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Article has an altmetric score of 3

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Referenced in 1 clinical guideline sources
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Research Article Free access | 10.1172/JCI114577

Gastrin-releasing peptide in human nasal mucosa.

J N Baraniuk, J D Lundgren, J Goff, D Peden, M Merida, J Shelhamer, and M Kaliner

Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

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Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

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Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

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Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

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Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

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Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

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Allergic Diseases Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

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Published April 1, 1990 - More info

Published in Volume 85, Issue 4 on April 1, 1990
J Clin Invest. 1990;85(4):998–1005. https://doi.org/10.1172/JCI114577.
© 1990 The American Society for Clinical Investigation
Published April 1, 1990 - Version history
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Abstract

Gastrin-releasing peptide (GRP), the 27 amino acid mammalian form of bombesin, was studied in human inferior turbinate nasal mucosa. The GRP content of the mucosa measured by radioimmunoassay was 0.60 +/- 0.25 pmol/g tissue (n = 9 patients; mean +/- SEM). GRP-immunoreactive nerves detected by the immunogold method of indirect immunohistochemistry were found predominantly in small muscular arteries, arterioles, venous sinusoids, and between submucosal gland acini. 125I-GRP binding sites determined by autoradiography were exclusively and specifically localized to nasal epithelium and submucosal glands. There was no binding to vessels. The effects of GRP on submucosal gland product release were studied in short-term explant culture. GRP (10 microM) significantly stimulated the release of the serous cell-specific product lactoferrin, and [3H]glucosamine-labeled glycoconjugates which are products of epithelial goblet cells and submucosal gland cells. These observations indicate that GRP released from nerve fibers probably acts on glandular GRP receptors to induce glycoconjugate release from submucosal glands and epithelium and lactoferrin release from serous cells, but that GRP would probably not affect vascular permeability.

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Referenced in 1 clinical guideline sources
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