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Citations to this article

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.
M S Simonson, … , J R Sedor, M J Dunn
M S Simonson, … , J R Sedor, M J Dunn
Published February 1, 1989
Citation Information: J Clin Invest. 1989;83(2):708-712. https://doi.org/10.1172/JCI113935.
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Research Article

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

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Abstract

A recently described peptide hormone, endothelin, is a potent vasoconstrictor, but it is unclear whether endothelin has other biological actions. These experiments extend the range of biological actions of endothelin to stimulation of mitogenesis. Endothelin at low concentrations (0.1-10 nM) induced mitogenesis by quiescent rat glomerular mesangial cells in culture. Mitogenesis induced by endothelin was accompanied by activation of phospholipase C with increased inositol phosphate turnover and increments of intracellular [Ca2+]. Endothelin also activated Na+/H+ exchange, causing cytosolic alkalinization, and enhanced transcription of the c-fos protooncogene, additional biochemical signals closely linked to proliferation. In addition to being a vasoconstrictor, endothelin thus also functions as a mitogen, presumably through activation of phospholipase C.

Authors

M S Simonson, S Wann, P Mené, G R Dubyak, M Kester, Y Nakazato, J R Sedor, M J Dunn

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T MORIYAMA, C XIA, A MIYAI, Y AKAGI, Y ISAKA, T KANEKO, N KAWADA, N UEDA, A YAMAUCHI, M HORIO, A ANDO, E IMAI, M HORI
Nephrology 1997
Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells
K Cadwallader, J Beltman, F McCormick, S Cook
Biochemical Journal 1997
Measurement and clinical significance of endothelin in neonatal urine
H Huijun, L Wanjun
Journal of Tongji Medical University 1997
Renoprotective effects of a combined endothelin type A/type B receptor antagonist in experimental malignant hypertension
M Kohno, K Yokokawa, K Yasunari, H Kano, M Minami, M Ueda, Y Tatsumi, J Yoshikawa
Metabolism 1997
Effect of beraprost sodium on DNA synthesis in cultured bovine mesangial cells
K Nitta, A Kawashima, K Uchida, K Matsugami, Y Eto, K Natori, W Yumura, H Nihei
Clinical and Experimental Nephrology 1997
Intralobular innervation and lipocyte contractility in the liver
T Ueno, K Tanikawa
Nutrition 1997
NEW DEVELOPMENTS IN DRUG THERAPY OF HYPERTENSION
I Kobrin, V Charlon, M Bursztyn
Medical Clinics of North America 1997
Oxidized low-density lipoprotein stimulates endothelin-1 release and mRNA expression from rat mesangial cells
MS Tan, YJ Lee, SJ Shin, JH Tsai
Journal of Laboratory and Clinical Medicine 1997
Endothelins and their role in hypertension
WH Frishman, P Tamirisa, A Kumar
Baillière's Clinical Anaesthesiology 1997
Differential Effects of Endothelin-1 on Basal and Isoprenaline-Enhanced Ca 2+ Current in Guinea-Pig Ventricular Myocytes
GP Thomas, SM Sims, M Karmazyn
The Journal of Physiology 1997
Ketamine Relaxes Airway Smooth Muscle Contracted by Endothelin:
T Sato, A Matsuki, EK Zsigmond, SF Rabito
Anesthesia & Analgesia 1997
The Endothelin System in Cardiovascular Physiology and Pathophysiology
RJ Parris, DJ Webb
Vascular medicine (London, England) 1997
Endothelin-1 increases rat distal tubule acidification in vivo
DE Wesson, GM Dolson
American journal of physiology. Renal physiology 1997
Adenosine Activates Mesangial Cell Proliferation
M MacLaughlin, C Martinez-Salgado, N Eleno, A Olivera, JM Lopez-Novoa
Cellular Signalling 1997
Endothelin-1 as an Autocrine/Paracrine Apoptosis Survival Factor for Endothelial Cells
M Shichiri, H Kato, F Marumo, Y Hirata
Hypertension 1997
Biphasic Regulation of the Preproendothelin-1 Gene by c-myc*
M Shichiri, S Adachi, JM Sedivy, F Marumo, Y Hirata
Endocrinology 1997
Absence of endothelin receptors and receptor mRNA in mammalian fibroblasts transformed with SV40 or ras oncogene
P Nambi, M R Mattern, H L Wu, M Pullen, P Nuthulaganti, G A Hofmann, C Kumar
Molecular and Cellular Biochemistry 1997
Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells
TS Chu, Y Peng, A Cano, M Yanagisawa, RJ Alpern
Journal of Clinical Investigation 1996
Differential inhibition of mesangial MAP kinase cascade by cyclic nucleotides
M Haneda, S Araki, T Sugimoto, M Togawa, D Koya, R Kikkawa
Kidney International 1996
Endothelin in renal pathophysiology: From experimental to therapeutic application
TJ Rabelink, KA Kaasjager, ES Stroes, HA Koomans
Kidney International 1996
PMA and Ionomycin Differently Affect Atrial Natriuretic Peptide Stimulated Cyclic GMP Production in Rat Mesangial Cells
Y Akai, E Kusano, M Amemiya, S Ono, S Takeda, S Homma, Y Asano
The Tohoku Journal of Experimental Medicine 1996
SYMPOSIUM Experimental Biology 1995 Endothelin Receptors: Role in Renal Function and Dysfunction ENDOTHELIN IS A KEY MODULATOR OF PROGRESSIVE RENAL INJURY: EXPERIMENTAL DATA AND NOVEL THERAPEUTIC STRATEGIES
I Bruzzi, A Benigni
Clinical and Experimental Pharmacology and Physiology 1996
Vasoactive hormones and renal sclerosis
J Egido
Kidney International 1996
Endothelin in organ transplantation
B Watschinger, MH Sayegh
American Journal of Kidney Diseases 1996
Protective Effect of the Specific Endothelin-1 Antagonist BQ610 on Mechanical Function and Energy Metabolism During Ischemia/Reperfusion Injury in Isolated Perfused Rat Hearts
B Illing, M Horn, H Han, S Hahn, P Bureik, G Ertl, S Neubauer
Journal of Cardiovascular Pharmacology 1996
Endothelin 1-21 Plasma Concentrations in Children and Adolescents with Insulin-Dependent Diabetes Mellitus
A Malamitsi-Puchner, E Economou, K Katsouyanni, F Karachaliou, D Delis, CS Bartsocas
Journal of Pediatric Endocrinology and Metabolism 1996
High resolution localization of endothelin receptors in rat renal medulla
T Yukimura, M Notoya, K Mizojiri, V Mizuhira, T Matsuura, T Ebara, K Miura, S Kim, H Iwao, K Song
Kidney International 1996
The endothelin system in the kidney
FE KARET, A PDAVENPORT
Nephrology 1996
Role of endothelin as a mitogen in experimental glomerulonephritis in rats
K Fukuda, T Yanagida, S Okuda, K Tamaki, T Ando, M Fujishima
Kidney International 1996
SYMPOSIUM Experimental Biology 1995 Endothelin Receptors: Role in Renal Function and Dysfunction SIGNALLING PATHWAYS ACTIVATED BY ENDOTHELIN STIMULATION OF RENAL CELLS
EP Nord
Clinical and Experimental Pharmacology and Physiology 1996
CELLULAR LOCALIZATION OF ENDOTHELIN RECEPTOR SUBTYPES IN THE RAT KIDNEY FOLLOWING IN VITRO LABELLING
R Dean, J Zhuo, D Alcorn, D Casley, FA Mendelsohn
