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Citations to this article

Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.
R Goldschmeding, … , C G Kallenberg, A E von dem Borne
R Goldschmeding, … , C G Kallenberg, A E von dem Borne
Published November 1, 1989
Citation Information: J Clin Invest. 1989;84(5):1577-1587. https://doi.org/10.1172/JCI114335.
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Research Article

Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.

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Abstract

Anti-neutrophil cytoplasmic autoantibodies (ANCA) specifically associated with Wegener's granulomatosis were found to be directed against a saline-soluble glycoprotein triplet that migrates on SDS gels as distinct bands of Mr 29,000, 30,500, and 32,000 and is present in the azurophilic granules. This antigen was specifically recognized by all cytoplasmic-staining (C)-ANCA-positive sera from patients with Wegener's disease. C-ANCA antigen bound [3H]diisopropylfluorophosphate, which indicates that it is a serine protease, but it could clearly be distinguished from the serine proteases elastase and cathepsin G. Stimulation of cytochalasin B-treated neutrophils with FMLP induced release of C-ANCA antigen. This indicates that in vivo C-ANCA might interact with the C-ANCA antigen after its release upon inflammatory stimulation. We further demonstrate that in some perinuclear staining (P-ANCA) patients' sera autoantibodies against other myeloid lysosomal enzymes can be detected, such as antimyeloperoxidase and antielastase. C-ANCA and P-ANCA thus represent a novel class of autoantibodies directed against myeloid lysosomal enzymes. The originally described Wegener-specific C-ANCA show an apparently uniform specificity for the 29,000 serine protease. In contrast, P-ANCA may recognize myeloperoxidase as well as elastase and/or other antigens.

Authors

R Goldschmeding, C E van der Schoot, D ten Bokkel Huinink, C E Hack, M E van den Ende, C G Kallenberg, A E von dem Borne

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American journal of respiratory cell and molecular biology 2001
Anti–Proteinase 3 Antibody Activation of Neutrophils Can Be Inhibited by α 1-Antitrypsin
CP Rooney, C Taggart, R Coakley, NG McElvaney, SJ O'Neill
American journal of respiratory cell and molecular biology 2001
Disease-modifying Therapy in Vasculitides
CG Kallenberg, JW Tervaert
2001
Methods for the detection of anti-neotrophil cytoplasmic antibodies: Recommendations for clinical use of ANCA serology and laboratory efforts to optimize the informative value of ANCA test results
A Wiik
Springer Seminars in Immunopathology 2001
Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants.
Yang JJ, Preston GA, Pendergraft WF, Segelmark M, Heeringa P, Hogan SL, Jennette JC, Falk RJ
The American Journal of Pathology 2001
Antiproteinase 3- and antimyeloperoxidase-associated vasculitis
CF Franssen, CA Stegeman, CG Kallenberg, RO Gans, PE de Jong, SJ Hoorntje, JW Tervaert
Kidney International 2000
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: Prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease
S Lindgren, S Nilsson, L Nassberger, H Verbaan, J Wieslander
Journal of Gastroenterology and Hepatology 2000
Treatment with Propylthiouracil is Associated with Appearance of Antineutrophil Cytoplasmic Antibodies in Some Patients with Graves' Disease
N Sera, K Ashizawa, T Ando, Y Abe, A Ide, T Usa, T Tominaga, E Ejima, N Yokoyama, K Eguchi
Thyroid 2000
In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG)
YM van der Geld, MG Huitema, CF Franssen, R der Zee, PC Limburg, CG Kallenberg
Clinical & Experimental Immunology 2000
Autoantibodies to early endosome antigen (EEA1) produce a staining pattern resembling cytoplasmic anti-neutrophil cytoplasmic antibodies (C-ANCA)
S Selak, RC Woodman, MJ Fritzler
Clinical & Experimental Immunology 2000
What you should know about PR3-ANCA. An introduction
A Wiik
Arthritis research 2000
Recombinant proteinase 3 produced in different expression systems: recognition by anti-PR3 antibodies
YM van der Geld, W Oost-Kort, PC Limburg, U Specks, CG Kallenberg
Journal of Immunological Methods 2000
Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver diseases
C Roozendaal, MA Jong, AP Berg, RT Wijk, PC Limburg, CG Kallenberg
Journal of Hepatology 2000
Utilidad clínica de los anticuerpos anticitoplasma de neutrófilo con especial referencia a la fibrosis quística
F Pérez-Aguilar, J Berenguer, JM Sánchez-Cuenca, E Carmona
Medicina Clínica 2000
On the Origin of Surface Proteinase 3 of Nonmyeloid Cells: Evidence Favoring an Exogenous Source
Z Zhou, A Dionne, C Richard, HA Ménard
Clinical Immunology 2000
Nosocomial Pneumonia
UL Specks
Nosocomial Pneumonia 2000
Immunology and Liver
MP Manns, G Paumgartner, U Leuschner
2000
What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)
E Peen, WR C
Arthritis Research & Therapy 2000
Upregulation of CD14 and CD18 on Monocytes In Vitro by Antineutrophil Cytoplasmic Autoantibodies
R Nowack, K Schwalbe, LF Flores-Suárez, B Yard, FJ Woude
Journal of the American Society of Nephrology : JASN 2000
MCF‐7 mammary tumour cells express the myeloid cell differentiation controlling factor, serine protease3/myeloblastin
S Horman, D Fokan, P Galand
Cell Proliferation 2000
Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis
P Cockwell, CJ Brooks, D Adu, CO Savage
Kidney International 1999
The prevalence and clinical significance of α1-antitrypsin deficiency (PiZ) and anca specificities (proteinase 3, BPI) in patients with ulcerative colitis
AN Elzouki, S Eriksson, R Löfberg, L Nässberger, JÖ Wieslander, S Lindgren
Inflammatory Bowel Diseases 1999
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications
CG Kallenberg, JW Tervaert
Current Opinion in Nephrology and Hypertension 1999
