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Article has an altmetric score of 8

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Posted by 7 X users
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Research Article Free access | 10.1172/JCI110771

Z-DNA-specific antibodies in human systemic lupus erythematosus.

E M Lafer, R P Valle, A Möller, A Nordheim, P H Schur, A Rich, and B D Stollar

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Published February 1, 1983 - More info

Published in Volume 71, Issue 2 on February 1, 1983
J Clin Invest. 1983;71(2):314–321. https://doi.org/10.1172/JCI110771.
© 1983 The American Society for Clinical Investigation
Published February 1, 1983 - Version history
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Abstract

Naturally occurring antibodies to left-handed Z-DNA have been shown to be present in the sera of human patients with systemic lupus erythematosus (SLE). These antibodies are of two types. One type reacts with both denatured DNA and Z-DNA. The other type is specific for Z-DNA and remained in the serum after removal of the cross-reactive antibody by extensive absorption on a denatured DNA affinity column. The antibodies appear to be specific for SLE and do not appear frequently in other rheumatic diseases. The presence of the antibody in SLE is correlated with the clinical manifestations of the disease, in parallel with antibodies to native and denatured DNA.

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Posted by 7 X users
Referenced in 4 Wikipedia pages
43 readers on Mendeley
See more details