Using a propagating cell culture system of adipocyte precursors from 70-400-g rats, we explored the possibility that regional variations in properties of adipose tissue may reflect site-specific characteristics intrinsic to the cells, rather than extracellular influences. Initially, studies were made of the nature of the fibroblastlike cells from perirenal adipose tissue stroma. Using colony-forming techniques, it was shown that these cells were adipocyte precursors; each confluent colony that was derived from a single cell displayed differentiated adipocytes. This characteristic was evident in cells from rats of all ages and persisted during secondary culture. At all ages of rats studied, perirenal cells replicated more rapidly than epididymal precursors, e.g., for 179-g rats the population-doubling times were 19.3 +/- 0.7 vs. 25.5 +/- 1.2 h (means +/- SEM, P less than 0.03). With aging of the rats, the replication rate of their perirenal cells decreased progressively. Under clonal conditions, the colony size distribution of both perirenal and epididymal precursors revealed heterogeneity in their capacity for replication, perirenal cells showing greater proliferation. These also differentiated more extensively by morphologic and enzymatic criteria. Age and site had effects that persisted through many cell generations; however, high-fat feeding had no perpetuating influence. The dissimilar properties of perirenal as compared with epididymal precursors may reflect differences in regulation of gene expression. The data are also compatible with a later development in embryological life of perirenal tissue. We suggest that the composition of the adipocyte precursor pool is an important determinant of the growth of adipose tissue that occurs in response to a nutrient load. Interregional or interindividual variation in composition may explain regional and individual differences in fat accumulation.
P Djian, A K Roncari, C H Hollenberg
Year: | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | Total |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Citations: | 1 | 1 | 1 | 2 | 5 | 3 | 2 | 2 | 6 | 4 | 1 | 8 | 5 | 5 | 114 | 10 | 5 | 4 | 7 | 3 | 2 | 2 | 6 | 7 | 3 | 2 | 4 | 4 | 2 | 3 | 4 | 4 | 1 | 1 | 1 | 7 | 1 | 5 | 3 | 3 | 2 | 256 |
Title and authors | Publication | Year |
---|---|---|
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health.
Lecoutre S, Rebière C, Maqdasy S, Lambert M, Dussaud S, Abatan JB, Dugail I, Gautier EL, Clément K, Marcelin G |
Nature reviews. Endocrinology | 2025 |
Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions.
Kar A, Alvarez M, Garske KM, Huang H, Lee SHT, Deal M, Das SS, Koka A, Jamal Z, Mohlke KL, Laakso M, Heinonen S, Pietiläinen KH, Pajukanta P |
Genome Medicine | 2024 |
Culture and Differentiation of Primary Preadipocytes from Mouse Subcutaneous White Adipose Tissue.
DeLuca JH, Reilly SM |
Methods in molecular biology (Clifton, N.J.) | 2023 |
Physiological Systems in Promoting Frailty
Perazza LR, Brown-Borg HM, Thompson LV |
Comprehensive Physiology | 2022 |
Modeling Obesity-Driven Pancreatic Carcinogenesis—A Review of Current In Vivo and In Vitro Models of Obesity and Pancreatic Carcinogenesis
Kfoury S, Michl P, Roth L |
Cells | 2022 |
Multi-omic Approaches to Identify Genetic Factors in Metabolic Syndrome
Clark KC, Kwitek AE |
Comprehensive Physiology | 2021 |
Metabolomic Profiles in Adipocytes Differentiated from Adipose-Derived Stem Cells Following Exercise Training or High-Fat Diet
S Osawa, H Kato, Y Maeda, H Takakura, J Ogasawara, T Izawa |
International journal of molecular sciences | 2021 |
Harnessing adipose stem cell diversity in regenerative medicine
C Gui, J Parson, GA Meyer |
2021 | |
In vitro and ex vivo models of adipocytes
J Dufau, JX Shen, M Couchet, TD Barbosa, N Mejhert, L Massier, E Griseti, E Mouisel, EZ Amri, VM Lauschke, M Rydén, D Langin |
American journal of physiology. Cell physiology | 2021 |