Anti-neutrophil cytoplasmic antibodies in a rat model of trinitrobenzenesulphonic acid-induced liver injury
Orth, Neurath, Schirmacher, Treichel, Meyer zum Buschenfelde, Mayet
European Journal of Clinical Investigation 1999
Antineutrophil cytoplasmic antibodies in Japanese patients with inflammatory bowel disease: prevalence and recognition of putative antigens
K Sugi, O Saitoh, R Matsuse, K Tabata, K Uchida, K Kojima, K Nakagawa, S Tanaka, T Teranishi, I Hirata, K Katsu
The American Journal of Gastroenterology 1999
Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies
YM van der Geld, PC Limburg, CG Kallenberg
Clinical & Experimental Immunology 1999
Diagnostic value of classical and atypical antineutrophil cytoplasmic antibody (ANCA) immunofluorescence patterns
RC Wong, RA Silvestrini, JA Savige, DA Fulcher, EM Benson
Journal of clinical pathology 1999
The biodegradation of poly(urethane)s by the esterolytic activity of serine proteases and oxidative enzyme systems
RS Labow, E Meek, JP Santerre
Journal of Biomaterials Science, Polymer Edition 1999
The Decade of Autoimmunity
BD Stollar
The Decade of Autoimmunity 1999
The Prevalence and Clinical Significance of α1-Antitrypsin Deficiency (PiZ) and ANCA Specificities (Proteinase 3, BPI) in Patients with Ulcerative Colitis:
AN Elzouki, S Eriksson, R Löfberg, L Nässberger, J Wieslander, S Lindgren
Inflammatory Bowel Diseases 1999
Antimyeloperoxidase-associated Lung Disease: An Experimental Model
P Foucher, P Heeringa, AH Petersen, MG Huitema, E Brouwer, JW Tervaert, J Prop, P Camus, JJ Weening, CG Kallenberg
American journal of respiratory and critical care medicine 1999
Does Analysis of the Antigenic Specificities of Anti-Neutrophil Cytoplasmic Antibodies Contribute to Their Clinical Significance in the Inflammatory Bowel Diseases?
CR Horst
Scandinavian Journal of Gastroenterology 1999
Presence of Proteinase 3 in Secretory Vesicles: Evidence of a Novel, Highly Mobilizable Intracellular Pool Distinct From Azurophil Granules
V Witko-Sarsat, EM Cramer, C Hieblot, J Guichard, P Nusbaum, S Lopez, P Lesavre, L Halbwachs-Mecarelli
Blood 1999
Clinical Utility of Testing for Antineutrophil Cytoplasmic Antibodies
D Vassilopoulos, GS Hoffman
1999
A Large Subset of Neutrophils Expressing Membrane Proteinase 3 Is a Risk Factor for Vasculitis and Rheumatoid Arthritis
V Witko-Sarsat, P Lesavre, S Lopez, G Bessou, C Hieblot, B Prum, LH Noël, L GUILLEVIN, P Ravaud, I Sermet-Gaudelus, J Timsit, JP Grünfeld, L Halbwachs-Mecarelli
Journal of the American Society of Nephrology : JASN 1999
Anti-Neutrophil Cytoplasm Autoantibodies (ANCA). The Need for Specific and Sensitive Assays
B Baslund, J Petersen
Autoimmunity 1998
Anticytokeratins are a potential source of false-positive indirect immunofluorescence assays for C-ANCA
J Streicher, B Fabian, K Herkner, H Pointner, PM Bayer
Journal of Clinical Laboratory Analysis 1998
Myeloperoxidase autoantibodies distinguish vasculitis mediated by anti-neutrophil cytoplasm antibodies from immune complex disease in MRL/Mp-lpr/lprmice: a spontaneous model for human microscopic angiitis
JM Harper, S Thiru, CM Lockwood, A Cooke
European Journal of Immunology 1998
Clinical evaluation of a capture ELISA for detection of proteinase-3 antineutrophil cytoplasmic antibody Technical Note
KW Westman, D Selga, P Bygren, M Segelmark, B Baslund, A Wiik, J Wieslander
Kidney International 1998
Animal models of anti-neutrophil cytoplasmic antibody associated vasculitis
P Heeringa, E Brouwer, JW Tervaert, JJ Weening, CG Kallenberg
Kidney International 1998
Expression of iNOS, eNOS, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis
P Heeringa, H Goor, H Moshage, PA Klok, MG Huitema, A Jager, AJ Schep, CG Kallenberg
Kidney International 1998
Anti-neutrophil cytoplasmic antibody (ANCA) target antigens, disease associations, and laboratory testing
HS Jethwa, RJ Falk, JC Jennette
Clinical Immunology Newsletter 1998
Anti-Phagocyte Antibodies and Infection
AM Forde, C Feighery, J Jackson
Autoimmunity 1998
Atypical antineutrophil cytoplasmic antibodies with perinuclear fluorescence in chronic inflammatory bowel diseases and hepatobiliary disorders colocalize with nuclear lamina proteins
B Terjung, V Herzog, HJ Worman, I Gestmann, C Bauer, T Sauerbruch, U Spengler
Hepatology 1998
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features
C Roozendaal, AW de Wit, EB Haagsma, G Horst, C Schwarze, HH Peter, JH Kleibeuker, JW Tervaert, PC Limburg, CG Kallenberg
The American Journal of Medicine 1998
Disease spectrum of patients with antineutrophil cytoplasmic autoantibodies of defined specificity: distinct differences between patients with anti-proteinase 3 and anti-myeloperoxidase autoantibodies
Franssen, Gans, Kallenberg, Hageluken, Hoorntje
Journal of Internal Medicine 1998
Critical Care Nephrology
C Ronco, R Bellomo
1998
Anticytokeratins are a potential source of false‐positive indirect immunofluorescence assays for C‐ANCA
Streicher J, Fabian B, Herkner K, Pointner H, Bayer PM
Journal of Clinical Laboratory Analysis 1998
Recombinant proteinase 3 (Wegener's antigen) expressed in Pichia pastoris is functionally active and is recognized by patient sera
MC Harmsen, P Heeringa, YM Geld, MG Huitema, A Klimp, A Tiran, CG Kallenberg
Clinical & Experimental Immunology 1997
Myeloperoxidase fragments reacting with serum from a patient with myeloperoxidase-anti-neutrophil cytoplasmic antibody-positive glomerulonephritis
I Otani, A Ishida-Okawara, S Yamagoe, T Miyoshi-Koshio, Y Arimura, T Nagasawa, S Mizuno, K Suzuki
Journal of Infection and Chemotherapy 1997
Perinuclear antineutrophil cytoplasmic antibody in rheumatoid arthritis. A marker of severe disease with associated nephropathy
A Mustila, M Korpel, J Mustonen, H Helin, H Huhtala, E Soppi, A Pasternack, A Miettinen
Arthritis & Rheumatism 1997
What causes ANCA?
