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Research Article Free access | 10.1172/JCI113027

Effects of norepinephrine infusion on myocardial high-energy phosphate content and turnover in the living rat.

J A Bittl, J A Balschi, and J S Ingwall

Find articles by Bittl, J. in: JCI | PubMed | Google Scholar

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Published June 1, 1987 - More info

Published in Volume 79, Issue 6 on June 1, 1987
J Clin Invest. 1987;79(6):1852–1859. https://doi.org/10.1172/JCI113027.
© 1987 The American Society for Clinical Investigation
Published June 1, 1987 - Version history
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Abstract

Using 31P-nuclear magnetic resonance, we studied the relationship between myocardial high-energy phosphate content and flux values for the creatine kinase reaction in the living rat under inotropic states achieved during norepinephrine infusion and halothane anesthesia. Under 2% halothane anesthesia (n = 4), 1% halothane anesthesia (n = 5) and norepinephrine infusion (n = 4), rats developed rate-pressure products of 19.5 +/- 1.6, 32.0 +/- 3.5, and 48.5 +/- 2.0 X 1,000 mmHg/min, respectively. Adenosine triphosphate content was not affected by inotropic state, ranging from 24.3 +/- 1.1 to 25.6 +/- 1.1 mumol/g dry weight, but creatine phosphate content varied inversely and reversibly with cardiac performance from 45.6 +/- 6.0 under 2% halothane to 26.0 +/- 6.5 mumol/g dry weight during norepinephrine infusion. The flux values for the creatine kinase reaction were 15.4 +/- 4.6, 20.5 +/- 2.0, and 30.1 +/- 7.9 mumol/g dry weight per s under 2% halothane, 1% halothane, and 1% halothane with norepinephrine, respectively. These results suggest that the turnover of myocardial high-energy phosphate compounds, not their tissue contents, matches cardiac performance during inotropic stimulation.

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