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Citations to this article

Oxidant-induced DNA damage of target cells.
I Schraufstätter, … , J H Jackson, C G Cochrane
I Schraufstätter, … , J H Jackson, C G Cochrane
Published September 1, 1988
Citation Information: J Clin Invest. 1988;82(3):1040-1050. https://doi.org/10.1172/JCI113660.
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Oxidant-induced DNA damage of target cells.

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Abstract

In this study we examined the leukocytic oxidant species that induce oxidant damage of DNA in whole cells. H2O2 added extracellularly in micromolar concentrations (10-100 microM) induced DNA strand breaks in various target cells. The sensitivity of a specific target cell was inversely correlated to its catalase content and the rate of removal of H2O2 by the target cell. Oxidant species produced by xanthine oxidase/purine or phorbol myristate acetate-stimulated monocytes induced DNA breakage of target cells in proportion to the amount of H2O2 generated. These DNA strand breaks were prevented by extracellular catalase, but not by superoxide dismutase. Cytotoxic doses of HOCl, added to target cells, did not induce DNA strand breakage, and myeloperoxidase added extracellularly in the presence of an H2O2-generating system, prevented the formation of DNA strand breaks in proportion to its H2O2 degrading capacity. The studies also indicated that H2O2 formed hydroxyl radical (.OH) intracellularly, which appeared to be the most likely free radical responsible for DNA damage: .OH was detected in cells exposed to H2O2; the DNA base, deoxyguanosine, was hydroxylated in cells exposed to H2O2; and intracellular iron was essential for induction of DNA strand breaks.

Authors

I Schraufstätter, P A Hyslop, J H Jackson, C G Cochrane

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Biochemical and Biophysical Research Communications 1999
Loss of GSH and thiol enzymes in endothelial cells exposed to sublethal concentrations of hypochlorous acid
JM Pullar, CC Winterbourn, MC Vissers
American journal of physiology. Heart and circulatory physiology 1999
Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells
F Okada, K Nakai, T Kobayashi, T Shibata, S Tagami, Y Kawakami, T Kitazawa, R Kominami, S Yoshimura, K Suzuki, N Taniguchi, O Inanami, M Kuwabara, H Kishida, D Nakae, Y Konishi, T Moriuchi, M Hosokawa
British Journal of Cancer 1999
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4
KV Honn, LJ Marnett, S Nigam, EA Dennis
1999
Biologic Effects of Light 1998
MF Holick, EG Jung
1999
Environmental Metal Pollutants, Reactive Oxygen Intermediaries and Genotoxicity
ME Ariza, GN Bijur, MV Williams
1999
Report From The Conference On Ultrasound-Assisted Liposuction Safety And Effects
VL Young, MW Schorr
Clinics in Plastic Surgery 1999
Effect of in vitro generation of oxygen free radicals on T cell function in young and old rats
MA Pahlavani, MD Harris
Free radical biology & medicine 1998
Reactive oxygen species activity and lipid peroxidation in Helicobacter pylori associated gastritis: relation to gastric mucosal ascorbic acid concentrations and effect of H pylori eradication
IM Drake, NP Mapstone, CJ Schorah, KL White, DM Chalmers, MF Dixon, AT Axon
Gut 1998
Role of poly(ADP-ribose)synthetase in inflammation
C Szabó
European Journal of Pharmacology 1998
Hypochlorous Acid Activates the Tumor Suppressor Protein p53 in Cultured Human Skin Fibroblasts
GF Vile, LA Rothwell, AJ Kettle
Archives of Biochemistry and Biophysics 1998
F2-isoprostane generation in isolated ferret lungs after oxidant injury or ventilated ischemia
P M Becker, S P Sanders, P Price, B W Christman
