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Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.
W B Graninger, … , P Goldman, S J Korsmeyer
W B Graninger, … , P Goldman, S J Korsmeyer
Published November 1, 1987
Citation Information: J Clin Invest. 1987;80(5):1512-1515. https://doi.org/10.1172/JCI113235.
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Research Article

Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.

Abstract

We examined the expression of the Bcl-2 gene at chromosome segment 18q21, that is translocated into the Ig heavy chain gene locus in t(14;18) bearing lymphomas. Bcl-2, while B cell associated, is expressed in a variety of hematopoietic lineages including T cells. Bcl-2 mRNA levels are high during pre-B cell development, the time at which the t(14;18) translocation occurs, but are down regulated with maturation. Like certain other oncogenes, Bcl-2 is quiescent in resting B cells but up-regulated with B cell activation. Mature B cell lymphomas with a t(14;18) have log-folds more mRNA than matched counterparts without the translocation. A sensitive S1 protection assay revealed that all transcripts in t(14;18) B cells were Bcl-2-Ig fusion mRNAs and originated from the translocated allele. Thus, there is a marked deregulation of Bcl-2 when it is introduced into the Ig locus in t(14;18) lymphomas.

Authors

W B Graninger, M Seto, B Boutain, P Goldman, S J Korsmeyer

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