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Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.

S S Kang, … , M Norusis, J V Messer

S S Kang, … , M Norusis, J V Messer

Published May 1, 1986
Citation Information: J Clin Invest. 1986;77(5):1482-1486. https://doi.org/10.1172/JCI112461.

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Title and authors	Publication	Year
Association between elevated homocysteine levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis He J, Zhou H, Xiong J, Huang Y, Huang N, Jiang J	Frontiers in Endocrinology	2024
Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress N Sumien, JT Cunningham, DL Davis, R Engelland, O Fadeyibi, GE Farmer, S Mabry, P Mensah-Kane, OT Trinh, PH Vann, EN Wilson, RL Cunningham	Endocrinology	2021
Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients J Levy, RM Rodriguez-Guéant, A Oussalah, E Jeannesson, D Wahl, S Ziuly, JL Guéant	The American journal of clinical nutrition	2021
The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment HJ Kim, IW Sohn, YS Kim, JB Jun	Nutrients	2020
Hydrolysis of homocysteine thiolactone results in the formation of Protein‐Cys‐S‐S‐homocysteinylation Y Silla, S Varshney, A Ray, T Basak, A Zinellu, V Sabareesh, C Carru, S Sengupta	Proteins: Structure, Function, and Genetics	2019
Sex-related differences in oxidative stress and neurodegeneration MA Tenkorang, B Snyder, RL Cunningham	Steroids	2018
Elevated Plasma Homocysteine Concentration in Opium-Addicted Individuals Mohammad Masoomi, Nahid Azdaki, Beydolah Shahouzehi	Addiction & Health	2015
Preventive Nutrition: The Comprehensive Guide for Health Professionals A Bendich, RJ Deckelbaum		2015
Seldin and Giebisch's The Kidney CJ Cooper, LD Dworkin, WL Henrich	Seldin and Giebisch's The Kidney	2013
Hyperhomocystéinémie : un vrai facteur de risque cardiovasculaire ? D Sène, P Cacoub	EMC - Cardiologie	2013
NO ASSOCIATION BETWEEN MTHFR C677T AND SERUM URIC ACID LEVELS AMONG JAPANESE WITH ABCG2 126QQ AND SLC22A12 258WW YUKAKO HINOHARA, MARIKO NAITO, RIEKO OKADA, GUAN YIN, TAKAHIRO HIGASHIBATA, TAKASHI TAMURA, SAYO KAWAI, EMI MORITA, KENJI WAKAI, HIROTAKA MATSUO, ATSUYOSHI MORI, NOBUYUKI HAMAJIMA	Nagoya Journal of Medical Science	2013
Meta-Analysis of the Association of the C677T Polymorphism of the Methylenetetrahydrofolate Reductase Gene with Hyperuricemia W Wei, S Liu, F Zeng, L Ma, K Li, B Wang	Annals of Nutrition and Metabolism	2012
The Effects of Muscle Mass on Homocyst(e)ine Levels in Plasma and Urine M. RENÉ MALINOW, CRAIG L. LISTER, CARL DE CRÉE	International journal of exercise science	2012
Nutritional Health NJ Temple, T Wilson, DR Jacobs		2012
The Effects of Muscle Mass on Homocyst(e)ine Levels in Plasma and Urine. Malinow MR, Lister CL, DE Crée C	International journal of exercise science	2012
Changes in Homocysteine and 8-iso-PGF 2a Levels in Football and Hockey Players After a Match A Papapanagiotou, I Gissis, C Papadopoulos, A Souglis, GC Bogdanis, I Giosos, A Sotiropoulos	RES SPORTS MED	2011
Association of the C677T MTHFR Polymorphism With Homocysteine, Ox-LDL Levels, and Thiolactonase Activities in the Severity of Coronary Syndrome N Koubaa, A Nakbi, S Hammami, S Mehri, N Attia, MB Farhat, M Hammami	Clinical and Applied Thrombosis/Hemostasis	2010
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Kinetics of albumin homocysteinylation measured with matrix-assisted laser/desorption ionization mass spectrometry versus with a radioactive tracer E Callegher, R Seraglia, M Vettore, L Puricelli, R Millioni, P Tessari	Rapid Communications in Mass Spectrometry	2009
Association of homocysteine thiolactonase activity and PON1 polymorphisms with the severity of acute coronary syndrome N Koubaa, A Nakbi, S Hammami, N Attia, S Mehri, KB Hamda, MB Farhat, A Miled, M Hammami	Clinical Biochemistry	2009
Novel markers of peripheral arterial disease FJ Khawaja, IJ Kullo	Vascular medicine (London, England)	2009
Preventive Nutrition A Bendich, RJ Deckelbaum		2009
Fundamental and Clinical Cardiology Series PD Stein	Cardiovascular Disease in the Elderly	2008
Relationship of asymmetric dimethylarginine with flow-mediated dilatation in subjects with newly detected severe hypercholesterolemia L Vladimirova-Kitova, T Deneva, E Angelova, F Nikolov, B Marinov, N Mateva	Clinical Physiology and Functional Imaging	2008
Molecular Targeting of Proteins by L-Homocysteine: Mechanistic Implications for Vascular Disease AV Glushchenko, DW Jacobsen	Antioxidants & Redox Signaling	2007