RJ FALK, PH NACHMAN, JC JENNETTE
Nephrology 1997
The spectrum of ANCA-associated small vessel vasculitis and glomerulonephritis
JC JENNETTE, RJ FALK
Nephrology 1997
Antineutrophil cytoplasm antibodies and vasculitis
MC Nash, MJ Dillon
Archives of disease in childhood 1997
Systemic injection of products of activated neutrophils and H2O2 in myeloperoxidase-immunized rats leads to necrotizing vasculitis in the lungs and gut
P Heeringa, P Foucher, PA Klok, MG Huitema, JW Tervaert, JJ Weening, CG Kallenberg
The American Journal of Pathology 1997
Granulomatous gastritis in Wegener's disease: differentiation from Crohn's disease supported by a positive test for antineutrophil antibodies
B Temmesfeld-Wollbrueck, C Heinrichs, A Szalay, W Seeger
Gut 1997
Small-Vessel Vasculitis
JC Jennette, RJ Falk
New England Journal of Medicine 1997
PATHOGENESIS OF VASCULITIS SYNDROMES
MC Sneller, AS Fauci
Medical Clinics of North America 1997
9 Laboratory findings in the vasculitides
CG Kallenberg
Baillière's Clinical Rheumatology 1997
Purification of Wegener's Granulomatosis Autoantigen, Proteinase 3, from Neutrophils by Triton X-114 Extraction of Azurophilic Granules
NH Heegaard, DR Jakobsen, D Klattschou
Analytical Biochemistry 1997
Identification of an autoantibody against alpha-enolase in primary biliary cirrhosis
N Akisawa, T Maeda, S Iwasaki, S Onishi
Journal of Hepatology 1997
Actin is a target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis type-1
T Orth, G Gerken, R Kellner, KH Büschenfelde, WJ Mayet
Journal of Hepatology 1997
Comparative evaluation of unfixed and fixed human neutrophils for determination of antineutrophil cytoplasmic antibodies by indirect immunofluorescence
P Yang
Journal of clinical pathology 1997
The pathophysiology of anti-neutrophil cytoplasmic antibodies (ANCA) and their clinical relevance
WJ Mayet, I Helmreich-Becker, KH Büschenfelde
Critical Reviews in Oncology/Hematology 1996
Azurocidin is a novel antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in systemic vasculitis
MH Zhao, CM Lockwood
Clinical & Experimental Immunology 1996
Classification, Pathogenesis, and Treatment of Systemic Vasculitis
ME Griffith, G Gaskin, CD Pusey
Renal Failure 1996
The Diagnostic and Prognostic Significance of ANCA
P Lesavre
Renal Failure 1996
Autoantibodies to myeloperoxidase aggravate mild anti-glomerular-basement-membrane-mediated glomerular injury in the rat
P Heeringa, E Brouwer, PA Klok, MG Huitema, J Born, JJ Weening, CG Kallenberg
The American Journal of Pathology 1996
Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase
JJ Yang, R Kettritz, RJ Falk, JC Jennette, ML Gaido
The American Journal of Pathology 1996
A comprehensive method to purify three major ANCA antigens: proteinase 3, myeloperoxidase and bactericidal/permeability-increasing protein from human neutrophil granule acid extract
MH Zhao, CM Lockwood
Journal of Immunological Methods 1996
Recombinant human proteinase 3, the Wegener's autoantigen, expressed in HMC-1 cells is enzymatically active and recognized by c-ANCA
U Specks, DN Fass, MP Fautsch, AM Hummel, MA Viss
FEBS Letters 1996
Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti-neutrophil cytoplasmic autoantibodies
V Witko-Sarsat, L Halbwachs-Mecarelli, RP Almeida, P Nusbaum, M Melchior, G Jamaleddine, P Lesavre, B Descamps-Latscha, JE Gabay
FEBS Letters 1996
Respiratory Failure in ANCA-Associated Vasculitis
JC Maaten, CF Franssen, RO Gans, RJ van Schijndel, SJ Hoorntje
Chest 1996
Manual of Biological Markers of Disease
WJ van Venrooij, RN Maini
1996
The Vasculitides
BM Ansell, PA Bacon, JT Lie, H Yazici
1996
Autoantibodies and target antigens in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides
JA Savige, L Chang, D Wilson, RR Buchanan
Rheumatology International 1996
Indirect immunofluorescence study of the cornea and the conjunctiva in a xenogeneic system: analysis of humoral reactivity in patients with Wegener's granulomatosis
U Przyklang, B Nölle, E Reinhold-Keller, G Duncker
Graefe's Archive for Clinical and Experimental Ophthalmology 1996
Antineutrophil cytoplasmic antibodies: Major autoantigens, pathophysiology, and disease associations
DR Schultz, EC Tozman
Seminars in Arthritis and Rheumatism 1995
Screening for anti-neutrophil cytoplasmic antibodies (ANCA): is indirect immunofluorescence the method of choice?