Influence of the patient’s somatic factors on the properties of lipoaspirate
IA Koen, AY Ustyugov, NE Manturova |
2021 | |
Adipose tissue, immune aging, and cellular senescence
D Frasca, BB Blomberg |
Seminars in Immunopathology | 2020 |
Postprandial triglyceride-rich lipoproteins-induced premature senescence of adipose-derived mesenchymal stem cells via the SIRT1/p53/Ac-p53/p21 axis through oxidative mechanism
Q Xiang, F Tian, X Du, J Xu, L Zhu, L Guo, T Wen, Y Liu, L Liu |
Aging | 2020 |
Glucagon-like Peptide-1: Actions and Influence on Pancreatic Hormone Function
Davis EM, Sandoval DA |
Comprehensive Physiology | 2020 |
Deciphering White Adipose Tissue Heterogeneity
Q Luong, J Huang, KY Lee |
Biology : open access journal | 2019 |
Metabolic Phenotyping of Adipose-Derived Stem Cells Reveals a Unique Signature and Intrinsic Differences between Fat Pads
C Lefevre, B Panthu, D Naville, S Guibert, C Pinteur, B Elena-Herrmann, H Vidal, GJ Rautureau, A Mey |
Stem Cells International | 2019 |
Adipocyte biology: It is time to upgrade to a new model: SADIE-VAN GIJSEN
HS Gijsen |
Journal of Cellular Physiology | 2018 |
Royal jelly supplementation reduces skeletal muscle lipotoxicity and insulin resistance in aged obese rats
SE Ibrahim, AA Kosba |
Pathophysiology : the official journal of the International Society for Pathophysiology / ISP | 2018 |
Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy
J Varghese, M Griffin, A Mosahebi, P Butler |
Stem Cell Research & Therapy | 2017 |
Fifty shades of white: Understanding heterogeneity in white adipose stem cells
L Cleal, T Aldea, YY Chau |
Adipocyte | 2017 |
Adipose Tissue Biology
ME Symonds |
Adipose Tissue Biology | 2017 |
Altered structure and function of adipose tissue in long-lived mice with growth hormone-related mutations
J Darcy, S McFadden, A Bartke |
Adipocyte | 2017 |
Proliferation and apoptosis in subcutaneous adipose tissue of lactating cows with different genetic merit for milk yield
M Colitti, N Pošćić, B Stefanon |
Tissue and Cell | 2017 |
Comparisons of extracellular matrix-related gene expression levels in different adipose tissues from Korean cattle
JY Jeong, M Ibrahim, MJ Kim, K So, YD Jeong, S Park, M Kim, HJ Lee |
Livestock Science | 2017 |
The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction
JP Castro, T Grune, B Speckmann |
Biological Chemistry | 2016 |
Relationships between Rodent White Adipose Fat Pads and Human White Adipose Fat Depots
DE Chusyd, D Wang, DM Huffman, TR Nagy |
Frontiers in Nutrition | 2016 |
A 3-month age difference profoundly alters the primary rat stromal vascular fraction phenotype
ML Quaade, CH Jensen, DC Andersen, SP Sheikh |
Acta Histochemica | 2016 |
Adipogenic potential of stem cells derived from rabbit subcutaneous and visceral adipose tissue in vitro
E Vachkova, D Bosnakovski, P Yonkova, N Grigorova, Z Ivanova, P Todorov, G Penchev, A Milanova, G Simeonova, S Stanilova, IP Georgiev |
In vitro cellular & developmental biology. Animal | 2016 |
Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits: Fat Depot-Specific Expression of HOXC9 and HOXC10
JE Brune, M Kern, A Kunath, G Flehmig, MR Schön, T Lohmann, M Dressler, A Dietrich, M Fasshauer, P Kovacs, M Stumvoll, M Blüher, N Klöting |
Obesity | 2015 |
Adipocytes in Skin Health and Disease
G Rivera-Gonzalez, B Shook, V Horsley |
Cold Spring Harbor Perspectives in Medicine | 2014 |
Detrimental and protective fat: body fat distribution and its relation to metabolic disease
A Booth, A Magnuson, M Foster |
Hormone Molecular Biology and Clinical Investigation | 2014 |
Muscle ectopic fat deposition contributes to anabolic resistance in obese sarcopenic old rats through eIF2α activation
N Tardif, J Salles, C Guillet, J Tordjman, S Reggio, JF Landrier, C Giraudet, V Patrac, J Bertrand-Michel, C Migne, ML Collin, JM Chardigny, Y Boirie, S Walrand |
Aging Cell | 2014 |
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.
Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL |
Aging | 2014 |
Gene expression profiling of SIRT1, FoxO1, and PPARγ in backfat tissues and subcutaneous adipocytes of Lilu bulls
X Liu, G Liu, X Tan, H Zhao, H Cheng, F Wan, N Wu, E Song |
Meat Science | 2014 |
Comparison of the adipogenesis in intramuscular and subcutaneous adipocytes from Bamei and Landrace pigs
GH Zhang, JX Lu, Y Chen, YQ Zhao, PH Guo, JT Yang, RX Zang |
Biochemistry and Cell Biology | 2014 |
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
MB Stout, T Tchkonia, T Pirtskhalava, AK Palmer, EO List, DE Berryman, ER Lubbers, C Escande, A Spong, MM Masternak, AL Oberg, NK LeBrasseur, RA Miller, JJ Kopchick, A Bartke, JL Kirkland |
Aging | 2014 |
Effect of age on bovine subcutaneous fat proteome: Molecular mechanisms of physiological variations during beef cattle growth1
JM Romao, ML He, TA McAllister, LL Guan |
Journal of animal science | 2014 |
Sex dimorphism and depot differences in adipose tissue function
UA White, YD Tchoukalova |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2013 |
Role of leptin resistance in the development of obesity in older patients
S Carter, A Caron, D Richard, F Picard |
Clinical Interventions in Aging | 2013 |
Comparative Transcriptome Analysis of Adipose Tissues Reveals that ECM-Receptor Interaction Is Involved in the Depot-Specific Adipogenesis in Cattle
HJ Lee, M Jang, H Kim, W Kwak, W Park, JY Hwang, CK Lee, GW Jang, MN Park, HC Kim, JY Jeong, KS Seo, H Kim, S Cho, BY Lee |
PloS one | 2013 |
Adipocyte and adipogenesis
AT Ali, WE Hochfeld, R Myburgh, MS Pepper |
European Journal of Cell Biology | 2013 |
Comparative Transcriptome Analysis of Adipose Tissues Reveals that ECM-Receptor Interaction Is Involved in the Depot-Specific Adipogenesis in Cattle
HJ Lee, M Jang, H Kim, W Kwak, WC Park, JY Hwang, CK Lee, GW Jang, MN Park, HC Kim, JY Jeong, KS Seo, H Kim, S Cho, BY Lee, A Torkamani |
PloS one | 2013 |
Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome
K Dasuri, P Ebenezer, SO Fernandez-Kim, L Zhang, Z Gao, AJ Bruce-Keller, LR Freeman, JN Keller |
Free Radical Research | 2012 |
Peripheral fat loss and decline in adipogenesis in older humans
G Caso, MA McNurlan, I Mileva, A Zemlyak, DC Mynarcik, MC Gelato |
Metabolism | 2012 |
A Modified Protocol to Maximize Differentiation of Human Preadipocytes and Improve Metabolic Phenotypes
MJ Lee, Y Wu, SK Fried |
Obesity | 2012 |
Aging-related Decrease of Human ASC Angiogenic Potential Is Reversed by Hypoxia Preconditioning Through ROS Production
SD Barros, S Dehez, E Arnaud, C Barreau, A Cazavet, G Perez, A Galinier, L Casteilla, V Planat-Bénard |
Molecular Therapy | 2012 |
Decreased Contact Inhibition in Mouse Adipose Mesenchymal Stem Cells
Y Jeon, MS Lee, YP Cheon |
Development and Reproduction | 2012 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Oxidative Stress Accumulates in Adipose Tissue during Aging and Inhibits Adipogenesis
HM Findeisen, KJ Pearson, F Gizard, Y Zhao, H Qing, KL Jones, D Cohn, EB Heywood, R Cabo, D Bruemmer, JM Gimble |
PloS one | 2011 |
Adipose tissue stem cells meet preadipocyte commitment: going back to the future
WP Cawthorn, EL Scheller, OA MacDougald |
Journal of lipid research | 2011 |
Physiological and conjugated linoleic acid-induced changes of adipocyte size in different fat depots of dairy cows during early lactation
SH Akter, S Häussler, S Dänicke, U Müller, D Soosten, J Rehage, H Sauerwein |
Journal of Dairy Science | 2011 |
Proteomic Functional Characterization of Bovine Stromal Vascular Cells from Omental, Subcutaneous and Intramuscular Adipose Depots
RV Rajesh, SK Kim, MR Park, JS Nam, NK Kim, S Kwon, DH Yoon, TH Kim, HJ Lee |