Are heterocygotes for classical homocystinuria at risk of vitamin B12 and folic acid deficiency? MF Elsaid, A Bener, M Lindner, M Alzyoud, N Shahbek, MO Abdelrahman, G Abdoh, MS Bessisso, J Zschocke, GF Hoffmann	Molecular Genetics and Metabolism	2007
Hyperhomocysteinaemia is Associated with the Rate of Abdominal Aortic Aneurysm Expansion KJ Halazun, KA Bofkin, S Asthana, C Evans, M Henderson, JI Spark	European Journal of Vascular and Endovascular Surgery	2007
The association of homocysteine and related factors to brachial artery diameter and flow-mediated dilation JB Wilson, M Welsch, J Allen, J Thomson, R Tulley, M Lefevre	Metabolism	2007
High Prevalence of Hyperhomocysteinemia in Chinese Adults Is Associated with Low Folate, Vitamin B-12, and Vitamin B-6 Status L Hao, J Ma, J Zhu, MJ Stampfer, Y Tian, WC Willett, Z Li	The Journal of nutrition	2007
Relationship between Metabolic Syndrome Categorized by Newly Recommended by International Diabetes Federation Criteria with Plasma Homocysteine Concentration EJ RHEE, ST HWANG, WY LEE, JH YOON, BJ KIM, BS KIM, JH KANG, MH LEE, JR PARK, KC SUNG	Endocrine Journal	2007
Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: An overview R Castro, I Rivera, HJ Blom, C Jakobs, IT de Almeida	Journal of Inherited Metabolic Disease	2006
Relationship between plasma S-adenosylhomocysteine concentration and glomerular filtration rate in children K Jabs, MJ Koury, WD Dupont, C Wagner	Metabolism	2006
Homocysteine, Folate, and Vitamins B6 and B12 Blood Levels in Relation to Cognitive Performance: The Maine-Syracuse Study: MF Elias, MA Robbins, MM Budge, PK Elias, SL Brennan, C Johnston, Z Nagy, CJ Bates	Psychosomatic medicine	2006
Plasma homocysteine levels and the left ventricular systolic function in coronary artery disease patients SW Bokhari, ZW Bokhari, JA Zell, DW Lee, DP Faxon	Coronary Artery Disease	2005
Molecular targeting by homocysteine: a mechanism for vascular pathogenesis DW Jacobsen, O Catanescu, PM DiBello, JC Barbato	Clinical Chemistry and Laboratory Medicine	2005
Workgroup report: Biomonitoring study design, interpretation, and communication--lessons learned and path forward MN Bates, JW Hamilton, JS LaKind, P Langenberg, M O'Malley, W Snodgrass	Environmental Health Perspectives	2005
The effect of estradiol valerate and dienogest combination on serum homocysteine levels in postmenopausal women: A clinical trial ZP Meltem, E Aygun, R Dansuk, I Kucukercan, O Unal, C Turan	Gynecological Endocrinology	2005
Conditional Risk Factors for Atherosclerosis IJ Kullo, CM Ballantyne	Mayo Clinic Proceedings	2005
Atherosclerosis: Diet and Drugs A von Eckardstein		2005
The C677 mutation in methylene tetrahydrofolate reductase gene: correlation with uric acid and cardiovascular risk factors in elderly Korean men YS Hong, MJ Lee, KH Kim, SH Lee, YH Lee, BG Kim, B Jeong, HR Yoon, H Nishio, JY Kim	Journal of Korean Medical Science	2004
Association between plasma homocysteine levels and coronary artery disease: a population-based study in northern Greece AI Boufidou, AD Makedou, DN Adamidis, HI Karvounis, JT Gourassas, HT Kesidis, KG Makedou, CE Papadopoulos, GE Parharidis, GE Louridas	Current Medical Research and Opinion	2004
Homocysteine and Lipoprotein Levels Following Resistance Training in Older Adults KR Vincent, RW Braith, T Bottiglieri, HK Vincent, DT Lowenthal	Preventive Cardiology	2003
Relevance of different apolipoprotein content in binding of homocysteine to plasma lipoproteins P Ventura, R Panini, MC Rosa, E Gaetti, G Salvioli	Nutrition, Metabolism and Cardiovascular Diseases	2003
Effects of estrogen and psychological stress on plasma homocysteine levels NH Farag, BA Barshop, PJ Mills	Fertility and Sterility	2003
Homocysteine and risk of coronary artery disease BJ Lee, PT Lin, YP Liaw, SJ Chang, CH Cheng, YC Huang	Nutrition	2003
Plasma homocysteine in subjects with familial combined hyperlipidemia MJ Veerkamp, J Graaf, M Heijer, HJ Blom, AF Stalenhoef	Atherosclerosis	2003
Plasma Homocysteine Levels in Indian Patients with Essential Hypertension and Their Siblings S Jain, H Ram, S Kumari, M Khullar	Renal Failure	2003
Homocysteine and hemostatic disorder as a risk factor for myocardial infarction at a young age M Ogawa, S Abe, M Saigo, S Biro, H Toda, T Matsuoka, H Torii, S Minagoe, I Maruyama, C Tei	Thrombosis Research	2003
Elevated plasma homocysteine as risk factor for peripheral arterial disease—what is the evidence? LM Taylor	Seminars in Vascular Surgery	2003