B Baslund, M Segelmark, A Wiik, W Szpirt, J Petersen, J Wieslander
Clinical & Experimental Immunology 1995
Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis
MH Zhao, SJ Jones, CM Lockwood
Clinical & Experimental Immunology 1995
Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration
M Blank, Y Tomer, M Stein, J Kopolovic, A Wiik, PL Meroni, G Conforti, Y Shoenfeld
Clinical & Experimental Immunology 1995
Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis
GH Daouk, R Palsson, MA Arnaout
Kidney International 1995
Proteolysis of classic anti-neutrophil cytoplasmic autoantibodies (C-ANCA) by neutrophil proteinase 3
KM Dolman, A Jager, A Sonnenberg, AE Borneo, R Goldschmeding
Clinical & Experimental Immunology 1995
Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells
R Dengler, U Muunstermann, S Al-Batran, I Hausner, S Faderl, C Nerl, B Emmerich
British Journal of Haematology 1995
Differences between anti-myeloperoxidase- and anti-proteinase 3-associated renal disease
CF Franssen, RO Gans, B Arends, C Hageluken, PM Wee, PG Gerlag, SJ Hoorntje
Kidney International 1995
Renal ischemia/reperfusion injury contributes to renal damage in experimental anti-myeloperoxidase-associated proliferative glomerulonephritis
E Brouwer, PA Klok, MG Huitema, JJ Weening, CG Kallenberg
Kidney International 1995
Clinicopathologic features of antineutrophil cytoplasm autoantibody (ANCA)-associated acute renal failure in Chinese patients
T Chan, K Chan, J Lawfon, C Lo, F Li, W Lo, M Ip, I Cheng
Nephrology 1995
Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3
W King, D Adu., M Daha, C Brooks, D Radford, A Pall, C Savage
Clinical & Experimental Immunology 1995
Cell-mediated autoimmunity in patients with Wegener's granulomatosis (WG)
BE Ballieux, SH Burg, EC Hagen, FJ Woude, CJ Melief, MR Daha
Clinical & Experimental Immunology 1995
Antineutrophil cytoplasmic antibodies and their relevance to the dermatologist
N Burrows, C Lockwood
British Journal of Dermatology 1995
Relationship between disease activity and anti-neutrophil cytoplasmic antibody concentration in long-term management of systemic vasculitis
J De'Oliviera, G Gaskin, A Dash, AJ Rees, CD Pusey
American Journal of Kidney Diseases 1995
A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells
R Kain, K Matsui, M Exner, S Binder, G Schaffner, EM Sommer, D Kerjaschki
Journal of Experimental Medicine 1995
Activation of granulocytes by anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis: a predominant role for the IgG3 subclass of ANCA
AH Mulder, CA Stegeman, CG Kallenberg
Clinical & Experimental Immunology 1995
Nuclear localization of the antigen detected by ulcerative colitis-associated perinuclear antineutrophil cytoplasmic antibodies
P Billing, S Tahir, B Calfin, G Gagne, L Cobb, S Targan, A Vidrich
The American Journal of Pathology 1995
Bimodal distribution of proteinase 3 (PR3) surface expression reflects a constitutive heterogeneity in the polymorphonuclear neutrophil pool
L Halbwachs-Mecarelli, G Bessou, P Lesavre, S Lopez, V Witko-Sarsat
FEBS Letters 1995
Vasculitis in the kidney
D Adu, AJ Howie
Current Diagnostic Pathology 1995
Segregation of pANCA antigenic recognition by DNase treatment of neutrophils: Ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis
A Vidrich, J Lee, E James, L Cobb, S Targan
Journal of Clinical Immunology 1995
WEGENER'S GRANULOMATOSIS
GF Duna, C Galperin, GS Hoffman
Rheumatic diseases clinics of North America 1995
Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration.
Blank M, Tomer Y, Stein M, Kopolovic J, Wiik A, Meroni PL, Conforti G, Shoenfeld Y
Clinical & Experimental Immunology 1995
Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3.
King WJ, Adu D, Daha MR, Brooks CJ, Radford DJ, Pall AA, Savage CO
Clinical & Experimental Immunology 1995
Proteolysis of classic anti-neutrophil cytoplasmic autoantibodies (C-ANCA) by neutrophil proteinase 3.
Dolman KM, Jager A, Sonnenberg A, von dem Borne AE, Goldschmeding R
Clinical & Experimental Immunology 1995
Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.
Zhao MH, Jones SJ, Lockwood CM
Clinical & Experimental Immunology 1995
Neutrophil activation in vitro and in vivo in Wegener's granulomatosis
E Brouwer, MG Huitema, AH Mulder, P Heeringa, H Goor, JW Tervaert, JJ Weening, CG Kallenberg
Kidney International 1994
T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis (WG)
E Brouwer, CA Stegeman, MG Huitema, PC Limburg, CG Kallenberg
Clinical & Experimental Immunology 1994
Detachment and cytolysis of human endothelial cells by proteinase 3
BE Ballieux, PS Hiemstra, N Klar-Mohamad, EC Hagen, LA van Es, FJ van der Woude, MR Daha
European Journal of Immunology 1994
Anti-neutrophil cytoplasmic antibodies: Current diagnostic and pathophysiological potential
CG Kallenberg, E Brouwer, JJ Weening, JW Tervaert
Kidney International 1994
Cross-reactivity of an anti-proteinase 3 antibody to elastase
G Dalpé, A Béliveau, HA Ménard, G Boire
Autoimmunity 1994
Anti-proteinase 3 antibodies, their characterization and disease associations
JG Jennings, L Chang, JA Savige
Clinical & Experimental Immunology 1994
Sensibilité et spécificité des anticorps anticytoplasme des neutrophiles (c-ANCA) au cours des vascularites systémiques
E Hachulla, PY Hatron, M Brouillard, JY Cesbron, D Reumaux, B Devulder
La Revue de Médecine Interne 1994
Rein et vascularites
LH Noël
La Revue de Médecine Interne 1994
Diagnostic value of anti-neutrophil cytoplasmic and anti-endothelial cell antibodies in early Kawasaki disease
J Guzman, M Fung, RE Petty
The Journal of Pediatrics 1994
Immunological Aspects of Cardiovascular Diseases: Implications for Treatment
DK Ledford
Clinical immunotherapeutics 1994
Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion
JJ Yang, GA Preston, WF Pendergraft, M Segelmark, P Heeringa, SL Hogan, JC Jennette, RJ Falk
Stroke; a journal of cerebral circulation 1994
Structure of the Azurocidin, Proteinase 3, and Neutrophil Elastase Genes: Implications for Inflammation and Vasculitis
DE Jenne
American journal of respiratory and critical care medicine 1994
Wegener's Granulomatosis
DR Jordan, DJ Addison
Ophthalmology 1994
Neutrophil autoantibodies in inflammatory Bowel disease: Are they important?
