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Article has an altmetric score of 6

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Referenced in 4 patents
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Research Article Free access | 10.1172/JCI114533

Pathogenesis of Campylobacter fetus infections. Role of surface array proteins in virulence in a mouse model.

Z Pei and M J Blaser

Medical Service, Veterans Administration Medical Center, Denver, Colorado.

Find articles by Pei, Z. in: JCI | PubMed | Google Scholar

Medical Service, Veterans Administration Medical Center, Denver, Colorado.

Find articles by Blaser, M. in: JCI | PubMed | Google Scholar

Published April 1, 1990 - More info

Published in Volume 85, Issue 4 on April 1, 1990
J Clin Invest. 1990;85(4):1036–1043. https://doi.org/10.1172/JCI114533.
© 1990 The American Society for Clinical Investigation
Published April 1, 1990 - Version history
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Abstract

We developed a mouse model to compare the virulence of Campylobacter fetus strains with (S-plus) and without (S-minus) surface array protein (S-protein) capsules. In adult HA/ICR mice pretreated with ferric chloride, the LD50 for S-plus strain 84-32 was 43.3 times lower than its spontaneous S-minus mutant 84-54. Seven strains of inbred mice were no more susceptible than the outbred strain. In contrast to the findings with Salmonella typhimurium by others, 3 X 10(7) CFU of strain 84-32 caused 90% mortality in C3H/HeN (LPSn) mice and 40% mortality in C3H/HeJ (LPSd) mice. High-grade bacteremia in HA/ICR mice occurred after oral challenge with S-plus C. fetus strains and continued for at least 2 d, but was not present in any mice challenged with S-minus strains. Bacteremia at 30 min after challenge was 51.6-fold lower in mice pretreated with 10 microliters of rabbit antiserum to purified S-protein than after pretreatment with normal rabbit serum. Challenge of mice with a mixture of S-minus strain 84-54 and free S-proteins at a concentration 31.1-fold higher than found in wild-type strain 84-32 caused 30% mortality, compared with 0% with strain 84-54 or S-protein alone. These findings in a mouse model point toward the central role of the S-protein in the pathogenesis of C. fetus infection. The S-protein is not toxic per se, but enhances virulence when present on the bacterial cell surface as a capsule.

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Referenced in 4 patents
18 readers on Mendeley
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