Clinical and Experimental Pharmacology and Physiology 1996
Blocking both type A and B endothelin receptors in the kidney attenuates renal injury and prolongs survival in rats with remnant kidney
A Benigni, C Zoja, D Corna, S Orisio, D Facchinetti, L Benatti, G Remuzzi
American Journal of Kidney Diseases 1996
EXPRESSION OF ENDOTHELIN-1 IN PANCREATIC TISSUE OF PATIENTS WITH CHRONIC PANCREATITIS
Y Kakugawa, A Giaid, M Yanagisawa, AG Baynash, P Melnyk, L Rosenberg, WP Duguid
The Journal of Pathology 1996
Voltage-insensitive Ca2+ channels and Ca2+/calmodulin-dependent protein kinases propagate signals from endothelin-1 receptors to the c-fos promoter
Y Wang, MS Simonson
Molecular and cellular biology 1996
Inhibition of endothelin- and phorbol ester-stimulated tyrosine kinase activity by corticotrophin in the rat adrenal zona glomerulosa
S Kapas, JP Hinson
Biochemical Journal 1996
Decrease in endothelin-1 renal receptors during the 1st month of life in the rat
L Abadie, I Blazy, P Roubert, P Plas, M Charbit, PE Chabrier, M Dechaux
Pediatric Nephrology 1996
Increased urinary endothelin excretion in patients with liver cirrhosis
M Kitano, J Uemasu, H Kawasaki
Journal of Gastroenterology and Hepatology 1996
Bradykinin stimulates c-fos expression, AP-1-DNA binding activity and proliferation of rat glomerular mesangial cells
SS El-Dahr, S Dipp, IV Yosipiv, WH Baricos
Kidney International 1996
The correlation of plasma and urine endothelin-1 with the severity of nephropathy in Chinese patients with Type 2 diabetes
SJ Shin, YJ Lee, JH Tsai
Scandinavian Journal of Clinical & Laboratory Investigation 1996
Endothelin-1 Modulates the Expression of Adhesion Molecules on Fibroblast-like Synovial Cells (FLS)
A Schwarting, J Schlaak, J Lotz, I Pfers, WJ Mayet
Scandinavian Journal of Rheumatology 1996
Endothelin degradation by vascular smooth muscle cells
H Bermek, KC Peng, K Angelova, A Ergul, D Puett
Regulatory Peptides 1996
Endothelin protein expression in tear glands of the rabbit
Y Takashima, H Takagi, M Takahashi, PS Reinach, AK Mircheff, DW Warren, N Yoshimura
Current Eye Research 1996
Activation of Multiple Mitogen-activated Protein Kinase Signal Transduction Pathways by the Endothelin B Receptor Requires the Cytoplasmic Tail
E Aquilla, A Whelchel, HJ Knot, M Nelson, J Posada
The Journal of biological chemistry 1996
Interaction of Adrenomedullin and Platelet-Derived Growth Factor on Rat Mesangial Cell Production of Endothelin
M Kohno, K Yasunari, K Yokokawa, T Horio, M Ikeda, H Kano, M Minami, T Hanehira, J Yoshikawa
Hypertension 1996
cGMP Formation in Rat Atrial Slices Is Ligand and Endothelin Receptor Subtype Specific
Z Shraga-Levine, M Sokolovsky
Circulation research 1996
Mammary Tumor Cell Cycle, Differentiation, and Metastasis
RB Dickson, ME Lippman
1996
Characterization of the Renal Phenotype of Transgenic Rats Expressing the Human Endothelin-2 Gene
B Hocher, L Liefeldt, C Thöne-Reineke, HD Orzechowski, A Distler, C Bauer, M Paul
Hypertension 1996
Mechanism of Catecholamine-Induced Proliferation of Vascular Smooth Muscle Cells
SM Yu, SY Tsai, JH Guh, FN Ko, CM Teng, JT Ou
Circulation 1996
Endothelin and Calcium Antagonists in the Skin Microcirculation of Patients With Coronary Artery Disease
RR Wenzel, N Duthiers, G Noll, J Bucher, U Kaufmann, TF Luscher
Circulation 1996
Endocrinology of the Vasculature
JR Sowers
1996
Biochemistry of Signal Transduction in Myocardium
JM Lamers, PD Verdouw
1996
Molecular Reviews in Cardiovascular Medicine
K Lindpaintner, D Ganten
1996
The Clinical Potential of Endothelin Receptor Antagonists in Cardiovascular Medicine:
CJ Ferro, DJ Webb
Drugs 1996
Endothelin and endothelin antagonists: Potential role in cardiovascular and renal disease
G Noll, RR Wenzel, TF Lscher
Molecular and Cellular Biochemistry 1996
Endothelin in congestive heart failure
M P Love, J J McMurray
Basic Research in Cardiology 1996
Influence of hypoxia on hepatic and renal endothelin gene expression
T Ritthaler, T Göpfert, JD Firth, PJ Ratcliffe, BK Kramer, A Kurtz
Pflügers Archiv - European Journal of Physiology 1996
Influence of endothelin 1 on human atrial myocardium--myocardial function and subcellular pathways
M Meyer, S Lehnart, B Pieske, K Schlottauer, S Munk, C Holubarsch, H Just, G Hasenfuss
Basic Research in Cardiology 1996
Prostaglandin E2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat
EP Silldorff, S Yang, TL Pallone
Journal of Clinical Investigation 1995
Diabetes Mellitus and Hypertension, Emerging Therapeutic Perspectives
JR Sowers, M Epstein
Cardiovascular Drug Reviews 1995
Nitric oxide and endothelin in pathophysiological settings
TE Hunley, S Iwasaki, T Homma, V Kon
Pediatric Nephrology 1995
Gentamicin activates rat mesangial cells. A role for platelet activating factor
A Rodriguez-Barbero, AM Rodriguez-Lopez, R Gonzalez-Sarmiento, JM López-Novoa
Kidney International 1995
ACE inhibition prevents renal failure and death in uninephrectomized MWF/Ztm rats
A Remuzzi, A Benigni, B Malanchini, I Bruzzi, C Foglieni, G Remuzzi
Kidney International 1995
Discrepant effects of vasoconstrictors on the growth of early passaged cultured rat mesangial cells
T ARAKAWA, T OKUDA, Y INISHI, K SEKITA, M KASUGA, K KUROKAWA
Nephrology 1995
Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat
A Yoshimura, S Iwasaki, K Inui, T Ideura, S Koshikawa, M Yanagisawa, T Masaki
Kidney International 1995
Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells
AK Hughes, E Padilla, WA Kutchera, JR Michael, DE Kohan
Kidney International 1995
Renal actions of endothelin-1 and endothelin-3: Interactions with the prostaglandin system and nitric oxide
SY Chou, JG Porush
American Journal of Kidney Diseases 1995
Dietary supplementation with L-arginine limits cell proliferation in the remnant glomerulus
A Ingram, A Parbtani, K Thai, H Ly, SJ Shankland, G Morrissey, JW Scholey
Kidney International 1995
Endothelin-I induces gene expression through stimulation of endothelin type a receptors in normal rat kidney cells
G Yumet, MH Chin, B Carey, KJ Soprano, KE Lipson
Journal of Cellular Physiology 1995
Effect of a specific endothelin A receptor antagonist on murine lupus nephritis
T Nakamura, I Ebihara, Y Tomino, H Koide
Kidney International 1995
Endothelial modulation of vasoconstrictor responses to endothelin-1 in human placental stem villi small arteries
S Sabry, F Mondon, M Levy, F Ferré, AT Dinh-Xuan
British Journal of Pharmacology 1995
Cardiac natriuretic peptides inhibit cyclosporine-induced production of endothelin in cultured rat mesangial cells
M Kohno, K Yokokawa, AK Mandal, T Horio, K Yasunari, T Takeda
Metabolism 1995
