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Research Article Free access | 10.1172/JCI113878

Evidence that insulin-like growth factor I increases renal plasma flow and glomerular filtration rate in fasted rats.

R Hirschberg and J D Kopple

Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, California 90509.

Find articles by Hirschberg, R. in: JCI | PubMed | Google Scholar

Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, Torrance, California 90509.

Find articles by Kopple, J. in: JCI | PubMed | Google Scholar

Published January 1, 1989 - More info

Published in Volume 83, Issue 1 on January 1, 1989
J Clin Invest. 1989;83(1):326–330. https://doi.org/10.1172/JCI113878.
© 1989 The American Society for Clinical Investigation
Published January 1, 1989 - Version history
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Abstract

The mechanisms whereby growth hormone may increase renal plasma flow (RPF) and GFR are not known, but circumstantial evidence has implicated insulin-like growth factor I (IGF-I) as a mediator of this effect. This study examined whether an infusion of IGF-I will increase RPF and GFR, whether this effect occurs quickly, and if this effect is dependent on eicosanoids or peptide hormones known to affect renal function. Rats fasted for 3 d to reduce IGF-I and IGF-I plasma binding proteins were anesthetized; then the rats received an intravenous injection of 25 micrograms/kg IGF-I, and an infusion of 25 micrograms/kg IGF-I within 20 min. Controls received infusion of the vehicle. RPF (para-aminohippurate clearances), GFR (inulin clearances), renal vascular resistance (RVR), mean arterial blood pressure (MABP), plasma IGF-I, and glucose concentrations were measured repeatedly. At the end of the 20-min infusion, plasma IGF-I tended to be increased in the animals that received IGF-I (P = 0.069), but did not increase in the control rats. IGF-I induced a significant and sustained fall in RVR and rise in RPF and GFR without any change in MABP. A small, transient, but significant decrease in plasma glucose concentrations was observed during IGF-I but not during vehicle infusion. Indomethacin, but not somatostatin, blocked the renal response to IGF-I infusion. Thus, IGF-I infusion increases RPF and GFR and reduces RVR in fasted rats. This effect requires the presence of eicosanoids but does not seem to require other peptide hormones suppressed by somatostatin.

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Posted by 2 X users
Referenced in 1 patents
10 readers on Mendeley
See more details