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Citations to this article

Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture.
P Djian, … , A K Roncari, C H Hollenberg
P Djian, … , A K Roncari, C H Hollenberg
Published October 1, 1983
Citation Information: J Clin Invest. 1983;72(4):1200-1208. https://doi.org/10.1172/JCI111075.
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Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture.

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Abstract

Using a propagating cell culture system of adipocyte precursors from 70-400-g rats, we explored the possibility that regional variations in properties of adipose tissue may reflect site-specific characteristics intrinsic to the cells, rather than extracellular influences. Initially, studies were made of the nature of the fibroblastlike cells from perirenal adipose tissue stroma. Using colony-forming techniques, it was shown that these cells were adipocyte precursors; each confluent colony that was derived from a single cell displayed differentiated adipocytes. This characteristic was evident in cells from rats of all ages and persisted during secondary culture. At all ages of rats studied, perirenal cells replicated more rapidly than epididymal precursors, e.g., for 179-g rats the population-doubling times were 19.3 +/- 0.7 vs. 25.5 +/- 1.2 h (means +/- SEM, P less than 0.03). With aging of the rats, the replication rate of their perirenal cells decreased progressively. Under clonal conditions, the colony size distribution of both perirenal and epididymal precursors revealed heterogeneity in their capacity for replication, perirenal cells showing greater proliferation. These also differentiated more extensively by morphologic and enzymatic criteria. Age and site had effects that persisted through many cell generations; however, high-fat feeding had no perpetuating influence. The dissimilar properties of perirenal as compared with epididymal precursors may reflect differences in regulation of gene expression. The data are also compatible with a later development in embryological life of perirenal tissue. We suggest that the composition of the adipocyte precursor pool is an important determinant of the growth of adipose tissue that occurs in response to a nutrient load. Interregional or interindividual variation in composition may explain regional and individual differences in fat accumulation.

