Journal of Periodontology | 2003 |
The Bisphosphonate Zoledronic Acid Induces Cytotoxicity in Human Myeloma Cell Lines with Enhancing Effects of Dexamethasone and Thalidomide
AU Ural, MI Yilmaz, F Avcu, A Pekel, M Zerman, O Nevruz, A Sengul, A Yalcin |
International Journal of Hematology | 2003 |
Bisphosphonate mechanism of action
AA Reszka, GA Rodan |
Current Rheumatology Reports | 2003 |
Mechanism of action of bisphosphonates
AA Reszka, GA Rodan |
Current Osteoporosis Reports | 2003 |
Antagonistic Effects of Different Classes of Bisphosphonates in Osteoclasts and Macrophages In Vitro
JC Frith, MJ Rogers |
Journal of Bone and Mineral Research | 2003 |
Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis
A Evdokiou, A Labrinidis, S Bouralexis, S Hay, DM Findlay |
Bone | 2003 |
Nitrogen Containing Bisphosphonates Induce Apoptosis and Inhibit the Mevalonate Pathway, Impairing Ras Membrane Localization in Prostate Cancer Cells
GM Oades, SG Senaratne, IA Clarke, RS Kirby, KW Colston |
The Journal of Urology | 2003 |
The bisphosphonates alendronate and zoledronate are inhibitors of canine and human osteosarcoma cell growth in vitro
VJ Poirier, MK Huelsmeyer, ID Kurzman, DH Thamm, DM Vail |
Veterinary and Comparative Oncology | 2003 |
The development and function of the skeleton and bone metastases
GA Rodan |
Cancer | 2003 |
Combined Local Application of Tetracycline and Bisphosphonate Reduces Alveolar Bone Resorption in Rats
A Yaffe, A Herman, H Bahar, I Binderman |
Journal of Periodontology | 2003 |
The Influence of Alendronate on Bone Formation and Resorption in a Rat Ectopic Bone Development Model
A Yaffe, R Kollerman, H Bahar, I Binderman |
Journal of Periodontology | 2003 |
Periodontal Host Modulation with Antiproteinase, Anti-Inflammatory, and Bone-Sparing Agents.A Systematic Review
MS Reddy, NC Geurs, JC Gunsolley |
Annals of Periodontology | 2003 |
Review of ibandronate in the treatment of osteoporosis
RD Chapurlat, PD Delmas |
Expert Opinion on Pharmacotherapy | 2003 |
Preventive effects of sequential treatment with alendronate and 1α-hydroxyvitamin D3 on bone mass and strength in ovariectomized rats
M Ito, Y Azuma, H Takagi, T Kamimura, K Komoriya, T Ohta, H Kawaguchi |
Bone | 2003 |
Involvement of vacuolar H+-ATPase in incorporation of risedronate into osteoclasts
M Takami, K Suda, T Sahara, K Itoh, K Nagai, T Sasaki, N Udagawa, N Takahashi |
Bone | 2003 |
Bisphosphonates antagonise bone growth factors' effects on human breast cancer cells survival
O Fromigue, N Kheddoumi, JJ Body |
British Journal of Cancer | 2003 |
New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects
C Denoyelle, L Hong, JP Vannier, J Soria, C Soria |
British Journal of Cancer | 2003 |
Regulation of MMP-9 (gelatinase B) in activated human monocyte/macrophages by two different types of bisphosphonates
H Valleala, R Hanemaaijer, J Mandelin, A Salminen, O Teronen, J Mönkkönen, YT Konttinen |
Life Sciences | 2003 |
Management of glucocorticoid induced osteoporosis in premenopausal women with autoimmune disease
Nathalie Franchimont, Ernesto Canalis |
Autoimmunity Reviews | 2003 |
Intracellular membrane trafficking in bone resorbing osteoclasts: Membrane Trafficking in Osteoclasts
M Mulari, J Vääräniemi, HK Väänänen |
Microscopy Research and Technique | 2003 |
A Simulation Model at Trabecular Level to Predict Effects of Antiresorptive Treatment after Menopause
JC van der Linden, JA Verhaar, HA Pols, H Weinans |
Calcified Tissue International | 2003 |
Mandible and Maxilla Bone Mineral Density and Threshold Analysis Studies by pQCT in Two Edentulous Women Receiving Pamidronate
VE Montangero, R Capiglioni, EJ Roldán |
CRANIO | 2003 |
OSTEOPOROSIS AND BISPHOSPHONATES☆:
GA Rodan, AA Reszka |
The Journal of Bone and Joint Surgery. American volume. | 2003 |
New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects
C Denoyelle, L Hong, JP Vannier, J Soria, C Soria |
British Journal of Cancer | 2003 |
Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro
P Tassone, P Tagliaferri, C Viscomi, C Palmieri, M Caraglia, A D'Alessandro, E Galea, A Goel, A Abbruzzese, CR Boland, S Venuta |
British Journal of Cancer | 2003 |
Cellular mechanism of inhibition of osteoclastic resorption of bone and calcified cartilage by long-term pamidronate administration in ovariectomized mature rats
M Mayahara, T Sasaki |
The Anatomical Record | 2003 |
The effect of sintered dicalcium pyrophosphate on osteoclast metabolism: An ultrastructural study
JS Sun, YC Huang, FH Lin, LT Chen |
Journal of Biomedical Materials Research | 2003 |
Bone as an Effect Compartment: Models for Uptake and Release of Drugs
D Stepensky, L Kleinberg, A Hoffman |
Clinical Pharmacokinetics | 2003 |
New Bone Formation with Teriparatide [Human Parathyroid Hormone-(1–34)] Is Not Retarded by Long-Term Pretreatment with Alendronate, Estrogen, or Raloxifene in Ovariectomized Rats
YL Ma, HU Bryant, Q Zeng, A Schmidt, J Hoover, HW Cole, W Yao, WS Jee, M Sato |
Endocrinology | 2003 |
Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
S Yaccoby, RN Pearse, CL Johnson, B Barlogie, Y Choi, J Epstein |
British Journal of Haematology | 2002 |
Dissociation of Angiogenesis and Osteoclastogenesis During Endochondral Bone Formation in Neonatal Mice
MM Deckers, ER van Beek, GV der Pluijm, A Wetterwald, LV der Wee-Pals, MG Cecchini, SE Papapoulos, CW Löwik |
Journal of Bone and Mineral Research | 2002 |
Drugs in development: bisphosphonates and metalloproteinase inhibitors
JB Catterall, TE Cawston |
Arthritis Research & Therapy | 2002 |
Synergistic Growth Inhibition of YM529 with Biologic Response Modifiers (BRMs) in Myeloma Cells
K Yata, T Otsuki, O Yamada, H Wada, Y Yawata, T Sugihara |
International Journal of Hematology | 2002 |
Pharmacological and clinical properties of alendronate sodium hydrate
T OHTA, S KOMATSU, N TOKUTAKE |
Folia Pharmacologica Japonica | 2002 |
Bisphosphonates and Periodontics: Potential Applications for Regulation of Bone Mass in the Periodontium and Other Therapeutic/ Diagnostic Uses
HC Tenenbaum, A Shelemay, B Girard, R Zohar, PC Fritz |
Journal of Periodontology | 2002 |
A Cysteine Protease Inhibitor Prevents Suspension-Induced Declines in Bone Weight and Strength in Rats