Asian-Australasian Journal of Animal Sciences | 2011 |
Interspecies Somatic Cell Nuclear Transfer Technique for Researching Dog Cloning and Embryonic Stem Cells
S Sugimura, E Sato |
Asian-Australasian Journal of Animal Sciences | 2011 |
Aging and Adipose Tissue
R Florido, T Tchkonia, JL Kirkland |
Handbook of the Biology of Aging | 2011 |
Fat tissue, aging, and cellular senescence
T Tchkonia, DE Morbeck, TV Zglinicki, JV Deursen, J Lustgarten, H Scrable, S Khosla, MD Jensen, JL Kirkland |
Aging Cell | 2010 |
From the Cover: Regional differences in cellular mechanisms of adipose tissue gain with overfeeding
YD Tchoukalova, SB Votruba, T Tchkonia, N Giorgadze, JL Kirkland, MD Jensen |
Proceedings of the National Academy of Sciences | 2010 |
Aging, Depot Origin, and Preadipocyte Gene Expression
MJ Cartwright, K Schlauch, ME Lenburg, T Tchkonia, T Pirtskhalava, A Cartwright, T Thomou, JL Kirkland |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2010 |
Caloric restriction attenuates the age-associated increase of adipose-derived stem cells but further reduces their proliferative capacity
EG Schmuck, JD Mulligan, KW Saupe |
AGE | 2010 |
Adipose Depots Possess Unique Developmental Gene Signatures
Y Yamamoto, S Gesta, KY Lee, TT Tran, P Saadatirad, CR Kahn |
Obesity | 2010 |
Characteristics of Proliferation and Differentiation-Dependent C/EBP, PPARγ and Leptin Gene Expression Patterns Intrinsic to Bovine Intramuscular, Perirenal and Subcutaneous Preadipocytes
M Yamamoto, Y Taniguchi, K Kano, T Yamada |
Journal of Animal and Veterinary Advances | 2010 |
Cellular models for understanding adipogenesis, adipose dysfunction, and obesity
A Armani, C Mammi, V Marzolla, M Calanchini, A Antelmi, GM Rosano, A Fabbri, M Caprio |
Journal of Cellular Biochemistry | 2010 |
Skeletal muscle stem cells from animals I. Basic cell biology
MV Dodson, GJ Hausman, L Guan, M Du, TP Rasmussen, SP Poulos, P Mir, WG Bergen, ME Fernyhough, DC McFarland, RP Rhoads, B Soret, JM Reecy, SG Velleman, Z Jiang |
International journal of biological sciences | 2010 |
Adipose Tissue in Health and Disease: LEFF:ADIPOSE TISSUE O-BK
LA Cassis, SB Police |
Adipose Tissue in Health and Disease: LEFF:ADIPOSE TISSUE O-BK | 2010 |
White adipose tissue re-growth after partial lipectomy in high fat diet induced obese Wistar rats
AA Bueno, CA Habitante, LM Oyama, D Estadella, EB Ribeiro, CM do Nascimento |
The Journal of Physiological Sciences | 2010 |
Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters
H Okura, H Komoda, Y Fumimoto, CM Lee, T Nishida, Y Sawa, A Matsuyama |
Journal of Artificial Organs | 2009 |
The effect of age on osteogenic, adipogenic and proliferative potential of female adipose-derived stem cells
M Zhu, E Kohan, J Bradley, M Hedrick, P Benhaim, P Zuk |
Journal of Tissue Engineering and Regenerative Medicine | 2009 |
Post-traumatic pseudolipomas – a review and postulated mechanisms of their development
LA Galea, AJ Penington, WA Morrison |
Journal of Plastic Reconstructive & Aesthetic Surgery | 2009 |
Selective adipogenic effects of propionate on bovine intramuscular and subcutaneous preadipocytes
R Wan, J Du, L Ren, Q Meng |
Meat Science | 2009 |
Étude analytique de la silhouette : les syndromes segmentaires et leurs conséquences thérapeutiques
JC Dardour |
Annales de Chirurgie Plastique Esthétique | 2009 |
Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: implications for cell-based therapies
WJ Jurgens, MJ Oedayrajsingh-Varma, MN Helder, B Zandiehdoulabi, TE Schouten, DJ Kuik, MJ Ritt, FJ van Milligen |
Cell and Tissue Research | 2008 |
SHORT- AND LONG-TERM EFFECTS OF CORN OIL ON SERUM LIPID AND LIPOPROTEIN AND VISCERAL ABDOMINAL FAT PAD PARAMETERS OF RATS