F Shanahan
Gastroenterology 1994
Pulmonary Pathology
DH Dail, SP Hammar
1994
Neutrophil cytoplasmic antibodies (p-ANCA) in ulcerative colitis
PM Ellerbroek, MO Pool, BU Ridwan, KM Dolman, BM von Blomberg, AE von dem Borne, SG Meuwissen, R Goldschmeding
Journal of clinical pathology 1994
Immunology of ENT Disorders
GK Scadding
1994
Mechanisms of endothelial cell injury in vasculitis
AA Pall, CO Savage
Springer Seminars in Immunopathology 1994
Anti-neutrophil cytoplasmic autoantibodies (ANCA) and vasculitis
B Baslund, A Wiik
Clinical Reviews in Allergy 1994
Anti-neutrophil cytoplasmic antibodies (ANCA) in sera from patients with inflammatory bowel disease (IBD): Relation to disease pattern and disease activity
J Broekroelofs, AH Mulder, GF Nelis, BD Westerveld, JW Tervaert, CG Kallenberg
Digestive Diseases and Sciences 1994
T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis (WG).
Brouwer E, Stegeman CA, Huitema MG, Limburg PC, Kallenberg CG
Clinical & Experimental Immunology 1994
Anti-neutrophil cytoplasmic antibodies (ANCA) in inflammatory bowel disease: characterization and clinical correlates.
Mulder AH, Broekroelofs J, Horst G, Limburg PC, Nelis GF, Kallenberg CG
Clinical & Experimental Immunology 1994
Anti-proteinase 3 antibodies, their characterization and disease associations.
Jennings JG, Chang L, Savige JA
Clinical & Experimental Immunology 1994
Cleavage and inactivation of human C1 inhibitor by the human leukocyte proteinase, proteinase 3
RW Leid, BE Ballieux, I der Heijden, CK der Keur, EC Hagen, LA van Es, FJ van der Woude, MR Daha
European Journal of Immunology 1993
Alpha1-antitrypsin genetic polymorphism in ANCA-positive systemic vasculitis
VL Esnault, A Testa, M Audrain, C Rogé, M Hamidou, JH Barrier, R Sesboüé, JP Martin, P Lesavre
Kidney International 1993
Relevance of classic anti-neutrophil cytoplasmic autoantibody (C-ANCA)-mediated inhibition of proteinase 3-α1-antitrypsin complexation to disease activity in Wegener's granulomatosis
KM Dolman, CA Stegeman, BA Wiel, CE Hack, AE Borne, CG Kallenberg, R Goldschmeding
Clinical & Experimental Immunology 1993
Cross-Reactivity of an Anti-Proteinase 3 Antibody to Elastase
G Dalpé, A Béliveau, HA Ménard
Autoimmunity 1993
ANCA and associated diseases: immunodiagnostic and pathogenetic aspects
WL Gross, WH Schmitt, E Csernok
Clinical & Experimental Immunology 1993
Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis
R Fienberg, EJ Mark, M Goodman, RT McCluskey, JL Niles
Human Pathology 1993
Neutrophil Alloantibodies React With Cytoplasmic Antigens: A Possible Cause of False-Positive Indirect Immunofluorescence Assays for Antibodies to Neutrophil Cytoplasmic Antigens
DF Stroncek, MS Egging, GA Eiber, ME Clay
American Journal of Kidney Diseases 1993
Tissue distribution of autoantigen specific for primary sclerosing cholangitis
SK Lo, RW Chapman, KA Fleming
Journal of clinical pathology 1993
ANCA-Associated Vasculitides
WL Gross
1993
Symposium in Immunology I and II
MM Eibl, C Huber, HH Peter, U Wahn
1993
NEUROLOGIC MANIFESTATIONS OF SYSTEMIC VASCULITIDES
JW Tervaert, C Kallenberg
Rheumatic diseases clinics of North America 1993
DO ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES CAUSE WEGENER’S GRANULOMATOSIS AND OTHER FORMS OF NECROTIZING VASCULITIS?
JC Jennette, BH Ewert, RJ Falk
Rheumatic diseases clinics of North America 1993
A novel specificity of anticytoplasmic autoantibodies directed against eosinophil peroxidase.
Dolman KM, Damsma I, Tool AT, Sonnenberg A, von dem Borne AE, Goldschmeding R
Clinical & Experimental Immunology 1993
ANCA and associated diseases: immunodiagnostic and pathogenetic aspects.