T Nikawa, M Ikemoto, C Watanabe, T Kitano, M Kano, M Yoshimoto, T Towatari, N Katunuma, F Shizuka, K Kishi |
Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science | 2002 |
Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines
P Heikkilä, O Teronen, M Moilanen, YT Konttinen, R Hanemaaijer, M Laitinen, P Maisi, G der Pluijm, JD Bartlett, T Salo, T Sorsa |
Anti-Cancer Drugs | 2002 |
Curative Effect of Combined Treatment With Alendronate and 1α-Hydroxyvitamin D3 on Bone Loss by Ovariectomy in Aged Rats
M Ito, Y Azuma, H Takagi, K Komoriya, T Ohta, H Kawaguchi |
The Japanese Journal of Pharmacology | 2002 |
Mechanisms of Bisphosphonate Effects on Osteoclasts, Tumor Cell Growth, and Metastasis
JR Green, P Clézardin |
American Journal of Clinical Oncology | 2002 |
Future Directions in the Treatment and Prevention of Bone Metastases
RE Coleman |
American Journal of Clinical Oncology | 2002 |
Bisphosphonates in cancer therapy
JR Green |
Current Opinion in Oncology | 2002 |
Pharmacologic profile of zoledronic acid: A highly potent inhibitor of bone resorption
JR Green, MJ Rogers |
Drug Development Research | 2002 |
Intravenous Zoledronic Acid in Postmenopausal Women with Low Bone Mineral Density
IR Reid, JP Brown, P Burckhardt, Z Horowitz, P Richardson, U Trechsel, A Widmer, JP Devogelaer, JM Kaufman, P Jaeger, JJ Body, ML Brandi, J Broell, RD Micco, AR Genazzani, D Felsenberg, J Happ, MJ Hooper, J Ittner, G Leb, H Mallmin, T Murray, S Ortolani, A Rubinacci, M Sääf, G Samsioe, L Verbruggen, PJ Meunier |
New England Journal of Medicine | 2002 |
Advances in Cell Aging and Gerontology
T Fülöp, K Hirokawa, G Dupuis, A Larbi, G Pawelec |
Advances in Cell Aging and Gerontology | 2002 |
Bisphosphonates influence the proliferation and the maturation of normal human osteoblasts
O Fromigué, JJ Body |
Journal of Endocrinological Investigation | 2002 |
Treatment of rheumatic diseases in children: special considerations
DS Milojevic, NT Ilowite |
Rheumatic Disease Clinics of North America | 2002 |
Generation and activity of equine osteoclasts in vitro: effects of the bisphosphonate pamidronate (APD)
AW Gray, ME Davies, LB Jeffcott |
Research in Veterinary Science | 2002 |
Effects of Alendronate on Particle-Induced Osteolysis in a Rat Model:
PJ Millett, MJ Allen, MP Bostrom |
The Journal of Bone and Joint Surgery. American volume. | 2002 |
Alendronate Does Not Inhibit Early Bone Apposition to Hydroxyapatite-Coated Total Joint Implants: A Preliminary Study
Y Mochida, TW Bauer, T Akisue, PR Brown |
The Journal of Bone and Joint Surgery. American volume. | 2002 |
Transport of inorganic phosphate in primary cultures of chondrocytes isolated from the tibial growth plate of normal adolescent chickens
LN Wu, Y Guo, BR Genge, Y Ishikawa, RE Wuthier |
Journal of Cellular Biochemistry | 2002 |
Localization of Osteoprotegerin (OPG) on Bone Surfaces and Cement Lines in Rat Tibia
H Nakamura, T Tsuji, A Hirata, T Yamamoto |
Journal of Histochemistry & Cytochemistry | 2002 |
Synergism of Aminobisphosphonates and Farnesyl Transferase Inhibitors on Tumor Metastasis:
VB Andela, JD Rosenblatt, EM Schwarz, EJ Puzas, RJ OKeefe, RN Rosier |
Clinical Orthopaedics and Related Research® | 2002 |
Peptides for the New Millennium
GB Fields, JP Tam, G Barany |
2002 | |
Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP Translocase by a Nonhydrolyzable, Adenine-Containing Metabolite
PP Lehenkari, M Kellinsalmi, JP Näpänkangas, KV Ylitalo, J Mönkkönen, MJ Rogers, A Azhayev, HK Väänänen, IE Hassinen |
Molecular pharmacology | 2002 |
Osteoporose
A Hedtmann, S Götte |
2002 | |
Sequential Treatment with Basic Fibroblast Growth Factor and PTH Is More Efficacious than Treatment with PTH Alone for Increasing Vertebral Bone Mass and Strength in Osteopenic Ovariectomized Rats
UT Iwaniec, L Mosekilde, NG Mitova-Caneva, JS Thomsen, TJ Wronski |
Endocrinology | 2002 |
Inhibition of Particulate Debris-Induced Osteolysis by Alendronate in a Rat Model
PJ Thadani, B Waxman, E Sladek, R Barmada, MH Gonzalez |
Orthopedics | 2002 |
Sintered dicalcium pyrophosphate increases bone mass in ovariectomized rats
JS Sun, YC Huang, YH Tsuang, LT Chen, FH Lin |
Journal of Biomedical Materials Research | 2001 |
The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis
JC Frith, J Mönkkönen, S Auriola, H Mönkkönen, MJ Rogers |
Arthritis & Rheumatism | 2001 |
Maintenance of cortical bone in human parathyroid hormone(1-84)-treated ovariectomized rats
E Samnegård, UT Iwaniec, DM Cullen, DB Kimmel, RR Recker |
Bone | 2001 |
Maintenance of vertebral body bone mass and strength created by human parathyroid hormone treatment in ovariectomized rats
E Samnegård, MP Akhter, RR Recker |
Bone | 2001 |
Molekulare Wirkmechanismen der Bisphosphonate: Osteoklasten im Fadenkreuz
HA Fleisch |
Pharmazie in unserer Zeit | 2001 |
Long-Term Effects of Withdrawal of Bisphosphonate Incadronate Disodium (YM175) on Bone Mineral Density, Mass, Structure, and Turnover in the Lumbar Vertebrae of Ovariectomized Rats
Y Tamura, N Miyakoshi, E Itoi, T Abe, T Kudo, T Tsuchida, Y Kasukawa, K Sato |
Journal of Bone and Mineral Research | 2001 |
Bisphosphonate acts on osteoclasts independent of ruffled borders in osteosclerotic (oc/oc) mice
M Ito, N Amizuka, T Nakajima, H Ozawa |
Bone | 2001 |
Alendronate Therapy of Primary Hyperparathyroidism
S Hassani, GD Braunstein, MJ Seibel, AS Brickman, F Geola, AE Pekary, JM Hershman |
The Endocrinologist | 2001 |
Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro
HL Benford, NW McGowan, MH Helfrich, ME Nuttall, MJ Rogers |
Bone | 2001 |
Bisphosphonates in renal osteodystrophy
SL Fan, J Cunningham |
Current Opinion in Nephrology and Hypertension | 2001 |
Effect of topical alendronate on root resorption of dried replanted dog teeth
L Levin, EC Bryson, D Caplan, M Trope |
Dental Traumatology | 2001 |
Pamidronate decreases tumor-induced osteoclastogenesis in osteopetrotic mice
DR Clohisy, PF O'Keefe, ML Ramnaraine |
Journal of Orthopaedic Research | 2001 |
Bisphosphonates and in vivo models of multiple myeloma
M Salomo, P Gimsing |
British Journal of Haematology | 2001 |
Reply to salomo and gimsing