EFFECTS OF A SELECTIVE ENDOTHELIN A-RECEPTOR ANTAGONIST, BQ-123, IN SALT-LOADED STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
M Okada, M Kobayashi, H Maruyama, R Takahashi, F Ikemoto, M Yano, M Nishikibe
Clinical and Experimental Pharmacology and Physiology 1995
ENDOTHELIN-INDUCED ACTIVATION OF MITOGEN-ACTIVATED PROTEIN KINASES IN GLOMERULAR MESANGIAL CELLS FROM NORMOTENSIVE AND STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS
I Kishimoto, T Yoshimasa, H Arai, K Takaya, Y Miyamoto, J Yamashita, S Suga, Y Komatsu, O Nakagawa, I Tanaka, H Itoh, K Nakao
Clinical and Experimental Pharmacology and Physiology 1995
Endothelin receptor subtypes and their role in transmembrane signaling mechanisms
M Sokolovsky
Pharmacology & Therapeutics 1995
Endothelins stimulate sodium uptake into rat brain capillary endothelial cells through endothelin A-like receptors
N Kawai, RM McCarron, M Spatz
Neuroscience Letters 1995
The Role of the Renin-Angiotensin System in Cisplatin Nephrotoxicity
PM Deegan, C Nolan, MP Ryan, MA Basinger, MM Jones, KR Hande
Renal Failure 1995
Effects and mechanisms of action of endothelins on non-vascular smooth muscle of the respiratory, gastrointestinal and urogenital tracts
GA Rae, JB Calixto, P D'Orléans-Juste
Regulatory Peptides 1995
Expression of endothelin-1 immunoreactivity in breast cancer
K Kojima, Z Nihei
Surgical Oncology 1995
Prognostic value of plasma soluble intercellular adhesion molecule-1 and endothelin-1 concentration in patients with chronic congestive heart failure
T Tsutamoto, T Hisanaga, D Fukai, A Wada, Y Maeda, K Maeda, M Kinoshita
The American Journal of Cardiology 1995
Endothelin and endothelin antagonism: Roles in cardiovascular health and disease
P Tamirisa, WH Frishman, A Kumar
American Heart Journal 1995
Endothelin-1 mediates erythropoietin-stimulated glomerular endothelial cell-dependent proliferation of mesangial cells
K Nitta, K Uchida, N Kimata, A Kawashima, W Yumura, H Nihei
European Journal of Pharmacology: Environmental Toxicology and Pharmacology 1995
Plasma endothelin and Kaposi's sarcoma
P Cacoub, A Coutellier, G Maistre, G Christian, C Frances, JC Piette, P Godeau
Journal of the American Academy of Dermatology 1995
Vascular and Myocardial Protective Effects of Converting Enzyme Inhibition in Experimental Heart Failure
P Mulder
The American Journal of Cardiology 1995
Ultraviolet B irradiation increases endothelin-1 and endothelin receptor expression in cultured human keratinocytes
R Tsuboi, C Sato, Y Oshita, H Hama, T Sakurai, K Goto, H Ogawa
FEBS Letters 1995
Signal sorting by G-protein-linked receptors
G Milligan
Advances in pharmacology (San Diego, Calif.) 1995
Endothelin-1, but not endothelin-3, suppresses lipoprotein lipase gene expression in brown adipocytes differentiated in culture
Y Uchida, K Irie, F Tsukahara, K Ohba, A Ogawa, E Fujii, T Muraki
European Journal of Pharmacology: Molecular Pharmacology 1995
Vascular and myocardial protective effects of converting enzyme inhibition in experimental heart failure
P Mulder, B Devaux, LE Fertak, P Compagnon, V Richard, JP Henry, E Scalbert, P Desché, B Macé, C Thuillez
The American Journal of Cardiology 1995
Characterization of Endothelin Receptor Subtypes on Airway Smooth Muscle Cells
A Ergul, MK Glassberg, A Wanner, D Puett
Experimental Lung Research 1995
Vascular smooth muscle cells metabolize endothelin-1 in the absence of a functional receptor
C R Gandhi
Biochimica et Biophysica Acta 1995
Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6:
MA McMillen, M Huribal, ME Cunningham, R Kumar, BE Sumpio
Critical Care Medicine 1995
Endothelin Receptor Subtype B Mediates Autoinduction of Endothelin-1 in Rat Mesangial Cells
S Iwasaki, T Homma, Y Matsuda, V Kon
The Journal of biological chemistry 1995
Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines: IMPLICATIONS FOR CELLULAR PROLIFERATION AND DIFFERENTIATION
E Coroneos, M Martinez, S McKenna, M Kester
The Journal of biological chemistry 1995
Endothelin Production in Cultured Mesangial Cells of Spontaneously Hypertensive Rats
M Ikeda, M Kohno, T Takeda
Hypertension 1995
Effect of Hypothalamic-Hypophysary Inhibitory Factor on Mesangial Cell Activation
A Rodríguez-Barbero, C Martínez-Salgado, AM Rodríguez-López, M Ricote, J Sancho, JM López-Novoa
Hypertension 1995
Hypertensive Cerebrovascular Disease and the Renin-Angiotensin System
GP Rossi, A Rossi, A Sacchetto, E Pavan, AC Pessina
Stroke; a journal of cerebral circulation 1995
Differential Effects of Pressure and Flow on DNA and Protein Synthesis and on Fibronectin Expression by Arteries in a Novel Organ Culture System
N Bardy, GJ Karillon, R Merval, JL Samuel, A Tedgui
Circulation research 1995
Stimulation of Na+/H+ exchange activity by endothelin in opossum kidney cells
R Walter, C Helmle-Kolb, J Forgo, U Binswanger, H Murer
Pflügers Archiv - European Journal of Physiology 1995
Endothelin-1 release from cultured endothelial cells induced by sera from patients with systemic lupus erythematosus
T Yoshio, J Masuyama, A Mimori, A Takeda, S Minota, S Kano
Annals of the rheumatic diseases 1995
The Endothelium in Cardiovascular Disease
TF Lüscher
1995
Mediators in the Cardiovascular System: Regional Ischemia
K Schrör, CR Pace-Asciak
1995
Astrocyte growth is regulated by neuropeptides through Tis 8 and basic fibroblast growth factor
RM Hu, ER Levin
Journal of Clinical Investigation 1994
Endothelin's biphasic effect on fluid absorption in the proximal straight tubule and its inhibitory cascade
NH Garcia, JL Garvin
Journal of Clinical Investigation 1994
Alpha 1 adrenergic receptor-induced c-fos gene expression in rat aorta and cultured vascular smooth muscle cells
M Okazaki, ZW Hu, M Fujinaga, BB Hoffman
Journal of Clinical Investigation 1994
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by protein kinase C activators
MS Tan, JC Tsai, YJ Lee, HC Chen, SJ Shin, YH Lai, MA Perrella, C Bianchi, S Higashiyama, W Endege, ME Lee, JH Tsai
Kidney International 1994
Heparin inhibits endothelin-1 production in cultured rat mesangial cells
M Kohno, K Yokokawa, T Horio, M Ikeda, N Kurihara, AK Mandal, T Takeda
Kidney International 1994
A selective endothelin ETA antagonist, BQ-123, inhibits125I-endothelin-1 (125I-ET-1) binding to human meningiomas and antagonizes ET-1-induced proliferation of meningioma cells
N Kitagawa, K Tsutsumi, M Niwa, S Yamaga, T Anda, H Khalid, A Himeno, K Taniyama, S Shibata
Cellular and Molecular Neurobiology 1994
Renal actions of endothelin: Linking cellular signaling pathways to kidney disease
TA Marsen, H Schramek, MJ Dunn
Kidney International 1994
Endothelin-1 acts as an autocrine growth factor for normal human keratinocytes
