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Research Article Free access | 10.1172/JCI113841

Identification of human immunodeficiency virus (HIV) envelope type-specific T helper cells in an HIV-infected individual.

C M Walker, K S Steimer, K L Rosenthal, and J A Levy

Cancer Research Institute, University of California, School of Medicine, San Francisco 94143.

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Cancer Research Institute, University of California, School of Medicine, San Francisco 94143.

Find articles by Steimer, K. in: JCI | PubMed | Google Scholar

Cancer Research Institute, University of California, School of Medicine, San Francisco 94143.

Find articles by Rosenthal, K. in: JCI | PubMed | Google Scholar

Cancer Research Institute, University of California, School of Medicine, San Francisco 94143.

Find articles by Levy, J. in: JCI | PubMed | Google Scholar

Published December 1, 1988 - More info

Published in Volume 82, Issue 6 on December 1, 1988
J Clin Invest. 1988;82(6):2172–2175. https://doi.org/10.1172/JCI113841.
© 1988 The American Society for Clinical Investigation
Published December 1, 1988 - Version history
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Abstract

Two T helper cell clones recognizing the gp 120 envelope protein of HIV were generated from the peripheral blood of a healthy seropositive individual. These cells were type specific as they proliferated and produced IL 2 when stimulated by an epitope in the amino-terminal half of gp 120 of HIVSF2, but not by a similar region of HIVZr6, a Zairian HIV-1 isolate. These two viruses differ by 26% in the deduced amino sequence of the gp 120 protein. Moreover, the antigenic site(s) recognized by the cloned T cells are distinct from those recognized by envelope-specific antibodies. These observations have important implications for the development and use of anti-HIV vaccines.

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