Advertisement
Research Article Free access | 10.1172/JCI112450
Find articles by Slater, L. in: JCI | PubMed | Google Scholar
Find articles by Sweet, P. in: JCI | PubMed | Google Scholar
Find articles by Stupecky, M. in: JCI | PubMed | Google Scholar
Find articles by Gupta, S. in: JCI | PubMed | Google Scholar
Published April 1, 1986 - More info
The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has little effect on vincristine or daunorubicin activity in drug-sensitive parental leukemia and corrects daunorubicin resistance without altering cellular daunorubicin accumulation.
Click on an image below to see the page. View PDF of the complete article