CM Shipman, PI Croucher, K Vanderkerken |
British Journal of Haematology | 2001 |
Statins and their potential for osteoporosis
GR Mundy |
Bone | 2001 |
Novel therapeutic approaches to cancer patients with bone metastasis
R Maisano, S Pergolizzi, S Cascinu |
Critical Reviews in Oncology/Hematology | 2001 |
Bisphosphonates: mechanisms of action
H Fleisch |
Expert Opinion on Therapeutic Patents | 2001 |
Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption
SM Violette, W Guan, C Bartlett, JA Smith, C Bardelay, E Antoine, RJ Rickles, E Mandine, MR Schravendijk, SE Adams, BA Lynch, WC Shakespeare, M Yang, VA Jacobsen, CS Takeuchi, KJ Macek, RS Bohacek, DC Dalgarno, M Weigele, D Lesuisse, TK Sawyer, R Baron |
Bone | 2001 |
Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis
JM Halasy-Nagy, GA Rodan, AA Reszka |
Bone | 2001 |
The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel
SP Jagdev, RE Coleman, CM Shipman, A Rostami-H, PI Croucher |
British Journal of Cancer | 2001 |
Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line
PS Mackie, JL Fisher, H Zhou, PF Choong |
British Journal of Cancer | 2001 |
A newly developed bisphosphonate, YM529, is a potent apoptosis inducer of human myeloma cells
R Takahashi, C Shimazaki, T Inaba, A Okano, M Hatsuse, A Okamoto, H Hirai, E Ashihara, M Nakagawa |
Leukemia Research | 2001 |
Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption
PA Price, SA Faus, MK Williamson |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Treatment of Osteoporosis with Bisphosphonates
NB Watts |
Rheumatic Disease Clinics of North America | 2001 |
Novel Drug Delivery System to Bone Using Acidic Oligopeptide: Pharmacokinetic Characteristics and Pharmacological Potential
T Sekido, N Sakura, Y Higashi, K Miya, Y Nitta, M Nomura, H Sawanishi, K Morito, Y Masamune, S Kasugai, K Yokogawa, KI Miyamoto |
Journal of Drug Targeting | 2001 |
Effect of 17ß-estradiol or alendronate on the bone densitometry, bone histomorphometry and bone metabolism of ovariectomized rats
LH Paz, V Falco, NC Teng, LM Reis, RM Pereira, V Jorgetti |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] | 2001 |
The role of bisphosphonates in breast cancer: Direct effects of bisphosphonates on breast cancer cells
SG Senaratne, KW Colston |
Breast Cancer Research | 2001 |
Osteoprotegerin Inhibits Artery Calcification Induced by Warfarin and by Vitamin D
PA Price, HH June, JR Buckley, MK Williamson |
Arteriosclerosis, thrombosis, and vascular biology | 2001 |
Alendronate: An Update of its Use in Osteoporosis
M Sharpe, S Noble, CM Spencer |
Drugs | 2001 |
Vγ2Vδ2 T-cell receptor–mediated recognition of aminobisphosphonates
H Das, L Wang, A Kamath, JF Bukowski |
Blood | 2001 |
The cellular uptake and metabolism of clodronate in RAW 264 macrophages
H Mönkkönen, M J Rogers, N Makkonen, S Niva, S Auriola, J Mönkkönen |
Pharmaceutical Research | 2001 |
Cellular and molecular mechanisms of action of bisphosphonates
MJ Rogers, S Gordon, HL Benford, FP Coxon, SP Luckman, J Monkkonen, JC Frith |
Cancer | 2000 |
Effects of Bisphosphonate on Matrix Metalloproteinase Enzymes in Human Periodontal Ligament Cells
H Nakaya, G Osawa, N Iwasaki, DL Cochran, K Kamoi, TW Oates |
Journal of Periodontology | 2000 |
Bisphosphonates Induce Breast Cancer Cell Death In Vitro
O Fromigue, L Lagneaux, JJ Body |
Journal of Bone and Mineral Research | 2000 |
Concentration of Bisphosphonate (Incadronate) in Callus Area and Its Effects on Fracture Healing in Rats
J Li, S Mori, Y Kaji, J Kawanishi, T Akiyama, H Norimatsu |
Journal of Bone and Mineral Research | 2000 |
Alendronate Stimulates Collagenase 3 Expression in Osteoblasts by Posttranscriptional Mechanisms
S Varghese, E Canalis |
Journal of Bone and Mineral Research | 2000 |
Bisphosphonate administration alters subcellular localization of vacuolar-type H+-ATPase and cathepsin K in osteoclasts during experimental movement of rat molars
Y Sato, H Sakai, Y Kobayashi, Y Shibasaki, T Sasaki |
The Anatomical Record | 2000 |
Effectiveness of Local Delivery of Alendronate in Reducing Alveolar Bone Loss Following Periodontal Surgery in Rats
I Binderman, M Adut, A Yaffe |
Journal of Periodontology | 2000 |
Chronic Intravenous Aminobisphosphonate Therapy Increases High-Density Lipoprotein Cholesterol and Decreases Low-Density Lipoprotein Cholesterol
S Adami, V Braga, G Guidi, D Gatti, D Gerardi, E Fracassi |
Journal of Bone and Mineral Research | 2000 |
Alendronate Administration and Skeletal Response During Chronic Alcohol Intake in the Adolescent Male Rat
FH Wezeman, MA Emanuele, SF Moskal, J Steiner, N Lapaglia |
Journal of Bone and Mineral Research | 2000 |
Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma
T Yoneda, T Michigami, B Yi, PJ Williams, M Niewolna, T Hiraga |
Cancer | 2000 |
The Effect of Topical Delivery of Novel Bisacylphosphonates in Reducing Alveolar Bone Loss in the Rat Model
A Yaffe, G Golomb, E Breuer, I Binderman |
Journal of Periodontology | 2000 |
Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI-298
FP Coxon, MH Helfrich, RV Hof, S Sebti, SH Ralston, A Hamilton, MJ Rogers |
Journal of Bone and Mineral Research | 2000 |
Bisphosphonates induce apoptosis in human breast cancer cell lines
SG Senaratne, G Pirianov, JL Mansi, TR Arnett, KW Colston |
British Journal of Cancer | 2000 |
Bisphosphonates in Bone Disease
H Fleisch |
Bisphosphonates in Bone Disease | 2000 |
Alendronate Is a Specific, Nanomolar Inhibitor of Farnesyl Diphosphate Synthase
JD Bergstrom, RG Bostedor, PJ Masarachia, AA Reszka, G Rodan |
Archives of Biochemistry and Biophysics | 2000 |
Mécanismes d'action des bisphosphonates sur les cellules tumorales et perspectives d'utilisation dans le traitement de l'ostéolyse maligne
P Clézardin, J Gligorov, P Delmas |
Revue du Rhumatisme | 2000 |
Bisphosphonates and atherosclerosis
R Ylitalo |
General Pharmacology: The Vascular System | 2000 |
Bisphosphonates - Mechanisms of Action in Multiple Myeloma
CM Karin |
Acta Oncologica | 2000 |
Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines
P Tassone, S Forciniti, E Galea, G Morrone, MC Turco, V Martinelli, P Tagliaferri, S Venuta |
Leukemia | 2000 |
