Advertisement

Research Article Free access | 10.1172/JCI112062

Deoxyribonucleic acid polymorphism in the apolipoprotein A-1-C-III gene cluster. Association with hypertriglyceridemia.

A Rees, J Stocks, C R Sharpe, M A Vella, C C Shoulders, J Katz, N I Jowett, F E Baralle, and D J Galton

Find articles by Rees, A. in: JCI | PubMed | Google Scholar

Find articles by Stocks, J. in: JCI | PubMed | Google Scholar

Find articles by Sharpe, C. in: JCI | PubMed | Google Scholar

Find articles by Vella, M. in: JCI | PubMed | Google Scholar

Find articles by Shoulders, C. in: JCI | PubMed | Google Scholar

Find articles by Katz, J. in: JCI | PubMed | Google Scholar

Find articles by Jowett, N. in: JCI | PubMed | Google Scholar

Find articles by Baralle, F. in: JCI | PubMed | Google Scholar

Find articles by Galton, D. in: JCI | PubMed | Google Scholar

Published September 1, 1985 - More info

Published in Volume 76, Issue 3 on September 1, 1985
J Clin Invest. 1985;76(3):1090–1095. https://doi.org/10.1172/JCI112062.
© 1985 The American Society for Clinical Investigation
Published September 1, 1985 - Version history
View PDF
Abstract

A DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst-1 and hybridization with an apolipoprotein A-I complementary DNA clone, has been shown to be located in or close to the 3' noncoding region of the apolipoprotein C-III gene. This polymorphism is found in significantly increased prevalence (P less than 0.001) in Caucasian hypertriglyceridemic subjects compared with race-matched controls, and its distribution in normal individuals of differing racial origins is reported. Furthermore, no alteration of high density lipoprotein or apolipoprotein A-I and apolipoprotein C-III phenotypes was observed in individuals with or without the polymorphism.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (September 1, 1985): No description
Advertisement
Advertisement