Free radical biology & medicine 1998
Free Radicals, Oxidative Stress, and Antioxidants
T Özben
1998
Critical Care Nephrology
C Ronco, R Bellomo
1998
Levels of DNA strand breaks and superoxide in phorbol ester-treated human granulocytes
HC Birnboim, JK Sandhu
Journal of Cellular Biochemistry 1997
Alterations in intracellular reactive oxygen species generation and redox potential modulate mast cell function
K Wolfreys, DB Oliveira
European Journal of Immunology 1997
Apoptotic vs. Nonapoptotic Cytotoxicity Induced by Hydrogen Peroxide
AM Gardner, F Xu, C Fady, FJ Jacoby, DC Duffey, Y Tu, A Lichtenstein
Free radical biology & medicine 1997
Effects of chloride channel blockers on hypoxic injury in rat proximal tubules
WB Reeves
Kidney International 1997
Overexpression of superoxide dismutase and catalase in immortalized neural cells: toxic effects of hydrogen peroxide
H Mann, MT McCoy, J Subramaniam, HV Remmen, JL Cadet
Brain Research 1997
Modulation of cisPlatin cytotoxicity by interleukin-1α and resident tumor macrophages
PG Braunschweiger, VS Basrur, D Cameron, L Sharpe, O Santos, JP Perras, BU Sevin, AM Markoe
Biotherapy 1997
Ex Vivo Induction of Apoptosis in Lymphocytes Is Mediated by Oxidative Stress: Role for Lymphocyte Loss in HIV Infection
TS Dobmeyer, S Findhammer, JM Dobmeyer, SA Klein, B Raffel, D Hoelzer, EB Helm, D Kabelitz, R Rossol
Free radical biology & medicine 1997
Immunogenicity of DNA Damaged by Reactive Oxygen Species—Implications for Anti-DNA Antibodies in Lupus
MS Cooke, N Mistry, C Wood, KE Herbert, J Lunec
Free radical biology & medicine 1997
Reinvestigation of in vivo genotoxicity studies in man. I. No induction of DNA strand breaks in peripheral lymphocytes after metronidazole therapy
R Fahrig, M Engelke
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 1997
Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells
PJ Borm, AM Knaapen, RP Schins, RW Godschalk, FJ Schooten
Environmental Health Perspectives 1997
DNA Damage Induced by Peroxynitrite: Subsequent Biological Effects
C Szabó, H Ohshima
Nitric Oxide 1997
Advances in Molecular and Cell Biology
KJ Clemetson
Advances in Molecular and Cell Biology 1997
Quercetin and myricetin protect against hydrogen peroxide-induced DNA damage (strand breaks and oxidised pyrimidines) in human lymphocytes
SJ Duthie, AR Collins, GG Duthie, VL Dobson
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 1997
The induction of apoptosis in proliferating human fibroblasts by oxygen radicals is associated with a p53- and p21WAF1CIP1 induction
S Gansauge, F Gansauge, H Gause, B Poch, M H Schoenberg, H G Beger
FEBS Letters 1997
The Influence of Cell Growth, Detoxifying Enzymes and DNA Repair on Hydrogen Peroxide-Mediated DNA Damage (Measured Using the Comet Assay) in Human Cells
SJ Duthie, AR Collins
Free radical biology & medicine 1996
Review
M Epstein
Renal Failure 1996
Involvement of oxidation in LDL-induced collagen gene regulation in mesangial cells
HS Lee, BC Kim, YS Kim, KH Choi, HK Chung
Kidney International 1996
DNA strand breakage and activation of poly-ADP ribosyltransferase: A cytotoxic pathway triggered by peroxynitrite
C SzabÓ
Free radical biology & medicine 1996
Mutagenic potential of peripheral blood leukocytes: in vivo exposure to the carcinogen 7,12-dimethylbenz[a]anthracene, and the tumor promoter 12-O-tetradecanoylphorbol acetate followed by in vitro co-culture with AS52 cells
ME Ariza, AS Oberyszyn, FM Robertson, MV Williams
Cancer Letters 1996
Evidence for involvement of multiple iron species in DNA single-strand scission by H2O2 in HL-60 cells
RW Byrnes
Free radical biology & medicine 1996
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite
C Szabó, B Zingarelli, M O'Connor, AL Salzman
