Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene.

T Demant; R S Houlston; M J Caslake; J J Series; J Shepherd; C J Packard; S E Humphries

doi:10.1172/JCI113681

Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland.

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Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland.

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Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland.

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Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland.

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Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland.

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Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland.

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Department of Pathological Biochemistry, Royal Infirmary, Glasgow, Scotland.

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Published in Volume 82, Issue 3 on September 1, 1988
J Clin Invest. 1988;82(3):797–802. https://doi.org/10.1172/JCI113681.
© 1988 The American Society for Clinical Investigation

Published September 1, 1988 - Version history

This study examines the potential influence of genetic variation on the metabolism of LDL. Restriction fragment length polymorphisms (RFLP) of the gene coding for apo B were identified using the endonucleases Xba I, Eco RI, and Msp I in a group of 19 subjects with moderate hyperlipidemia. There was a significant association between the Xba I polymorphism and the total fractional clearance rate (FCR) of LDL. The individuals with the X1X1 genotype had, on average, a 22% higher FCR (P less than 0.025) than those with the genotype X2X2 (X2 allele = presence of Xba I cutting site). This difference was attributable to increased clearance by the receptor-mediated pathway of LDL catabolism. In this group of subjects, there was no association of LDL kinetic parameters and RFLPs of the LDL receptor gene or the AI- CIII- AIV gene cluster. The data suggest that variation in apo B itself, presumably acting through variable binding to the LDL receptor, makes a significant contribution to the rate of catabolism of LDL.

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Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene.

T Demant, R S Houlston, M J Caslake, J J Series, J Shepherd, C J Packard, and S E Humphries

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Catabolic rate of low density lipoprotein is influenced by variation in the apolipoprotein B gene.

T Demant, R S Houlston, M J Caslake, J J Series, J Shepherd, C J Packard, and S E Humphries

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