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Research Article Free access | 10.1172/JCI110780

Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood.

R R Montgomery, T J Kunicki, C Taves, D Pidard, and M Corcoran

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Published February 1, 1983 - More info

Published in Volume 71, Issue 2 on February 1, 1983
J Clin Invest. 1983;71(2):385–389. https://doi.org/10.1172/JCI110780.
© 1983 The American Society for Clinical Investigation
Published February 1, 1983 - Version history
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Abstract

Two hereditary platelet disorders, Bernard-Soulier syndrome and Glanzmann's thrombasthenia, are characterized by selective deficiencies of platelet membrane glycoproteins. Murine monoclonal antibodies were developed against platelet membrane glycoprotein Ib and against the glycoprotein IIb/IIIa complex. A rapid whole blood assay for the deficiency of these glycoproteins was developed and used to study whole blood samples from six patients with Glanzmann's thrombasthenia and three patients with Bernard-Soulier syndrome. Patients with type I and type II Glanzmann's thrombasthenia were easily detectable with this assay. This permits the diagnosis of these disorders on 200 microliters of whole blood within 2 h of blood sampling.

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