Proceedings of the National Academy of Sciences 1996
Research communication copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical
SY Tsang, SC Tam, I Bremner, MJ Burkitt
Biochemical Journal 1996
Mobilization of iron from cellular ferritin by ascorbic acid in neuroblastoma SK-N-SH cells: an EPR study
SL Baader, E Bill, AX Trautwein, G Bruchelt, BF Matzanke
FEBS Letters 1996
Peroxynitrite formed by simultaneous generation of nitric oxide and superoxide selectively inhibits bovine aortic prostacyclin synthase
MH Zou, V Ullrich
FEBS Letters 1996
Sodium nitroprusside-induced apoptotic cellular death via production of hydrogen peroxide in murine neuroblastoma N1E-115 cells
M Yamada, K Momose, E Richelson, M Yamada
Journal of Pharmacological and Toxicological Methods 1996
Isolation and preliminary characterization of a Chinese hamster ovary cell line with high-degree resistance to hydrogen peroxide
O Cantoni, P Sestili, L Palomba, A Guidarelli, F Cattabeni, D Murray
Biochemical Pharmacology 1996
Cellular injury induced by oxidative stress is mediated through lysosomal damage
K Öllinger, UT Brunk
Free radical biology & medicine 1995
Hydrogen peroxide as a potent bacteriostatic antibiotic: Implications for host defense
PA Hyslop, DB Hinshaw, IU Scraufstatter, CG Cochrane, S Kunz, K Vosbeck
Free radical biology & medicine 1995
TWO GENES CONTRIBUTE TO DIFFERENT EXTENTS TO THE HEME OXYGENASE ENZYME ACTIVITY MEASURED IN CULTURED HUMAN SKIN FIBROBLASTS AND KERATINOCYTES: IMPLICATIONS FOR PROTECTION AGAINST OXIDANT STRESS
LA Applegate, A Noël, G Vile, E Frenk, RM Tyrrell
Photochemistry and Photobiology 1995
Toxicity of oxygen from naturally occurring redox-active pro-oxidants
RS Pardini
Archives of Insect Biochemistry and Physiology 1995
Effects of oxidative stress and Ca2+ agonists on molecular chaperones in human umbilical vein endothelial cells
D Dreher, JR Vargas, DF Hochstrasser, AF Junod
Electrophoresis 1995
The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells
AR Collins, M Ai-guo, SJ Duthie
Mutation Research/DNA Repair 1995
DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells
JP Spencer, A Jenner, K Chimel, OI Aruoma, CE Cross, R Wu, B Halliwell
FEBS Letters 1995
Menadione-induced DNA fragmentation without 8-oxo-2′-deoxyguanosine formation in isolated rat hepatocytes
A Fischer-Nielsen, GB Corcoran, HE Poulsen, LM Kamendulis, S Loft
Biochemical Pharmacology 1995
Oxidative defense in cultured human skin fibroblasts and keratinocytes from sun-exposed and non-exposed skin
LA Applegate, E Frenk
Photodermatology, Photoimmunology & Photomedicine 1995
Induction of DNA recombination by activated 3-amino-1-methyl-5H-pyrido[4,3-b]indole
K Hiramoto, S Kanamitsu, K Negishi, H Ikeda, H Hayatsu
Japanese journal of cancer research : Gann 1995
Antioxidant defence mechanism of the skin against UV irradiation: Study of the role of catalase using acatalasaemia fibroblasts
Y Shindo, T Hashimoto
Archives of Dermatological Research 1995
Induction of DNA Recombination by Activated 3‐Amino‐1‐methyl‐5H‐pyrido[4,3‐b]indole
Hiramoto K, Kanamitsu S, Negishi K, Ikeda H, Hayatsu H
Japanese journal of cancer research : Gann 1995
Activation of potassium channels contributes to hypoxic injury in proximal tubules
WB Reeves, SV Shah
Journal of Clinical Investigation 1994
Cultured AIDS-related Kaposi's sarcoma cells retain a proliferative bioenergetic profile but demonstrate reduced cytoprotective capabilities
SR Mallery, CL Ng-Bautista, LE Lantry, GM Ness, AK Hegtvedt, A Lazo, RT Bailer, BL Hout, RE Stephens, GP Brierley
Journal of Cellular Biochemistry 1994
Role of active oxygen species in DNA damage by pentachlorophenol metabolites
