Shared idiotypes and restricted immunoglobulin variable region heavy chain genes characterize murine autoantibodies of various specificities.

M Monestier; A Manheimer-Lory; B Bellon; C Painter; H Dang; N Talal; M Zanetti; R Schwartz; D Pisetsky; R Kuppers

doi:10.1172/JCI112637

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Published in Volume 78, Issue 3 on September 1, 1986
J Clin Invest. 1986;78(3):753–759. https://doi.org/10.1172/JCI112637.
© 1986 The American Society for Clinical Investigation

Published September 1, 1986 - Version history

The study of the Ig variable region heavy chain (VH) genes used to encode antibodies specific for self-epitopes from murine hybridomas showed that three VH families are primarily utilized: VH J558, the largest family, and VH QPC52 and VH 7183, the families most proximal to the Ig joining region heavy chain genes. These monoclonal autoantibodies express cross-reactive idiotopes shared by rheumatoid factors and antibodies specific for Sm. The expression of these idiotypes is independent of major histocompatibility complex and Ig constant region heavy chain haplotypes, self-antigen specificity, and even the VH gene family utilized. Though the experiments described here are limited to murine autoantibodies, similarities exist between murine and human autoimmune diseases. Studies that aim to investigate the relationship between VH gene expression and the presence of cross-reactive idiotypes among human autoantibodies should enable us to better understand the mechanisms of autoimmunity and self-tolerance.

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Shared idiotypes and restricted immunoglobulin variable region heavy chain genes characterize murine autoantibodies of various specificities.

M Monestier, A Manheimer-Lory, B Bellon, C Painter, H Dang, N Talal, M Zanetti, R Schwartz, D Pisetsky, and R Kuppers

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Shared idiotypes and restricted immunoglobulin variable region heavy chain genes characterize murine autoantibodies of various specificities.

M Monestier, A Manheimer-Lory, B Bellon, C Painter, H Dang, N Talal, M Zanetti, R Schwartz, D Pisetsky, and R Kuppers

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