Role of Charge and Hydrophobic Interactions in the Action of Bactericidal/Permeability-increasing Protein of Neutrophils on Gram-negative Bacteria

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Abstract

We have recently provided evidence suggesting that the action of purified cationic bactericidal/permeability-increasing protein (BPI) from neutrophils on susceptible gram-negative bacteria requires saturation binding to negatively charged surface sites (Weiss, J., S. Beckerdite-Quagliata, and P. Elsbach, 1980, J. Clin. Invest., 65: 619-628.)

Authors

Jerrold Weiss, Michael Victor, Peter Elsbach