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Article has an altmetric score of 272

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Picked up by 33 news outlets
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Research Article Free access | 10.1172/JCI111557

Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol).

W F Rigby, T Stacy, and M W Fanger

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Published October 1, 1984 - More info

Published in Volume 74, Issue 4 on October 1, 1984
J Clin Invest. 1984;74(4):1451–1455. https://doi.org/10.1172/JCI111557.
© 1984 The American Society for Clinical Investigation
Published October 1, 1984 - Version history
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Abstract

Recent studies have suggested that vitamin D may have other important biologic activities in addition to its well-characterized role in the maintenance of calcium homeostasis. Discovery of cytosolic receptors for vitamin D in human peripheral blood monocytes and lectin-stimulated lymphocytes prompted us to study the effects of 1,25-dihydroxyvitamin D3 (calcitriol), the most biologically active metabolite of vitamin D, upon phytohemagglutinin (PHA)-induced lymphocyte blast transformation. We have found that calcitriol is a potent inhibitor of PHA-induced lymphocyte proliferation, achieving 70% inhibition of tritiated thymidine incorporation after 72 h in culture. Furthermore, calcitriol suppressed interleukin-2 (IL-2) production by PHA-stimulated peripheral blood mononuclear cells in a concentration-dependent fashion. Lastly, the suppressive effect of calcitriol on cellular proliferation was partially reversed by the addition of saturating amounts of purified IL-2. We conclude that calcitriol is a potent inhibitor of PHA-induced lymphocyte blast transformation and that this effect is mediated, in part, through suppression of IL-2 production. Thus, calcitriol appears to possess immunoregulatory properties that have been unappreciated heretofore.

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Picked up by 33 news outlets
Blogged by 1
Referenced in 3 patents
107 readers on Mendeley
See more details