F Asadi, A Shahriari, M Pourkabir, R Maclaren |
Journal of Food Lipids | 2008 |
Role of Gender and Anatomical Region on Induction of Osteogenic Differentiation of Human Adipose-derived Stem Cells
AE Aksu, JP Rubin, JR Dudas, KG Marra |
Annals of Plastic Surgery | 2008 |
The significance of Epstein Barr virus (EBV) & DNA topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC)
AA Shamaa, MM Zyada, M Wagner, SS Awad, MM Osman, AA Azeem |
Diagnostic Pathology | 2008 |
Maternal protein restriction permanently programs adipocyte growth and development in adult male rat offspring
T Zhang, H Guan, E Arany, DJ Hill, K Yang |
Journal of Cellular Biochemistry | 2007 |
Biological character of human adipose-derived adult stem cells and influence of donor age on cell replication in culture
L Lei, WM Liao, PY Sheng, M Fu, AS He, G Huang |
Science in China Series C: Life Sciences | 2007 |
Obesity and the metabolic syndrome in Mediterranean countries: A hypothesis related to olive oil
F Soriguer, G Rojo-Martínez, FR de Fonseca, E García-Escobar, EG Fuentes, G Olveira |
Molecular Nutrition & Food Research | 2007 |
Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes
JY Kim, Y Wu, CM Smas |
Physiological genomics | 2007 |
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity
W Guo, T Pirtskhalava, T Tchkonia, W Xie, T Thomou, J Han, T Wang, S Wong, A Cartwright, FG Hegardt, BE Corkey, JL Kirkland |
American journal of physiology. Endocrinology and metabolism | 2007 |
Increased TNFα and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis
T Tchkonia, T Pirtskhalava, T Thomou, MJ Cartwright, B Wise, I Karagiannides, A Shpilman, TL Lash, JD Becherer, JL Kirkland |
American journal of physiology. Endocrinology and metabolism | 2007 |
Adipose Tissue and Adipokines in Health and Disease
G Fantuzzi, T Mazzone |
2007 | |
Fat Depot-Specific Characteristics Are Retained in Strains Derived From Single Human Preadipocytes
T Tchkonia, N Giorgadze, T Pirtskhalava, T Thomou, M DePonte, A Koo, RA Forse, D Chinnappan, C Martin-Ruiz, T Zglinicki, JL Kirkland |
Diabetes | 2006 |
Evidence for a role of developmental genes in the origin of obesity and body fat distribution
S Gesta, M Blüher, Y Yamamoto, AW Norris, J Berndt, S Kralisch, J Boucher, C Lewis, CR Kahn |
Proceedings of the National Academy of Sciences | 2006 |
Increased CUG Triplet Repeat-binding Protein-1 Predisposes to Impaired Adipogenesis with Aging
I Karagiannides, T Thomou, T Tchkonia, T Pirtskhalava, KE Kypreos, A Cartwright, G Dalagiorgou, TL Lash, SR Farmer, NA Timchenko, JL Kirkland |
The Journal of biological chemistry | 2006 |
Greffe d'adipocytes : applications en chirurgie plastique et esthétique
A Mojallal, P Breton, E Delay, JL Foyatier |
EMC - Chirurgie | 2005 |
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots
T Tchkonia, YD Tchoukalova, N Giorgadze, T Pirtskhalava, I Karagiannides, RA Forse, A Koo, M Stevenson, D Chinnappan, A Cartwright, MD Jensen, JL Kirkland |
American journal of physiology. Endocrinology and metabolism | 2005 |
Age-dependent regulation of lipogenesis in human and rat adipocytes
AF Kamel, S Norgren, K Strigård, A Thörne, H Fakhrai-Rad, J Galli, C Marcus |
The Journal of clinical endocrinology and metabolism | 2004 |
Fatty acid composition of fats is an early determinant of childhood obesity: a short review and an opinion
G Ailhaud, P Guesnet |
Obesity Reviews | 2004 |
Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes
T Tchkonia, N Giorgadze, T Pirtskhalava, Y Tchoukalova, I Karagiannides, RA Forse, M DePonte, M Stevenson, W Guo, J Han, G Waloga, TL Lash, MD Jensen, JL Kirkland |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2002 |
Adipogenesis and aging: does aging make fat go MAD?