Authors

P Djian, A K Roncari, C H Hollenberg

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Proceedings of the National Academy of Sciences 2006
Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging
I Karagiannides, T Thomou, T Tchkonia, T Pirtskhalava, KE Kypreos, A Cartwright, G Dalagiorgou, TL Lash, SR Farmer, NA Timchenko, JL Kirkland
The Journal of biological chemistry 2006
Greffe d'adipocytes : applications en chirurgie plastique et esthétique
A Mojallal, P Breton, E Delay, JL Foyatier
EMC - Chirurgie 2005
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots
T Tchkonia, YD Tchoukalova, N Giorgadze, T Pirtskhalava, I Karagiannides, RA Forse, A Koo, M Stevenson, D Chinnappan, A Cartwright, MD Jensen, JL Kirkland
American journal of physiology. Endocrinology and metabolism 2005
Age-dependent regulation of lipogenesis in human and rat adipocytes
AF Kamel, S Norgren, K Strigård, A Thörne, H Fakhrai-Rad, J Galli, C Marcus
The Journal of clinical endocrinology and metabolism 2004
Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion
G Ailhaud, P Guesnet
Obesity Reviews 2004
Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes
T Tchkonia, N Giorgadze, T Pirtskhalava, Y Tchoukalova, I Karagiannides, RA Forse, M DePonte, M Stevenson, W Guo, J Han, G Waloga, TL Lash, MD Jensen, JL Kirkland
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2002
Adipogenesis and aging: does aging make fat go MAD?
JL Kirkland, T Tchkonia, T Pirtskhalava, J Han, I Karagiannides
Experimental Gerontology 2002
Long-Term Implantation of Preadipocyte-Seeded PLGA Scaffolds
CW Patrick, B Zheng, C Johnston, GP Reece
Tissue Engineering 2002
Epithelial Cell Culture
T Berney, A Pileggi, RD Molano, C Ricordi
2002
Breast Reconstruction
GL Robb, MJ Miller, CW Patrick
2002
Proadipogenic effect of leptin on rat preadipocytes in vitro: activation of MAPK and STAT3 signaling pathways
F Machinal-Quélin, MN Dieudonné, MC Leneveu, R Pecquery, Y Giudicelli
American journal of physiology. Cell physiology 2002
The biology of white adipocyte proliferation
DB Hausman, M DiGirolamo, TJ Bartness, GJ Hausman, RJ Martin
Obesity Reviews 2001
Different fat depots are distinct mini-organs
T Tchkonia, I Karagiannides, RA Forse, JL Kirkland
Current Opinion in Endocrinology & Diabetes 2001
Tissue engineering strategies for adipose tissue repair
CW Patrick
The Anatomical Record 2001
Differentiation of Stromal-Vascular Cells Isolated from Canine Adipose Tissues in Primary Culture
P WU, K SATO, S YUKAWA, Y HIKASA, K KAGOTA
Journal of Veterinary Medical Science 2001
Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes
F Caserta, T Tchkonia, VN Civelek, M Prentki, NF Brown, JD McGarry, RA Forse, BE Corkey, JA Hamilton, JL Kirkland
American journal of physiology. Endocrinology and metabolism 2001
Altered expression of C/EBP family members results in decreased adipogenesis with aging
I Karagiannides, T Tchkonia, DE Dobson, CM Steppan, P Cummins, G Chan, K Salvatori, M Hadzopoulou-Cladaras, JL Kirkland
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2001
Cloning of BUG demonstrates the existence of a brown preadipocyte distinct from a white one
K Moulin, E Arnaud, M Nibbelink, N Viguerie-Bascands, L Pénicaud, L Casteilla
International Journal of Obesity 2001
Effects of Lipid-Related Factors on Adipocyte Differentiation of Bovine Stromal-Vascular Cells in Primary Culture
P WU, K SATO, F SUZUTA, Y HIKASA, K KAGOTA
Journal of Veterinary Medical Science 2000
Adipose tissue engineering: The future of breast and soft tissue reconstruction following tumor resection
CW Patrick
Seminars in Surgical Oncology 2000
Dietary Conjugated Linoleic Acid Reduces Rat Adipose Tissue Cell Size Rather than Cell Number
MJ Azain, DB Hausman, MB Sisk, WP Flatt, DE Jewell
The Journal of nutrition 2000
Various stimulators of the cyclic AMP pathway fail to promote adipose conversion of porcine preadipocytes in primary culture
C Boone, F Gregoire, C Remacle
Differentiation 1999
Proliferation and Differentiation of Unilocular Fat Cells in the Bone Marrow
M Shigematsu, H Watanabe, H Sugihara
Cell Structure and Function 1999
A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating predipocytes
W Guo, JL Kirkland, B Corkey, JA Hamilton
Lipids 1998
A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes
W Guo, JL Kirkland, B Corkey, JA Hamilton
Lipids 1998
Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum
M DiGirolamo, JB Fine, K Tagra, R Rossmanith
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 1998
Inhibitors of Cell Growth
A Macieira-Coelho
1998
Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes
NF Brown, JK Hill, V Esser, JL Kirkland, BE Corkey, DW Foster, JD McGarry
Biochemical Journal 1997
Preadipocyte Function and Aging: Links Between Age-Related Changes in Cell Dynamics and Altered Fat Tissue Function
JL Kirkland, DE Dobson
Journal of the American Geriatrics Society 1997
Control of Rat Preadipocyte Adipose Conversion by Ovarian Status: Regional Specificity and Possible Involvement of the Mitogen-Activated Protein Kinase-Dependent and c-fos Signaling Pathways*
D Lacasa, E Garcia, B Agli, Y Giudicelli
Endocrinology 1997
Site-Related Specificities of the Control by Androgenic Status of Adipogenesis and Mitogen-Activated Protein Kinase Cascade/c-fos Signaling Pathways in Rat Preadipocytes*
D Lacasa, E Garcia, D Henriot, B Agli, Y Giudicelli
Endocrinology 1997
Influence of Androgenicity on Adipocytes and Precursor Cells in Female Rats
RG James, GR Krakower, AH Kissebah
Obesity research 1996
G proteins in adipocytes and preadipocytes: Characterization, subcellular distribution, and potential roles for Gi2 and/or Gi3 in the control of cell proliferation