L’hyperhomocystéinémie : facteur de risque cardiovasculaire ou simple marqueur ? JC Guilland, A Favier, GP de Courcy, P Galan, S Hercberg	Pathologie Biologie	2003
Homocysteine Levels and C677T Polymorphism of Methylenetetrahydrofolate Reductase in Women with Polycystic Ovary Syndrome F Orio, S Palomba, SD Biase, A Colao, L Tauchmanova, S Savastano, D Labella, T Russo, F Zullo, G Lombardi	The Journal of clinical endocrinology and metabolism	2003
Homocysteine and the stage of atherosclerotic disease: a study in patients suffering from clinically silent and clinically manifest atherosclerotic disease G Pasterkamp, A Algra, DE Grobbee, PP de Jaegere, JD Banga, Y der Graaf	European Journal of Clinical Investigation	2002
Detection of homocysteine by conventional and microchip capillary electrophoresis/electrochemistry SA Pasas, NA Lacher, MI Davies, SM Lunte	Electrophoresis	2002
Homocysteine and arterial disease JW Cook, LM Taylor, SL Orloff, GJ Landry, GL Moneta, JM Porter	Vascular Pharmacology	2002
Hyperhomocysteinemia and venous thrombosis P Lee, K Prasad	The International Journal of Lower Extremity Wounds	2002
Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies ES Ford, SJ Smith, DF Stroup, KK Steinberg, PW Mueller, SB Thacker	International Journal of Epidemiology	2002
Plasma Homocysteine Levels in Taiwanese Vegetarians Are Higher than Those of Omnivores CJ Hung, PC Huang, SC Lu, YH Li, HB Huang, BF Lin, SJ Chang, HF Chou	The Journal of nutrition	2002
Association of Plasma Homocysteine Concentration With Atherosclerotic Carotid Plaques and Lacunar Infarction T Sasaki, M Watanabe, Y Nagai, T Hoshi, M Takasawa, M Nukata, A Taguchi, K Kitagawa, N Kinoshita, M Matsumoto	Stroke; a journal of cerebral circulation	2002
Trace Elements in Man and Animals 10 AM Roussel, RA Anderson, AE Favrier		2002
Protein-bound Homocystamide Measured in Human Plasma by HPLC Y Uji, Y Motomiya, N Hanyu, F Ukaji, H Okabe	Clinical chemistry	2002
Folate, homocysteine, endothelial function and cardiovascular disease. What is the link? PA Ashfield-Watt, SJ Moat, SN Doshi, IF McDowell	Biomedicine & Pharmacotherapy	2001
Hiperhomocisteinemia. Diagnóstico y tratamiento XP Sala	Clínica e Investigación en Arteriosclerosis	2001
The methylenetetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other populations SH Jee, TH Beaty, I Suh, Y Yoon, LJ Appel	Atherosclerosis	2000
Evaluating the Need and Potential Benefits of Testing for Plasma Homocyst(e)ine, an Independent Risk Factor for Atherosclerotic Disease A Irvin-Jones, PB Duell, MR Malinow	Preventive Cardiology	2000
Nutritional aspects and possible pathological mechanisms of hyperhomocysteinaemia: an independent risk factor for vascular disease MC McKinley	Proceedings of the Nutrition Society	2000
Plasma total homocysteine levels in subjects with hyperinsulinemia H Bar-On, M Kidron, Y Friedlander, A Ben-Yehuda, J Selhub, IH Rosenberg, G Friedman	Journal of Internal Medicine	2000
Homocysteine, vitamins, and coronary artery disease. Comprehensive review of the literature BV Taylor, GY Oudit, M Evans	Canadian family physician Médecin de famille canadien	2000
Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care GL Booth, EE Wang	CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne	2000
Increased plasma homocysteine after menopause AE Hak, KH Polderman, IC Westendorp, C Jakobs, A Hofman, JC Witteman, CD Stehouwer	Atherosclerosis	2000
Mechanisms for the Formation of Protein-Bound Homocysteine in Human Plasma T Togawa, S Sengupta, H Chen, K Robinson, I Nonevski, AK Majors, DW Jacobsen	Biochemical and Biophysical Research Communications	2000
Novel Risk Factors for Atherosclerosis IJ Kullo, GT Gau, AJ Tajik	Mayo Clinic Proceedings	2000
The Effect of Estrogen Replacement Therapy on Total Plasma Homocysteine in Healthy Postmenopausal Women PB Berger, RR Herrmann, DA Dumesic	Mayo Clinic Proceedings	2000
Homocysteine, a risk factor for coronary artery disease or not? a meta-analysis TJ Cleophas, N Hornstra, B Hoogstraten, J der Meulen	The American Journal of Cardiology	2000
Women and Health R Ramsey-Goldman, S Manzi	Women and Health	2000
Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia J Duan, T Murohara, H Ikeda, K Sasaki, S Shintani, T Akita, T Shimada, T Imaizumi	Arteriosclerosis, thrombosis, and vascular biology	2000