Management of Fractures in Severely Osteoporotic Bone
K Obrant |
2000 | |
Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma
V Kunzmann, E Bauer, J Feurle, HP Weißinger, M Wilhelm |
Blood | 2000 |
Phosphate depletion in the rat: Effect of bisphosphonates and the calcemic response to PTH
A Jara, E Lee, D Stauber, F Moatamed, AJ Felsenfeld, CR Kleeman |
Kidney International | 1999 |
Bisphosphonates: from the laboratory to the clinic and back again
RG Russell, MJ Rogers |
Bone | 1999 |
The Role of Geranylgeranylation in Bone Resorption and Its Suppression by Bisphosphonates in Fetal Bone Explants In Vitro: A Clue to the Mechanism of Action of Nitrogen-Containing Bisphosphonates
EV Beek, C Löwik, GV der Pluijm, S Papapoulos |
Journal of Bone and Mineral Research | 1999 |
Relationship between bisphosphonate concentration and osteoclast activity and viability
DJ Rowe, LA Etre, MJ Lovdahl, DJ Pietrzyk |
In Vitro Cellular & Developmental Biology - Animal | 1999 |
Effect of Prostaglandin and Bisphosphonate on Cancellous Bone Volume and Structure in the Ovariectomized Rat Studied by Quantitative Three-Dimensional Nuclear Magnetic Resonance Microscopy
M Takahashi, FW Wehrli, SL Wehrli, SN Hwang, MW Lundy, J Hartke, B Borah |
Journal of Bone and Mineral Research | 1999 |
Molecular mechanisms of action of bisphosphonates
MJ Rogers, JC Frith, SP Luckman, FP Coxon, HL Benford, J M̈onkk̈onen, S Auriola, KM Chilton, RG Russell |
Bone | 1999 |
Bisphosphonates as anticancer drugs
GR Mundy |
Expert Opinion on Investigational Drugs | 1999 |
The Effects of Nitrogen-Containing Bisphosphonates on Human Epithelial (Caco-2) Cells, an In Vitro Model for Intestinal Epithelium
IM Twiss, O Pas, W Ramp-Koopmanschap, JD Hartigh, P Vermeij |
Journal of Bone and Mineral Research | 1999 |
Short-term effects of bisphosphonates on the biomechanical properties of canine bone
X Wang, AS Shanbhag, HE Rubash, CM Agrawal |
Journal of Biomedical Materials Research | 1999 |
Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats
N Patlas, G Golomb, P Yaffe, T Pinto, E Breuer, A Ornoy |
Teratology | 1999 |
Zoledronate Is a Potent Inhibitor of Myeloma Cell Growth and Secretion of IL-6 and MMP-1 by the Tumoral Environment
S Derenne, M Amiot, S Barillé, M Collette, N Robillard, P Berthaud, JL Harousseau, R Bataille |
Journal of Bone and Mineral Research | 1999 |
Intermittent and Continuous Administration of the Bisphosphonate Ibandronate in Ovariohysterectomized Beagle Dogs: Effects on Bone Morphometry and Mineral Properties
MC Monier-Faugere, Z Geng, EP Paschalis, Q Qi, I Arnala, F Bauss, AL Boskey, HH Malluche |
Journal of Bone and Mineral Research | 1999 |
Qualitative Analysis of Peripheral Peri-Implant Bone and Influence of Alendronate Sodium on Early Bone Regeneration
SJ Meraw, CM Reeve |
Journal of Periodontology | 1999 |
Disposition of Alendronate Following Local Delivery in a Rat Jaw
A Yaffe, I Binderman, E Breuer, T Pinto, G Golomb |
Journal of Periodontology | 1999 |
Use of bisphosphonates for the treatment of bone metastasis in experimental animal models
T Yoneda, T Michigami, B Yi, PJ Williams, M Niewolna, T Hiraga |
Cancer Treatment Reviews | 1999 |
Ultrastructural and cytochemical studies on cell death of osteoclasts induced by bisphosphonate treatment
M Ito, N Amizuka, T Nakajima, H Ozawa |
Bone | 1999 |
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro
JE Fisher, MJ Rogers, JM Halasy, SP Luckman, DE Hughes, PJ Masarachia, G Wesolowski, RG Russell, GA Rodan, AA Reszka |
Proceedings of the National Academy of Sciences | 1999 |
The pharmacology of bisphosphonates and new insights into their mechanisms of action
RG Russell, MJ Rogers, JC Frith, SP Luckman, FP Coxon, HL Benford, PI Croucher, C Shipman, HA Fleisch |
Journal of Bone and Mineral Research | 1999 |
The Bisphosphonate Odyssey. A Journey from Chemistry to the Clinic
R Graham, G Russell |
Phosphorus Sulfur and Silicon and the Related Elements | 1999 |
Amino-Substituted <i>GEM</i>-Bisphosphonates
L Widler, KA Jaeggi, JR Green |
Phosphorus Sulfur and Silicon and the Related Elements | 1999 |
The Aging Skeleton
AB Hodsman, LJ Fraher, PH Watson |
The Aging Skeleton | 1999 |
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
HL Benford, JC Frith, S Auriola, J Mönkkönen, MJ Rogers |
Molecular pharmacology | 1999 |
An ultrastructural study of the effects of bisphosphonate administration on osteoclastic bone resorption during relapse of experimentally moved rat molars
TW Kim, Y Yoshida, K Yokoya, T Sasaki |
American Journal of Orthodontics and Dentofacial Orthopedics | 1999 |
Disposition of tiludronate (Skelid) in animals
H Davi, C Tronquet, J Caix, J Simiand, C Briot, Y Berger, JF Thiercelin |
Xenobiotica | 1999 |
Bisphosphonates: From Grandparents to Grandchildren
T Srivastava, US Alon |
Clinical Pediatrics | 1999 |
Pharmacokinetics of Bisphosphonates in Rabbits
S Luurila, S Kautiainen, P Ylitalo, R Ylitalo |
Pharmacology and Toxicology | 1999 |
Selective inhibition of β-1,4- and α-1,3-galactosyltransferases: donor sugar-nucleotide based approach
S Takayama, SJ Chung, Y Igarashi, Y Ichikawa, A Sepp, RI Lechler, J Wu, T Hayashi, G Siuzdak, CH Wong |
Bioorganic & Medicinal Chemistry | 1999 |
Bisphosphonates Act Directly on the Osteoclast to Induce Caspase Cleavage of Mst1 Kinase during Apoptosis: A LINK BETWEEN INHIBITION OF THE MEVALONATE PATHWAY AND REGULATION OF AN APOPTOSIS-PROMOTING KINASE
AA Reszka, JM Halasy-Nagy, PJ Masarachia, GA Rodan |
The Journal of biological chemistry | 1999 |
Inorganic Polyphosphates
HC Schröder, WE Müller |
1999 | |
New Bisphosphonates in the Treatment of Bone Diseases:
D Gatti, S Adami |
Drugs & Aging | 1999 |
Relationship between bisphosphonate concentration and osteoclast activity and viability
DJ Rowe, LA Etre, MJ Lovdahl, DJ Pietrzyk |
In vitro cellular & developmental biology. Animal | 1999 |
Pharmacokinetics of Alendronate:
AG Porras, SD Holland, BJ Gertz |
Clinical Pharmacokinetics | 1999 |
Heterocycle-Containing Bisphosphonates Cause Apoptosis and Inhibit Bone Resorption by Preventing Protein Prenylation: Evidence from Structure-Activity Relationships in J774 Macrophages
SP Luckman, FP Coxon, FH Ebetino, RG Russell, MJ Rogers |