S Naito, Y Ono, I Somiya, S Inoue, K Ito, K Yamamoto, S Kawanishi
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1994
Involvement of inflammatory reactions and elevated cell proliferation in the development of bladder cancer in schistosomiasis patients
MP Rosin, SS el Zaki, AJ Ward, WA Anwar
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1994
Decreased expression of liver glutathione peroxidase in Long-Evans cinnamon mutant rats predisposed to hepatitis and hepatoma
H Suemizu, S Yoshimura, N Takeichi, T Moriuchi
Hepatology 1994
Mechanisms of cell injury by activated oxygen species
JL Farber
Environmental Health Perspectives 1994
Potential molecular mechanisms of oxidant-induced carcinogenesis
JH Jackson
Environmental Health Perspectives 1994
Relative importance of oxidation and Ca2+ in DNA strand breakage by H2O2 in the 2sFou cell line
J Davies, JK Chipman
Toxicology in Vitro 1994
The induction/loss of the oxidant-resistant phenotype of Chinese hamster ovary (CHO) cell variants does not correlate with sensitivity to DNA single strand breakage by hydrogen peroxide
P Sestili, F Cattabeni, O Cantoni
Biochemical Pharmacology 1994
Effects of Nicotinamide and Niacin on Bleomycin-Induced Acute Injury and Subsequent Fibrosis in Hamster Lungs
A Nagai, H Matsumiya, M Hayashi, S Yasui, H Okamoto, K Konno
Experimental Lung Research 1994
8-Hydroxydeoxyguanosine in DNA from TPA-Stimulated Human Granulocytes
HC Birnboim, L Maidt, T Raynor, RA Floyd
Free Radical Research 1994
Abnormal glutathione metabolism and increased cytotoxicity caused by H2O2 in human umbilical vein endothelial cells cultured in high glucose medium
A Kashiwagi, T Asahina, M Ikebuchi, Y Tanaka, Y Takagi, Y Nishio, R Kikkawa, Y Shigeta
Diabetologia 1994
Ascorbic-acid-mediated iron release from cellular ferritin and its relation to the formation of DNA strand breaks in neuroblastoma cells
SL Baader, G Bruchelt, TC Carmine, HN Lode, AG Rieth, D Niethammer
Journal of Cancer Research and Clinical Oncology 1994
Etiopathogenesis
Y Mizuno, DB Calne, R Horowski
1994
Down-regulation of P4501A1 and P4501A2 mRNA expression in isolated hepatocytes by oxidative stress
CW Barker, JB Fagan, DS Pasco
The Journal of biological chemistry 1994
Activated murine neutrophils induce unscheduled DNA synthesis in B lymphocytes
S Janz, E Shacter
Mutation Research/DNA Repair 1993
Toxicity, single-strand breaks, and 5-hydroxymethyl-2′-deoxyuridine formation in human breast epithelial cells treated with hydrogen peroxide☆
Z Djuric, CK Everett, DA Luongo
Free radical biology & medicine 1993
Acridine orange-mediated photodamage to cultured cells
JM Zdolsek
APMIS 1993
Protection of human endothelial cells from oxidant injury by adenovirus-mediated transfer of the human catalase cDNA
SC Erzurum, P Lemarchand, MA Rosenfeld, JH Yoo, RG Crystal
Nucleic Acids Research 1993
Effect of medium pH on glutathione redox cycle in cultured human umbilical vein endothelial cells
M Ikebuchi, A Kashiwagi, T Asahina, Y Tanaka, Y Takagi, Y Nishio, H Hidaka, R Kikkawa, Y Shigeta
Metabolism 1993
A cellular model of oxidant-mediated neuronal injury
DB Hinshaw, MT Miller, GM Omann, TF Beals, PA Hyslop
Brain Research 1993
Suppression of development of anti-nuclear antibody and glomerulonephritis in NZB x NZWF1 mice by persistent infection with lactic dehydrogenase virus: possible involvement of superoxide anion as a progressive effector
T Hayashi, Y Noguchi, Y Kameyama
International Journal of Experimental Pathology 1993
Differential effect of l-histidine in human lymphocytes damaged by different oxygen radical producing systems
M Marini, F Frabetti, G Zunica, G Brandi, O Cantoni
Mutation Research Letters 1993