Hyperhomocysteinemia and pregnancy — review of our present understanding and therapeutic implications Y Aubard, N Darodes, M Cantaloube	European Journal of Obstetrics & Gynecology and Reproductive Biology	2000
Plasma Homocysteine and Severity of Thoracic Aortic Atherosclerosis CM Tribouilloy, M Peltier, MC Peltier, F Trojette, M Andrejak, JP Lesbre	Chest	2000
Vitamin B-12 Deficiency and Hyperhomocysteinemia Are Partly Ameliorated by Cobalt and Nickel Supplementation in Pigs GI Stangl, DA Roth-Maier, M Kirchgessner	The Journal of nutrition	2000
Textbook of Angiology JB Chang		2000
Homocysteine and Vascular Disease K Robinson		2000
Total homocysteine and cardiovascular disease O Nygard, SE Vollset, H Refsum, L Brattstrom, PM Ueland	Journal of Internal Medicine	1999
Homocysteine, a risk factor for cardiovascular disease K Prasad	International Journal of Angiology	1999
Hyperhomocysteinaemia DJ Perry	Best Practice & Research Clinical Haematology	1999
Whole blood folate, homocysteine in serum, and risk of first acute myocardial infarction B Christensen, S Landaas, I Stensvold, S Djurovic, L Retterstøl, J Ringstad, K Berg, DS Thelle	Atherosclerosis	1999
Plasma Homocysteine in Women Taking Hormone Replacement Therapy: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial VM Barnabei, TM Phillips, J Hsia	Journal of Women's Health & Gender-Based Medicine	1999
Moderate Hyperhomocyst(e)inemia Is Associated with the Presence of Coronary Artery Disease and the Severity of Coronary Atherosclerosis in Koreans JH Yoo, JE Park, KP Hong, SH Lee, DK Kim, WR Lee, SC Park	Thrombosis Research	1999
The C677T Methylenetetrahydrofolate Reductase Polymorphism Influences the Homocysteine-Lowering Effect of Hormone Replacement Therapy CA Brown, KQ McKinney, KB Young, HJ Norton	Molecular Genetics and Metabolism	1999
N -ACETYL-CYSTEINE REDUCES HOMOCYSTEINE PLASMA LEVELS AFTER SINGLE INTRAVENOUS ADMINISTRATION BY INCREASING THIOLS URINARY EXCRETION P Ventura, R Panini, MC Pasini, G Scarpetta, G Salvioli	Pharmacological Research	1999
Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age L Todesco, C Angst, P Litynski, F Loehrer, B Fowler, W E Haefeli	European Journal of Clinical Investigation	1999
Nutritional Biochemistry T Brody	The Journal of Nutritional Biochemistry	1999
Association between Hyperhomocysteinaemia and Hypertension in Sri Lankans S Mendis, SB Athauda, M Naser, K Takahashi	J INT MED RES	1999
Maternal folate status during extended lactation and the effect of supplemental folic acid AD Mackey, MF Picciano	The American journal of clinical nutrition	1999
Influence of systemic factors on pre-existing intimal hyperplasia and their effect on the outcome of infrainguinal arterial reconstruction with vein: Infrainguinal arterial reconstruction with vein DK Beattie, M Sian, RM Greenhalgh, AH Davies	The British journal of surgery	1999
Plasma Homocysteine Distribution and Its Association With Parental History of Coronary Artery Disease in Black and White Children: The Bogalusa Heart Study KJ Greenlund, SR Srinivasan, JH Xu, E Dalferes, L Myers, A Pickoff, GS Berenson	Circulation	1999
Plasma homocysteine levels in indigenous Australians JT Shaw, JB Kesting, DP Cameron, B McWhinney, JR Tate, PE Hickman, H Gibbs, M Marczak, D Purdie	The Medical Journal of Australia	1999
C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations V Gudnason, D Stansbie, J Scott, A Bowron, V Nicaud, S Humphries	Atherosclerosis	1998
HOMOCYSTEINE AND CARDIOVASCULAR DISEASE HR MD, PM MD, ON MD, SE Dr.PH	Annual Review of Medicine	1998
Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease C Motti, A Gnasso, S Bernardini, R Massoud, A Pastore, P Rampa, G Federici, C Cortese	Atherosclerosis	1998
Plasma total homocysteine levels in patients with early-onset coronary heart disease and a low cardiovascular risk profile MG Donner, GK Klein, PB Mathes, P Schwandt, WO Richter	Metabolism	1998
Age and cystathionine beta-synthase activity in cultured fibroblasts from patients with arterial and venous vascular disease M Nordström, T Kjellström	Atherosclerosis	1998
Relation of Plasma Homocyst(e)ine to Cerebral Infarction and Cerebral Atherosclerosis JH Yoo, CS Chung, SS Kang	Stroke; a journal of cerebral circulation	1998
Methylenetetrahydrofolate Reductase Mutation and Coronary Artery Disease NJ Samani	Circulation	1998
Homocysteine and vitamins in cardiovascular disease DW Jacobsen	Clinical chemistry	1998
Homocysteinemia as a Risk Factor for Atherosclerosis: A Review MR MD, LM MD, JM MD	Cardiovascular Pathology	1997