Gross WL, Schmitt WH, Csernok E
Clinical & Experimental Immunology 1993
Anti-myeloperoxidase autoantibodies react with native but not denatured myeloperoxidase
RJ Falk, M Becker, R Terrell, JC Jennette
Clinical & Experimental Immunology 1992
Anti-neutrophil cytoplasmic autoantibodies in patients with symptomatic HIV infection
RJ Klaassen, R Goldschmeding, KM Dolman, AB Vlekke, HM Weigel, JK Schattenkerk, JW Mulder, ML Westedt, AE Borne
Clinical & Experimental Immunology 1992
Determination of proteinase 3—α1-antitrypsin complexes in inflammatory fluids
KM Dolman, BA van de Wiel, CM Kam, JJ Abbink, CE Hack, A Sonnenberg, JC Powers, AE von Borne, R Goldschmeding
FEBS Letters 1992
FUNDAMENTAL AND CLINICAL ASPECTS OF ANTI NEUTROPHIL CYTOPLASMIC ANTIBODIES (ANCA)
EC Hagen, BE Ballieux, MR Daha, LA van Es, FJ van der Woude
Autoimmunity 1992
Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity
BA Wiel, KM Dolman, CH Meer-Gerritsen, CE Hack, AE Borne, R Goldschmeding
Clinical & Experimental Immunology 1992
Substrate and inhibitor studies on proteinase 3
CM Kam, JE Kerrigan, KM Dolman, R Goldschmeding, AE von Borne, JC Powers
FEBS Letters 1992
Antibodies to Cathepsin G in Crohn's disease
WJ Mayet, E Hermann, J Finsterwalder, H Rieder, T Poralla, KH Meyer, Z Büschenfelde
European Journal of Clinical Investigation 1992
Determination of anti-neutrophil cytoplasm antibodies (ANCA) specificity by immunofluorescence on chronic myelocytic leukemia cells
A Chevailler, LH Noel, G Renier, M Gardembas-Pain, JF Subra, P Nusbaum, D Hurez, P Lesavre
Journal of Immunological Methods 1992
Antineutrophil cytoplasmic antibodies: A still-growing class of autoantibodies in inflammatory disorders
CG Kallenberg, AH Mulder, JW Tervaert
The American Journal of Medicine 1992
The Autoimmune Diseases II
CC Bernard, TE Mandel, IR Mackay
The Autoimmune Diseases II 1992
Diagnostic Value of Anti-neutrophil Cytoplasmic Antibodies in Scleritis Associated with Wegener's Granulomatosis
SH Soukiasian, CS Foster, JL Niles, MB Raizman
Ophthalmology 1992
Anti-myeloperoxidase Autoantibodies in Patients With Necrotizing Glomerular and Alveolar Capillaritis
X Bosch, E Mirapeix, J Font, R Cervera, M Ingelmo, MA Khamashta, L Revert, GR Hughes, A Urbano-Márquez
American Journal of Kidney Diseases 1992
Association of IgM with IgG ANCA in patients presenting with pulmonary hemorrhage
VL Esnault, B Soleimani, MT Keogan, AA Brownlee, DR Jayne, M Lockwood
Kidney International 1992
HLA class II specificities in vasculitis with antibodies to neutrophil cytoplasmic antigens
SJ Spencer, A Burns, G Gaskin, CD Pusey, AJ Rees
Kidney International 1992
Neutrophil autoantibodies in ulcerative colitis: Familial aggregation and genetic heterogeneity
F Shanahan, RH Duerr, JI Rotter, H Yang, LR Sutherland, C McElree, CJ Landers, SR Targan
Gastroenterology 1992
Pathogenesis of Systemic Vasculitides
CO Savage
1992
Collagen Vascular Disease
JD DeSpain, RW Swinfard
Dermatologic Clinics 1992
Endothelial Cell Dysfunctions
N Simionescu, M Simionescu
1992
The antigenic significance and methods of detection of the anti-neutrophil cytoplasmic autoantibodies (ANCA)
X Bosch, RA Asherson
Postgraduate medical journal 1992
Biochemistry of Pulmonary Emphysema
C Grassi, J Travis, L Casali, M Luisetti
1992
Anti-myeloperoxidase autoantibodies react with native but not denatured myeloperoxidase.
Falk RJ, Becker M, Terrell R, Jennette JC
Clinical & Experimental Immunology 1992
Anti-neutrophil cytoplasmic autoantibodies in patients with symptomatic HIV infection.
Klaassen RJ, Goldschmeding R, Dolman KM, Vlekke AB, Weigel HM, Eeftinck Schattenkerk JK, Mulder JW, Westedt ML, von dem Borne AE
Clinical & Experimental Immunology 1992
Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity.
van de Wiel BA, Dolman KM, van der Meer-Gerritsen CH, Hack CE, von dem Borne AE, Goldschmeding R
Clinical & Experimental Immunology 1992
An acquired antithrombin autoantibody directed toward the catalytic center of the enzyme
P Sié, A Bezeaud, D Dupouy, G Archipoff, JM Freyssinet, JM Dugoujon, G Serre, MC Guillin, B Boneu
Journal of Clinical Investigation 1991
Anti-Granulocyte Antibodies (C-ANCA, P-ANCA, GS-ANA) Studied by Confocal Scanning Laser Fluorescence Microscopy, ELISA, and Chemiluminescence Techniques
T Skogh, C Dahlgren, K Holmgren, E Peen, O Stendahl
Scandinavian Journal of Immunology 1991
Neutrophil autoantibodies as disease markers for ulcerative colitis
F Shanahan, C Landers, R Duerr, SR Targan
Immunologic Research 1991
Antineutrophil cytoplasmic antibody?A useful serological marker for vasculitis
JA Goeken
Journal of Clinical Immunology 1991
Comparison of immunofluorescence and an immunohistochemical technique for the detection of perinuclear anti-neutrophil cytoplasmic antibody
AM McKane, SA McMillan, SK Conlan, TA McNeill
Irish Journal of Medical Science 1991
Anti-pyruvate dehydrogenase autoantibodies in primary biliary cirrhosis
N Zurgil, R Bakimer, M Kaplan, P Youinou, Y Shoenfeld
Journal of Clinical Immunology 1991
New horizons in renal vasculitis
JS Cameron
Klinische Wochenschrift 1991
Autoantibodies in systemic vasculitis
JA Savige, M Gallicchio, L Chang, JD Parkin
Australian and New Zealand Journal of Medicine 1991
Predominance of IgGl and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders
E Brouwer, JW Tervaert, G Horst, MG Huitema, M Giessen, P Limburg, CG Kallenberg
Clinical & Experimental Immunology 1991
Autoimmunity to lysosomal enzymes: new clues to vasculitis and glomerulonephritis?
CG Kallenberg, JW Tervaert, FJ der Woude, R Goldschmeding, AE Borne, JJ Weening
Immunology Today 1991
Detection of autoantibodies against myeloid lysosomal enzymes: A useful adjunct to classification of patients with biopsy-proven necrotizing arteritis
JW Tervaert, PC Limburg, JD Elema, MG Huitema, G Horst, TH The, CG Kallenberg
The American Journal of Medicine 1991
Nasal biopsy in Wegener's granulomatosis
TV Colby, HD Tazelaar, U Specks, RA DeRemee
Human Pathology 1991
How Are Antineutrophil Cytoplasmic Autoantibodies Detected?
