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Research Article Free access | 10.1172/JCI115499

Role of oxidized low density lipoprotein in atherogenesis.

J L Witztum and D Steinberg

Department of Medicine, University of California, San Diego, La Jolla 92093.

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Department of Medicine, University of California, San Diego, La Jolla 92093.

Find articles by Steinberg, D. in: JCI | PubMed | Google Scholar

Published December 1, 1991 - More info

Published in Volume 88, Issue 6 on December 1, 1991
J Clin Invest. 1991;88(6):1785–1792. https://doi.org/10.1172/JCI115499.
© 1991 The American Society for Clinical Investigation
Published December 1, 1991 - Version history
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Abstract

Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.

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