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Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

P J Simpson, … , J D Griffin, B R Lucchesi

Published February 1, 1988
Citation Information: J Clin Invest. 1988;81(2):624-629. https://doi.org/10.1172/JCI113364.

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Research Article

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

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Abstract

A monoclonal antibody (904) that binds to a leukocyte cell adhesion-promoting glycoprotein, (Mo1; CD11b/CD18) was administered (1 mg/kg, iv.) to open chest anesthetized dogs 45 min after the induction of regional myocardial ischemia. Ischemia was produced by occluding the left circumflex coronary artery (LCX) for 90 min and then reperfusing for 6 h. There was no difference between control and antibody treated groups with respect to arterial blood pressure, heart rate, or LCX blood flow. Administration of antibody produced no observable effect on circulating neutrophil counts, suggesting that antibody-bound neutrophils were not cleared from the circulation. The mean size of myocardial infarct expressed as percentage of the area at risk of infarction that resulted was reduced by 46% with anti-Mo1 treatment (25.8 +/- 4.7%, n = 8) compared to control (47.6 +/- 5.7%, n = 8; P less than 0.01). The area at risk of infarction was similar between groups. Circulating (serum) antibody excess was confirmed in all 8 anti-Mo1 treated dogs by immunofluorescence analysis. Analysis of ST segment elevation on the electrocardiogram as an indicator of the severity of ischemia suggests that the anti-Mo1 reduces infarct size independent of the severity of ischemia. An additional group of dogs (n = 5) was tested with a control monoclonal antibody of the same subtype (murine IgG1) and was found to produce no significant reduction in myocardial infarct size. Accumulation of neutrophils within the myocardium was significantly attenuated with 904 treatment when analyzed by histological methods. These data demonstrate that administration of anti-Mo1 monoclonal antibody after the induction of regional myocardial ischemia results in reduced myocardial reperfusion injury as measured by ultimate infarct size.

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P J Simpson, R F Todd 3rd, J C Fantone, J K Mickelson, J D Griffin, B R Lucchesi

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Sialyl LewisX oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs ML Schermerhorn, M Tofukuji, PR Khoury, L Phillips, PR Hickey, FW Sellke, JE Mayer, DP Nelson	The Journal of Thoracic and Cardiovascular Surgery	2000
In vivo models of myocardial ischemia and reperfusion injury SC Black	Journal of Pharmacological and Toxicological Methods	2000
T-lymphocytes contribute to hepatic leukostasis and hypoxic stress induced by gut ischemia-reperfusion Y Horie, R Wolf, R P Chervenak, S R Jennings, D N Granger	Microcirculation (New York, N.Y. : 1994)	2000
Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits P Golino, M Ragni, P Cirillo, A Scognamiglio, A Ravera, C Buono, A Guarino, O Piro, C Lambiase, F Botticella, M Ezban, M Condorelli, M Chiariello	American journal of physiology. Heart and circulatory physiology	2000
Antibody‐induced modulation of the leukocyte CD11b integrin prevents mild but not major renal ischaemic injury LC Tajra, X Martin, J Margonari, N BlancBrunat, M Ishibashi, G Vivier, JP Steghens, H Kawashima, M Miyasaka, JM Dubernard, JP Revillard	Nephrology Dialysis Transplantation	2000
Leukocyte and endothelial cell adhesion molecules in a chronic murine model of myocardial reperfusion injury SP Jones, SD Trocha, MB Strange, DN Granger, CG Kevil, DC Bullard, DJ Lefer	American journal of physiology. Heart and circulatory physiology	2000
Effect of Leukocyte-Endothelial Adhesion Antagonism on Neutrophil Migration and Neurologic Outcome after Cortical Trauma: KD Weaver, CA Branch, L Hernandez, CH Miller, KB Quattrocchi	The Journal of trauma	2000
Recombinant Humanized Monoclonal Antibody against CD18 (rhu MAb CD18) in Traumatic Hemorrhagic Shock: Results of a Phase II Clinical Trial: P Rhee, J Morris, R Durham, C Hauser, M Cipolle, R Wilson, F Luchette, N McSwain, R Miller	The Journal of trauma	2000
Immune Response in the Critically Ill JC Marshall, J Cohen		2000
The αMβ2 integrin and its role in neutrophil function L ZHANG	Cell Research	1999
Adhesion molecules in cardiovascular disease JE Prince, CM Ballantyne	Expert Opinion on Therapeutic Targets	1999
Effect of glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction FJ Neumann, D Zohlnhöfer, L Fakhoury, I Ott, M Gawaz, A Schömig	Journal of the American College of Cardiology	1999
Pump prime only aprotinin inhibits cardiopulmonary bypass-induced neutrophil CD11b up-regulation A Alonso, CW Whitten, GE Hill	The Annals of Thoracic Surgery	1999
Mechanisms of myocardial reperfusion injury JL Park, BR Lucchesi	The Annals of Thoracic Surgery	1999
Differential expression of neutrophil adhesion molecules during coronary artery surgery with cardiopulmonary bypass MK Ilton, PE Langton, ML Taylor, NL Misso, M Newman, PJ Thompson, J Hung	The Journal of Thoracic and Cardiovascular Surgery	1999
In Vivo Effects of Monoclonal Antibodies against Rat β2 Integrins on Kidney Ischemia–Reperfusion Injury LC Tajra, X Martin, J Margonari, N Blanc-Brunat, M Ishibashi, G Vivier, G Panaye, JP Steghens, H Kawashima, M Miyasaka, D Treille-Ritouet, JM Dubernard, JP Revillard	Journal of Surgical Research	1999
Advances in Cellular and Molecular Biology of Membranes and Organelles MA Horwitz, DL Clemens	Advances in Cellular and Molecular Biology of Membranes and Organelles	1999
Combination treatment for acute ischemic stroke: A ray of Hope? SC Fagan, MP Bowes, SA Berri, JA Zivin	Journal of Stroke and Cerebrovascular Diseases	1999
S(+)-Ketamine, but Not R(-)-Ketamine, Reduces Postischemic Adherence of Neutrophils in the Coronary System of Isolated Guinea Pig Hearts: A Szekely, B Heindl, S Zahler, PF Conzen, BF Becker	Anesthesia & Analgesia	1999
Bradykinin prevents postischemic leukocyte adhesion and emigration and attenuates microvascular barrier disruption S Shigematsu, S Ishida, DC Gute, RJ Korthuis	American journal of physiology. Heart and circulatory physiology	1999
Ultrastructural assessment of myocardial necrosis occurring during ischemia and 3-h reperfusion in the dog LC Becker, RW Jeremy, J Schaper, W Schaper	American journal of physiology. Heart and circulatory physiology	1999
Concentration-dependent effects of bradykinin on leukocyte recruitment and venular hemodynamics in rat mesentery S Shigematsu, S Ishida, DC Gute, RJ Korthuis	American journal of physiology. Heart and circulatory physiology	1999
E-selectin Gene Expression Is Induced Synergistically with the Coexistence of Activated Classic Protein Kinase C and Signals Elicited by Interleukin-1β but Not Tumor Necrosis Factor-α M Tamaru, S Narumi	The Journal of biological chemistry	1999
A CD18 monoclonal antibody reduces multiple organ injury in a model of ruptured abdominal aortic aneurysm AJ Boyd, BB Rubin, PM Walker, A Romaschin, TB Issekutz, TF Lindsay	American journal of physiology. Heart and circulatory physiology	1999
Endothelial Injuries of Coronary Arteries Distal to Thrombotic Sites: Role of Adhesive Interaction Between Endothelial P-Selectin and Leukocyte Sialyl Lewis X H Eguchi, H Ikeda, T Murohara, H Yasukawa, N Haramaki, S Sakisaka, T Imaizumi	Circulation research	1999