J Wieslander
American Journal of Kidney Diseases 1991
Antineutrophil Cytoplasmic Autoantibodies Antigen Specificity
P Lesavre
American Journal of Kidney Diseases 1991
Neutrophil Cytoplasmic Antibodies: A Link Between Primary Sclerosing Cholangitis and Ulcerative Colitis
RH Duerr, SR Targan, CJ Landers, NF Larusso, KL Lindsay, RH Wiesner, F Shanahan
Gastroenterology 1991
Anti-neutrophil cytoplasmic antibodies in ulcerative colitis
RH Duerr, SR Targan, CJ Landers, LR Sutherland, F Shanahan
Gastroenterology 1991
Molecular Aspects of Inflammation
H Sies, L Flohé, G Zimmer
1991
Nephrology
M Hatano
Nephrology 1991
New Aspects of Human Polymorphonuclear Leukocytes
WH Hörl, PJ Schollmeyer
1991
Autoantibodies to native myeloperoxidase in patients with pulmonary hemorrhage and acute renal failure
DE Roberts, C Peebles, JG Curd, EM Tan, RL Rubin
Journal of Clinical Immunology 1991
Antigen specificities and clinical distribution of ANCA in kidney diseases
P Lesavre, LH Noël, D Chauveau, C Geffriaud, JP Grünfeld
Klinische Wochenschrift 1991
Antineutrophil cytoplasmic autoantibodies: Immunobiological aspects
WL Gross, E Csernok, WH Schmitt
Klinische Wochenschrift 1991
Antimyeloperoxidase antibodies in the Churg-Strauss syndrome
JW Tervaert, R Goldschmeding, JD Elema, AE von dem Borne, CG Kallenberg
Thorax 1991
Immunology of Renal Disease
CD Pusey
1991
The effect of anti-neutrophil cytoplasm autoantibodies on the signal transduction in human neutrophils.
Lai KN, Lockwood CM
Clinical & Experimental Immunology 1991
Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties
D Campanelli, PA Detmers, CF Nathan, JE Gabay
Journal of Clinical Investigation 1990
ANCA-associated renal disease
RJ Falk
Kidney International 1990
Antineutrophil cytoplasmic antibodies in inflammatory bowel disease and collagenous colitis: No association with lactoferrin, β-glucuronidase, myeloperoxidase, or proteinase 3
P Yang, J Bohr, C Tysk, D Danielsson, G Järnerot
Inflammatory Bowel Diseases
Influence of total colectomy on serum antineutrophil cytoplasmic antibodies in inflammatory bowel disease
RT Patel, R Stokes, D Birch, J Ibbotson, MR Keighley
British Journal of Surgery 1994
Antineutrophil cytoplasmic autoantibodies in the immunodiagnosis of systemic necrotizing vasculitis
DE Roberts
Journal of Clinical Laboratory Analysis 1994
Autoantibodies to lactoferrin and histone in systemic vasculitis identified by anti-myeloperoxidase solid phase assays
VL Esnault, AK Short, MA Audrain, SJ Jones, SJ Martin, JM Skehel, CM Lockwood
Kidney International 1994
Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC?
BE Ballieux, KT Zondervan, P Kievit, EC Hagen, LA Es, FJ Woude, MR Daha
Clinical & Experimental Immunology 1994
Anti-neutrophil cytoplasmic antibodies (ANCA) in inflammatory bowel disease: characterization and clinical correlates
AH Mulder, J Broekroelofs, G Horst, PC Limburg, GF Nelis, CG Kallenberg
Clinical & Experimental Immunology 1994
Structural and functional characterization of elastases from horse neutrophils
A Dubin, J Potempa, J Travis
Biochemical Journal 1994
Measurements of proteinase 3 and its complexes with α1-proteinase inhibitor and Anti-Neutrophil Cytoplasm Antibodies (ANCA) in plasma
B Baslund, J Petersen, H Permin, A Wiik, J Wieslander
Journal of Immunological Methods 1994
High immunoreactivity of lactoferrin contaminating commercially purified myeloperoxidase
MA Audrain, TA Baranger, CM Lockwood, VL Esnault
Journal of Immunological Methods 1994
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases
AH Mulder, G Horst, EB Haagsma, PC Limburg, JH Kleibeuker, CG Kallenberg
Hepatology 1993
Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with wegener's granulomatosis
GS Kerr, TA Fleisher, CW Hallahan, RY Leavitt, AS Fauci, GS Hoffman
Arthritis & Rheumatism 1993
Alpha-enolase: A novel cytosolic autoantigen in ANCA positive vasculitis
FD Moodie, B Leaker, G Cambridge, NF Totty, AW Segal
Kidney International 1993
A novel specificity of anticytoplasmic autoantibodies directed against eosinophil peroxidase
KM Dolman, I Damsma, AT Tool, A Sonnenberg, AE Borne, R Goldschmeding
Clinical & Experimental Immunology 1993
Serum antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease are mainly associated with ulcerative colitis. A correlation study between perinuclear antineutrophil cytoplasmic autoantibodies and clinical parameters, medical, and surgical treatment
MO Pool, PM Ellerbroek, BU Ridwan, R Goldschmeding, BM von Blomberg, AS Peña, KM Dolman, H Bril, W Dekker, JJ Nauta
Gut 1993
Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model
E Brouwer, MG Huitema, PA Klok, H Weerd, JW Tervaert, JJ Weening, CG Kallenberg
Journal of Experimental Medicine 1993
Relevance of classic anti-neutrophil cytoplasmic autoantibody (C-ANCA)-mediated inhibition of proteinase 3-alpha 1-antitrypsin complexation to disease activity in Wegener's granulomatosis
KM Dolman, CA Stegeman, BA van de Wiel, CE Hack, AE von Borne, CG Kallenberg, R Goldschmeding
Clinical & Experimental Immunology 1993
Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory disorders
JW Tervaert, L Mulder, C Stegeman, J Elema, M Huitema, H The, C Kallenberg
Annals of the rheumatic diseases 1993
