Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
Article has an altmetric score of 6

See more details

Referenced in 5 patents
6 readers on Mendeley
  • Article usage
  • Citations to this article (68)

Advertisement

Research Article Free access | 10.1172/JCI115049

Chronic neutropenia. A new canine model induced by human granulocyte colony-stimulating factor.

W P Hammond, E Csiba, A Canin, H Hockman, L M Souza, J E Layton, and D C Dale

Department of Medicine, University of Washington School of Medicine, Seattle 98195.

Find articles by Hammond, W. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle 98195.

Find articles by Csiba, E. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle 98195.

Find articles by Canin, A. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle 98195.

Find articles by Hockman, H. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle 98195.

Find articles by Souza, L. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle 98195.

Find articles by Layton, J. in: PubMed | Google Scholar

Department of Medicine, University of Washington School of Medicine, Seattle 98195.

Find articles by Dale, D. in: PubMed | Google Scholar

Published February 1, 1991 - More info

Published in Volume 87, Issue 2 on February 1, 1991
J Clin Invest. 1991;87(2):704–710. https://doi.org/10.1172/JCI115049.
© 1991 The American Society for Clinical Investigation
Published February 1, 1991 - Version history
View PDF
Abstract

Normal dogs were treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF) at 10 micrograms/kg/day for 30 d, which caused an initial neutrophilia, followed by a prolonged period of chronic neutropenia. A control dog treated with recombinant canine G-CSF (rcG-CSF) showed persistent neutrophilia over 3 mo. Serum from dogs during neutropenia contained an antibody to rhG-CSF, which neutralized the stimulatory effects of both rhG-CSF and rcG-CSF on dog marrow neutrophilic progenitor cell growth and on NFS-60 cell proliferation. 4 mo after discontinuation of rhG-CSF, the dogs' neutrophil counts returned to the normal range. Rechallenge with the rhG-CSF re-induced severe neutropenia in 1 wk. Neutropenia was transferred by plasma infusion from a neutropenic dog to a previously normal dog. These data suggest that human rhG-CSF immunizes normal dogs and thereby induces neutralization of endogenous canine G-CSF and neutropenia. This model system should allow more precise definition of the in vivo role of G-CSF.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 704
page 704
icon of scanned page 705
page 705
icon of scanned page 706
page 706
icon of scanned page 707
page 707
icon of scanned page 708
page 708
icon of scanned page 709
page 709
icon of scanned page 710
page 710
Version history
  • Version 1 (February 1, 1991): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

Article has an altmetric score of 6
  • Article usage
  • Citations to this article (68)

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 5 patents
6 readers on Mendeley
See more details