Journal of Bone and Mineral Research | 1998 |
Bisphosphonates
JJ Body |
European Journal of Cancer | 1998 |
MECHANISMS OF ACTION OF BISPHOSPHONATES
GA Rodan |
Annual Review of Pharmacology and Toxicology | 1998 |
Human Osteoclast Formation and Activity In Vitro: Effects of Alendronate
V Breuil, F Cosman, L Stein, W Horbert, J Nieves, V Shen, R Lindsay, DW Dempster |
Journal of Bone and Mineral Research | 1998 |
A Third-Generation Bisphosphonate, YM175, Inhibits Osteoclast Formation in Murine Cocultures by Inhibiting Proliferation of Precursor Cells via Supporting Cell-Dependent Mechanisms
M Nishikawa, M Yamamoto, T Murakami, T Akatsu, N Kugai, N Nagata |
Journal of Bone and Mineral Research | 1998 |
Effect of a newly developed bisphosphonate, YH529, on osteolytic bone metastases in nude mice
A Sasaki, K Kitamura, RE Alcalde, T Tanaka, A Suzuki, Y Etoh, T Matsumura |
International Journal of Cancer | 1998 |
Effect of alendronate on cultured normal human osteoblasts
C García-Moreno, S Serrano, M Nacher, M Farré, A Díez, ML Mariñoso, J Carbonell, L Mellibovsky, X Nogués, J Ballester, J Aubía |
Bone | 1998 |
Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
SP Luckman, DE Hughes, FP Coxon, RG Russell, MJ Rogers |
Journal of Bone and Mineral Research | 1998 |
Preadministration of incadronate disodium can prevent bone loss in rat proximal tibial metaphysis when induced by hindlimb immobilization by bandage
J Li, S Mori, T Mashiba, Y Kaji, M Taki, S Komatsubara, J Kawanishi, H Norimatsu |
Bone | 1998 |
Bisphosphonates Stimulate Formation of Osteoblast Precursors and Mineralized Nodules in Murine and Human Bone Marrow Cultures In Vitro and Promote Early Osteoblastogenesis in Young and Aged Mice In Vivo
N Giuliani, M Pedrazzoni, G Negri, G Passeri, M Impicciatore, G Girasole |
Bone | 1998 |
The interpretation of preclinical data in predicting bisphosphonate response in the treatment of osteoporosis
JD Ringe |
Clinical Therapeutics | 1998 |
The Morbidity of Bone Disease in Thalassemia
EP Vichinsky |
Annals of the New York Academy of Sciences | 1998 |
Alendronate/Interleukin-1β Cotreatment Increases Interleukin-6 in Bone and UMR-106 Cells: Dose Dependence and Relationship to the Antiresorptive Effect of Alendronate
JL Sanders, G Tarjan, SA Foster, PH Stern |
Journal of Bone and Mineral Research | 1998 |
Structurally different bisphosphonates exert opposing effects on alkaline phosphatase and mineralization in marrow osteoprogenitors
BY Klein, H Ben-Bassat, E Breuer, V Solomon, G Golomb |
Journal of Cellular Biochemistry | 1998 |
Alendronate and osteoporosis
AJ Yates, GA Rodan |
Drug Discovery Today | 1998 |
Accumulation of Bisphosphonates in Human Artery and their Effects on Human and Rat Arterial Functionin vitro
R Ylitalo, J Kalliovalkama, X Wu, H Kankaanranta, JP Salenius, T Sisto, T Lähteenmäki, P Ylitalo, I Pörsti |
Pharmacology & Toxicology | 1998 |
Acute Lymphoblastic Leukemia Accompanied by Severe Hypercalcemia: Successful Treatment Including Aminohydroxypropylidene Bisphosphonate (Pamidronate Disodium)
M Takagi, K Takahiashi, T Maruyama, K Kaneko, K Obinata, R Tadokoro, K Kastumata, Y Miura, H Fujita, A Tokita, K Ishimoto, K Yabuta |
Pediatric Hematology-Oncology | 1998 |
Withdrawal of Parathyroid Hormone Treatment Causes Rapid Resorption of Newly Formed Vertebral Cancellous and Endocortical Bone in Old Rats
C Ejersted, H Oxlund, EF Eriksen, TT Andreassen |
Bone | 1998 |
Advances in Organ Biology
AJ Liedtke |
Advances in Organ Biology | 1998 |
Metabolic Bone Disease and Clinically Related Disorders
FR Singer, SM Krane |
Metabolic Bone Disease and Clinically Related Disorders | 1998 |
TREATMENT OF OSTEOPOROSIS WITH BISPHOSPHONATES
NB Watts |
Endocrinology and metabolism clinics of North America | 1998 |
Effects of alendronate sodium on severe osteodystrophy in postmenopausal patients with primary biliary cirrhosis: a pilot study
A Floreani, L Tizian, G Luisetto, A Buda, A Mega, R Naccarato |
Current Therapeutic Research | 1998 |
Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro
J Mönkkönen, J Similä, MJ Rogers |
Life Sciences | 1998 |
Bisphosphonates: a potential role in the prevention of osteoporosis in laying hens
S Wilson, SE Solomon, BH Thorp |
Research in Veterinary Science | 1998 |
Histomorphometric Evidence for Echistatin Inhibition of Bone Resorption in Mice with Secondary Hyperparathyroidism
P Masarachia, M Yamamoto, CT Leu, G Rodan, L Duong |
Endocrinology | 1998 |
Non HRT Options for the Treatment of Osteoporosis
M Davies |
1998 | |
Macrophage Activation Results in Bone Resorption:
J Lassus, J Salo, WA Jiranek, S Santavirta, J Nevalainen, M Matucci-Cerinic, P Hork, Y Konttinen |
Clinical Orthopaedics and Related Research® | 1998 |
Bisphosphonates: Mechanisms of Action
H Fleisch |
Endocrine reviews | 1998 |
Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis
PM Chavassieux, ME Arlot, C Reda, L Wei, AJ Yates, PJ Meunier |
Journal of Clinical Investigation | 1997 |
Osteoporosis
DL Glaser, FS Kaplan |
Spine | 1997 |
Bisphosphonates: Preclinical Aspects and Use in Osteoporosis
HA Fleisch |
Annals of Medicine | 1997 |
Clodronate and Liposome-Encapsulated Clodronate Are Metabolized to a Toxic ATP Analog, Adenosine 5′-(β,γ-Dichloromethylene) Triphosphate, by Mammalian Cells In Vitro
JC Frith, J Mönkkönen, GM Blackburn, RG Russell, MJ Rogers |
Journal of Bone and Mineral Research | 1997 |
Overview of bisphosphonates
MJ Rogers, DJ Watts, RG Russell |
Cancer | 1997 |
Osteoclast activation: Potent inhibition by the bisphosphonate alendronate through a nonresorptive mechanism
JM Owens, K Fuller, TJ Chambers |
Journal of Cellular Physiology | 1997 |
Bisphosphonate Therapy
AA Licata |
The American Journal of the Medical Sciences | 1997 |
Alendronate prevents cyclosporin A-induced osteopenia in the rat
DA Sass, AR Bowman, Z Yuan, Y Ma, WS Jee, S Epstein |
Bone | 1997 |
Pamidronate content and turnover in sternum, vertebral body, and iliac bones of dogs
LE King, MD Grynpas, G Tomlinson, R Vieth |
Bone | 1997 |
Cell death in oral tissues and diseases
T Kaku, Y Abiko |
Oral Medicine & Pathology | 1997 |