D Denis-Henriot, P Mazancourt, PK Goldsmith, Y Giudicelli
Cellular Signalling 1996
Evidence for a regional-specific control of rat preadipocyte proliferation and differentiation by the androgenic status
D Lacasa, B Agli, D Moynard, Y Giudicelli
Endocrine 1995
Growth and maturation of primary-cultured adipocytes from lean and ob/ob mice
MA Black, N Bégin-Heick
Journal of Cellular Biochemistry 1995
Control of adipocyte differentiation
CM Smas, HS Sul
Biochemical Journal 1995
Long-chain fatty acids decrease lipoprotein lipase activity of cultured rat adipocyte precursors
JL Kirkland, CH Hollenberg, S Kindler, DA Roncari
Metabolism 1994
Rat preadipocyte adenylyl cyclase: influence of fat localization and androgenic status
D Lacasa, D Denis, B Agli, PD Mazancourt, Y Giudicelli
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1994
Regulation of new fat cell formation in rats: the role of dietary fats
G Shillabeer, DC Lau
Journal of lipid research 1994
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases
A Bouloumié, V Planat, JC Devedjian, P Valet, JS Saulnier-Blache, M Record, M Lafontan
The Journal of biological chemistry 1994
Effects of aging on ribosomal protein L7 messenger RNA levels in cultured rat preadipocytes
JL Kirkland, CH Hollenberg, WS Gillon
Experimental Gerontology 1993
The Endocrinology of Growth, Development, and Metabolism in Vertebrates
CB Schreck
The Endocrinology of Growth, Development, and Metabolism in Vertebrates 1993
Two Preadipocyte Subtypes Cloned from Human Omental Fat
JL Kirkland, CH Hollenberg, WS Gillon
Obesity research 1993
Proliferation and triglyceride synthesizing activities of fibroblast-like cells derived from epididymal and subcutaneous adipose tissues of rats
H Inadera, Y Ishikawa, K Shirai, Y Saito, S Yoshida
Scandinavian Journal of Clinical & Laboratory Investigation 1993
Some new aspects on adipose tissue development
G Ailhaud
Diabetes / Metabolism Reviews 1992
Differences in insulin action as a function of original anatomical site of newly differentiated adipocytes obtained in primary culture
C Sztalryd, S Azhar, GM Reaven
Journal of Clinical Investigation 1991
Age, anatomic site, and the replication and differentiation of adipocyte precursors
JL Kirkland, CH Hollenberg, WS Gillon
American journal of physiology. Cell physiology 1990
Varying capacities for replication of rat adipocyte precursor clones and adipose tissue growth
H Wang, JL Kirkland, CH Hollenberg
Journal of Clinical Investigation 1989
17-beta-estradiol increases mitogenic activity of medium from cultured preadipocytes of massively obese persons
SC Cooper, DA Roncari
Journal of Clinical Investigation 1989
Induction of preadipocyte differentiation by mature fat cells in the rat
G Shillabeer, JM Forden, DC Lau
Journal of Clinical Investigation 1989
Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium
H Hauner, G Entenmann, M Wabitsch, D Gaillard, G Ailhaud, R Negrel, EF Pfeiffer
Journal of Clinical Investigation 1989
Preadipocyte stimulating factor in rat serum: Evidence for a discrete 63 kDa protein that promotes cell differentiation of rat preadipocytes in primary cultures
ZH Li, Z Lu, JL Kirkland, RI Gregerman
Journal of Cellular Physiology 1989
The Aging Fat Cell
C Remacle, N Hauser
Journal of the American Geriatrics Society 1989
The Fat Cell
J Hirsch, SK Fried, NK Edens, RL Leibel
Medical Clinics of North America 1989
Regional adipocyte precursors in the female rat. Influence of ovarian factors
GR Krakower, RG James, C Arnaud, J Etienne, RH Keller, AH Kissebah
Journal of Clinical Investigation 1988
Hormone-sensitive adenylyl cyclase in preadipocytes cultured from adipose tissue: Comparison with 3T3-L1 cells and adipocytes
JL Kirkland, MA Pi�eyro, Z Lu, RI Gregerman
Journal of Cellular Physiology 1987
Development of a chemically defined serum-free medium for differentiation of rat adipose precursor cells
S Deslex, R Negrel, G Ailhaud
Experimental Cell Research 1987
Regional differences in the replication rate of cultured rat microvascular endothelium from retroperitoneal and epididymal fat pads
DC Lau, KL Wong, SC Tough
Metabolism 1987
Proliferation of unilocular fat cells in the primary culture
H Sugihara, N Yonemitsu, S Miyabara, S Toda
Journal of lipid research 1987
Adipose tissue development: The role of precursor cells and adipogenic factors: Part I: Adipose tissue development and the role of precursor cells
H Hauner, G Löffler
Klinische Wochenschrift 1987
A method for separating cultured preadipocytes according to their density: Application to stromal cells from overfed suckling rats
I Dugail, A Quignard-Boulange, B Ardouin, L Brigant
In Vitro Cellular & Developmental Biology 1986
Excessive proliferation in culture of reverted adipocytes from massively obese persons
DA Roncari, S Kindler, CH Hollenberg
Metabolism 1986
A method for separating cultured preadipocytes according to their density: Application to stromal cells from overfed suckling rats
I Dugail, A Quignard-Boulange, B Ardouin, L Brigant
In Vitro Cellular & Developmental Biology – Animal 1986
Adipocyte precursor cells in obese and nonobese humans
P Pettersson, R Van, M Karlsson, P Björntorp
Metabolism 1985
Adipocyte precursor clones vary in capacity for differentiation
P Djian, DA Roncari, CH Hollenberg
Metabolism 1985
New Perspectives in Adipose Tissue
A Cryer
New Perspectives in Adipose Tissue 1985
Pre-adipose cell replication and differentiation
DA Roncari
Trends in Biochemical Sciences 1984
Research on adipose tissue and the first 25 years of the Journal of Lipid Research
J Hirsch
Journal of lipid research 1984

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