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Research Article Free access | 10.1172/JCI112605

Combined influences of Gm and HLA phenotypes upon multiple sclerosis susceptibility and severity.

J P Salier, R Sesboüé, C Martin-Mondière, M Daveau, P Cesaro, B Cavelier, A Coquerel, L Legrand, J M Goust, and J D Degos

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Published August 1, 1986 - More info

Published in Volume 78, Issue 2 on August 1, 1986
J Clin Invest. 1986;78(2):533–538. https://doi.org/10.1172/JCI112605.
© 1986 The American Society for Clinical Investigation
Published August 1, 1986 - Version history
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Abstract

In some Caucasian populations, multiple sclerosis (MS) susceptibility has been independently related to given alleles of HLA or Gm systems that respectively code for major histocompatibility complex class I and II antigens or immunoglobulin G heavy chains. Whether given combinations of alleles at both series of loci simultaneously influence MS susceptibility and/or severity was investigated by comparing 147 French MS patients and 226 geographically-matched healthy controls. The G2m(-23)/HLA-B35 phenotype and G1m(-1)/HLA-B7(-)/HLA-DR2 phenotype were respectively associated with significant protection against (relative risk = 0.05) and susceptibility to (relative risk = 4.3) MS. When considering MS severity, the presence of HLA-B7 antigen correlated with a more severe disease in Gm1/Gm3 heterozygous patients, but not in Gm3/Gm3 homozygous patients. Conversely, an HLA-B12-associated milder disease was restricted to Gm3/Gm3 homozygotes. These results demonstrate the combined influence on MS of genetic loci that are unlinked but immune response-associated. Combined Gm and HLA typing is very likely able to serve as a prognostic indicator in this disease.

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