JL Kirkland, T Tchkonia, T Pirtskhalava, J Han, I Karagiannides |
Experimental Gerontology | 2002 |
Long-Term Implantation of Preadipocyte-Seeded PLGA Scaffolds
CW Patrick, B Zheng, C Johnston, GP Reece |
Tissue Engineering | 2002 |
Epithelial Cell Culture
T Berney, A Pileggi, RD Molano, C Ricordi |
2002 | |
Breast Reconstruction
GL Robb, MJ Miller, CW Patrick |
2002 | |
Proadipogenic effect of leptin on rat preadipocytes in vitro: activation of MAPK and STAT3 signaling pathways
F Machinal-Quélin, MN Dieudonné, MC Leneveu, R Pecquery, Y Giudicelli |
American journal of physiology. Cell physiology | 2002 |
The biology of white adipocyte proliferation
DB Hausman, M DiGirolamo, TJ Bartness, GJ Hausman, RJ Martin |
Obesity Reviews | 2001 |
Different fat depots are distinct mini-organs
T Tchkonia, I Karagiannides, RA Forse, JL Kirkland |
Current Opinion in Endocrinology & Diabetes | 2001 |
Tissue engineering strategies for adipose tissue repair
CW Patrick |
The Anatomical Record | 2001 |
Differentiation of Stromal-Vascular Cells Isolated from Canine Adipose Tissues in Primary Culture
P WU, K SATO, S YUKAWA, Y HIKASA, K KAGOTA |
Journal of Veterinary Medical Science | 2001 |
Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes
F Caserta, T Tchkonia, VN Civelek, M Prentki, NF Brown, JD McGarry, RA Forse, BE Corkey, JA Hamilton, JL Kirkland |
American journal of physiology. Endocrinology and metabolism | 2001 |
Altered expression of C/EBP family members results in decreased adipogenesis with aging
I Karagiannides, T Tchkonia, DE Dobson, CM Steppan, P Cummins, G Chan, K Salvatori, M Hadzopoulou-Cladaras, JL Kirkland |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2001 |
Cloning of BUG demonstrates the existence of a brown preadipocyte distinct from a white one
K Moulin, E Arnaud, M Nibbelink, N Viguerie-Bascands, L Pénicaud, L Casteilla |
International Journal of Obesity | 2001 |
Effects of Lipid-Related Factors on Adipocyte Differentiation of Bovine Stromal-Vascular Cells in Primary Culture
P WU, K SATO, F SUZUTA, Y HIKASA, K KAGOTA |
Journal of Veterinary Medical Science | 2000 |
Adipose tissue engineering: The future of breast and soft tissue reconstruction following tumor resection
CW Patrick |
Seminars in Surgical Oncology | 2000 |
Dietary Conjugated Linoleic Acid Reduces Rat Adipose Tissue Cell Size Rather than Cell Number
MJ Azain, DB Hausman, MB Sisk, WP Flatt, DE Jewell |
The Journal of nutrition | 2000 |
Various stimulators of the cyclic AMP pathway fail to promote adipose conversion of porcine preadipocytes in primary culture
C Boone, F Gregoire, C Remacle |
Differentiation | 1999 |
Proliferation and Differentiation of Unilocular Fat Cells in the Bone Marrow
M Shigematsu, H Watanabe, H Sugihara |
Cell Structure and Function | 1999 |
A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating predipocytes
W Guo, JL Kirkland, B Corkey, JA Hamilton |
Lipids | 1998 |
A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes
W Guo, JL Kirkland, B Corkey, JA Hamilton |
Lipids | 1998 |
Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum
M DiGirolamo, JB Fine, K Tagra, R Rossmanith |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 1998 |
Inhibitors of Cell Growth
A Macieira-Coelho |
1998 | |
Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes
NF Brown, JK Hill, V Esser, JL Kirkland, BE Corkey, DW Foster, JD McGarry |
Biochemical Journal | 1997 |