Hyperhomocyst(e)inemia and Atherothrombosis GN Welch, G Upchurch, J Loscalzo	Annals of the New York Academy of Sciences	1997
Stimulation of endothelial nitric oxide production by homocyst(e)ine G Upchurch	Atherosclerosis	1997
Effects of homocysteine on acetylcholine- and adenosine-induced vasodilatation of pancreatic vascular bed in rats I Quéré, D Hillaire-Buys, C Brunschwig, J Chapal, C Janbon, JP Blayac, P Petit, MM Loubatières-Mariani	British Journal of Pharmacology	1997
Vitamin intake: A possible determinant of plasma homocyst(e)ine among middle-aged adults T Shimakawa, FJ Nieto, MR Malinow, LE Chambless, PJ Schreiner, M Szklo	Annals of Epidemiology	1997
The effects of homocysteine and copper ions on the concentration and redox status of thiols in cell line cultures B Hultberg, A Andersson, A Isaksson	Clinica Chimica Acta	1997
Fasting Total Plasma Homocysteine and Atherosclerotic Peripheral Vascular Disease SW Cheng, AC Ting, J Wong	Annals of Vascular Surgery	1997
Homocyst(e)ine Decreases Bioavailable Nitric Oxide by a Mechanism Involving Glutathione Peroxidase GR Upchurch, GN Welch, AJ Fabian, JE Freedman, JL Johnson, JF Keaney, J Loscalzo	The Journal of biological chemistry	1997
Plasma Total Homocysteine, B Vitamins, and Risk of Coronary Atherosclerosis P Verhoef, FJ Kok, DA Kruyssen, EG Schouten, JC Witteman, DE Grobbee, PM Ueland, H Refsum	Arteriosclerosis, thrombosis, and vascular biology	1997
Thermolabile Methylenetetrahydrofolate Reductase in Coronary Artery Disease LA Kluijtmans, JJ Kastelein, J Lindemans, GH Boers, SG Heil, AV Bruschke, JW Jukema, LP van den Heuvel, FJ Trijbels, GJ Boerma, FW Verheugt, F Willems, HJ Blom	Circulation	1997
Homocysteine Metabolism: From Basic Science to Clinical Medicine I Graham, H Refsum, IH Rosenberg, PM Ueland, JM Shuman		1997
Homocysteine and Thrombotic Disease A D'Angelo, J Selhub	Blood	1997
Total Homocysteine in Pediatric Patients MA Vilaseca, D Moyano, I Ferrer, R Artuch	Clinical chemistry	1997
Plasma homocyst(e)ine levels and graded risk for myocardial infarction: findings in two populations at contrasting risk for coronary heart disease MR Malinow, P Ducimetiere, G Luc, AE Evans, D Arveiler, F Cambien, BM Upson	Atherosclerosis	1996
Biological Chemistry of Thiols in the Vasculature and in Vascular-related Disease JS Stamler, A Slivka	Nutrition Reviews	1996
Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine D Matthias, CH Becker, R Riezler, PM Kindling	Atherosclerosis	1996
Homocysteine and coronary atherosclerosis EL Mayer, DW Jacobsen, K Robinson	Journal of the American College of Cardiology	1996
Hyperhomocysteinaemia—a common finding in a psychogeriatric population K Nilsson, L Gustafson, R Fäldt, A Andersson, L Brattström, A Lindgren, B Israelsson, B Hultberg	European Journal of Clinical Investigation	1996
Coronary risk factors measured in childhood and young adult life are associated with coronary artery calcification in young adults: The muscatine study LT Mahoney, TL Burns, W Stanford, BH Thompson, JD Witt, CA Rost, RM Lauer	Journal of the American College of Cardiology	1996
Folic acid, pyridoxine, cobalamin, and homocysteine and their relationship to cardiovascular disease in end-stage renal disease R Makoff, J Dwyer, MV Rocco	Journal of Renal Nutrition	1996
Hyperhomocysteinemia: A risk factor for cardiovascular disease … Influence of sex hormones on homocysteine metabolism HJ Blom, MJ van der Moorent	Gynecological Endocrinology	1996
The Vascular Biology of S -Nitrosothiols, Nitrosated Derivatives of Thiols GR Upchurch, GN Welch, J Loscalzo	Vascular medicine (London, England)	1996
Low Whole-Blood S -Adenosylmethionine and Correlation Between 5-Methyltetrahydrofolate and Homocysteine in Coronary Artery Disease FM Loehrer, CP Angst, WE Haefeli, PP Jordan, R Ritz, B Fowler	Arteriosclerosis, thrombosis, and vascular biology	1996
Homocysteine and Risk of Premature Coronary Heart Disease: Evidence for a Common Gene Mutation PM Gallagher, R Meleady, DC Shields, KS Tan, D McMaster, R Rozen, A Evans, IM Graham, AS Whitehead	Circulation	1996
Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease JJ Sung, JE Sanderson	Heart (British Cardiac Society)	1996
Homocysteine and vascular disease CS Berwanger, JY Jeremy, G Stansby	British Journal of Surgery	1995
Measurement of Homocyst(e)ine in the Prediction of Arteriosclerosis L Fortin	Clinical Biochemistry	1995