R Tsuboi, C Sato, CM Shi, T Nakamura, T Sakurai, H Ogawa
Journal of Cellular Physiology 1994
Regulation of Endothelin-1 Biosynthesisa
L Benatti, MS Fabbrini, C Patrono
Annals of the New York Academy of Sciences 1994
Inhibitory effects of antihypertensive drugs on mesangial cell proliferation after anti-thymocyte serum (ATS) — induced mesangiolysis in spontaneously hypertensive rats
S Kiyama, F Nanishi, S Tomooka, S Okuda, K Onoyama, M Fujishima
Life Sciences 1994
Endothelin in Vascular Biology
T Masaki
Annals of the New York Academy of Sciences 1994
Intracellular calcium responses and shape conversions induced by endothelin in cultured subepithelial fibroblasts of rat duodenal villi
K Furuya, S Furuya, S Yamagishi
Pfl�gers Archiv European Journal of Physiology 1994
MITOGENIC ACTIONS OF ENDOTHELIN-1 AND EPIDERMAL GROWTH FACTOR IN CULTURED AIRWAY SMOOTH MUSCLE
AG Stewart, G Grigoriadis, T Harris
Clinical and Experimental Pharmacology and Physiology 1994
Plasma Endothelin-1 Concentrations in Patients with Behçet' Disease
AU Ural, A Yalcin, C Beyan, A Isimer, H Bayhan
Scandinavian Journal of Rheumatology 1994
Effects of total fasting or chronic food restriction on plasma endothelin levels in rats
RS Mehta, DK Hartle
Physiology & Behavior 1994
Stimulation of DNA synthesis by endothelin-1 in primary cultures of human dental pulp
A Casasco, E Maserati, M Giordano, M Casasco, M Ciuffreda, S Sander, M Danova, S Scappaticci, A Calligaro, DR Springall, JM Polak
Archives of Oral Biology 1994
The control of endothelin-1 secretion
K Tasaka, K Kitazumi
General Pharmacology: The Vascular System 1994
Glomerular Hypertrophy and Chronic Renal Failure in Focal .Segmental Glomerulosclerosis
AO Muda, S Feriozzi, GA Cinotti, T Faraggiana
American Journal of Kidney Diseases 1994
Endothelioma Cells Express and Secrete Endothelin-1 and Inhibit Platelet Aggregation through Nitric Oxide Formation
L Monaco, F Pellegatta, R Tagliabue, Y Lu, L Benatti, A Isacchi, JS Pollock, SL Chierchia, MR Sonia, MJ Vidal
Endothelium : journal of endothelial cell research 1994
Endothelin-1 promotes corneal epithelial wound healing in rabbits
H Takagi, PS Reinach, N Yoshimura, Y Honda
Current Eye Research 1994
Role of endothelin in hypertension
BK Krämer, M Ackermann, SM Kohler, GA Riegger
Journal of Molecular Medicine 1994
Identification of specific regions of the human endothelin-B receptor required for high affinity binding with endothelin-3
M Adachi, Y Furuichi, C Miyamoto
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1994
Muscarinic receptor-mediated inhibition of mitogenesis via a protein kinase C-independent mechanism in m1-transfected A9 L cells
J Baumgold, K Dyer
Cellular Signalling 1994
Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor
JJ Yohn, C Smith, T Stevens, JG Morelli, LR Shurnas, SJ Walchak, TA Hoffman, KK Kelley, A Escobedo-Morse, M Yanagisawa, MA Kane, MR Zamora
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1994
Endothelin in human congestive heart failure
CM Wei, A Lerman, RJ Rodeheffer, CG McGregor, RR Brandt, S Wright, DM Heublein, PC Kao, WD Edwards, JC Burnett
Circulation 1994
Role of Na(+)-H+ exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts
N Khandoudi, J Ho, M Karmazyn
Circulation research 1994
Hemodynamic and inotropic effects of endothelin-1 in vivo
ME Beyer, S Nerz, BK Krmer, HM Hoffmeister
Basic Research in Cardiology 1994
A transformed murine Leydig cell line expresses the ETA receptor subtype
A Ergul, MK Glassberg, ME Freeman, D Puett
Molecular and Cellular Biochemistry 1994
Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells
M Kester, E Coroneos, PJ Thomas, MJ Dunn
The Journal of biological chemistry 1994
Endothelins: A Potential Target for Pharmacological Intervention in Diseases of the Elderly
H Lévesque, N Moore, N Cailleux, V Richard, C Thuillez, H Courtois
Drugs & Aging 1994
Intracellular calcium responses and shape conversions induced by endothelin in cultured subepithelial fibroblasts of rat duodenal villi
K Furuya, S Furuya, S Yamagishi
Pflügers Archiv - European Journal of Physiology 1994
Two preproendothelin 1 mRNAs transcribed by alternative promoters
L Benatti, L Bonecchi, L Cozzi, P Sarmientos
Journal of Clinical Investigation 1993
Mechanisms involved in the increased vascular resistance in hypertension
J Marín
Journal of Autonomic Pharmacology 1993
A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression
A Benigni, C Zoja, D Corna, S Orisio, L Longaretti, T Bertani, G Remuzzi
Kidney International 1993
Renal actions of endothelin
EP Nord
Kidney International 1993
Recombinant human erythropoietin (rHuEPO) increases endothelin-1 release by endothelial cells
RG Carlini, AS Dusso, CI Obialo, UM Alvarez, M Rothstein
Kidney International 1993
Endothelin-1 in the rabbit: interactions with cyclo-oxygenase and NO-synthase products
ME Rogerson, HS Cairns, LD Fairbanks, J Westwick, GH Neild
British Journal of Pharmacology 1993
Expression and differential regulation of Id1, a dominant negative regulator of basic helix-loop-helix transcription factors, in glomerular mesangial cells
MS Simonson, A Rooney, WH Herman
Nucleic Acids Research 1993
In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate
A Pecci, CE Gomez-Sanchez, ME de Bedners, CP Lantos, EN Cozza
The Journal of Steroid Biochemistry and Molecular Biology 1993
Growth regulatory properties of endothelins
B Battistini, P Chailler, P D'Orléans-Juste, N Brière, P Sirois
Peptides 1993
Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression
S Orisio, A Benigni, I Bruzzi, D Corna, N Perico, C Zoja, L Benatti, G Remuzzi
Kidney International 1993
A role for platelet-activating factor in endothelin-1-induced rat mesangial cell proliferation
A Montero, A Rodriguez-Barbero, JM López-Novoa
European Journal of Pharmacology 1993
Novel ligands BQ123 and BQ3020 characterize endothelin receptor subtypes ETA and ETB in human kidney
FE Karet, RE Kuc, AP Davenport
Kidney International 1993
Cultured Human Keratinocytes Synthesize and Secrete Endothelin-1
JJ Yohn, JG Morelli, SJ Walchak, KB Rundell, DA Norris, MR Zamora
Journal of Investigative Dermatology 1993
Characterization of Endothelin-Binding Sites in Human Skin and their Regulation in Primary Raynaud's Phenomenon and Systemic Sclerosis
GA Knock, G Terenghi, CB Bunker, HA Bull, PM Dowd, JM Polak
Journal of Investigative Dermatology 1993
The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus
N KAWADA, TA TRAN-THI, H KLEIN, K DECKER
European Journal of Biochemistry 1993
Glucose and scyllo-inositol impair phosphoinositide hydrolysis in the 10.5-day cultured rat conceptus: A role in dysmorphogenesis?