A sensitivity to oxidative stress is linked to chromosome 11 but is not due to a difference in single strand DNA breakage or repair
AJ Ward, PL Olive, AH Burr, MP Rosin
Mutation Research/DNA Repair 1993
Mutational specificity of oxidative DNA damage
J Retèl, B Hoebee, JE Braun, JT Lutgerink, E Akker, AH Wanamarta, H Joenje, MV Lafleur
Mutation Research/Genetic Toxicology 1993
Shock, Sepsis, and Organ Failure
G Schlag, H Redl, D Traber
1993
Oxidative Stress, Cell Activation and Viral Infection
C Pasquier, RY Olivier, C Auclair, L Packer
1993
Pathophysiology of Shock, Sepsis, and Organ Failure
G Schlag, H Redl
1993
Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases
S Bashir, G Harris, MA Denman, DR Blake, PG Winyard
Annals of the rheumatic diseases 1993
Hydrogen peroxide induces DNA single strand breaks in respiratory epithelial cells
RJ McDonald, LC Pan, JA George, DM Hyde, JM Ducore
Inflammation 1993
Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide
V Natarajan, MM Taher, B Roehm, NL Parinandi, HH Schmid, Z Kiss, JG Garcia
The Journal of biological chemistry 1993
Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells
N Ueda, SV Shah
Journal of Clinical Investigation 1992
The role of free radicals in asbestos-induced diseases
DW Kamp, P Graceffa, WA Pryor, SA Weitzman
Free radical biology & medicine 1992
Cell death and lipid peroxidation in isolated hepatocytes incubated in the presence of hydrogen peroxide and iron salts
I Latour, JL Pregaldien, P Buc-Calderon
Archives of Toxicology 1992
Hypochlorous acid potentiates hydrogen peroxide-mediated DNA-strand breaks in human mononuclear leucocytes
CE Rensburg, AM Staden, R Anderson, EJ Rensburg
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1992
Genetic and environmental influences on baseline SCE
BA Hirsch, KK Sentz, M McGue
Environmental and Molecular Mutagenesis 1992
Nucleosomal histone protein protects DNA from iron-mediated damage
HU Enright, WJ Miller, RP Hebbel
Nucleic Acids Research 1992
Inhibition of organic anion transport in endothelial cells by hydrogen peroxide
DB Hinshaw, JM Burger, RE Delius, PA Hyslop, GM Omann
Archives of Biochemistry and Biophysics 1992
The role of thiol oxidation in cobalt(II)-induced toxicity in hamster lung
CP Lewis, M Demedts, B Nemery
Biochemical Pharmacology 1992
Effect of lipophilic chelators on oxyradical-induced DNA strand breaks in human granulocytes: Paradoxical effect of 1,10-phenanthroline
HC Birnboim
Archives of Biochemistry and Biophysics 1992
Ceruloplasmin and Transferrin Levels Are Altered in Serum and Bronchoalveolar Lavage Fluid of Patients with the Adult Respiratory Distress Syndrome
JA Krsek-Staples, RR Kew, RO Webster
American journal of respiratory and critical care medicine 1992
Biological Oxidants: Generation and Injurious Consequences
AW Segal, JH Nugent
Biological Oxidants: Generation and Injurious Consequences 1992
Repair of DNA damage induced by oxygen radicals in human non-proliferating and proliferating lymphocytes
E Kaminskas, JC Li
Mutation Research/DNA Repair 1992
Immunosuppressive effect of emodin, a free radical generator
HC Huang, JH Chang, SF Tung, RT Wu, ML Foegh, SH Chu
European Journal of Pharmacology 1992
Bleomycin-induced unscheduled DNA synthesis in non-permeabilized human and rat hepatocytes is not paralleled by 8-oxo-7,8-dihydrodeoxyguanosine formation
PG Winyard, SP Faux, AJ Smith, JE Davies, JK Chipman
Biochemical Pharmacology 1992
Ferritin: a cytoprotective antioxidant strategem of endothelium
G Balla, HS Jacob, J Balla, M Rosenberg, K Nath, F Apple, JW Eaton, GM Vercellotti
The Journal of biological chemistry 1992
Reactive oxygen molecules, oxidant injury and renal disease
SP Andreoli
Pediatric Nephrology 1991
