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Research Article Free access | 10.1172/JCI114849

In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat.

C Cavard, A Zider, M Vernet, M Bennoun, S Saragosti, G Grimber, and P Briand

Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.

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Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.

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Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.

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Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.

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Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.

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Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.

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Unité 152 Institut Cochin de Génétique Moléculaire, Institut National de la Santé et de la Recherche Medical, Paris, France.

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Published October 1, 1990 - More info

Published in Volume 86, Issue 4 on October 1, 1990
J Clin Invest. 1990;86(4):1369–1374. https://doi.org/10.1172/JCI114849.
© 1990 The American Society for Clinical Investigation
Published October 1, 1990 - Version history
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Abstract

It has been previously shown in vitro that the human immunodeficiency virus type 1 long terminal repeat (LTR) is activated by ultraviolet irradiation. In order to analyze if a similar effect could occur in vivo, transgenic mice carrying the lacZ gene under the control of the viral LTR were irradiated at 280-300 and 254 nm. These mice spontaneously expressed the transgene in the epidermis and the lens of both adults and embryos. Irradiations caused a significant increase in skin beta-galactosidase activity. This phenomenon might be involved in viral activation and could be of interest in regard to the skin pathology observed during an HIV infection.

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