PJ Strieleman, BE Metzger
Teratology 1993
Endothelins Stimulate c-fos and Nerve Growth Factor Expression in Astrocytes and Astrocytoma
RG Ladenheim, I Lacroix, N Foignant-Chaverot, AD Strosberg, PO Couraud
Journal of Neurochemistry 1993
Trophoblastic localization of [125I] endothelin-1binding sites in human placenta
A Malassiné, F Mondon, C Robaut, M Vial, J Bandet, G Tanguy, W Rostène, I Cavero, F Ferré
Placenta 1993
Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis
G A, RP Michel, D Stewart, M Sheppard, Q Hamid, B Corrin
The Lancet 1993
Expression of Endothelin-1 in the Lungs of Patients with Pulmonary Hypertension
A Giaid, M Yanagisawa, D Langleben, RP Michel, R Levy, H Shennib, S Kimura, T Masaki, WP Duguid, DJ Stewart
New England Journal of Medicine 1993
Signal transduction mediated by angiotensin II receptor subtypes expressed in rat renal mesangial cells
ZT Madhun, P Ernsberger, FC Ke, J Zhou, U Hopfer, JG Douglas
Regulatory Peptides 1993
Manidipine inhibits endothelin-1-induced [Ca2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells
S Huang, MS Simonson, MJ Dunn
American Heart Journal 1993
Regulation of cortical collecting duct function: Effect of endothelin
K Kurokawa, K Yoshitomi, M Ikeda, S Uchida, M Naruse, M Imai
American Heart Journal 1993
Endothelin-1 is an autocrine/paracrine regulator of porcine granulosa cells
S Kamada, T Kubota, Y Hirata, T Imai, K Ohta, M Taguchi, F Marumo, T Aso
Journal of Endocrinological Investigation 1993
Chronic transplant rejection: Magnitude of the problem and pathogenetic mechanisms
LC Paul, H Benediktsson
Transplantation Reviews 1993
Endothelins in the Kidney: Physiology and Pathophysiology
DE Kohan
American Journal of Kidney Diseases 1993
Effect of Angiotensin II Blockade on Dietary Protein-Induced Renal Growth
LJ Smith, ME Rosenberg, TH Hostetter
American Journal of Kidney Diseases 1993
Potential Role of Endothelin in the Physiological and Pathological Regulation of Kidney Function: Mini-Review
P Gross, C Renn, R Waldherr, M Seifert, RV Baehr, B Hocher
Endothelium : journal of endothelial cell research 1993
The endothelin-1 binding site in rat liver tissue: Light- and electron-microscopic autoradiographic studies
K Gondo, T Ueno, M Sakamoto, S Sakisaka, M Sata, K Tanikawa
Gastroenterology 1993
Supernatant of endothelial cells exposed to laminar flow inhibits mesangial cell proliferation
M Morigi, C Zoja, M Figliuzzi, G Remuzzi, A Remuzzi
American journal of physiology. Cell physiology 1993
Interaction of PDGF and natriuretic peptides on mesangial cell proliferation and endothelin secretion
M Kohno, M Ikeda, M Johchi, T Horio, K Yasunari, N Kurihara, T Takeda
American journal of physiology. Endocrinology and metabolism 1993
Mechanisms of ET-1 potentiation of angiotensin II stimulation of aldosterone production
EN Cozza, CE Gomez-Sanchez
American journal of physiology. Endocrinology and metabolism 1993
Regulation of endothelin-1 mRNA by angiotensin II in rat heart endothelial cells
BH Chua, CC Chua, CA Diglio, BB Siu
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1993
Potential role of endothelin in hypertension. Controversy on endothelin in hypertension
TF Lüscher, BG Seo, FR Bühler
Hypertension 1993
Host Defense Dysfunction in Trauma, Shock and Sepsis
E Faist, JL Meakins, FW Schildberg
1993
Endothelin: potential role in development and disease
V Kon, A Fogo
Pediatric Nephrology 1993
Urinary endothelin excretion in the neonate: influence of maturity and perinatal pathology
E Sulyok, T Ertl, K Adamovit, S Hovanyovszky, W Rascher
Pediatric Nephrology 1993
Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src
MS Simonson, WH Herman
The Journal of biological chemistry 1993
Cloning and characterization of an endothelin-3 specific receptor (ETC receptor) from Xenopus laevis dermal melanophores
S Karne, CK Jayawickreme, MR Lerner
The Journal of biological chemistry 1993
Role of cytoplasmic domain of the Na+/H+ exchanger in hormonal activation
GK Winkel, C Sardet, J Pouyssegur, HE Ives
The Journal of biological chemistry 1993
Messenger RNA expression and synthesis of endothelin-1 along rat nephron segments
K Ujiie, Y Terada, H Nonoguchi, M Shinohara, K Tomita, F Marumo
Journal of Clinical Investigation 1992
Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells
M Kohno, T Horio, M Ikeda, K Yokokawa, T Fukui, K Yasunari, N Kurihara, T Takeda, M Johchi
Kidney International 1992
Endothelin-1 stimulates the Na+/H+ and Na+/HCO3− transporters in rabbit renal cortex
S Eiam-Ong, SA Hilden, AJ King, CA Johns, NE Madias
Kidney International 1992
Physiology and pharmacology of endothelins
T Masaki, M Yanagisawa, K Goto
Medicinal Research Reviews 1992
Endothelin stimulates phosphatidic acid formation in cultured rat mesangial cells: Role of a protein kinase C-regulated phospholipase D
M Kester, MS Simonson, RG McDermott, E Baldi, MJ Dunn
Journal of Cellular Physiology 1992
Endothelin Peptides: Biological Activities, Cellular Signalling and Clinical Significance
J Leppäluoto, H Ruskoaho
Annals of Medicine 1992
Endothelin mechanisms in the central nervous system: A target for drug development
A Gulati, RC Srimal
Drug Development Research 1992
Endothelins and sarafotoxins: Physiological regulation, receptor subtypes and transmembrane signaling
M Sokolovsky
Pharmacology & Therapeutics 1992
Endothelins
AM Vollmar
Journal of Veterinary Medicine Series A 1992
Autoradiographic localization of endothelin-1 binding sites in human colonic cancer tissue
H Inagaki, AE Bishop, T Eimoto, JM Polak
The Journal of Pathology 1992
Hepatic effects of endothelin. Receptor characterization and endothelin-induced signal transduction in hepatocytes
CR Gandhi, RH Behal, SA Harvey, TA Nouchi, MS Olson
Biochemical Journal 1992
Adenosine stimulates Ca2+ fluxes and increases cytosolic free Ca2+ in cultured rat mesangial cells
A Olivera, A López-Rivas, JM López-Novoa
Biochemical Journal 1992
Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells
Y Wang, MS Simonson, J Pouysségur, MJ Dunn
Biochemical Journal 1992
Increased production of endothelin-1 in patients with inflammatory arthritides
N Miyasaka, Y Hirata, K Ando, K Sato, H Morita, M Shichiri, K Kanno, K Tomita, F Marumo
Arthritis & Rheumatism 1992
Concomitant expression of receptor subtype and isopeptide of endothelin by human adrenal gland
T Imai, Y Hirata, S Eguchi, K Kanno, K Ohta, T Emori, A Sakamoto, M Yanagisawa, T Masaki, F Marumo
Biochemical and Biophysical Research Communications 1992
Endothelin-1 stimulates c-fos mRNA expression and acts as a modulator on cell proliferation of rat FRTL5 thyroid cells
M Miyakawa, T Tsushima, O Isozaki, H Demura, K Shizume, M Arai
Biochemical and Biophysical Research Communications 1992
Effect of hypoxia on endothelin-1 production by pulmonary vascular endothelial cells
JL Wiebke, C Montrose-Rafizadeh, PL Zeitlin, WB Guggino
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1992
The endothelin receptor antagonist, BQ-123, inhibits angiotensin II-induced contractions in rabbit aorta
ML Webb, KE Dickinson, CL Delaney, EC Liu, R Serafino, RB Cohen, H Monshizadegan, S Moreland
Biochemical and Biophysical Research Communications 1992
No effect of a Taql polymorphism in DNA at the endothelin I (EDN1) locus on normal blood pressure level or variability
KL Berge, K Berg
Clinical Genetics 1992
Solution conformation of endothelin and point mutants by nuclear magnetic resonance spectroscopy
DC Dalgarno, L Slater, S Chackalamannil, M M.