Differential protective effects of O-phenanthroline and catalase on H2O2-induced DNA damage and inhibition of protein synthesis in endothelial cells
L Jornot, H Petersen, AF Junod
Journal of Cellular Physiology 1991
Mechanisms of oxidant injury of cells
CG Cochrane
Molecular Aspects of Medicine 1991
Methods of assessing oxidant injury in renal tubular epithelial cells in vitro
SP Andreoli, CH Mallett
Journal of Tissue Culture Methods 1991
DNA damage by oxygen-derived species Its mechanism and measurement in mammalian systems
B Halliwell, OI Aruoma
FEBS Letters 1991
Inactivation of poly(ADP-ribose) polymerase by hypochlorous acid
CE Rensburg, AM Staden, R Anderson
Free radical biology & medicine 1991
DNA strand breaks and DNA repair response in lymphocytes after chronic in vivo exposure to very low doses of ionizing radiation in mice
SJ James, SM Enger, T Makinodan
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1991
The measurement of DNA strand breaks in rat colonic mucosa by fluorometric analysis of DNA unwinding
AJ Percy, JK Chipman
Toxicology Letters 1991
Pro-oxidative interactions of dithranol with human phagocytes promote oxidative damage to DNA of bystander leucocytes
DM Forrester, CE Rensburg, R Anderson
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1991
Repeated exposures to enzyme-generated oxidants cause alveolitis, epithelial hyperplasia, and fibrosis in hamsters
JM Nakashima, JR Levin, DM Hyde, SN Giri
The American Journal of Pathology 1991
Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide
OI Aruoma, B Halliwell, E Gajewski, M Dizdaroglu
Biochemical Journal 1991
Ionic and radical oxidations of DNA by hydrogen peroxide
JF Mouret, M Polverelli, F Sarrazini, J Cadet
Chemico-Biological Interactions 1991
Metabolic inhibition potentiates oxidant injury
RE Delius, DB Hinshaw
Journal of Surgical Research 1991
Inhibition of the myeloperoxidase-H2O2-Cl− system of neutrophils by indomethacin and other non-steroidal anti-inflammatory drugs
E Shacter, RL Lopez, S Pati
Biochemical Pharmacology 1991
Reactive oxygen injury to cultured pulmonary artery endothelial cells: Mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance
RL Thies, AP Autor
Archives of Biochemistry and Biophysics 1991
Oxidative Damage & Repair
A Sevanian
Oxidative Damage & Repair 1991
DNA Strand Break Formation Following Exposure of Bovine Pulmonary Artery and Aortic Endothelial Cells to Reactive Oxygen Products
RG Spragg
American journal of respiratory cell and molecular biology 1991
Flavonoids, but not protein kinase c inhibitors, prevent stress protein synthesis during erythrophagocytosis
S Kantengwa, BS Polla
Biochemical and Biophysical Research Communications 1991
Reactive Oxygen Species Production by Monocytes and Polymorphonuclear Leukocytes During Dialysis
J Himmelfarb, JM Lazarus, R Hakim
American Journal of Kidney Diseases 1991
Purine and Pyrimidine Metabolism in Man VII
RA Harkness, GB Elion, N Zöllner
1991
Molecular Aspects of Inflammation
H Sies, L Flohé, G Zimmer
1991
Blood Cell Biochemistry Volume 3
JR Harris
1991
Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury
KV Honn, LJ Marnett, S Nigam, TL Walden
1991
Site-specific DNA damage induced by hydrazine in the presence of manganese and copper ions. The role of hydroxyl radical and hydrogen atom
K Yamamoto, S Kawanishi
The Journal of biological chemistry 1991
Mechanisms of hypochlorite injury of target cells
IU Schraufstätter, K Browne, A Harris, PA Hyslop, JH Jackson, O Quehenberger, CG Cochrane
Journal of Clinical Investigation 1990
Oxygen radicals in lung pathology
CJ Doelman, A Bast
Free radical biology & medicine 1990
Reactive oxygen molecule-mediated injury in endothelial and renal tubular epithelial cells in vitro