Elimination and Biochemical Responses to Intravenous Alendronate in Postmenopausal Osteoporosis
SA Khan, JA Kanis, S Vasikaran, WF Kline, BK Matuszewski, EV McCloskey, MN Beneton, BJ Gertz, DG Sciberras, SD Holland, J Orgee, GM Coombes, SR Rogers, AG Porras |
Journal of Bone and Mineral Research | 1997 |
Short-Term Intravenous Bisphosphonates in Prevention of Postmenopausal Bone Loss
JE Heikkinen, KS Selander, K Laitinen, I Arnala, HK Väänänen |
Journal of Bone and Mineral Research | 1997 |
Pamidronate and biochemical markers of bone turnover
ME Martínez, MT Campo, MA Plaza, A Torrijos, J Gijón |
Scandinavian Journal of Clinical & Laboratory Investigation | 1997 |
Inhibition of Bone Resorption by Pamidronate Cannot Restore Normal Gain in Cortical Bone Mass and Strength in Tail-Suspended Rapidly Growing Rats
Y Kodama, K Nakayama, H Fuse, S Fukumoto, H Kawahara, H Takahashi, T Kurokawa, C Sekiguchi, T Nakamura, T Matsumoto |
Journal of Bone and Mineral Research | 1997 |
Mineralization of cancellous bone after alendronate and sodium fluoride treatment: A quantitative backscattered electron imaging study on minipig ribs
P Roschger, P Fratzl, K Klaushofer, G Rodan |
Bone | 1997 |
Decrease in canine proximal femoral ultimate strength and stiffness due to fatigue damage
SJ Hoshaw, DD Cody, AM Saad, DP Fyhrie |
Journal of Biomechanics | 1997 |
Effects of bisphosphonates on alkaline phosphatase activity, mineralization, and prostaglandin E2 synthesis in the clonal osteoblast-like cell line MC3T3-E1
K Igarashi, M Hirafuji, H Adachi, H Shinoda, H Mitani |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 1997 |
Local Delivery of an Amino Bisphosphonate Prevents the Resorptive Phase of Alveolar Bone Following Mucoperiosteal Flap Surgery in Rats
A Yaffe, M Iztkovich, Y Earon, I Alt, R Lilov, I Binderman |
Journal of Periodontology | 1997 |
EFFECTS OF LIPOSOME-ENCAPSULATED BISPHOSPHONATES ON ACETYLATED LDL METABOLISM, LIPID ACCUMULATION AND VIABILITY OF PHAGOCYTING CELLS
R Ylitalo, J Monkkonen, S Ylä-Herttuala |
Life Sciences | 1997 |
Alendronate inhibition of protein-tyrosine-phosphatase-meg1
EE Opas, SJ Rutledge, E Golub, A Stern, Z Zimoio, GA Rodan, A Schmidt |
Biochemical Pharmacology | 1997 |
Increments in bone mineral density of the lumbar spine and hip and suppression of bone turnover are maintained after discontinuation of alendronate in postmenopausal women
J L Stock, N H Bell, C H Chesnut 3rd, K E Ensrud, H K Genant, S T Harris, M R McClung, F R Singer, R A Yood, S Pryor-Tillotson, L Wei, A C Santora 2nd |
The American Journal of Medicine | 1997 |
Drug disposition of incadronate, a new bisphosphonate, in rats with bone metastases
T USUI, S TANAKA, T SONODA, Y OZAWA, K TERAMURA, E NAKAMURA, T WATANABE, S HIGUCHI |
Xenobiotica | 1997 |
Human Neutrophil Collagenase MMP-8 in Peri-implant Sulcus Fluid and its Inhibition by Clodronate
O Teronen, YT Konttinen, C Lindqvist, T Salo, T Ingman, A Lauhio, Y Ding, S Santavirta, T Sorsa |
Journal of dental research | 1997 |
How Does Alendronate Inhibit Protein-tyrosine Phosphatases?
K Skorey, HD Ly, J Kelly, M Hammond, C Ramachandran, Z Huang, MJ Gresser, Q Wang |
The Journal of biological chemistry | 1997 |
Inhibition of Wear Debris Mediated Osteolysis in a Canine Total Hip Arthroplasty Model:
AS Shanbhag, CT Hasselman, HE Rubash |
Clinical Orthopaedics and Related Research® | 1997 |
Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake
M J Rogers, X Xiong, X Ji, J Mönkkönen, R G Russell, M P Williamson, F H Ebetino, D J Watts |
Pharmaceutical Research | 1997 |
Alendronate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Postmenopausal Osteoporosis
W Jeal, LB Barradell, D McTavish |
Drugs | 1997 |
Bisphosphonates: mechanisms of action
GA Rodan, HA Fleisch |
Journal of Clinical Investigation | 1996 |
Inhibitory effects of bisphosphonate (YM175) on bone resorption induced by a metastatic bone tumor
T Hiraga, S Tanaka, M Yamamoto, T Nakajima, H Ozawa |
Bone | 1996 |
Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
MJ Rogers, KM Chilton, FP Coxon, J Lawry, MO Smith, S Suri, RG Russel |
Journal of Bone and Mineral Research | 1996 |
Use of bisphosphonates in cancer patients
JJ Body, RE Coleman, M Piccart |
Cancer Treatment Reviews | 1996 |
Comparison of the distribution of 3H-alendronate and 3H-Etidronate in rat and mouse bones
P Masarachia, M Weinreb, R Balena, GA Rodan |
Bone | 1996 |
Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures
M Nishikawa, T Akatsu, Y Katayama, Y Yasutomo, S Kado, N Kugai, M Yamamoto, N Nagata |
Bone | 1996 |
Theoretical perspective: A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates
AM Parfitt, GR Mundy, GD Roodman, DE Hughes, BF Boyce |
Journal of Bone and Mineral Research | 1996 |
The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H+-ATPase
PE David, H Nguyen, A Barbier, R Baron |
Journal of Bone and Mineral Research | 1996 |
Effect of alendronate on fracture healing and bone remodeling in dogs
CP Peter, WO Cook, DM Nunamaker, MT Provost, JG Seedor, GA Rodan |
Journal of Orthopaedic Research | 1996 |
Treatment of osteoporosis: bisphosphonates as an alternative to hormone replacement therapy
C Parker, D Hosking |
Current Obstetrics & Gynaecology | 1996 |
Interaction between effects of parathyroid hormone and bisphosphonate on regulation of osteoclast activity by the osteoblast-like cell line UMR-106
X Yu, J Schøller, NT Foged |
Bone | 1996 |
Human protein tyrosine phosphatase-σ: Alternative splicing and inhibition by bisphosphonates
N Endo, SJ Rutledge, EE Opas, R Vogel, GA Rodan, A Schmidt |
Journal of Bone and Mineral Research | 1996 |
Effects of sodium fluoride and alendronate on the bone mineral in minipigs: A small-angle X-ray scattering and backscattered electron imaging study
P Fratzl, S Schreiber, P Roschger, MH Lafage, G Rodan, K Klaushofer |
Journal of Bone and Mineral Research | 1996 |
Bisphosphonates: A review of their pharmacokinetic properties
JH Lin |
Bone | 1996 |
Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate
A Schmidt, SJ Rutledge, N Endo, EE Opas, H Tanaka, G Wesolowski, CT Leu, Z Huang, C Ramachandaran, SB Rodan, GA Rodan |
Proceedings of the National Academy of Sciences | 1996 |