International Journal of Peptide and Protein Research 1992
Structure-Function Relationships of Endothelins, Sarafotoxins, and Their Receptor Subtypes
M Sokolovsky
Journal of Neurochemistry 1992
Endothelin: Systemic Arterial and Pulmonary Effects of a New Peptide with Potent Biologic Properties
TF Lüscher
American journal of respiratory and critical care medicine 1992
Stimulation of c-fos and c-jun gene expression and down-regulation of proenkephalin gene expression in C6 glioma cells by endothelin-1
J Yin, JA Lee, RD Howells
Molecular Brain Research 1992
Effect of cell density on endothelin release from endothelial cells and phosphoramidon dependent inhibition
R Zaragoza, GP Budzik, TP Dillon, TJ Opgenorth
Biochemical Pharmacology 1992
The selective endothelin ETA receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis
EH Ohlstein, A Arleth, H Bryan, JD Elliott, CP Sung
European Journal of Pharmacology: Molecular Pharmacology 1992
Platelet-derived growth factor: A potentially important cytokine in glomerular disease
R Johnson, H Iida, A Yoshimura, J Floege, DF Bowen-Pope
Kidney International 1992
Regulation of endothelin-1 production in cultured rat mesangial cells
H Sakamoto, S Sasaki, Y Nakamura, K Fushimi, F Marumo
Kidney International 1992
Cytosolic and nuclear signaling by endothelin peptides: Mesangial response to glomerular injury
MS Simonson, JM Jones, MJ Dunn
Kidney International 1992
Endothelin-1 receptor antagonist: Effects on endothelin- and cyclosporine-treated mesangial cells
M Takeda, MD Breyer, TD Noland, T Homma, RL Hoover, T Inagami, V Kon, DM Fredin, SE Hellings
Kidney International 1992
Cloning and Expression of a Human Endothelin Receptor: Subtype A
DJ Hayzer, PM Rose, JS Lynch, ML Webb, BK Kienzle, EC Liu, EA Bogosian, E Brinson, MS Runge
The American Journal of the Medical Sciences 1992
Endothelin-1 stimulates DNA synthesis and proliferation of pulmonary artery smooth muscle cells
K Janakidevi, MA Fisher, PJ Vecchio, C Tiruppathi, J Figge, AB Malik
American journal of physiology. Cell physiology 1992
Endothelin increases [Ca2+]i in rat pancreatic acinar cells by intracellular release but fails to increase amylase secretion
DI Yule, GT Blevins, AC Wagner, JA Williams
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1992
Endothelium-derived contracting factors
TF Lüscher, CM Boulanger, Y Dohi, ZH Yang
Hypertension 1992
Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium
CM Boulanger, FC Tanner, ML Béa, AW Hahn, A Werner, TF Lüscher
Circulation research 1992
Hypertension, the endothelial cell, and the vascular complications of diabetes mellitus
WA Hsueh, PW Anderson
Hypertension 1992
Endothelins. Myocardial actions of a new class of cytokines
BK Krämer, M Nishida, RA Kelly, TW Smith
Circulation 1992
Effect of endothelin on production of cerebrospinal fluid in rabbits
KA Schalk, FM Faraci, DD Heistad
Stroke; a journal of cerebral circulation 1992
Renovascular and Renal Parenchymatous Hypertension
TF Lüscher, NM Kaplan
1992
Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells
I Aramori, S Nakanishi
The Journal of biological chemistry 1992
Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes
R Hilal-Dandan, K Urasawa, LL Brunton
The Journal of biological chemistry 1992
Dexamethasone down-regulates the expression of endothelin receptors in vascular smooth muscle cells
P Nambi, M Pullen, HL Wu, P Nuthulaganti, N Elshourbagy, C Kumar
The Journal of biological chemistry 1992
Differential regulation of fos and jun gene expression and AP-1 cis-element activity by endothelin isopeptides. Possible implications for mitogenic signaling by endothelin
MS Simonson, JM Jones, MJ Dunn
The Journal of biological chemistry 1992
Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes
G Imokawa, Y Yada, M Miyagishi
The Journal of biological chemistry 1992
Endothelin action in rat liver. Receptors, free Ca2+ oscillations, and activation of glycogenolysis
CS Gal, C Jouneaux, A Sanchez-Bueno, D Raufaste, B Roche, AM Préaux, JP Maffrand, PH Cobbold, J Hanoune, S Lotersztajn
Journal of Clinical Investigation 1991
Arginine vasopressin stimulates human mesangial cell production of endothelin
GL Bakris, R Fairbanks, AM Traish
Journal of Clinical Investigation 1991
Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines
M Shichiri, Y Hirata, T Nakajima, K Ando, T Imai, M Yanagisawa, T Masaki, F Marumo
Journal of Clinical Investigation 1991
Urinary excretion of endothelin-1 in normal subjects and patients with renal disease
K Ohta, Y Hirata, M Shichiri, K Kanno, T Emori, K Tomita, F Marumo
Kidney International 1991
Dual mechanism of angiotensin II inhibits ANP-induced mesangial cGMP accumulation
M Haneda, R Kikkawa, S Maeda, M Togawa, D Koya, N Horide, N Kajiwara, Y Shigeta
Kidney International 1991
Renal effects and mesangial cell contraction induced by endothelin are mediated by PAF
A López-Farré, D Gómez-Garre, F Bernabeu, I Montañés, I Millás, JM López-Novoa
Kidney International 1991
Endothelium-derived relaxing and contracting factors: Perspectives in nephrology
TF Lüscher, HA Bock, Z Yang, D Diederich
Kidney International 1991
Atrial natriuretic peptide and endothelin: Interactions in the central nervous system and the periphery
ER Levin
Molecular and Cellular Neuroscience 1991
Biological actions and pathophysiologic significance of endothelin in the kidney
V Kon, KF Badr
Kidney International 1991
Haemodynamic and renal tubular effects of low doses of endothelin in anaesthetized rats
PJ Harris, J Zhuo, FA Mendelsohn, SL Skinner
The Journal of Physiology 1991
Increased endothelin excretion in rats with renal failure induced by partial nephrectomy
DP Brooks, LC Contino, B Storer, EH Ohlstein
British Journal of Pharmacology 1991
Endothelin as an autocrine factor in the regulation of parathyroid cells
Y Fujii, JE Moreira, C Orlando, M Maggi, GD Aurbach, ML Brandi, K Sakaguchi
Proceedings of the National Academy of Sciences 1991
Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts
R Plevin, EE MacNulty, S Palmer, MJ Wakelam
Biochemical Journal 1991
Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture
B Kanyicska, TP Burris, ME Freeman
Biochemical and Biophysical Research Communications 1991
cDNA cloning and chromosomal assignment of the endothelin 2 gene: Vasoactive intestinal contractor peptide is rat endothelin 2
KD Bloch, CC Hong, RL Eddy, TB Shows, T Quertermous
Genomics 1991
Activation of protein kinase C by phorbol esters induces DNA synthesis and protein phosphorylations in glomerular mesangial cells
M Issandou, JM Darbon
FEBS Letters 1991
Importance of the phenotypic state of vascular smooth muscle cells on the binding and the mitogenic activity of endothelin
CS Gal, JM Herbert, C Garcia, M Boutin, JP Maffrand
Peptides 1991
Ca2+ signaling by distinct endothelin peptides in glomerular mesangial cells