Plasma homocysteine and menopausal status MG Wouters, MT MOORREES, MJ van der Mooren, HJ Blom, GH Boers, LA Schellekens, CM Thomas, TK Eskes	European Journal of Clinical Investigation	1995
Role of blood pressure, uric acid, and hemorheological parameters on plasma homocyst(e)ine concentration MR Malinow, J Levenson, P Giral, FJ Nieto, M Razavian, P Segond, A Simon	Atherosclerosis	1995
Metabolism of homocysteine, its relation to the other cellular thiols and its mechanism of cell damage in a cell culture line (human histiocytic cell line U-937) B Hultberg, A Andersson, A Isaksson	Biochimica et Biophysica Acta	1995
Multiple Risk Factors in Cardiovascular Disease AM Gotto, C Lenfant, AL Catapano, R Paoletti		1995
Hyperhomocysteinemia and Low Pyridoxal Phosphate: Common and Independent Reversible Risk Factors for Coronary Artery Disease K Robinson, EL Mayer, DP Miller, R Green, F van Lente, A Gupta, K Kottke-Marchant, SR Savon, J Selhub, SE Nissen, M Kutner, EJ Topol, DW Jacobsen	Circulation	1995
Higher Plasma Homocyst(e)ine and Increased Susceptibility to Adverse Effects of Low Folate in Early Familial Coronary Artery Disease PN Hopkins, LL Wu, J Wu, SC Hunt, BC James, GM Vincent, RR Williams	Arteriosclerosis, thrombosis, and vascular biology	1995
Homocyst(e)ine and arterial occlusive diseases MR Malinow	Journal of Internal Medicine	1994
Combined vitamin B6 plus folic acid therapy in young patients with arteriosclerosis and hyperhomocysteinemia M Berg, DG Franken, GH Boers, HJ Blom, C Jakobs, CD Stehouwer, JA Rauwerda	Journal of Vascular Surgery	1994
Hormone replacement therapy may reduce high serum homocysteine in postmenopausal women MJ van der Mooren, MG Wouters, HJ Blom, LA Schellekens, TK Eskes, R Rolland	European Journal of Clinical Investigation	1994
Plasma homocysteine and thiol compound fractions after oral administration of N-acetylcysteine B Hultberg, A Andersson, P Masson, M Larson, A Tunek	Scandinavian Journal of Clinical & Laboratory Investigation	1994
Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study G Alfthan, J Pekkanen, M Jauhiainen, J Pitkäniemi, M Karvonen, J Tuomilehto, JT Salonen, C Ehnholm	Atherosclerosis	1994
Importance of elevated plasma homocysteine levels as a risk factor for atherosclerosis PA Masser, LM Taylor, JM Porter	The Annals of Thoracic Surgery	1994
Treatment of mild hyperhomocysteinemia in vascular disease patients DG Franken, GH Boers, HJ Blom, FJ Trijbels, PW Kloppenborg	Arteriosclerosis Thrombosis and Vascular Biology	1994
Genetic factors in coronary heart disease U Goldbourt, U de Faire, K Berg		1994
Vascular Diagnostics P Lanzer, J Rösch		1994
Diet and Health: What Should We Eat? WC Willett	Science	1994
Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen JS Stamler, JA Osborne, O Jaraki, LE Rabbani, M Mullins, D Singel, J Loscalzo	Journal of Clinical Investigation	1993
Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment A Araki, Y Sako, H Ito	Atherosclerosis	1993
Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents DS Celermajer, K Sorensen, M Ryalls, J Robinson, O Thomas, JV Leonard, JE Deanfield	Journal of the American College of Cardiology	1993
Elevated Plasma Homocysteine in Alcoholics B Hultberg, M Berglund, A Andersson, A Frank	Alcoholism, clinical and experimental research	1993
Homocysteinemia: Association of a metabolic disorder with vascular disease and thrombosis MM Rees, GM Rodgers	Thrombosis Research	1993
Elevated total plasma homocysteine, a risk factor for thrombosis. Relation to coagulation and fibrinolytic parameters T Bienvenu, A Ankri, B Chadefaux, G Montalescot, P Kamoun	Thrombosis Research	1993
Current understanding of the mechanisms of atherogenesis BA Kottke	The American Journal of Cardiology	1993
Homocysteine in frozen plasma samples. A short cut to establish hyperhomocysteinaemia as a risk factor for arteriosclerosis? B Israelsson, L Brattström, H Refsum	Scandinavian Journal of Clinical & Laboratory Investigation	1993
Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease SS Kang, EL Passen, N Ruggie, PW Wong, H Sora	Circulation	1993
Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status A Andersson, L Brattström, B Israelsson, A Isaksson, A Hamfelt, B Hultberg	European Journal of Clinical Investigation	1992
Age dependency of cystathionine beta-synthase activity in human fibroblasts in homocyst(e)inemia and atherosclerotic vascular disease M Nordström, T Kjellström	Atherosclerosis	1992