Amino Acid Sequences within the α Subunit of Integrin α M β 2 (Mac-1) Critical for Specific Recognition of C3bi L Zhang, EF Plow	Biochemistry	1999
Endothelin-1–Induced Interleukin-8 Production in Human Brain-Derived Endothelial Cells Is Mediated by the Protein Kinase C and Protein Tyrosine Kinase Pathways R Zidovetzki, P Chen, M Chen, FM Hofman	Blood	1999
Histochemical and morphological characteristics of canine cardiac mast cells N G Frangogiannis, A R Burns, L H Michael, M L Entman	The Histochemical Journal	1999
Increased release of the soluble form of the adhesion molecules L-selectin and ICAM-1 but not E-selectin during attacks of angina pectoris T Siminiak, J Smielecki, JF Dye, M Baliñski, H El-Gendi, H Wysocki, DJ Sheridan	Heart and Vessels	1998
LEUCOCYTE ADHESION MOLECULES IN ISCHAEMIC RENAL INJURY: KIDNEY SPECIFIC PARADIGMS? H Rabb, G Postler	Clinical and Experimental Pharmacology and Physiology	1998
Sulfatide reduces leucocyte accumulation and reverts vascular failure in splanchnic artery occlusion shock F Squadrito, D Altavilla, G Squadrito, GM Campo, M Arlotta, C Quartarone, L Minutoli, M Ferlito, A Saitta, AP Caputi	European Journal of Pharmacology	1998
Effect oftrans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function S Rotondo, G Rajtar, S Manarini, A Celardo, D Rotilio, G Gaetano, V Evangelista, C Cerletti	British Journal of Pharmacology	1998
The role of P-selectin, sialyl Lewis X and sulfatide in myocardial ischemia and reperfusion injury K Yamada, SJ Tojo, M Hayashi, S Morooka	European Journal of Pharmacology	1998
A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits C Rogers, ER Edelman, DI Simon	Proceedings of the National Academy of Sciences	1998
Serum proteins facilitate neutrophil induction of endothelial leukocyte adhesion molecule 1 JM van Bogaerde, KL Hynes, ET Clark, BL Gewertz	Surgery	1998
EFFECT OF HYPERBARIC OXYGEN THERAPY ON TESTICULAR ISCHEMIA-REPERFUSION INJURY JM Kolski, PJ Mazolewski, LL Stephenson, J Texter, VE Grigoriev, WA Zamboni	The Journal of Urology	1998
Interactive Role of Infection, Inflammation and Traditional Risk Factors in Atherosclerosis and Coronary Artery Disease JL Mehta, TG Saldeen, K Rand	Journal of the American College of Cardiology	1998
Pretreatment with Polynitroxyl Albumin (PNA) Inhibits Ischemia-Reperfusion Induced Leukocyte-Endothelial Cell Adhesion 11This work is supported in-part by grants from the National Institutes of Health, NS 36119 (CJCH) and HL26441 (DNG) J Russell, N Okayama, JS Alexander, DN Granger, CJ Hsia	Free radical biology & medicine	1998
Inhibition Of Interleukin-8 Blocks Myocardial Ischemia-Reperfusion Injury EM Boyle, JC Kovacich, CA Hèbert, TG Canty, E Chi, EN Morgan, TH Pohlman, ED Verrier	The Journal of Thoracic and Cardiovascular Surgery	1998
Iloprost Added to the Cardioplegic Solutions Improves Myocardial Performance SF Katircioğlu, Z Saritaş, AT Ulus, B Yamak, D Yücel, S Ayaz	Prostaglandins & Other Lipid Mediators	1998
Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion NG Frangogiannis, ML Lindsey, LH Michael, KA Youker, RB Bressler, LH Mendoza, RN Spengler, CW Smith, ML Entman	Circulation	1998
The nature of ischemia/reperfusion injury S Massberg, K Messmer	Transplantation Proceedings	1998
The molecular and cellular basis of reperfusion injury following organ transplantation W Jassem, J Roake	Transplantation Reviews	1998
The role of leukocyte-endothelial cell adhesion in cardiovascular disease MJ Eppihimer	Pathophysiology	1998
Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669): PC Rimensberger, L Fedorko, E Cutz, DJ Bohn	Critical Care Medicine	1998
Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice AJ Palazzo, SP Jones, WG Girod, DC Anderson, DN Granger, DJ Lefer	American journal of physiology. Heart and circulatory physiology	1998
Postischemic inflammation: a role for mast cells in intestine but not in skeletal muscle S Kanwar, MJ Hickey, P Kubes	AJP Gastrointestinal and Liver Physiology	1998
Nitric oxide generation is increased in experimental renal warm ischaemia-reperfusion injury Weight, Furness, Nicholson	The British journal of surgery	1998
Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats Y Yamaguchi, F Matsumura, M Takeya, O Ichiguchi, JI Kuratsu, T Horiuchi, E Akizuki, T Matsuda, K Okabe, H Ohshiro, J Liang, K Mori, S Yamada, K Takahashi, M Ogawa	Hepatology	1998
Progression of Myocardial Necrosis During Reperfusion of Ischemic Myocardium K Matsumura, RW Jeremy, J Schaper, LC Becker	Circulation	1998
Monoclonal Antibodies Against ICAM-1 and CD18 Attenuate Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Rabbits M Bavbek, R Polin, AL Kwan, AS Arthur, NF Kassell, KS Lee	Stroke; a journal of cerebral circulation	1998
Interleukin-1β Induces Tissue- and Cell Type–Specific Expression of Adhesion Molecules In Vivo M Tamaru, K Tomura, S Sakamoto, K Tezuka, T Tamatani, S Narumi	Arteriosclerosis, thrombosis, and vascular biology	1998
Angiotensin II Receptor Blockade Physiological and Clinical Implications NS Dhalla, P Zahradka, IM Dixon, RE Beamish		1998
Neuroprotective Signal Transduction MP Mattson		1998
Endothelin-1 Induces Production of the Neutrophil Chemotactic Factor Interleukin-8 by Human Brain-Derived Endothelial Cells FM Hofman, P Chen, R Jeyaseelan, F Incardona, M Fisher, R Zidovetzki	Blood	1998
In vivo recruitment of neutrophils: consistent requirements for L-arginine and variable requirements for complement and adhesion molecules M S Mulligan, A B Lentsch, P A Ward	Inflammation	1998
Hepatic leukostasis and hypoxic stress in adhesion molecule-deficient mice after gut ischemia/reperfusion Y Horie, R Wolf, DC Anderson, DN Granger	Journal of Clinical Investigation	1997
LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice H Lu, CW Smith, J Perrard, D Bullard, L Tang, SB Shappell, ML Entman, AL Beaudet, CM Ballantyne	Journal of Clinical Investigation	1997
Leukocyte?Endothelial Cell Interactions in Ischemia-Reperfusion Injury RK Winn, C Ramamoorthy, NB Vedder, SR Sharar, JM Harlan	Annals of the New York Academy of Sciences	1997
The leukocyte cell adhesion cascade and its role in myocardial ischemia-reperfusion injury RJ Gumina, PJ Newman, D Kenny, DC Warltier, GJ Gross	Basic Research in Cardiology	1997
Increased surface expression of CD18 and CD11b in leukocytes after tourniquet ischemia during elective hand surgery PM Sutter, GC Spagnoli, A Marx, L Gürke, H Troeger, R Fricker, F Harder, M Heberer	World Journal of Surgery	1997
Ischemia-Reperfusion Injury EM MD, TH MD, CJ MD, ED MD	The Annals of Thoracic Surgery	1997
The Procoagulant Response to Injury EM MD, ED MD, BD MD	The Annals of Thoracic Surgery	1997
Endothelial Cell Injury in Cardiovascular Surgery: An Overview ED MD, EM MD	The Annals of Thoracic Surgery	1997
Protective effect of monoclonal antibodies to adhesion molecules on rat liver ischemia-reperfusion injury S Marubayashi, Y Oshiro, T Maeda, K Fukuma, K Okada, T Hinoi, M Ikeda, K Yamada, H Itoh, K Dohi	Surgery	1997
The therapeutic potential of interleukin-6 hyperagonists and antagonists KJ Kallen, KH Büschenfelde, S Rose-John	Expert Opinion on Investigational Drugs	1997
Interleukin 8 released after acute myocardial infarction is mainly bound to erythrocytes RJ de Winter, A Manten, YP de Jong, R Adams, SJ van Deventer, KI Lie	Heart (British Cardiac Society)	1997