Preadipocyte Function and Aging: Links Between Age-Related Changes in Cell Dynamics and Altered Fat Tissue Function
JL Kirkland, DE Dobson |
Journal of the American Geriatrics Society | 1997 |
Control of Rat Preadipocyte Adipose Conversion by Ovarian Status: Regional Specificity and Possible Involvement of the Mitogen-Activated Protein Kinase-Dependent and c-fos Signaling Pathways*
D Lacasa, E Garcia, B Agli, Y Giudicelli |
Endocrinology | 1997 |
Site-Related Specificities of the Control by Androgenic Status of Adipogenesis and Mitogen-Activated Protein Kinase Cascade/c-fos Signaling Pathways in Rat Preadipocytes*
D Lacasa, E Garcia, D Henriot, B Agli, Y Giudicelli |
Endocrinology | 1997 |
Influence of Androgenicity on Adipocytes and Precursor Cells in Female Rats
RG James, GR Krakower, AH Kissebah |
Obesity research | 1996 |
G proteins in adipocytes and preadipocytes: Characterization, subcellular distribution, and potential roles for Gi2 and/or Gi3 in the control of cell proliferation
D Denis-Henriot, P Mazancourt, PK Goldsmith, Y Giudicelli |
Cellular Signalling | 1996 |
Evidence for a regional-specific control of rat preadipocyte proliferation and differentiation by the androgenic status
D Lacasa, B Agli, D Moynard, Y Giudicelli |
Endocrine | 1995 |
Growth and maturation of primary-cultured adipocytes from lean and ob/ob mice
MA Black, N Bégin-Heick |
Journal of Cellular Biochemistry | 1995 |
Control of adipocyte differentiation
CM Smas, HS Sul |
Biochemical Journal | 1995 |
Long-chain fatty acids decrease lipoprotein lipase activity of cultured rat adipocyte precursors
JL Kirkland, CH Hollenberg, S Kindler, DA Roncari |
Metabolism | 1994 |
Rat preadipocyte adenylyl cyclase: influence of fat localization and androgenic status
D Lacasa, D Denis, B Agli, PD Mazancourt, Y Giudicelli |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 1994 |
Regulation of new fat cell formation in rats: the role of dietary fats
G Shillabeer, DC Lau |
Journal of lipid research | 1994 |
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases
A Bouloumié, V Planat, JC Devedjian, P Valet, JS Saulnier-Blache, M Record, M Lafontan |
The Journal of biological chemistry | 1994 |
Effects of aging on ribosomal protein L7 messenger RNA levels in cultured rat preadipocytes
JL Kirkland, CH Hollenberg, WS Gillon |
Experimental Gerontology | 1993 |
The Endocrinology of Growth, Development, and Metabolism in Vertebrates
CB Schreck |
The Endocrinology of Growth, Development, and Metabolism in Vertebrates | 1993 |
Two Preadipocyte Subtypes Cloned from Human Omental Fat
JL Kirkland, CH Hollenberg, WS Gillon |
Obesity research | 1993 |
Proliferation and triglyceride synthesizing activities of fibroblast-like cells derived from epididymal and subcutaneous adipose tissues of rats
H Inadera, Y Ishikawa, K Shirai, Y Saito, S Yoshida |
Scandinavian Journal of Clinical & Laboratory Investigation | 1993 |
Some new aspects on adipose tissue development
G Ailhaud |
Diabetes / Metabolism Reviews | 1992 |
Differences in insulin action as a function of original anatomical site of newly differentiated adipocytes obtained in primary culture
C Sztalryd, S Azhar, GM Reaven |
Journal of Clinical Investigation | 1991 |
Age, anatomic site, and the replication and differentiation of adipocyte precursors
JL Kirkland, CH Hollenberg, WS Gillon |
American journal of physiology. Cell physiology | 1990 |