MS Simonson, MJ Dunn
Experimental Cell Research 1991
An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis
M Ihara, T Fukuroda, T Saeki, M Nishikibe, K Kojiri, H Suda, M Yano
Biochemical and Biophysical Research Communications 1991
A role for Na+/H+ exchange in contraction of guinea pig airways by endothelin-1 in vitro
B Battistini, JG Filep, EJ Cragoe, A Fournier, P Sirois
Biochemical and Biophysical Research Communications 1991
Inhibition of endothelin-1 induced myocardial protein synthesis by an antisense oligonucleotide against the early growth response gene-1
L Neyses, J Nouskas, H Vetter
Biochemical and Biophysical Research Communications 1991
Effects of inhibitors of protein kinase C and phosphodiesterase on the contractile effects of endothelin in dog femoral artery
HC Cheng, RC Dage
Neurochemistry International 1991
Autoradiographic Localization of Endothelin-1 Binding Sites in Porcine Skin
YD Zhao, DR Springall, J Wharton, JM Polak
Journal of Investigative Dermatology 1991
Effects of endothelins, Bay K 8644 and other oxytocics in non-pregnant and late pregnant rat isolated uterus
JB Calixto, GA Rae
European Journal of Pharmacology 1991
Synergistic effects of endothelin-1 (ET-1) and transforming growth factor alpha (TGF-?) or epidermal growth factor (EGF) on DNA replication and G1 to S phase transition
YC Yeh, ER Burns, J Yeh, HW Yeh
Bioscience Reports 1991
Diacylglycerol formation and DNA synthesis in endothelin-stimulated rat C6 glioma cells: the possible role of phosphatidylcholine breakdown
W Zhang, N Sakai, T Fu, Y Okano, H Hirayama, K Takenaka, H Yamada, Y Nozawa
Neuroscience Letters 1991
Hypertension, endothelium, and cardiovascular risk factors
L Raij
The American Journal of Medicine 1991
Distribution of Endothelin-like Immunoreactivity and mRNA in the Developing and Adult Human Lung
A Giaid, JM Polak, V Gaitonde, QA Hamid, G Moscoso, S Legon, D Uwanogho, M Roncalli, O Shinmi, T Sawamura, S Kimura, M Yanagisawa, T Masaki, DR Springall
American journal of respiratory cell and molecular biology 1991
Functional endothelin-1 receptors in rat astrocytoma C6
PO Couraud, O Durieu-Trautmann, DL Nguyen, P Marin, F Glibert, AD Strosberg
European Journal of Pharmacology: Molecular Pharmacology 1991
Basic Fibroblast Growth Factor Stimulates Glomerular Mesangial Cell Proliferation Through a Protein Kinase C-Independent Pathway
M Issandou, JM Darbon
Growth Factors 1991
Intracellular ramification of endothelin signal
K Iijima, L Lin, A Nasjletti, MS Goligorsky
American journal of physiology. Cell physiology 1991
Role of endothelium-derived relaxing factor in regulation of vascular tone and remodeling. Update on humoral regulation of vascular tone
JP Tolins, PJ Shultz, L Raij
Hypertension 1991
Endothelins: a family of regulatory peptides. State-of-the-art lecture
MS Simonson, MJ Dunn
Hypertension 1991
Mechanism of endothelin-1-induced pulmonary vasoconstriction
MJ Horgan, JM Pinheiro, AB Malik
Circulation research 1991
Endothelin and increased contractility in adult rat ventricular myocytes. Role of intracellular alkalosis induced by activation of the protein kinase C-dependent Na(+)-H+ exchanger
BK Krämer, TW Smith, RA Kelly
Circulation research 1991
Mechanism of the enhanced epidermal growth factor-induced growth response of genetically hypertensive vascular myocytes
RD Bukoski, P DeWan, J Bo
Circulation research 1991
Molecular Basis of Neurological Disorders and Their Treatment
JW Gorrod, O Albano, E Ferrari, S Papa
1991
Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores
T Force, G Hyman, R Hajjar, A Sellmayer, JV Bonventre
The Journal of biological chemistry 1991
Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells
ME Lee, DH Temizer, JA Clifford, T Quertermous
The Journal of biological chemistry 1991
Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells
T Force, JM Kyriakis, J Avruch, JV Bonventre
The Journal of biological chemistry 1991
Endogenous non-cyclooxygenase metabolites of arachidonic acid modulate growth and mRNA levels of immediate-early response genes in rat mesangial cells
A Sellmayer, WM Uedelhoven, PC Weber, JV Bonventre
The Journal of biological chemistry 1991
Effects of endothelins on signal transduction and proliferation in human melanocytes
Y Yada, K Higuchi, G Imokawa
The Journal of biological chemistry 1991
Insulin-like growth factor-1 induces tyrosyl phosphorylation of nuclear proteins
BS Oemar, NM Law, SA Rosenzweig
The Journal of biological chemistry 1991
Des-Arg9 bradykinin modulates DNA synthesis, phospholipase C, and protein kinase C in cultured mesangial cells. Distinction from effects of bradykinin
M Issandou, JM Darbon
The Journal of biological chemistry 1991
Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain
A Giaid, SJ Gibson, MT Herrero, S Gentleman, S Legon, M Yanagisawa, T Masaki, NB Ibrahim, GW Roberts, ML Rossi, JM Polak
Histochemistry 1991
Sinusoidal endothelial liver cells in vitro release endothelin — Augmentation by transforming growth factorβ and Kupffer cell-conditioned media
H Rieder, G Ramadori, KH zum Büschenfelde
Klinische Wochenschrift 1991
Immunohistochemical localization of endothelin-like immunoreactivity in human tooth germ and mature dental pulp
A Casasco, A Calligaro, M Casasco, DR Springall, P Tenti, C Marchetti, P Poggi, JM Polak
Anatomy and Embryology 1991
Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation
MS Simonson, MJ Dunn
Journal of Clinical Investigation 1990
Effects of endothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of the rat
K Tomita, H Nonoguchi, F Marumo
Journal of Clinical Investigation 1990
Expression of the potent vasoconstrictor endothelin in the human central nervous system
ME Lee, SM de la Monte, SC Ng, KD Bloch, T Quertermous
Journal of Clinical Investigation 1990
Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway
RA Kelly, H Eid, BK Krämer, M O'Neill, BT Liang, M Reers, TW Smith
Journal of Clinical Investigation 1990
Brain-gut peptides, renal function and cell growth
RJ Unwin, MD Ganz, RB Sterzel
Kidney International 1990
Endothelin and eicosanoid synthesis in cultured mesangial cells
C Zoja, A Benigni, D Renzi, A Piccinelli, N Perico, G Remuzzi
Kidney International 1990
Endothelin stimulates PDGF secretion in cultured human mesangial cells
FE Jaffer, TC Knauss, E Poptic, HE Abboud
Kidney International 1990
[D-Arg1, D-Phe5,D-Trp7,9,Leu11] substance P, a neuropeptide antagonist, blocks binding, Ca2+-mobilizing, and mitogenic effects of endothelin and vasoactive intestinal contractor in mouse 3T3 cells
I Fabregat, E Rozengurt
Journal of Cellular Physiology 1990
On Radiation Damage to Normal Tissues and its Treatment: I. Growth factors
A Michalowski
Acta Oncologica 1990