Prevention of Remote Organ Injury in Cardiopulmonary Bypass: The Impact of Flow Generation Technique JA Hyde, DW Riddington, P Hutton, IC Wilson, CM Boivin, G Nash, TR Graham	Artificial Organs	1997
Preinfection In Vitro Chemotaxis, Phagocytosis, Oxidative Burst, and Expression of CD11/CD18 Receptors and Their Predictive Capacity on the Outcome of Mastitis Induced in Dairy Cows with Escherichia coli TV Werven, EN Noordhuizen-Stassen, AJ Daemen, YH Schukken, A Brand, C Burvenich	Journal of Dairy Science	1997
Advances in Molecular and Cell Biology KJ Clemetson	Advances in Molecular and Cell Biology	1997
Complement inhibitors in myocardial ischemia/reperfusion injury BR Lucchesi, KS Kilgore	Immunopharmacology	1997
Controlling the complement system in inflammation M Kirschfink	Immunopharmacology	1997
Myeloperoxidase mediates cell adhesion via the alpha M beta 2 integrin (Mac-1, CD11b/CD18) AM Lefer	Journal of cell science	1997
The influence of cardiopulmonary bypass on cytokines and cell-cell communication GE Hill, CW Whitten, DF Landers	Journal of Cardiothoracic and Vascular Anesthesia	1997
Pharmacology and pharmacokinetics of LEX 032, a bioengineered serpin: the first of a potential new class of drugs H Sands, J B Hook	Drug Metabolism Reviews	1997
Reperfusion injury: a review of the pathophysiology, clinical manifestations and therapeutic options SR Maxwell, GY Lip	International Journal of Cardiology	1997
Leukocyte Adhesion Molecules TW Penberthy, Y Jiang, DT Graves	Critical Reviews in Oral Biology & Medicine	1997
Magnesium: Current Status and New Developments T Theophanides, J Anastassopoulou		1997
7E3 Monoclonal Antibody Directed Against the Platelet Glycoprotein IIb/IIIa Cross-reacts With the Leukocyte Integrin Mac-1 and Blocks Adhesion to Fibrinogen and ICAM-1 DI Simon, H Xu, S Ortlepp, C Rogers, NK Rao	Arteriosclerosis, thrombosis, and vascular biology	1997
Procurement, Preservation and Allocation of Vascularized Organs GM Collins, JM Dubernard, W Land, GG Persijn		1997
The Role of Immune Mechanisms in Cardiovascular Disease HP Schultheiss, P Schwimmbeck		1997
Textbook of Coronary Thrombosis and Thrombolysis RC Becker		1997
Lipid peroxide and leukotriene B3 production in patients undergoing cardiopulmonary bypass T Kawamura, H Sakurada, K Okada, R Wakusawa, H Ito	Journal of Anesthesia	1996
Role of polymorphonuclear leukocytes in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion R Kapoor, K Prasad	Free radical biology & medicine	1996
Neutrophils and myocardial reperfusion injury FM Williams	Pharmacology & Therapeutics	1996
Increased leukocyte adhesiveness/ aggregation in patients with inflammatory bowel disease during remission N Arber, A Hallak, I Dotan, Y Bujanover, E Liberman, M Santo, M Moshkowitz, E Tiomny, M Aronson, S Berliner, T Gilat	Diseases of the Colon & Rectum	1996
Renal ischaemia-reperfusion injury SC Weight, PR Bell, ML Nicholson	British Journal of Surgery	1996
Improvement in rheumatoid arthritis following application of an extracorporeal granulotrap column, G-1 J Fujimori, S Yoshino, M Koiwa, H Hirai, H Shiga, N Hayama, Y Iino	Rheumatology International	1996
Role of endothelin in the pathophysiology of renal ischemia-reperfusion in normal rabbits G Espinosa, AL Farré, MR Cernadas, F Manzarbeitia, D Tan, E Digiuni, JR Mosquera, M Montón, I Millás, L Hernando, S Casado, C Caramelo	Kidney International	1996
Endothelial cell injury in cardiovascular surgery: The procoagulant response EM Boyle, ED Verrier, BD Spiess	The Annals of Thoracic Surgery	1996
Endothelial Cell Injury in Cardiovascular Surgery ED Verrier, EM Boyle	The Annals of Thoracic Surgery	1996
Lidocaine reduces reperfusion injury and neutrophil migration in canine lung allografts RA Schmid, M Yamashita, K Ando, Y Tanaka, JD Cooper, GA Patterson	The Annals of Thoracic Surgery	1996
Amplification of the Inflammatory Response: Adhesion Molecules Associated with Platelet/White Cell Responses C Rinder, J Fitch	Journal of Cardiovascular Pharmacology	1996
EXPRESSION OF SIALYL LEWISX IN RAT HEART WITH ISCHAEMIA/REPERFUSION AND REDUCTION OF MYOCARDIAL REPERFUSION INJURY BY A MONOCLONAL ANTIBODY AGAINST SIALYL LEWISX Y Seko, Y Enokawa, T Tamatani, R Kannagi, H Yagita, K Okumura, Y Yazaki	The Journal of Pathology	1996
REDUCTION OF RAT MYOCARDIAL ISCHAEMIA/REPERFUSION INJURY BY A SYNTHETIC SELECTIN OLIGOPEPTIDE Y Seko, Y Enokawa, T Nakao, H Yagita, K Okumura, Y Yazaki	The Journal of Pathology	1996
Iloprost effects on phagocytes in patients suffering from ischaemic diseases: in vivo evidence for down-regulation of αMβ2integrin A Mazzone, I Mazzucchelli, G Fossati, D Gritti, S Girola, C Canale, C Cusa, G Ricevuti	European Journal of Clinical Investigation	1996
Endothelial Cell Injury in Cardiovascular Surgery: Ischemia-Reperfusion EM Boyle, TH Pohlman, CJ Cornejo, ED Verrier	The Annals of Thoracic Surgery	1996
Cardioprotective actions of oligotide, a single stranded polydeoxyribonucleotide complex, in myocardial ischaemia and reperfusion injury T Murohara, M Buerke, AM Lefer	British Journal of Pharmacology	1996
Myocardial viability Y Birnbaum, RA Kloner	The Western journal of medicine	1996
Effects of CD11b/18 monoclonal antibody on rats with permanent middle cerebral artery occlusion JH Garcia, KF Liu, MP Bree	The American Journal of Pathology	1996
Expression of polymorphonuclear leukocyte adhesion molecules and its clinical significance in patients treated with percutaneous transluminal coronary angioplasty T Inoue, Y Sakai, S Morooka, T Hayashi, K Takayanagi, Y Takabatake	Journal of the American College of Cardiology	1996
Influence of ischemic preconditioning and blood cardioplegia protection on postischemic endothelial activation in coronary bypass surgery G Steinhoff, M Karck, J Cremer, T Ahnsel, D Hollander, A Haverich	European Surgery	1996
Effects of Calcium Blockers on the Cytosolic Calcium, H2O2Production and Elastase Release in Human Neutrophils Y Haga, A Dumitrescu, Y Zhang, R Stain-Malmgren, PO Sjöquist	Pharmacology & Toxicology	1996
Enhanced isolated lung function after ischemia with antinintercellular adhesion molecule antibody SA Buchanan, MC Mauney, NF deLima, OA Binns, JS Cope, KS Shockey, SG Gordon, MB Erwin, G Sutherland, IL Kron, CG Tribble	The Journal of Thoracic and Cardiovascular Surgery	1996
Acute myocardial infarction, reperfusion injury, and intravenous magnesium therapy: Basic concepts and clinical implications G Steurer, P Yang, V Rao, W Mohl, D Glogar, R Smetana	American Heart Journal	1996
The Impact of Ischemia/Reperfusion Injury on Specific and Non-Specific, Early and Late Chronic Events After Organ Transplantation W Land, K Messmer, E Events	Transplantation Reviews	1996
Methods for studying experimental myocardial ischemic and reperfusion injury SC Black, IW Rodger	Journal of Pharmacological and Toxicological Methods	1996
Effects of low dose intra-arterial monoclonal antibodies to ICAM-1 and CD11/CD18 on local and systemic consequences of ischaemia-reperfusion injury in skeletal muscle AF Breidahl, MJ Hickey, AG Stewart, PG Hayward, WA Morrison	British Journal of Plastic Surgery	1996
The Effect of Low Molecular Weight Heparin (Fragmin) on Myocardial Neutrophil Accumulation and Infarct Size in a Rat Model of Myocardial Infarction D Hasdai, N Varda-Bloom, N Blumberg, D Ohad, R Kornowski, A Battler	Angiology	1996
