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Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells.
E Dejana, … , F Breviario, R Giavazzi
E Dejana, … , F Breviario, R Giavazzi
Published October 1, 1988
Citation Information: J Clin Invest. 1988;82(4):1466-1470. https://doi.org/10.1172/JCI113753.
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Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells.

Abstract

We report that IL 1 acts on the endothelium, inducing a long-lasting increase in its adhesivity to tumor cells. Selective pretreatment of cultured human umbilical vein endothelial cells (EC) with IL 1 caused a significant increase in adhesion of three human colorectal carcinoma (HT-29, HCC-P2988, and HCC-M1410) cell lines and one human melanoma (A-375) cell line. Tumor necrosis factor (TNF) was as effective as IL 1 in promoting tumor cell adhesion to EC, whereas IFN gamma and IL 2 were inactive. The IL 1 and TNF induction of EC adhesivity was both concentration (threshold concentration 1 U/ml) and time dependent (peak 4-6 h), reversible within 24 h, and blocked by a protein synthesis inhibitor. The IL 1 and TNF action on EC may play a role in tumor cell lodgement.

Authors

E Dejana, F Bertocchi, M C Bortolami, A Regonesi, A Tonta, F Breviario, R Giavazzi

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