Insulin-dependent contractility of glomerular mesangial cells in response to angiotensin II, platelet-activating factor and endothelin is attenuated by prostaglandin E2
ME Dunlop, RG Larkins
Biochemical Journal 1990
Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function
AW Hahn, TJ Resink, T Scott-Burden, J Powell, Y Dohi, FR Bühler
Cell regulation 1990
Inositol phosphate release and steroidogenesis in rat adrenal glomerulosa cells. Comparison of the effects of endothelin, angiotensin II and vasopressin
EA Woodcock, PJ Little, JK Tanner
Biochemical Journal 1990
Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts
EE MacNulty, R Plevin, MJ Wakelam
Biochemical Journal 1990
Endothelin stimulates phosphatidylinositol hydrolysis and DNA synthesis in brain capillary endothelial cells
P Vigne, R Marsault, JP Breittmayer, C Frelin
Biochemical Journal 1990
Endothelins, peptides with potent vasoactive properties, are produced by human macrophages
H Ehrenreich, RW Anderson, CH Fox, P Rieckmann, GS Hoffman, WD Travis, JE Coligan, JH Kehrl, AS Fauci
Journal of Experimental Medicine 1990
Production of endothelin-1 by rat cultured mesangial cells
H Sakamoto, S Sasaki, Y Hirata, T Imai, K Ando, T Ida, T Sakurai, M Yanagisawa, T Masaki, F Marumo
Biochemical and Biophysical Research Communications 1990
Vasoactive intestinal contractor, a novel peptide, shares a common receptor with endothelin-1 and stimulates Ca2+ mobilization and DNA synthesis in Swiss 3T3 cells
I Fabregat, E Rozengurt
Biochemical and Biophysical Research Communications 1990
Localization of endothelin-like immunoreactivity in airway epithelium of rats and mice
N Rozengurt, DR Springall, JM Polak
The Journal of Pathology 1990
Detection of endothelin immunoreactivity and mRNA in pulmonary tumours
A Giaid, QA Hamid, DR Springall, M Yanagisawa, O Shinmi, T Sawamura, T Masaki, S Kimura, B Corrin, JM Polak
The Journal of Pathology 1990
ET-1 receptors in C-6 cells: homologous down-regulation and modulation by protein kinase C
EN Cozza, MC Vila, CE Gomez-Sanchez
Molecular and Cellular Endocrinology 1990
Effects of endothelins on nerve-mediated contractions of the mouse vas deferens
GA Rae, JB Calixto
Life Sciences 1990
Effect of endothelins on cytosolic free calcium concentration in neuroblastoma NG108-15 and NCB-20 cells
TL Yue, MM Gleason, PG Lysko, G Feuerstein
Neuropeptides 1990
Inhibition of endothelin-mediated topoisomerase I activation by pertussis toxin
P Nambi, HL Wu, RD Woessner, MR Mattern
FEBS Letters 1990
Distribution of inositol 1,4,5-trisphosphate receptor mRNA in mouse tissues
T Furuichi, C Shiota, K Mikoshiba
FEBS Letters 1990
Endothelin: A New Cardiovascular Regulatory Peptide
A Lerman, FR HILDEBRAND, KB Margulies, B O'murchu, MA Perrella, DM Heublein, TR Schwab, JO BURNETT
Mayo Clinic Proceedings 1990
Mucosal Inflammation in Asthma
R Djukanović, WR Roche, JW Wilson, CR Beasley, OP Twentyman, PH Howarth, ST Holgate
American journal of respiratory and critical care medicine 1990
Myofibroblasts and Subepithelial Fibrosis in Bronchial Asthma
CE Brewster, PH Howarth, R Djukanovic, J Wilson, ST Holgate, WR Roche
American journal of respiratory cell and molecular biology 1990
Contractile Responses to Endothelin in Feline Cortical Vessels in situ
MJ Robinson, J McCulloch
Journal of Cerebral Blood Flow & Metabolism 1990
Endothelin isopeptides evoke Ca2+ signaling and oscillations of cytosolic free [Ca2+] in human mesangial cells
MS Simonson, T Osanai, MJ Dunn
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1990
The endothelin explosion. A pathophysiological reality or a biological curiosity?
BJ Whittle, S Moncada
Circulation 1990
Effect of endothelin-1 in man
H Vierhapper, O Wagner, P Nowotny, W Waldhäusl
Circulation 1990
H(+)-induced vasodilation of rat aorta is mediated by alterations in intracellular calcium sequestration
R Loutzenhiser, Y Matsumoto, W Okawa, M Epstein
Circulation research 1990
Detecting bladder cancer
A Schattner
BMJ : British Medical Journal 1990
Localization and quantification of [125I]-endothelin binding sites in human fetal and adult kidneys — Relevance to renal ontogeny and pathophysiology
HJ Gröne, A Laue, E Fuchs
Klinische Wochenschrift 1990
International Yearbook of Nephrology 1991
VE Andreucci, LG Fine
1990
Endothelin. Pathways of transmembrane signaling
MS Simonson, MJ Dunn
Hypertension 1990
Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence
ME Lee, KD Bloch, JA Clifford, T Quertermous
The Journal of biological chemistry 1990
Heterogeneity of cell surface endothelin receptors
ER Martin, BM Brenner, BJ Ballermann
The Journal of biological chemistry 1990
Endothelins.
Hamblin TJ
BMJ 1990
Endothelium-dependent vascular responses. Mediators and mechanisms
BM Brenner, JL Troy, BJ Ballermann
Journal of Clinical Investigation 1989
Cross-talk between transmembrane signalling systems: a prerequisite for the delicate regulation of glomerular haemodynamics by mesangial cells
J Pfeilschifter
European Journal of Clinical Investigation 1989
Endothelin stimulates short circuit current in a cultured epithelium
PY Wong, WO Fu, SJ Huang
British Journal of Pharmacology 1989
Streptozotocin-induced diabetes reduces the density of [125I]-endothelin-binding sites in rat cardiac membranes
WG Nayler, JJ Liu, S Panagiotopoulos, DJ Casley
British Journal of Pharmacology 1989
Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors
KD Brown, CJ Littlewood
Biochemical Journal 1989
High and low affinity binding sites for endothelin on cultured rat glomerular mesangial cells
KF Badr, KA Munger, M Sugiura, RM Snajdar, M Schwartzberg, T Inagami
Biochemical and Biophysical Research Communications 1989
Identification of two types of specific endothelin receptors in rat mesangial cell
M Sugiura, RM Snajdar, M Schwartzberg, KF Badr, T Inagami
Biochemical and Biophysical Research Communications 1989
Hemodynamic and tubular effects of endothelin and thromboxane in the isolated perfused rat kidney
RG Ferrario, R Foulkes, P Salvati, C Patrono
European Journal of Pharmacology 1989
Rat mesangial cell-matrix interactions in culture
MS Simonson, LA Culp, MJ Dunn
Experimental Cell Research 1989
Solubilization and identification of human placental endothelin receptor
S Nakajo, M Sugiura, RM Snajdar, FH Boehm, T Inagami
Biochemical and Biophysical Research Communications 1989
Endothelin, its diverse biological activities and mechanisms of action
Y Takuwa, M Yanagisawa, N Takuwa, T Masaki
Progress in Growth Factor Research 1989
Paracrine and autocrine functions of glomerular mesangial cells
P Menè, GA Cinotti
Journal of Endocrinological Investigation 1989
cDNA cloning and chromosomal assignment of the gene encoding endothelin 3
KD Bloch, RL Eddy, TB Shows, T Quertermous
The Journal of biological chemistry 1989
Congestive Heart Failure
L Werkö
Acta Medica Scandinavica 1987

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