Reduction of Myocardial Infarct Size in the Rabbit by a Carbohydrate Analog of Sialyl Lewisx KS Kilgore, JL Park, L Chi, JH Musser, V Date, S Abbas, BR Lucchesi	Journal of cardiovascular pharmacology and therapeutics	1996
The Challenges of Lower Extremity Ischemia-Reperfusion Injury M Belkin	Vascular and endovascular surgery	1996
Antibodies against Mac-1 Attenuate Neutrophil Accumulation after Traumatic Brain Injury in Rats RS Clark, TM Carlos, JK Schiding, M Bree, LA Fireman, ST DeKOSKY, PM Kochanek	Journal of Neurotrauma	1996
ANTIBODY TO CD18 REDUCES NEUTROPHIL AND T LYMPHOCYTE INFILTRATION AND VASCULAR CELL ADHESION MOLECULE-1 EXPRESSION IN CARDIAC REJECTION1: H Akimoto, TO McDonald, JT Weyhrich, R Thomas, CL Rothnie, MD Allen	Transplantation	1996
Role of Endothelium-Related Mechanisms in the Pathophysiology of Renal Ischemia/Reperfusion in Normal Rabbits C Caramelo, G Espinosa, F Manzarbeitia, MR Cernadas, GP Tejerizo, D Tan, JR Mosquera, E Digiuni, M Monton, I Millas, L Hernando, S Casado, A Lopez-Farre	Circulation research	1996
An Oligosaccharide Sialyl-Lewis x Analogue Does Not Reduce Myocardial Infarct Size After Ischemia and Reperfusion in Dogs EA Gill, Y Kong, LD Horwitz	Circulation	1996
Antibody to Platelet/Endothelial Cell Adhesion Molecule-1 Reduces Myocardial Infarct Size in a Rat Model of Ischemia-Reperfusion Injury RJ Gumina, JE Schultz, Z Yao, D Kenny, DC Warltier, PJ Newman, GJ Gross	Circulation	1996
Molecular Biology of Membrane Transport Disorders SG Schultz, TE Andreoli, AM Brown, DM Fambrough, JF Hoffman, MJ Welsh		1996
Anesthesiology and the Cardiovascular Patient TH Stanley, PL Bailey		1996
59. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie e.V G Muhr, KE Rehm		1996
Renal ischaemia-reperfusion injury: RENAL ISCHAEMIA-REPERFUSION INJURY SC Weight, PR Bell, ML Nicholson	The British journal of surgery	1996
REPERFUSION AND WOUND HEALING SL Stevens, JW Hudson	Oral and Maxillofacial Surgery Clinics of North America	1996
Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo GL Kukielka, CW Smith, GJ LaRosa, AM Manning, LH Mendoza, TJ Daly, BJ Hughes, KA Youker, HK Hawkins, LH Michael	Journal of Clinical Investigation	1995
Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8 CL Ivey, FM Williams, PD Collins, PJ Jose, TJ Williams	Journal of Clinical Investigation	1995
Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation CS Rinder, HM Rinder, BR Smith, JC Fitch, MJ Smith, JB Tracey, LA Matis, SP Squinto, SA Rollins	Journal of Clinical Investigation	1995
Role of early reperfusion in the induction of adhesion molecules and cytokines in previously ischemic myocardium GL Kukielka, KA Youker, LH Michael, AG Kumar, CM Ballantyne, CW Smith, ML Entman	Molecular and Cellular Biochemistry	1995
Treatment of acute myocardial infarction with streptokinase does not appear to modulate circulating neutrophil function SA Adams, SP Froese, RE Kirsch, EG Shephard, SC Robson, BK Green, PJ Commerford	Clinical Cardiology	1995
Anti-CD18 Attenuates Deleterious Effects of Cardiopulmonary Bypass and Hypothermic Circulatory Arrest in Piglets M Aoki, RA Jonas, F Nomura, H Kawata, PR Hickey	Journal of Cardiac Surgery	1995
Methylprednisolone inhibits increase of interleukin 8 and 6 during open heart surgery T Kawamura, K Inada, H Okada, K Okada, R Wakusawa	Canadian Journal of Anaesthesia	1995
A P-selectin-immunoglobulin G chimera is protective in a rabbit ear model of ischemia-reperfusion WP Lee, P Gribling, LD Guzman, N Ehsani, SR Watson	Surgery	1995
Microvascular function and rheologic changes in hyperdynamic sepsis ME Astiz, GE DeGent, RY Lin, EC Rackow	Critical Care Medicine	1995
Anti-CD11b monoclonal antibody improves myocardial function after six hours of hypothermic storage JM Forbess, T Hiramatsu, F Nomura, T Miura, GK Farrington, K Sokolowski, M Bree, JE Mayer	The Annals of Thoracic Surgery	1995
A chimeric IgG4 monoclonal antibody directed against CD18 reduces infarct size in a primate model of myocardial ischemia and reperfusion T Aversano, W Zhou, M Nedelman, M Nakada, H Weisman	Journal of the American College of Cardiology	1995
Interleukin-8 and monocyte chemotactic activating factor responses to cardiopulmonary bypass K Kawahito, M Kawakami, T Fujiwara, H Adachi, T Ino	The Journal of Thoracic and Cardiovascular Surgery	1995
In vitro and in vivo inhibition of complement activity by a single-chain Fv fragment recognizing human C5 MJ Evans, SA Rollins, DW Wolff, RP Rother, AJ Norin, DM Therrien, GA Grijalva, JP Mueller, SH Nye, SP Squinto, JA Wilkins	Molecular Immunology	1995
Myocardial and coronary endothelial protective effects of acetylcholine after myocardial ischaemia and reperfusion in rats: role of nitric oxide V Richard, T Blanc, N Kaeffer, C Tron, C Thuillez	British Journal of Pharmacology	1995
Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass JP Mathew, CS Rinder, JB Tracey, LA Auszura, T O'Connor, E Davis, BR Smith	The Journal of Thoracic and Cardiovascular Surgery	1995
Transvalvular Left Ventricular Assistance in Acute Myocardial Infarction with Cardiogenic Shock and High Risk Angioplasty: Experimental and Clinical Results with the Hemopump RW Smalling	Journal of Interventional Cardiology	1995
Purification and characterization of canine manganese superoxide dismutase and its immunohistochemical localization in canine heart compared with that of copper-zinc superoxide dismutase K Ikeda, S Matsumi, T Magara, S Nakagawa	The International Journal of Biochemistry & Cell Biology	1995
Efficacy of intraportal injection of anti-ICAM-1 monoclonal antibody against liver cell injury following warm ischemia in the rat H Nakano, M Kuzume, K Namatame, M Yamaguchi, K Kumada	The American Journal of Surgery	1995
Protective effect of monoclonal antibodies against LFA-1 and ICAM-1 on myocardial reperfusion injury following global ischemia in rat hearts Y Tamiya, N Yamamoto, T Uede	Immunopharmacology	1995
Neutrophil-independent myocardial dysfunction during an early stage of global ischemia and reperfusion of isolated hearts Y Kamikubo, M Murakami, M Imamura, T Murashita, K Yasuda, T Uede	Immunopharmacology	1995
Neutrophil Antiadhesion Therapy For Myocardial Ischaemia: Clinical Potential MC Johnson, TH Pohlman, ED Verrier	Clinical immunotherapeutics	1995
Sepsis in the critically ill patient CC Baker, T Huynh	Current Problems in Surgery	1995
Alterations in Leukocyte Adhesion Molecule Expression after Burn Injury: FE Nwariaku, WJ Mileski, E Lightfoot, PJ Sikes, PE Lipsky	The Journal of Trauma: Injury, Infection and Critical Care	1995
Ischemia-Induced Interleukin-8 Release After Human Heart Transplantation: A Potential Role for Endothelial Cells MC Oz, H Liao, Y Naka, A Seldomridge, DN Becker, RE Michler, CR Smith, EA Rose, DM Stern, DJ Pinsky	Circulation	1995
Infarct Salvage With Liposomal Prostaglandin E 1 Administered by Intravenous Bolus Immediately Before Reperfusion in a Canine Infarction-Reperfusion Model RW Smalling, S Feld, N Ramanna, J Amirian, P Felli, WK Vaughn, C Swenson, A Janoff	Circulation	1995
Cellular Interactions in Cardiac Pathophysiology J Slezák, A Ziegelhöffer		1995
Increased leucocyte adhesiveness/aggregation is a most useful indicator of disease activity in patients with inflammatory bowel disease N Arber, S Berliner, A Hallak, Y Bujanover, I Dotan, E Liberman, M Santo, M Moshkowitz, J Ratan, G Dotan	Gut	1995
Cell-cell and cell-matrix adhesion molecules in human heart and lung transplants G Steinhoff, A Haverich	Molecular and Cellular Biochemistry	1995
