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Research Article Free access | 10.1172/JCI114820

Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas.

M Smidt, I Kirsch, and L Ratner

Department of Medicine, Washington University, St. Louis, Missouri 63110.

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Department of Medicine, Washington University, St. Louis, Missouri 63110.

Find articles by Kirsch, I. in: JCI | PubMed | Google Scholar

Department of Medicine, Washington University, St. Louis, Missouri 63110.

Find articles by Ratner, L. in: JCI | PubMed | Google Scholar

Published October 1, 1990 - More info

Published in Volume 86, Issue 4 on October 1, 1990
J Clin Invest. 1990;86(4):1151–1157. https://doi.org/10.1172/JCI114820.
© 1990 The American Society for Clinical Investigation
Published October 1, 1990 - Version history
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Abstract

An abnormality in the c-sis protooncogene was identified in leukocyte DNA from members of a family predisposed to the development of meningioma, and was found to be associated with the development of the tumor in those individuals. Molecular analysis of this abnormality demonstrated a deletion within the fifth intron of the c-sis gene. The normal c-sis gene has an Alu sequence in this region which includes two perfect 130 nucleotide repeated sequences separated by 5 bp. The deleted c-sis allele is missing precisely one copy of the 130 bp repeat and the intervening 5 bp. An identical deletion was also found in DNA from 1 of 13 sporadic meningiomas.

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