Effects of alendronate on bone loss in pre- and postmenopausal hyperthyroid women treated with methimazole
G Lupoli, V Nuzzo, CD Carlo, P Affmito, M Vollery, G Vitale, E Cascone, F Arlotta, C Nappi |
Gynecological Endocrinology | 1996 |
Drug Evaluation Oncologic, Endocrine & Metabolic: Alendronate (Fosamax®): clinical utility in metabolic bone disease
J Hayes, P Sambrook |
Expert Opinion on Investigational Drugs | 1996 |
Inhibitory Effect of the Topical Administration of a Bisphosphonate (Risedronate) on Root Resorption Incident to Orthodontic Tooth Movement in Rats
K Igar, H Adachi, H Mitani, H Shinoda |
Journal of dental research | 1996 |
Development of Alendronate (Preclinical Studies)
GA Rodan |
Proceedings (Baylor University. Medical Center) | 1996 |
Oral Alendronate in the Treatment of Postmenopausal Osteoporosis
A Lombardi, D Freedholm, AJ Yates |
Proceedings (Baylor University. Medical Center) | 1996 |
Alendronate treatment for osteoporosis: A review of the clinical evidence
P Selby |
Osteoporosis International | 1996 |
Prevention of Bone Loss by Bisphosphonate YM175 in Ovariectomized Dogs with Dietary Calcium Restriction
H Motoie, H Kanoh, S Ogata, K Kawamuki, H Shikama, T Fujikura |
The Japanese Journal of Pharmacology | 1996 |
The Molecular Biology of Paget’s Disease
PT Sharpe |
1996 | |
α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase
DR Magnin, SA Biller, Y Chen, JK Dickson, OM Fryszman, RM Lawrence, JV Logan, ES Sieber-McMaster, RB Sulsky, SC Traeger, DC Hsieh, SJ Lan, JK Rinehart, TW Harrity, KG Jolibois, LK Kunselman, LC Rich, DA Slusarchyk, CP Ciosek |
Journal of Medicinal Chemistry | 1996 |
Adverse Effects of Bisphosphonates: A Comparative Review
S Adami, N Zamberlan |
Drug Safety | 1996 |
Comparative Clinical Pharmacology and Therapeutic Use of Bisphosphonates in Metabolic Bone Diseases:
CJ Rosen, CR Kessenich |
Drugs | 1996 |
Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study
MH Lafage, R Balena, MA Battle, M Shea, JG Seedor, H Klein, WC Hayes, GA Rodan |
Journal of Clinical Investigation | 1995 |
Acid extrusion is induced by osteoclast attachment to bone. Inhibition by alendronate and calcitonin
Z Zimolo, G Wesolowski, GA Rodan |
Journal of Clinical Investigation | 1995 |
Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate
LA Ruml, SK Dubois, ML Roberts, CY Pak |
Journal of Bone and Mineral Research | 1995 |
Rationale for the use of alendronate in osteoporosis
JA Kanis, BJ Gertz, F Singer, S Ortolani |
Osteoporosis International | 1995 |
Studies of the oral bioavailability of alendronate*
BJ Gertz, SD Holland, WF Kline, BK Matuszewski, A Freeman, H Quan, KC Lasseter, JC Mucklow, AG Porras |
Clinical Pharmacology & Therapeutics | 1995 |
Effects of the bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovariectomized beagles on concomitant dietary calcium restriction
H Motoie, T Nakamura, N O'Uchi, H Nishikawa, H Kanoh, T Abe, H Kawashima |
Journal of Bone and Mineral Research | 1995 |
Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models
Y Azuma, H Sato, Y Oue, K Okabe, T Ohta, M Tsuchimoto, M Kiyoki |
Bone | 1995 |
A possible mechanism of the specific action of bisphosphonates on osteoclasts: Tiludronate preferentially affects polarized osteoclasts having ruffled borders
H Murakami, N Takahashi, T Sasaki, N Udagawa, S Tanaka, I Nakamura, D Zhang, A Barbier, T Suda |
Bone | 1995 |
Inhibition of antigen-presenting cell function by alendronate in vitro
P Sansoni, G Passeri, F Fagnoni, N Mohagheghpour, G Snelli, V Brianti, EG Engleman |
Journal of Bone and Mineral Research | 1995 |
17β-hydroxywortmannin: A potent inhibitor of bone resorption and phosphatidylinositol-3-kinase
JA Dodge, HU Bryant, J Kim, WF Matter, BH Norman, U Srinivasan, CJ Vlahos, M Sato |
Bioorganic & Medicinal Chemistry Letters | 1995 |
Different effects of bisphosphonate and estrogen therapy on free and peptide-bound bone cross-links excretion
P Garnero, E Gineyts, P Arbault, C Christiansen, PD Delmas |
Journal of Bone and Mineral Research | 1995 |
Stimulation of bone formation by dynamic mechanical loading of rat caudal vertebrae is not suppressed by 3-amino-1-hydroxypropylidene-1-bisphosphonate (AHPrBP)
CJ Jagger, TJ Chambers, JW Chow |
Bone | 1995 |
Effects of oral alendronate and intranasal salmon calcitonin on bone mass and biochemical markers of bone turnover in postmenopausal women with osteoporosis
S Adami, M Passeri, S Ortolani, M Broggini, L Carratelli, I Caruso, G Gandolini, L Gnessi, M Laurenzi, A Lombardi, G Norbiato, S Pryor-Tillotson, C Reda, L Romanini, D Subrizi, L Wei, AJ Yates |
Bone | 1995 |
Influence of disodium (1-hydroxythylidene) diphosphonate on bone ingrowth into porous, titanium fiber-mesh implants
T Kitsugi, T Yamamuro, T Nakamura, M Oka |
The Journal of Arthroplasty | 1995 |
Alendronate Treatment of Naturally-Occurring Periodontitis in Beagle Dogs*
MS Reddy, TW Weatherford, CA Smith, BD West, MK Jeffcoat, TM Jacks |
Journal of Periodontology | 1995 |
Osteotropic Drug Delivery System (ODDS) Based on Bisphosphonic Prodrug. I: Synthesis and in Vivo Characterization of Osteotropic Carboxyfluorescein
J Fujisaki, Y Tokunaga, T Takahashi, T Hirose, F Shimojo, A Kagayama, T Hata |
Journal of Drug Targeting | 1995 |
Section Review: Oncologic, Endocrine & Metabolic: The vacuolar H + -ATPase: A potential target for drug development in bone diseases
PE David, R Baron |
Expert Opinion on Investigational Drugs | 1995 |
Inhibitory effect of a bisphosphonate (risedronate) on experimental periodontities in rats
K Shoji, H Horiuchi, H Shinoda |
Journal of Periodontal Research | 1995 |
Matrix metalloproteinases are obligatory for the migration of preosteoclasts to the developing marrow cavity of primitive long bones
L Blavier, JM Delaisse |
Journal of cell science | 1995 |
Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro
N Pennanen, S Lapinjoki, A Urtti, J Mönkkönen |
Pharmaceutical Research | 1995 |
Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold dictyostelium discoideum
MJ Rogers, DJ Watts, RG Russell, X Ji, X Xiong, GM Blackburn, AV Bayless, FH Ebetino |
Journal of Bone and Mineral Research | 1994 |