The Role of Free Radicals as Mediators of Endothelial Cell Injury in Hyperhomocysteinemia R Clarke, E Naughten, S Cahalane, KO Sullivan, P Mathias, T McCall, I Graham	Irish Journal of Medical Science	1992
The Effects of Vitamins B12, B6, and Folate on Blood Homocysteine Levels JB Mason, JW Miller	Annals of the New York Academy of Sciences	1992
Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors L Brattström, A Lindgren, B Israelsson, MR Malinow, B Norrving, B Upson, A Hamfelt	European Journal of Clinical Investigation	1992
Hyperhomocyst(e)inemia, anti-estrogen antibodies and other risk factors for thrombosis in women on oral contraceptives V Beaumont, MR Malinow, G Sexton, D Wilson, N Lemort, B Upson, JL Beaumont	Atherosclerosis	1992
The effect of blood sample aging and food consumption on plasma total homocysteine levels JB Ubbink, WJ Vermaak, AD der Merwe, PJ Becker	Clinica Chimica Acta	1992
Population variation and genetics of plasma homocyst(e)ine level K Berg, MR Malinow, P Kiarulf, B Upson	Clinical Genetics	1992
High-performance liquid chromatographic method with fluorescence detection for the determination of total homocyst(e)ine in plasma I Fermo, C Arcelloni, ED Vecchi, S Vigano', R Paroni	Journal of Chromatography A	1992
Measurement of total plasma and cerebrospinal fluid homocysteine by fluorescence following high-performance liquid chromatography and precolumn derivatization with o-phthaldialdehyde K Hyland, T Bottiglieri	Journal of Chromatography B Biomedical Sciences and Applications	1992
Hyperhomocysteinaemia: a risk factor for extracranial carotid artery atherosclerosis R Clarke, D Fitzgerald, C OBrien, C OFarrell, G Roche, RA Parker, I Graham	Irish Journal of Medical Science	1992
Influence of hydrolysis on plasma homocysteine determination in healthy subjects and patients with myocardial infarction A Andersson, A Isaksson, L Brattström, B Israelsson, B Hultberg	Atherosclerosis	1991
Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins T Reed, MR Malinow, JC Christian, B Upson	Clinical Genetics	1991
The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease LM Taylor, RD DeFrang, EJ Harris, JM Porter	Journal of Vascular Surgery	1991
Increased levels of plasma homocysteine are associated with nephropathy, but not severe retinopathy in type 1 diabetes mellitus B Hultberg, E Agardh, A Andersson, L Brattström, A Isaksson, B Israelsson, CD Agardh	Scandinavian Journal of Clinical & Laboratory Investigation	1991
The prevalence of homocysteinemia and hypercholesterolemia in angiographically defined coronary heart disease JB Ubbink, WJ Vermaak, JM Bennett, PJ Becker, DA Staden, S Bissbort	Klinische Wochenschrift	1991
Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease SS Kang, PW Wong, A Susmano, J Sora, M Norusis, N Ruggie	The American Journal of Human Genetics	1991
Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease R Clarke, L Daly, K Robinson, E Naughten, S Cahalane, B Fowler, I Graham	New England Journal of Medicine	1991
Detection of hereditary metabolic disorders involving amino acids and organic acids V Shih	Clinical Biochemistry	1991
A prospective study of parental history off myocardial infarction and coronary artery disease in men GA Colditz, EB Rimm, E Giovannucci, MJ Stampfer, B Rosner, WC Willett	The American Journal of Cardiology	1991
Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum JB Ubbink, WJ Vermaak, S Bissbort	Journal of Chromatography B Biomedical Sciences and Applications	1991
Prevalence of familial hyperhomocyst(e)inemia in men with premature coronary artery disease JJ Genest, JR McNamara, B Upson, DN Salem, JM Ordovas, EJ Schaefer, MR Malinow	Arteriosclerosis Thrombosis and Vascular Biology	1991
Methionine metabolism in mammals JD Finkelstein	The Journal of Nutritional Biochemistry	1990
Detection of heterozygotes for recessive alleles. Homocyst(e)inemia: Paradigm of Pitfalls in phenotypes JJ McGill, G Mettler, DS Rosenblatt, CR Scriver	American Journal of Medical Genetics	1990
Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatment L Brattström, B Israelsson, B Norrving, D Bergqvist, J Thörne, B Hultberg, A Hamfelt	Atherosclerosis	1990
Clinical significance of pharmacological modulation of homocysteine metabolism H Refsum, PM Ueland	Trends in Pharmacological Sciences	1990
Plasma homocyst(e)ine levels in men with premature coronary artery disease JJ Genest, JR McNamara, DN Salem, PW Wilson, EJ Schaefer, MR Malinow	Journal of the American College of Cardiology	1990