Varying capacities for replication of rat adipocyte precursor clones and adipose tissue growth
H Wang, JL Kirkland, CH Hollenberg |
Journal of Clinical Investigation | 1989 |
17-beta-estradiol increases mitogenic activity of medium from cultured preadipocytes of massively obese persons
SC Cooper, DA Roncari |
Journal of Clinical Investigation | 1989 |
Induction of preadipocyte differentiation by mature fat cells in the rat
G Shillabeer, JM Forden, DC Lau |
Journal of Clinical Investigation | 1989 |
Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium
H Hauner, G Entenmann, M Wabitsch, D Gaillard, G Ailhaud, R Negrel, EF Pfeiffer |
Journal of Clinical Investigation | 1989 |
Preadipocyte stimulating factor in rat serum: Evidence for a discrete 63 kDa protein that promotes cell differentiation of rat preadipocytes in primary cultures
ZH Li, Z Lu, JL Kirkland, RI Gregerman |
Journal of Cellular Physiology | 1989 |
The Aging Fat Cell
C Remacle, N Hauser |
Journal of the American Geriatrics Society | 1989 |
The Fat Cell
J Hirsch, SK Fried, NK Edens, RL Leibel |
Medical Clinics of North America | 1989 |
Regional adipocyte precursors in the female rat. Influence of ovarian factors
GR Krakower, RG James, C Arnaud, J Etienne, RH Keller, AH Kissebah |
Journal of Clinical Investigation | 1988 |
Hormone-sensitive adenylyl cyclase in preadipocytes cultured from adipose tissue: Comparison with 3T3-L1 cells and adipocytes
JL Kirkland, MA Pi�eyro, Z Lu, RI Gregerman |
Journal of Cellular Physiology | 1987 |
Development of a chemically defined serum-free medium for differentiation of rat adipose precursor cells
S Deslex, R Negrel, G Ailhaud |
Experimental Cell Research | 1987 |
Regional differences in the replication rate of cultured rat microvascular endothelium from retroperitoneal and epididymal fat pads
DC Lau, KL Wong, SC Tough |
Metabolism | 1987 |
Proliferation of unilocular fat cells in the primary culture
H Sugihara, N Yonemitsu, S Miyabara, S Toda |
Journal of lipid research | 1987 |
Adipose tissue development: The role of precursor cells and adipogenic factors: Part I: Adipose tissue development and the role of precursor cells
H Hauner, G Löffler |
Klinische Wochenschrift | 1987 |
A method for separating cultured preadipocytes according to their density: Application to stromal cells from overfed suckling rats
I Dugail, A Quignard-Boulange, B Ardouin, L Brigant |
In Vitro Cellular & Developmental Biology | 1986 |
Excessive proliferation in culture of reverted adipocytes from massively obese persons
DA Roncari, S Kindler, CH Hollenberg |
Metabolism | 1986 |
A method for separating cultured preadipocytes according to their density: Application to stromal cells from overfed suckling rats
I Dugail, A Quignard-Boulange, B Ardouin, L Brigant |
In Vitro Cellular & Developmental Biology – Animal | 1986 |
Adipocyte precursor cells in obese and nonobese humans
P Pettersson, R Van, M Karlsson, P Björntorp |
Metabolism | 1985 |
Adipocyte precursor clones vary in capacity for differentiation
P Djian, DA Roncari, CH Hollenberg |
Metabolism | 1985 |
New Perspectives in Adipose Tissue
A Cryer |
New Perspectives in Adipose Tissue | 1985 |
Pre-adipose cell replication and differentiation
DA Roncari |
Trends in Biochemical Sciences | 1984 |
Research on adipose tissue and the first 25 years of the Journal of Lipid Research
J Hirsch |
Journal of lipid research | 1984 |