Case 13-1993 : A 74-Year-Old Woman with Rapidly Progressing Renal Failure after an Upper Respiratory Tract Infection
RC Cabot, RE Scully, EJ Mark, WF McNeely, BU McNeely, JL Seifter, JL Niles, RT McCluskey
New England Journal of Medicine 1993
The value of indirect immunofluorescence and solid phase techniques for ANCA detection
EC Hagen, K Andrassy, E Chernok, MR Daha, G Gaskin, W Gross, P Lesavre, J Lüdemann, CD Pusey, N Rasmussen, CO Savage, A Sinico, A Wiik, FJ van der Woude
Journal of Immunological Methods 1993
Isolation of a protein complex from purulent sputum consisting of proteinase-3 and α1-antitrypsin reactive with anti neutrophil cytoplasmic antibodies
BE Ballieux, EC Hagen, C der Keur, ND Zegers, LA Es, FJ der Woude, MR Daha
Journal of Immunological Methods 1993
Analysis of Antibody Reactivity in the Sera of 42 Patients with Paraproteinaemia
AJ Macgregor, J Kalsi, CT Ravirajan, B Leaker, R Watts, H Winska-Wiloch, B Knight, A Norden, DA Isenberg, G Cambridge
Autoimmunity 1992
Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role
G Cambridge, DS Rampton, TR Stevens, DA McCarthy, M Kamm, B Leaker
Gut 1992
Production of human monoclonal antibodies to myeloperoxidase
MR Ehrenstein, B Leaker, D Isenberg, G Cambridge
Immunology 1992
Case 18-1992 : Asthma, Peripheral Neuropathy, and Eosinophilia in a 52-Year-Old Man
RC Cabot, RE Scully, EJ Mark, WF McNeely, BU McNeely, SM Helfgott, JL Niles, RT McCluskey
New England Journal of Medicine 1992
The nephritogenic immune response
SL Karp, SE Albert, EG Neilson
Current Opinion in Immunology 1991
Anti-myeloperoxidase antibodies: Immunological characteristics and clinical associations
P Gueirard, A Delpech, D Gilbert, M Godin, XL Loet, F Tron
Journal of Autoimmunity 1991
The effect of anti-neutrophil cytoplasm autoantibodies on the signal transduction in human neutrophils
KN Lai, CM Lockwood
Clinical & Experimental Immunology 1991
Predominance of IgG1 and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders
E Brouwer, JW Tervaert, G Horst, MG Huitema, M der Giessen, PC Limburg, CG Kallenberg
Clinical & Experimental Immunology 1991
IgG subclass distribution and relative functional affinity of anti-myeloperoxidase antibodies in systemic vasculitis at presentation and during follow-up
VL Esnault, DR Jayne, AP Weetman, CM Lockwood
Immunology 1991
Association of autoantibodies to myeloperoxidase with different forms of vasculitis
JW Tervaert, R Goldschmeding, JD Elema, PC Limburg, M der Giessen, MG Huitema, MI Koolen, RJ Hené, TH The, GK van der Hem, AE von Borne, CG Kallenberg
Arthritis & Rheumatism 1990
Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro
RJ Falk, RS Terrell, LA Charles, JC Jennette
Proceedings of the National Academy of Sciences 1990
Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils
D Campanelli, M Melchior, Y Fu, M Nakata, H Shuman, C Nathan, JE Gabay
Journal of Experimental Medicine 1990
Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis
E Csernok, J Lüdemann, WL Gross, DF Bainton
The American Journal of Pathology 1990
Case 47-1990 : A 51-Year-Old Man with Hemoptysis and Cavitary Lesions of the Left Lung
RC Cabot, RE Scully, EJ Mark, WF McNeely, BU McNeely, PC Pairolero, EJ Mark
New England Journal of Medicine 1990
Criteria for disease activity in Wegener's granulomatosis: A requirement for longitudinal clinical studies
CG Kallenberg, JW Tervaert, CA Stegeman
APMIS 1990
The relation of 29 kD C-ANCA antigen to proteinase 3
R Goldschmeding, KM Dolman, ME Ende, CH Meer-Gerritsen, A Sonnenberg, AE Borne
APMIS 1990
New strategies for plasma exchange in systemic vasculitis
DR Jayne
Transfusion Science 1990
Laboratory methods for detection of antineutrophil cytoplasm antibodies
J Lüdemann, B Utecht, WL Gross
Clinical Immunology Newsletter 1990
Role of Testing for Anticytoplasmic Autoantibodies in the Differential Diagnosis of Scleritis and Orbital Pseudotumor
PH Kalina, JA Garrity, DC Herman, RI DeREMEE, U Specks
Mayo Clinic Proceedings 1990
Antineutrophilic Cytoplasmic Antibodies in Systemic Vasculitis: The author replies
DL Conn
Mayo Clinic Proceedings 1990
Antineutrophil cytoplasmic autoantibody in renal disease
RJ Falk, JC Jennette
Clinical Immunology Newsletter 1990
Antineutrophil Cytoplasmic Autoantibodies and Associated Diseases: A Review
JC Jennette, RJ Falk
American Journal of Kidney Diseases 1990
Recent Advances in Systemic Vasculitis
GS Panayi
Journal of the Royal Society of Medicine 1990
The ANCA test: its clinical relevance
G Ramirez, MA Khamashta, GR Hughes
Annals of the rheumatic diseases 1990
Anti-neutrophil cytoplasmic antibodies and vasculitis
B Leaker, G Cambridge
Postgraduate medical journal 1990
Granulomatous Vasculitis
U Specks, RA DeRemee
Rheumatic diseases clinics of North America 1990
International Review of Experimental Pathology
P Hoedemaeker
International Review of Experimental Pathology 1988
Autoantibodies
MH Lessof, SP Asper
American Heart Journal 1960
Antineutrophil Cytoplasmic Antibodies in Inflammatory Bowel Disease and Collagenous Colitis: No Association with Lactoferrin, β-Glucuronidase, Myeloperoxidase, or Proteinase 3:
P Yang, J Bohr, C Tysk, D Danielsson, G Järnerot
Inflammatory Bowel Diseases

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