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Research Article Free access | 10.1172/JCI113561
Third Department of Internal Medicine, Okayama University Medical School, Japan.
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Third Department of Internal Medicine, Okayama University Medical School, Japan.
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Third Department of Internal Medicine, Okayama University Medical School, Japan.
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Third Department of Internal Medicine, Okayama University Medical School, Japan.
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Third Department of Internal Medicine, Okayama University Medical School, Japan.
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Third Department of Internal Medicine, Okayama University Medical School, Japan.
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Third Department of Internal Medicine, Okayama University Medical School, Japan.
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Published July 1, 1988 - More info
1.0 micrograms/kg body wt human corticotropin-releasing factor (hCRF) and 0.005 IU/kg body wt lysine vasopressin (LVP) were administered in a bolus dose to patients receiving daily or alternate-day glucocorticoid therapy. In normal subjects with this hCRF-LVP test, the plasma ACTH increment was significantly greater (approximately 2.5-fold) 15 min after injection than under the CRF test. In patients receiving daily glucocorticoid therapy (greater than 15 mg prednisolone or an equivalent daily dose), the plasma ACTH and cortisol responses to hCRF-LVP were suppressed 2 wk to 1 mo after the beginning of glucocorticoid administration but partially improved at 2-10 mo, and was markedly suppressed several years later. On the other hand, in patients receiving alternate-day glucocorticoid therapy, the plasma ACTH response was normal at 2 wk, normal or higher at 1-3 mo, and normal after 4 mo. A normal plasma cortisol response was observed throughout the test period in patients receiving alternate-day therapy after pulse therapy, whereas plasma cortisol response was gradually improved in patients receiving alternate-day therapy after several months of daily therapy.
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