Effects of two different bisphosphonates on Paget's disease of bone: ICTP assessed
P Filipponi, M Pedetti, F Beghe, B Giovagnini, M Miam, S Cristallini |
Bone | 1994 |
Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage
DD Bikle, ER Morey-Holton, SB Doty, PA Currier, SJ Tanner, BP Halloran |
Journal of Bone and Mineral Research | 1994 |
Structural requirements for bisphosphonate actions in vitro
E Beek, M Hoekstra, MD de Ruit, C Löwik, S Papapoulos |
Journal of Bone and Mineral Research | 1994 |
Dual-energy X-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats
M Sato, C McClintock, J Kim, CH Turner, HU Bryant, D Magee, CW Slemenda |
Journal of Bone and Mineral Research | 1994 |
Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis
M Rossini, D Gatti, N Zamberlan, V Braga, R Dorizzi, S Adami |
Journal of Bone and Mineral Research | 1994 |
Use of a rat model for the simultaneous assessment of pharmacokinetic and pharmacodynamic aspects of bisphosphonate treatment: Application to the study of intravenous 14C-labeled 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate
SJ Koopmans, LV der Wee-Pals, CW Löwik, SE Papapoulos |
Journal of Bone and Mineral Research | 1994 |
Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum
MJ Rogers, X Ji, RG Russell, GM Blackburn, MP Williamson, AV Bayless, FH Ebetino, DJ Watts |
Biochemical Journal | 1994 |
The effect of alendronate on renal tubular reabsorption of phosphate
SD Vasikaran, DP O’Doherty, EV McCloskey, B Gertz, S Kahn, JA Kanis |
Bone and Mineral | 1994 |
Renal and Nonrenal Clearance of Clodronate in Patients with Malignancy and Renal Impairment
NP O’Rourke, EV McCloskey, G Neugebauer, JA Kanis |
Drug Investigation | 1994 |
Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movements in rats
K Igarashi, H Mitani, H Adachi, H Shinoda |
American Journal of Orthodontics and Dentofacial Orthopedics | 1994 |
Duration of the effects of intravenous alendronate in postmenopausal women and in patients with primary hyperparathyroidism and Paget's disease of bone
S Adami, N Zamberlan, M Mian, R Dorizzi, M Rossini, B Braga, D Gatti, F Bertoldo, V Locascio |
Bone and Mineral | 1994 |
Effects of Topical Administration of a Bisphosphonate (Risedronate) on Orthodontic Tooth Movements in Rats
H Adachi, K Igarashi, H Mitani, H Shinoda |
Journal of dental research | 1994 |
The effects of bisphosphonates on the resorption cycle of isolated osteoclasts
K Selander, P Lehenkari, HK Vnnen |
Calcified Tissue International | 1994 |
Osteolytic bone metastasis in breast cancer
T Yoneda, A Sasaki, GR Mundy |
Breast Cancer Research and Treatment | 1994 |
Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys
M Weinreb, H Quartuccio, JG Seedor, TB Aufdemorte, M Brunsvold, E Chaves, KS Kornman, GA Rodan |
Journal of Periodontal Research | 1994 |
Alendronate Modulates Osteogenesis of Human Osteoblastic Cells In Vitro
M Tsuchimoto, Y Azuma, O Higuchi, I Sugimoto, N Hiraia, M Kiyoki, I Yamamoto |
The Japanese Journal of Pharmacology | 1994 |
Bisphosphonates act on rat bone resorption through the mediation of osteoblasts
M Sahni, HL Guenther, H Fleisch, P Collin, TJ Martin |
Journal of Clinical Investigation | 1993 |
New bisphosphonates in osteoporosis
H Fleisch |
Osteoporosis International | 1993 |
A new bisphosphonate, BM 21.0955, prevents bone loss associated with cessation of ovarian function in experimental dogs
MC Monier-Faugere, RM Friedler, F Bauss, HH Malluche |
Journal of Bone and Mineral Research | 1993 |
Clinical effects of bisphosphonates in involutional osteoporosis
SM Ott |
Journal of Bone and Mineral Research | 1993 |
Skeletal effects of withdrawal of estrogen and diphosphonate treatment in ovariectomized rats
TJ Wronski, LM Dann, H Qi, CF Yen |
Calcified Tissue International | 1993 |
Prevention and treatment of osteoporosis
R Lindsay |
The Lancet | 1993 |
Bisphosphonates in osteoporosis: An introduction
H Fleisch |
Osteoporosis International | 1993 |
Bisphosphonates in the Treatment of Metabolic Bone Diseases
GA Rodan, R Balena |
Annals of Medicine | 1993 |
A New Schedule for Clodronate Treatment in Patients with Breast Cancer and Bone Metastases
F Beghé, M Luzzani |
Annals of the New York Academy of Sciences | 1993 |
New bisphosphonates in the treatment of bone metastases
SD Averbuch |
Cancer | 1993 |
Alternatives to HRT in prevention and treatment
MS Marsh, JC Stevenson |
Baillière's Clinical Rheumatology | 1993 |
The role of bisphosphonates in the prevention and treatment of osteoporosis
SE Papapoulos |
The American Journal of Medicine | 1993 |
Aminoalkylbisphosphonates, potent inhibitors of bone resorption, induce a prolonged stimulation of histamine synthesis and increase macrophages, granulocytes, and osteoclasts in vivo
Y Endo, M Nakamura, T Kikuchi, H Shinoda, Y Takeda, Y Nitta, K Kumagai |
Calcified Tissue International | 1993 |
Characterization of the bisphosphonate recognition site on hydroxyapatite using radioligand binding techniques with [14C]citric acid
MF Jarvis, CJ Burns, HW Pauls, A Assal, JS Kim, DL Cheney, RD Youssefyeh |
Calcified Tissue International | 1993 |
Physiology and Pharmacology of Bone
GR Mundy, TJ Martin |
1993 | |
Treatment of postmenopausal osteoporosis with continuous daily oral alendronate in comparison with either placebo or intranasal salmon calcitonin
S Adami, MC Baroni, M Broggini, L Carratelli, I Caruso, L Gnessi, M Laurenzi, A Lombardi, G Norbiato, S Ortolani, E Ricerca, L Romanini, S Subrizi, J Weinberg, AJ Yates |
Osteoporosis International | 1993 |
Clinical pharmacology of alendronate sodium
BJ Gertz, SD Holland, WF Kline, BK Matuszewski, AG Porras |
Osteoporosis International | 1993 |
Preclinical pharmacology of alendronate
GA Rodan, JG Seedor, R Balena |
Osteoporosis International | 1993 |
Drugs Used in the Treatment of Metabolic Bone Disease: Clinical Pharmacology and Therapeutic Use
S Patel, AR Lyons, DJ Hosking |
Drugs | 1993 |
Skeletal effects of withdrawal of estrogen and diphosphonate treatment in ovariectomized rats
TJ Wronski, LM Dann, H Qi, |
Calcified Tissue International | 1993 |
The Prevention and Treatment of Osteoporosis
AJ Wood, BL Riggs, LJ Melton |
New England Journal of Medicine | 1992 |