Plasma mediated neutrophil stimulation during coronary angioplasty: autocrine effect of platelet activating factor T Siminiak, DJ O'Gorman, M Shahi, D Hackett, DJ Sheridan	Heart (British Cardiac Society)	1995
Methylprednisolone inhibits increase of interleukin 8 and 6 during open heart surgery T Kawamura, K Inada, H Okada, K Okada, R Wakusawa	Canadian Journal of Anesthesia/Journal canadien d'anesthésie	1995
Modulation of neutrophil activity by nitric oxide during acute myocardial ischaemia and reperfusion RM Egdell, T Siminiak, DJ Sheridan	Basic Research in Cardiology	1994
Up-Regulation of Endothelial Cell Adhesion Molecules Characterizes Disease Activity in Systemic Lupus Erythematosus HM Belmont, J Buyon, R Giorno, S Abramson	Arthritis & Rheumatism	1994
Ischaemia-reperfusion injury PA Grace	British Journal of Surgery	1994
Role of neutrophil-endothelial cell adhesion in inflammatory disorders RJ Korthuis, DC Anderson, DN Granger	Journal of Critical Care	1994
Evidence Implicating Xanthine Oxidase and Neutrophils in Reperfusion-Induced Microvascular Dysfunction I Kurose, DN Granger	Annals of the New York Academy of Sciences	1994
ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULES IN HUMAN DISEASE MP Ph.D, RM Ph.D, GM Ph.D, OC M.D	Annual Review of Medicine	1994
Complement and neutrophil activation during cardiopulmonary bypass: A study in the complement-deficient dog AM Gillinov, JM Redmond, JA Winkelstein, KJ Zehr, A Herskowitz, WA Baumgartner, DE Cameron	The Annals of Thoracic Surgery	1994
Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat H Chen, M Chopp, RL Zhang, G Bodzin, Q Chen, JR Rusche, RF Todd	Annals of Neurology	1994
Vascular Endothelium MA Gimbrone, MI Cybulsky, N Kume, T Collins, N Resnick	Annals of the New York Academy of Sciences	1994
Amelioration of postischemic reperfusion injury by antiarrhythmic drugs in isolated perfused rat lung KC Das, HP Misra	Environmental Health Perspectives	1994
Effect of duration of ischaemia on reduction of myocardial infarct size by inhibition of neutrophil accumulation using an anti-CD18 monoclonal antibody FM Williams, M Kus, K Tanda, TJ Williams	British Journal of Pharmacology	1994
Role of leukocyte adhesion molecules in lung and dermal vascular injury after thermal trauma of skin MS Mulligan, GO Till, CW Smith, DC Anderson, M Miyasaka, T Tamatani, RF 3rd, TB Issekutz, PA Ward	The American Journal of Pathology	1994
Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of enterocolitis complicating Hirschsprung's disease H Kobayashi, H Hirakawa, DS O'Briain, P Puri	Pediatric Surgery International	1994
Skeletal Muscle Ischemia-Reperfusion Injury: A Review of Endothelial Cell-Leukocyte Interactions F Sabido, VJ Milazzo, RW Hobson, WN Duran	Journal of Investigative Surgery	1994
Factors Affecting Milk Somatic Cells and Their Role in Health of the Bovine Mammary Gland ME Kehrli, DE Shuster	Journal of Dairy Science	1994
Human neutrophil cathepsin G is a potent platelet activator CA LaRosa, MJ Rohrer, SE Benoit, LJ Rodino, MR Barnard, AD Michelson	Journal of Vascular Surgery	1994
Advances in Pharmacology B Drenger, Y Ginosar, Y Gozal	Advances in Pharmacology	1994
Prevention of cardiac reperfusion injury following global ischemia by a monoclonal antibody, R2-1A6 N Yamamoto, Y Tamiya, T Uede	Immunopharmacology	1994
Transforming growth factor β1 preserves endothelial function after multiple brief coronary artery occlusions and reperfusion D Kenny, MG Coughlan, PS Pagel, JP Kampine, DC Warltier	American Heart Journal	1994
Potent new cell adhesion inhibitory compounds from the root of Trichilia rubra LL Musza, LM Killar, P Speight, S McElhiney, CJ Barrow, AM Gillum, R Cooper	Tetrahedron	1994
Neutrophil activation after percutaneous transluminal coronary angioplasty H Ikeda, H Nakayama, T Oda, K Kuwano, A Yamaga, T Ueno, M Yoh, K Hiyamuta, Y Koga, H Toshima	American Heart Journal	1994
Beraprost sodium protects occlusion/reperfusion injury in the dog by inhibition of neutrophil migration Y Ueno, Y Miyauchi, S Nishio	General Pharmacology: The Vascular System	1994
Inhibition of neutrophil adhesion during cardiopulmonary bypass AM Gillinov, JM Redmond, KJ Zehr, IC Wilson, WE Curtis, JM Bator, RM Burch, BA Reitz, WA Baumgartner, A Herskowitz, DE Cameron	The Annals of Thoracic Surgery	1994
Anti-adhesive therapeutics: A new class of anti-inflammatory agents F Dasgupta, BN Rao	Expert Opinion on Investigational Drugs	1994
The Clinical Importance of Leucocyte and Endothelial Cell Adhesion Molecules in Inflammation JC Mason, DO Haskard		1994
Endothelium as a therapeutical target in peripheral occlusive arterial diseases: consideration for pharmacological interventions R Cirillo, G Aliev, EJ Hornby, M Prosdocimi	Pharmacological research : the official journal of the Italian Pharmacological Society	1994
The Therapeutic Potential of Targeting Adhesion Molecules in Rheumatoid Arthritis DO Haskard	Cell Communication and Adhesion	1994
Inhibition of neutrophil adhesion does not prevent ischemic spinal cord injury AD Forbes, JC Slimp, RK Winn, ED Verrier	The Annals of Thoracic Surgery	1994
Molecular evidence for induction of intracellular adhesion molecule-1 in the viable border zone associated with ischemia-reperfusion injury of the dog heart KA Youker, HK Hawkins, GL Kukielka, JL Perrard, LH Michael, CM Ballantyne, CW Smith, ML Entman	Circulation	1994
Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats M Chopp, RL Zhang, H Chen, Y Li, N Jiang, JR Rusche	Stroke; a journal of cerebral circulation	1994
A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion DJ Lefer, DM Flynn, ML Phillips, M Ratcliffe, AJ Buda	Circulation	1994
Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage I Kurose, DC Anderson, M Miyasaka, T Tamatani, JC Paulson, RF Todd, JR Rusche, DN Granger	Circulation research	1994
Modulation of ischemia/reperfusion-induced microvascular dysfunction by nitric oxide I Kurose, R Wolf, MB Grisham, DN Granger	Circulation research	1994
Cytokine and murine coxsackievirus B3 myocarditis. Interleukin-2 suppressed myocarditis in the acute stage but enhanced the condition in the subsequent stage C Kishimoto, Y Kuroki, Y Hiraoka, H Ochiai, M Kurokawa, S Sasayama	Circulation	1994
Cerebral Ischemia and Basic Mechanisms A Hartmann, F Yatsu, W Kuschinsky		1994
Cellular Adhesion BW Metcalf, BJ Dalton, G Poste, J Schatz		1994
Anticoagulation C Doutremepuich		1994
Membrane Biogenesis AH Maddy, JR Harris	Membrane Biogenesis	1994
Cardiopulmonary Bypass, Myocardial Management, and Support Techniques PM Kilbridge, JE Mayer, JW Newburger, PR Hickey, AZ Walsh, EJ Neufeld	The Journal of Thoracic and Cardiovascular Surgery	1994
Superoxide dismutase mimetics inhibit neutrophil-mediated human aortic endothelial cell injury in vitro MM Hardy, AG Flickinger, DP Riley, RH Weiss, US Ryan	The Journal of biological chemistry	1994
Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass CS Rinder, D Gaal, LA Student, BR Smith	The Journal of Thoracic and Cardiovascular Surgery	1994
Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization HA Hennein, H Ebba, JL Rodriguez, SH Merrick, FM Keith, MH Bronstein, JM Leung, DT Mangano, LJ Greenfield, JS Rankin	The Journal of Thoracic and Cardiovascular Surgery	1994
Requirements for leukocyte adhesion molecules in nephrotoxic nephritis MS Mulligan, KJ Johnson, RF 3rd, TB Issekutz, M Miyasaka, T Tamatani, CW Smith, DC Anderson, PA Ward	Journal of Clinical Investigation	1993
Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium GL Kukielka, HK Hawkins, L Michael, AM Manning, K Youker, C Lane, ML Entman, CW Smith, DC Anderson	Journal of Clinical Investigation	1993
Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear RK Winn, D Liggitt, NB Vedder, JC Paulson, JM Harlan	Journal of Clinical Investigation	1993
Pathophysiology and Mediators of Ischemia-Reperfusion Injury with Special Reference to Cardiac Surgery: A Review J Vaage, G Valen	Scandinavian Cardiovascular Journal	1993
Inhibition of neutrophil adhesion reduces myocardial infarct size WE Curtis, AM Gillinov, IC Wilson, JM Bator, RM Burch, DE Cameron, TJ Gardner	The Annals of Thoracic Surgery	1993
Current status of antioxidant therapy CA Rice-Evans, AT Diplock	Free radical biology & medicine	1993
Reactive oxygen metabolites, neutrophils, and the pathogenesis of ischemic-tissue/reperfusion RJ Korthuis, DN Granger	Clinical Cardiology	1993
Biosynthesis and function of membrane bound and secreted forms of recombinant CD11b/CD18 (Mac-1) PW Berman, GR Nakamura, L Riddle, H Chiu, K Fisher, M Champe, AM Gray, P Ward, S Fong	Journal of Cellular Biochemistry	1993
Ischemia reperfusion injury: A review CL Kerrigan, MA Stotland	Microsurgery	1993
Lymphocyte Adherence in the Reperfused Rat Liver: Mechanisms and Effects PA Clavien, PR Harvey, JR Sanabria, R Cywes, GA Levy, SM Strasberg	Hepatology	1993
Oxygen tension regulates neutrophil adhesion to human endothelial cells via an LFA-1-dependent mechanism I Ginis, SJ Mentzer, DV Faller	Journal of Cellular Physiology	1993
ell adhesion molecules and their role in haemopoiesis id in haematological diseases Straetmans, D. F. Ma	Australian and New Zealand Journal of Medicine	1993
Neutrophil adhesion molecule expression during cardiopulmonary bypass with bubble and membrane oxygenators AM Gillinov, JM Bator, KJ Zehr, JM Redmond, RM Burch, C Ko, JA Winkelstein, RS Stuart, WA Baumgartner, DE Cameron	The Annals of Thoracic Surgery	1993
Intercellular immune adhesion molecules in human liver transplants: Overview on expression patterns of leukocyte receptor and ligand molecules G Steinhoff, M Behrend, B Schrader, R Pichlmayr	Hepatology	1993
The effect of cloricromene, a coumarine derivative, on leukocyte accumulation, myocardial necrosis and TNF-α production in myocardial ischaemia-reperfusion injury F Squadrito, D Altavilla, B Zingarelli, M Ioculano, G Calapai, GM Campo, A Miceli, M Prosdocimi, AP Caputi	Life Sciences	1993
The role of the neutrophil and formed elements of the blood in an in vitro model of reperfusion injury JA Barrett, CK Derian, RS Swillo, RF Woltmann, MH Perrone	Mediators of Inflammation	1993
A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen MS Diamond, TA Springer	The Journal of Cell Biology	1993
Transient rise in serum interleukin-8 concentration during acute myocardial infarction Y Abe, M Kawakami, M Kuroki, T Yamamoto, M Fujii, H Kobayashi, T Yaginuma, A Kashii, M Saito, K Matsushima	British heart journal	1993
Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart G Montrucchio, G Alloatti, F Mariano, A Comino, G Cacace, R Polloni, PG de Filippi, G Emanuelli, G Camussi	The American Journal of Pathology	1993
Expression of intercellular adhesion molecule-1 in rat heart with ischemia/reperfusion and limitation of infarct size by treatment with antibodies against cell adhesion molecules T Yamazaki, Y Seko, T Tamatani, M Miyasaka, H Yagita, K Okumura, R Nagai, Y Yazaki	The American Journal of Pathology	1993
Reperfusion Plasma Contains a Neutrophil Activator I Paterson, F Smith, G Tsang, J Hamer, C Shearman	Annals of Vascular Surgery	1993
Future Cardioprotective Considerations AS Wechsler, A Abd-Elfattah	Journal of Cardiac Surgery	1993
Reperfusion injury after myocardial infarction: The role of free radicals and the inflammatory response KS Kilgore, BR Lucchesi	Clinical Biochemistry	1993
The adhesion molecules of inflammation BN Cronstein, G Weissmann	Arthritis & Rheumatism	1993
Neutrophil mediated myocardial injury T Siminiak, T Ozawa	International Journal of Biochemistry	1993
Cytokines and Reperfusion Injury PS Nosé	Journal of Cardiac Surgery	1993
Neutrophil adherence-augmenting and chemotactic plasma activities in acute myocardial infarction: effect of fibrynolytic treatment R Klimas, T Siminiak, H Wysocki	International Journal of Cardiology	1993
Acting via A2 Receptors, Adenosine Inhibits the Upregulation of Mac-1 (CD11b/CD18) Expression on FMLP-stimulated Neutrophils A Wollner, S Wollner, JB Smith	American journal of respiratory cell and molecular biology	1993
Lymphocyte adhesion mediated by integrins Y Kooyk, CG Figdor	Research in Immunology	1993
Designing Antibodies RD Mayforth	Designing Antibodies	1993
Potential Role of Neutrophil Anti-Adhesion Therapy in Myocardial Stunning, Myocardial Infarction, and Organ Dysfunction After Cardiopulmonary Bypass ED Verrier, I Shen	Journal of Cardiac Surgery	1993
Cloricromene inhibits leukotriene formation by human polymorphonuclear leucocytes by suppressing arachidonate release from membrane phospholipids P Gresele, E Ribaldi, AM Mezzasoma, E Quero, M Stasi, M Prosdocimi, G Goracci, GG Nenci	Biochemical Pharmacology	1993
Anti-CD18 Attenuates Myocardial Stunning in the Isolated Neonatal Lamb Heart PR Hickey, JE Mayer	Journal of Cardiac Surgery	1993
Immunologic Therapy for ARDS, Septic Shock, and Multiple-Organ Failure RC st. John, PM Dorinsky	Chest	1993
Current Concepts in Cerebral Protection BJ Kelly, JM Luce	Chest	1993
The Damaging Potential of Leukocyte Activation in the Microcirculation GW Schmid-Schönbein	Angiology	1993
Sources of Free Radicals JM Mccord, BA Omar	Toxicology and industrial health	1993
Secondary Organ Dysfunction: From Clinical Perspectives to Molecular Mediators MD Cipolle, MD Pasquale, FB Cerra	Critical Care Clinics	1993
Cardioprotective actions of a monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury DJ Lefer, SM Shandelya, CV Serrano, LC Becker, P Kuppusamy, JL Zweier	Circulation	1993
Effect of anti-CD18 antibody on myocardial neutrophil accumulation and infarct size after ischemia and reperfusion in dogs M Tanaka, SE Brooks, VJ Richard, GP FitzHarris, RC Stoler, RB Jennings, KE Arfors, KA Reimer	Circulation	1993
Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs DJ Lefer, K Nakanishi, WE Johnston, J Vinten-Johansen	Circulation	1993
Increased expression of neutrophil and monocyte adhesion molecules in unstable coronary artery disease A Mazzone, SD Servi, G Ricevuti, I Mazzucchelli, G Fossati, D Pasotti, E Bramucci, L Angoli, F Marsico, G Specchia	Circulation	1993
Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium XL Ma, AS Weyrich, DJ Lefer, M Buerke, KH Albertine, TK Kishimoto, AM Lefer	Circulation	1993
Host Defense Dysfunction in Trauma, Shock and Sepsis E Faist, JL Meakins, FW Schildberg		1993
Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion PE Lipsky, R Rothlein, TK Kishimoto, RB Faanes, CW Smith		1993
Pathophysiology of Shock, Sepsis, and Organ Failure G Schlag, H Redl		1993
Monoclonal Antibodies—Immunotherapy for the Critically Ill S Peake	ANAESTH INTENS CARE	1993
Macrophages and Related Cells MA Horton		1993
New Drugs in Allergy and Asthma TT Hansel, J Morley		1993
Proteases, Protease Inhibitors and Protease-Derived Peptides JC Cheronis, JE Repine		1993
Ischemia-reperfusion in cardiac surgery HM Piper, CJ Preusse		1993