SP Andreoli, JA McAteer, C Mallett
Kidney International 1990
Activation of Human Immunodeficiency Virus Type 1 by Oxidative Stress
S Legrand-Poels, D Vaira, J Pincemail, AV de Vorst, J Piette
AIDS Research and Human Retroviruses 1990
Effects of variation in glutathione peroxidase activity on DNA damage and cell survival in human cells exposed to hydrogen peroxide and t-butyl hydroperoxide
BE Sandström, SL Marklund
Biochemical Journal 1990
High Performance Liquid Chromatography-Electrochemical Assay for Monitoring the Formation of 8-Oxo-7,8-dihydroadenine and its Related 2′-Deoxyribonucleoside
M Berger, C Anselmino, JF Mouret, J Cadet
Journal of Liquid Chromatography 1990
Reoxygenation injury and antioxidant protection: A tale of two paradoxes
JM Gutteridge, B Halliwell
Archives of Biochemistry and Biophysics 1990
Protection from cellular oxidative injury and calcium intrusion by N-(2-mercaptoethyl)-1,3-propanediamine, WR 1065
BS Polla, Y Donati, M Kondo, HJ Tochon-Danguy, JP Bonjour
Biochemical Pharmacology 1990
Protection by Deferoxamine from Endothelial Injury: A Possible Link with Inhibition of Intracellular Xanthine Oxidase
JE Rinaldo, M Gorry
American journal of respiratory cell and molecular biology 1990
Mineral dust exposure and free radical-mediated lung damage
C J Doelman, R Leurs, W C Oosterom, A Bast
Experimental Lung Research 1990
Vitamin C and Cellular Immune Functions: Protection Against Hypochlorous Acid-Mediated Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase and ATP Generation in Human Leukocytes as A Pos
R Anderson, MJ Smit, GK Joone, AM van Staden
Annals of the New York Academy of Sciences 1990
Selective Degeneration of Oligodendrocytes Mediated by Reactive Oxygen Species
C Griot, M Vandevelde, A Richard, E Peterhans
Free Radical Research 1990
Peptide Growth Factors and Their Receptors II
MB Sporn, AB Roberts
1990
DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals
E Shacter, RL Lopez, EJ Beecham, S Janz
The Journal of biological chemistry 1990
Damage to the bases in DNA induced by stimulated human neutrophils
JH Jackson, E Gajewski, IU Schraufstatter, PA Hyslop, AF Fuciarelli, CG Cochrane, M Dizdaroglu
Journal of Clinical Investigation 1989
Differential effects of hyperoxia and hydrogen peroxide on DNA damage, polyadenosine diphosphate-ribose polymerase activity, and nicotinamide adenine dinucleotide and adenosine triphosphate contents in cultured endothelial cells and fibroblasts
AF Junod, L Jornot, H Petersen
Journal of Cellular Physiology 1989
Differential lymphocyte growth-modifying effects of oxidants: Changes in cytosolic Ca+2
DD Duncan, DA Lawrence
Toxicology and Applied Pharmacology 1989
Tobacco-borne siderophoric activity
M Qian, JW Eaton
Archives of Biochemistry and Biophysics 1989
Cytotoxic Effects of 6-Hydroxydopamine, Merocyanine-540 and Related Compounds on Human Neuroblastoma-and Hematopoietic Stem Cells
G Bruchelt, G Grygar, J Treuner, H Esterbauer, D Niethammer
Free Radical Research 1989
Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status
P Merry, PG Winyard, CJ Morris, M Grootveld, DR Blake
Annals of the rheumatic diseases 1989
Stimulation of Collagen Gene Expression by Ascorbic Acid in Cultured Human Fibroblasts
M Chojkier, K Houglum, J Solis-Herruzo, DA Brenner
The Journal of biological chemistry 1989
Dynamics of the Diradylglycerol Responses of Stimulated Phagocytes
RW Dougherty, GR Dubay, JE Niedel
The Journal of biological chemistry 1989
Iron Ion-dependent Modification of Bases in DNA by the Superoxide Radical-generating System Hypoxanthine/Xanthine Oxidase
OI Aruoma, B Halliwell, M Dizdaroglu
The Journal of biological chemistry 1989

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