The effect of excess daily methionine intake on plasma homocysteine after a methionine loading test in humans A Andersson, L Brattström, B Israelsson, A Isaksson, B Hultberg	Clinica Chimica Acta	1990
Atherosclerosis, Serum Cholesterol and the Homocysteine Theory: A Study of 194 Consecutive Autopsies KS McCully	The American Journal of the Medical Sciences	1990
Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke BM Coull, MR Malinow, N Beamer, G Sexton, F Nordt, P de Garmo	Stroke; a journal of cerebral circulation	1990
Hyperhomocyst(e)inemia. A common and easily reversible risk factor for occlusive atherosclerosis MR Malinow	Circulation	1990
Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis AJ Olszewski, WB Szostak, M Bialkow, S Rudnicki, KS McCully	Atherosclerosis	1989
Azarbine-homocystinemia-thrombosis in historical perspective W Drell, AD Welch	Pharmacology & Therapeutics	1989
Free and protein-bound homocysteine and cysteine in cystathionine β-synthase deficiency: Interrelations during short- and long-term changes in plasma concentrations VC Wiley, NP Dudman, DE Wilcken	Metabolism	1989
Homocysteinemia in rats induced by folic acid deficiency JY Lin, SS Kang, J Zhou, PW Wong	Life Sciences	1989
Low vitamin B6 in patients with acute myocardial infarction FJ Kok, J Schrijver, A Hofman, JC Witteman, DA Kruyssen, WJ Remme, HA Valkenburg	The American Journal of Cardiology	1989
Determination of homocysteine in plasma by ion-exchange chromatography A Andersson, L Brattström, A Isaksson, B Israelsson, B Hultberg	Scandinavian Journal of Clinical & Laboratory Investigation	1989
Increased Hepatic Lipid Peroxidation with Methionine Toxicity in the Rat SM Lynch, JJ Strain	Free Radical Research	1989
Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease MR Malinow, SS Kang, LM Taylor, PW Wong, B Coull, T Inahara, D Mukerjee, G Sexton, B Upson	Circulation	1989
Folic acid—an innocuous means to reduce plasma homocysteine LE Brattström, B Israelsson, JO Jeppsson, BL Hultberg	Scandinavian Journal of Clinical & Laboratory Investigation	1988
Homocysteine and myocardial infarction B Israelsson, LE Brattström, BL Hultberg	Atherosclerosis	1988
The gene for cystathionine beta-synthase (CBS) maps to the subtelomeric region on human chromosome 21q and to proximal mouse chromosome 17 M Münke, JP Kraus, T Ohura, U Francke	The American Journal of Human Genetics	1988
Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase SS Kang, J Zhou, PW Wong, J Kowalisyn, G Strokosch	The American Journal of Human Genetics	1988
Differences between premenopausal women and young men in the transamination pathway of methionine catabolism, and the protection against vascular disease HJ Blom, GH Boers, JP Elzen, JJ Roessel, JM Trijbels, A Tangerman	European Journal of Clinical Investigation	1988
Homocysteine content of plasma proteins in ischemic heart disease AJ Olszewski, WB Szostak	Atherosclerosis	1988
Higher total plasma homocysteine in vitamin B12 deficiency than in heterozygosity for homocystinuria due to cystathionine β-synthase deficiency L Brattström, B Israelsson, F Lindgärde, B Hultberg	Metabolism	1988
Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: Possible implications for prevention of vascular disease DE Wilcken, NP Dudman, PA Tyrrell, MR Robertson	Metabolism	1988
Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease SS Kang, PW Wong, J Zhou, J Sora, M Lessick, N Ruggie, G Grcevich	Metabolism	1988
Accelerated atherosclerosis PW Wong, SS Kang	The American Journal of Medicine	1988
Assay for d-penicillamine-protein conjugate in human plasma utilising chemical reduction followed by high-performance liquid chromatography with gold/ mercury electrochemical detection DA Joyce, DN Wade	Journal of Chromatography B Biomedical Sciences and Applications	1988
Homocysteinemia due to folate deficiency SS Kang, PW Wong, M Norusis	Metabolism	1987
Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection A Araki, Y Sako	Journal of Chromatography B: Biomedical Sciences and Applications	1987
Tumor Cell Differentiation J Aarbakke, PK Chiang, HP Koeffler		1987
Total homocyst(e)ine in plasma and amniotic fluid of pregnant women SS Kang, PW Wong, J Zhou, HY Cook	Metabolism	1986
Protein-Bound Homocyst(e)ine in Patients With Rheumatoid Arthritis Undergoing D-Penicillamine Treatment SS Kang, PW Wong, PB Glickman, CM MacLeod, IA Jaffe	The Journal of Clinical Pharmacology	1986

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