Thrombolytic Therapy in Acute Ischemic Stroke II GJ del Zoppo, E Mori, W Hacke		1993
Neutrophil adherence to isolated adult cardiac myocytes. Induction by cardiac lymph collected during ischemia and reperfusion K Youker, CW Smith, DC Anderson, D Miller, LH Michael, RD Rossen, ML Entman	Journal of Clinical Investigation	1992
Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-alpha in conscious dogs FD Pagani, LS Baker, C Hsi, M Knox, MP Fink, MS Visner	Journal of Clinical Investigation	1992
Anoxia-hyperoxia induces monocyte-derived interleukin-8 AP Metinko, SL Kunkel, TJ Standiford, RM Strieter	Journal of Clinical Investigation	1992
Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood LE DeForge, JC Fantone, JS Kenney, DG Remick	Journal of Clinical Investigation	1992
Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface R Shreeniwas, S Koga, M Karakurum, D Pinsky, E Kaiser, J Brett, BA Wolitzky, C Norton, J Plocinski, W Benjamin	Journal of Clinical Investigation	1992
Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence or epiphenomenon? ML Harris, HJ Schiller, PM Reilly, M Donowitz, MB Grisham, GB Bulkley	Pharmacology & Therapeutics	1992
Free radicals, lipoproteins and cardiovascular dysfunction C Rice-Evans, KR Bruckdorfer	Molecular Aspects of Medicine	1992
Heparin, urokinase, and ancrod alter neutrophil function JA Freischlag, MD Colburn, WJ Quiñones-Baldrich, WS Moore	Journal of Vascular Surgery	1992
Cell adhesion/signalling: biology and clinical applications MW Makgoba, A Bernard, ME Sanders	European Journal of Clinical Investigation	1992
Amelioration of antigen-induced arthritis in rabbits treated with monoclonal antibodies to leukocyte adhesion molecules HE Jasin, E Lightfoot, LS Davis, R Rothlein, RB Faanes, PE Lipsky	Arthritis & Rheumatism	1992
Reduction of infarct size by cell-permeable oxygen metabolite scavengers EJ Lesnefsky	Free radical biology & medicine	1992
Adherent neutrophils mediate permeability after atelectasis G Goldman, R Welbourn, R Rothlein, M Wiles, L Kobzik, CR Valeri, D Shepro, HB Hechtman	Annals of Surgery	1992
Activated neutrophils impair rabbit heart recovery after hypothermic global ischemia ML Myers, C Webb, M Moffat, D McIver, RD Maestro	The Annals of Thoracic Surgery	1992
Neutrophils as mediators of human skeletal muscle ischemia-reperfusion syndrome L Formigli, LD Lombardo, C Adembri, S Brunelleschi, E Ferrari, GP Novelli	Human Pathology	1992
The value and limitation of iloprost infusion in decreasing skeletal muscle necrosis C Mohan, C Marini, M Gennaro, E Ascer	Journal of Vascular Surgery	1992
Novel antibody drug products JT DiPiro, RG Hamilton, JP Wei	The American Journal of Surgery	1992
Reduction of the extent of ischemic skeletal muscle necrosis by perfusion with oxygenated perfluorocarbon C Mohan, M Gennaro, C Marini, E Ascer	The American Journal of Surgery	1992
Antibody against neutrophil adhesion improves reperfusion and limits alveolar infiltrate following unilateral pulmonary artery occlusion MJ Bishop, TF Kowalski, SM Guidotti, JM Harlan	Journal of Surgical Research	1992
Neutrophil-endothelial cell binding in neutrophil-mediated tissue injury JC de la Ossa, M Malago, BL Gewertz	Journal of Surgical Research	1992
Synthesis and evaluation of CE-0266: A new human neutrophil elastase inhibitor RT Cunningham, SE Mangold, LW Spruce, QL Ying, SR Simon, M Wieczorek, S Ross, JC Cheronis, GP Kirschenheuter	Bioorganic chemistry	1992
Synergism between leukotriene B4 and thromboxane A2 in mediating acid-aspiration injury ME Wiles, R Welbourn, G Goldman, HB Hechtman, D Shepro	Surgery	1992
The role of endothelial cell adhesion molecules in the development of atherosclerosis JW Berman, TM Calderon	Cardiovascular Pathology	1992
Biological Oxidants: Generation and Injurious Consequences AW Segal, JH Nugent	Biological Oxidants: Generation and Injurious Consequences	1992
Reperfusion injury in the ischemic myocardium R Virmani, FD Kolodgie, MB Forman, A Farb, RM Jones	Cardiovascular Pathology	1992
Role of leukocyte adhesion in clinical stroke WM Clark, BM Coull, L Corliss, N Bearner, T Austin, P Garmo, DP Briley	Journal of Stroke and Cerebrovascular Diseases	1992
Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation M Carry, V Korley, JT Willerson, L Weigelt, AW Ford-Hutchinson, P Tagari	Circulation	1992
Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion XL Ma, DJ Lefer, AM Lefer, R Rothlein	Circulation	1992
Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis SC Smith, PM Allen	Circulation research	1992
Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia FC Barone, DB Schmidt, LM Hillegass, WJ Price, RF White, GZ Feuerstein, RK Clark, EV Lee, DE Griswold, HM Sarau	Stroke; a journal of cerebral circulation	1992
Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke PM Kochanek, JM Hallenbeck	Stroke; a journal of cerebral circulation	1992
Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue DM Kerins, L Roy, S Kunitada, A Adedoyin, GA FitzGerald, DJ Fitzgerald	Circulation	1992
Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons E Mori, GJ del Zoppo, JD Chambers, BR Copeland, KE Arfors	Stroke; a journal of cerebral circulation	1992
Yearbook of Intensive Care and Emergency Medicine 1992 JL Vincent		1992
Endothelial Cell Dysfunctions N Simionescu, M Simionescu		1992
Mediators of Sepsis M Lamy, LG Thijs		1992
CAMs and anti-CAMs. The clinical potential of cell adhesion molecules E Keelan, D O Haskard	Journal of the Royal College of Physicians of London	1992
Microbial Adhesion and Invasion M Hook, L Switalski		1992
Mikrochirurgische Rekonstruktion nach Trauma C Braun, A Olinger		1992
Myocardial Response to Acute Injury JR Parratt		1992
Exogenous adenosine accelerates recovery of cardiac function and improves coronary flow after long-term hypothermic storage and transplantation M Galiñanes, DJ Hearse	The Journal of Thoracic and Cardiovascular Surgery	1992
Evidence for the role of neutrophils in reperfusion injury after cold cardioplegic ischemia in neonatal lambs H Kawata, K Sawatari, JE Mayer	The Journal of Thoracic and Cardiovascular Surgery	1992
Novel leukocyte agonists are released by endothelial cells exposed to peroxide KD Patel, GA Zimmerman, SM Prescott, TM McIntyre	The Journal of biological chemistry	1992
Leukotrienes as mediators in ischemia-reperfusion injury in a microcirculation model in the hamster HA Lehr, A Guhlmann, D Nolte, D Keppler, K Messmer	Journal of Clinical Investigation	1991
Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1 CW Smith, ML Entman, CL Lane, AL Beaudet, TI Ty, K Youker, HK Hawkins, DC Anderson	Journal of Clinical Investigation	1991
Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion XL Ma, PS Tsao, AM Lefer	Journal of Clinical Investigation	1991
Monoclonal Antibodies to Platelet Glycoprotein IIb/IIIa as Antithrombotic Agents BS Coller, LE Scudder, J Beer, HK Gold, JD Folts, J Cavagnaro, R Jordan, C Wagner, J Iuliucci, D Knight, J Ghrayeb, C Smith, HF Weisman, H Berger	Annals of the New York Academy of Sciences	1991
Pathophysiology of ischaemia reperfusion injury: Central role of the neutrophil CR Welbourn, G Goldman, IS Paterson, CR Valeri, D Shepro, HB Hechtman	British Journal of Surgery	1991
Low-dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: Effects on Mac-1 and MEL-14 adhesion protein expression and function MA Jutila, TK Kishimoto, M Finken	Cellular Immunology	1991
Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule WM Clark, KP Madden, R Rothlein, JA Zivin	Journal of Neurosurgery	1991
Cardioprotective and endothelial protective effects of [Ala-IL8]77 in a rabbit model of myocardial ischaemia and reperfusion AM Lefer, GJ 3rd, XL Ma, PS Tsao, GR Thomas	British Journal of Pharmacology	1991
Interleukin-2 induces early multisystem organ edema mediated by neutrophils R Welbourn, G Goldman, L Kobzik, I Paterson, D Shepro, HB Hechtman	Annals of Surgery	1991
Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification FC Barone, LM Hillegass, WJ Price, RF White, EV Lee, GZ Feuerstein, HM Sarau, RK Clark, DE Griswold	Journal of Neuroscience Research	1991
Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites PM Reilly, HJ Schiller, GB Bulkley	The American Journal of Surgery	1991
Mechanisms of neutrophil-mediated tissue injury BO Anderson, JM Brown, AH Harken	Journal of Surgical Research	1991
Leukocyte activation in ischemia-reperfusion injury of skeletal muscle RA Cambria, RJ Anderson, G Dikdan, EP Teehan, JJ Hernandez-Maldonado, RW Hobson	Journal of Surgical Research	1991
Monoclonal Antibodies to Platelet Glycoprotein IIb/IIIa as Antithrombotic Agentsa BS Coller, LE Scudder, J Beer, HK Gold, JD Folts, J Cavagnaro, R Jordan, C Wagner, J Iuliucci, D Knight, J Ghrayeb, C Smith, HF Weisman, H Berger	Annals of the New York Academy of Sciences	1991
Monoclonal antibodies in diagnosis and therapy T Waldmann	Science	1991
Receptors for Extracellular Matrix M Jalkanen, S Jalkanen, M Bernfield	Receptors for Extracellular Matrix	1991
Steroids and Biologic Agents in the Intensive Care Unit RP Allen, TE Albertson	Critical Care Clinics	1991
Thromboxane mediates diapedesis after ischemia by activation of neutrophil adhesion receptors interacting with basally expressed intercellular adhesion molecule-1 G Goldman, R Welbourn, JM Klausner, CR Valeri, D Shepro, HB Hechtman	Circulation research	1991
Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion WJ Dreyer, LH Michael, MS West, CW Smith, R Rothlein, RD Rossen, DC Anderson, ML Entman	Circulation	1991
Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion FM Sheridan, IM Dauber, IF McMurtry, EJ Lesnefsky, LD Horwitz	Circulation research	1991
Neutrophil-mediated vasoconstriction and endothelial dysfunction in low-flow perfusion-reperfused cat coronary artery XL Ma, PS Tsao, GE Viehman, AM Lefer	Circulation research	1991
Adenosine. The signal of life? RL Engler	Circulation	1991
Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment WM Clark, KP Madden, R Rothlein, JA Zivin	Stroke; a journal of cerebral circulation	1991
Hydrogen peroxide pretreatment of perfused canine vessels induces ICAM-1 and CD18-dependent neutrophil adherence AC Gasic, G McGuire, S Krater, AI Farhood, MA Goldstein, CW Smith, ML Entman, AA Taylor	Circulation	1991
Do neutrophils contribute to myocardial stunning? LC Becker	Cardiovascular Drugs and Therapy	1991
Free radical ablation for the prevention of post-ischemic renal failure following renal transplantation HJ Schiller, KA Andreoni, GB Bulkley	Klinische Wochenschrift	1991
Blood Cell Biochemistry Volume 3 JR Harris		1991
Cellular and Mechanical Effects of Myocardial Ischemia D Bose	Anesthesiology Clinics of North America	1991
Myocardial reperfusion injury W Ko, AS Hawes, WD Lazenby, SE Calvano, YT Shin, JA Zelano, AC Antonacci, OW Isom, KH Krieger	The Journal of Thoracic and Cardiovascular Surgery	1991
PMN adhesion and extravasation as a paradigm for tumor cell dissemination CW Smith, DC Anderson	Cancer and Metastasis Reviews	1991
Thromboxane-induced neutrophil adhesion to pulmonary microvascular and aortic endothelium is regulated by CD18. Wiles ME, Welbourn R, Goldman G, Hechtman HB, Shepro D	Inflammation	1991
Neutrophil adherence to isolated adult canine myocytes. Evidence for a CD18-dependent mechanism ML Entman, K Youker, SB Shappell, C Siegel, R Rothlein, WJ Dreyer, FC Schmalstieg, CW Smith	Journal of Clinical Investigation	1990
Endothelial, platelet and leukocyte interactions in ischemic heart disease: Insights into potential mechanisms and their clinical relevance JL Dinerman, JL Mehta	Journal of the American College of Cardiology	1990
Leukocyte Adhesion Molecules Deficiency: Its Structural Basis, Pathophysiology and Implications for Modulating the Inflammatory Response MA Arnaout	Immunological Reviews	1990
Oxygen-derived free radicals and postischemic myocardial reperfusion: therapeutic implications VJ Richard, CE Murry, RB Jennings, KA Reimer	Fundamental & Clinical Pharmacology	1990
Early Polymorphonuclear Leukocyte Accumulation Correlates with the Development of Posttraumatic Cerebral Edema in Rats RJ Schoettle, PM Kochanek, MJ Magargee, MW Uhl, EM Nemoto	Journal of Neurotrauma	1990
Inhibition of hypochlorous acid-mediated reactions by desferrioxamine. Implications for the mechanism of cellular injury by neutrophils MC Vissers, JC Fantone	Free radical biology & medicine	1990
Reduction in reperfusion injury by blood-free reperfusion after experimental myocardial infarction GL Schaer, SP Karas, EC Santoian, C Gold, MS Visner, R Virmani	Journal of the American College of Cardiology	1990
Structure and Function of Leukocyte Integrins RS Larson, TA Springer	Immunological Reviews	1990
Membrane Proteins Involved in Phagocyte Adherence to Endothelium TM Carlos, JM Harlan	Immunological Reviews	1990
Coronary endothelial dysfunction from ischemia and reperfusion: Effect of reactive oxygen metabolite scavengers LD Horwitz, KM VanBenthuysen, FM Sheridan, EJ Lesnefsky, IM Dauber, IF McMurtry	Free radical biology & medicine	1990
Leucocyte adhesion molecules K Forsyth	Journal of Paediatrics and Child Health	1990
Leukocyte-Cell Adhesion: A Molecular Process Fundamental in Leukocyte Physiology M Patarroyo, J Prieto, J Rincon, T Timonen, C Lundberg, L Lindbom, B Asjo, CG Gahmbekg	Immunological Reviews	1990
Leucocyte adhesion to endothelium A Wardlaw	Clinical & Experimental Allergy	1990
Prevention of neutrophil-mediated injury to endothelial cells by perfluorochemical DG Babbitt, MB Forman, R Jones, AK Bajaj, RL Hoover	The American Journal of Pathology	1990
Leukocyte adhesion proteins: their role in neutrophil function RK Root	Transactions of the American Clinical and Climatological Association	1990
Inhibition of leukocyte adherence by anti-CD18 monoclonal antibody attenuates reperfusion injury in the rabbit ear NB Vedder, RK Winn, CL Rice, EY Chi, KE Arfors, JM Harlan	Proceedings of the National Academy of Sciences	1990
Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions C Hession, L Osborn, D Goff, G Chi-Rosso, C Vassallo, M Pasek, C Pittack, R Tizard, S Goelz, K McCarthy	Proceedings of the National Academy of Sciences	1990
Ischemia activates neutrophils but inhibits their local and remote diapedesis G Goldman, R Welbourn, JM Klausner, IS Paterson, L Kobzik, CR Valeri, D Shepro, HB Hechtman	Annals of Surgery	1990
Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction BL Zaret, FJ Wackers	Annals of the New York Academy of Sciences	1990
Induction of endogenous tissue antioxidant enzyme activity attenuates myocardial reperfusion injury DD Bensard, JM Brown, BO Anderson, A Banerjee, PF Shanley, MA Grosso, GJ Whitman, AH Harken	Journal of Surgical Research	1990
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Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

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