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Article has an altmetric score of 3

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Research Article Free access | 10.1172/JCI114193

T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation.

F Griesinger, J M Greenberg, and J H Kersey

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.

Find articles by Griesinger, F. in: PubMed | Google Scholar

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.

Find articles by Greenberg, J. in: PubMed | Google Scholar

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.

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Published August 1, 1989 - More info

Published in Volume 84, Issue 2 on August 1, 1989
J Clin Invest. 1989;84(2):506–516. https://doi.org/10.1172/JCI114193.
© 1989 The American Society for Clinical Investigation
Published August 1, 1989 - Version history
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Abstract

We have studied recombinatorial events of the T cell receptor delta and gamma chain genes in hematopoietic malignancies and related these to normal stages of lymphoid differentiation. T cell receptor delta gene recombinatorial events were found in 91% of acute T cell lymphoblastic leukemia, 68% of non-T, non-B lymphoid precursor acute lymphoblastic leukemia (ALL) and 80% of mixed lineage acute leukemias. Mature B-lineage leukemias and acute nonlymphocytic leukemias retained the T-cell receptor delta gene in the germline configuration. The incidence of T cell receptor gamma and delta was particularly high in CD10+CD19+ non-T, non-B lymphoid precursor ALL. In lymphoid precursor ALL, T cell receptor delta was frequently rearranged while T cell receptor gamma was in the germline configuration. This suggests that TCR delta rearrangements may precede TCR gamma rearrangements in lymphoid ontogeny. In T-ALL, only concordant T cell receptor delta and gamma rearrangements were observed. Several distinct rearrangements were defined using a panel of restriction enzymes. Most of the rearrangements observed in T-ALL represented joining events of J delta 1 to upstream regions. In contrast, the majority of rearrangements in lymphoid precursor ALL most likely represented D-D or V-D rearrangements, which have been found to be early recombinatorial events of the TCR delta locus. We next analyzed TCR delta rearrangements in five CD3+TCR gamma/delta+ ALL and cell lines. One T-ALL, which demonstrated a different staining pattern with monoclonal antibodies against the products of the TCR gamma/delta genes than the PEER cell line, rearranges J delta 1 to a currently unidentified variable region.

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Referenced in 4 Wikipedia pages
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