The role of the enzyme hepatic triglyceride lipase was investigated in a primate model, the cynomolgus monkey. Antisera produced against human postheparin hepatic lipase fully inhibited cynomolgus monkey posttheparin plasma hepatic triglyceride lipase activity. Lipoprotein lipase activity was not inhibited by this antisera. Hepatic triglyceride lipase activity in liver biopsies was decreased by 65-90% after intravenous infusion of this antisera into the cynomolgus monkey. After a 3-h infusion of the antisera, analytic ultracentrifugation revealed an increase in mass of very low density lipoproteins (Sf 20-400). Very low density lipoprotein triglyceride isolated by isopycnic ultracentrifugation increased by 60-300%. Analytic ultracentrifugation revealed an increase in mass of lipoproteins with flotation greater than Sf 9 (n = 4). The total mass of intermediate density lipoproteins (Sf 12-20) approximately doubled during the 3 h of in vivo enzyme inhibition. While more rapidly floating low density lipoproteins (Sf 9-12) increased, the total mass of low density lipoproteins decreased after infusion of the antibodies. The changes in high density lipoproteins did not differ from those in control experiments.
Ira J. Goldberg, Ngoc-Anh Le, James R. Paterniti Jr., Henry N. Ginsberg, Frank T. Lindgren, W. Virgil Brown
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2010 | |
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Hypertriglyceridemia-induced pancreatitis created by oral estrogen and in vitro fertilization ovulation induction
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Wiley Encyclopedia of Molecular Medicine
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HL Dichek, SM Johnson, H Akeefe, GT Lo, E Sage, CE Yap, RW Mahley |
Journal of lipid research | 2001 |
In Vivo Evidence for Both Lipolytic and Nonlipolytic Function of Hepatic Lipase in the Metabolism of HDL
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G Lambert, MJ Amar, P Martin, J Fruchart-Najib, B Föger, RD Shamburek, HB Brewer, S Santamarina-Fojo |
Journal of lipid research | 2000 |
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CJ Schultz, EJ Blanchette-Mackie, RO Scow |
Journal of lipid research | 2000 |
Binding of hepatic lipase to heparin: identification of specific heparin-binding residues in two distinct positive charge clusters
RA Sendak, DE Berryman, G Gellman, K Melford, A Bensadoun |
Journal of lipid research | 2000 |
Functional variants in the lipoprotein lipase gene and risk of cardiovascular disease
JE Hokanson |
Current Opinion in Lipidology | 1999 |
Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice. Effects on lipoproteins and atherosclerosis
IJ Goldberg, JR Paterniti, DS France, G Martinelli, JA Cornicelli |
Journal of lipid research | 1999 |
Apolipoprotein C-III displacement of apolipoprotein E from VLDL: effect of particle size
ED Breyer, NA Le, X Li, D Martinson, WV Brown |
Journal of lipid research | 1999 |
Omega-3 fatty acids alter lipoprotein subfraction distributions and the in vitro conversion of very low density lipoproteins to low density lipoproteins
G Lu, SL Windsor, WS Harris |
The Journal of Nutritional Biochemistry | 1999 |
Hepatic triglyceride lipase promotes low density lipoprotein receptor-mediated catabolism of very low density lipoproteins in vitro
JD Medh, SL Bowen, GL Fry, S Ruben, J Hill, H Wong, DA Chappell |
Journal of lipid research | 1999 |
Plasma clearance and liver uptake of chylomicron remnants generated by hepatic lipase lipolysis: evidence for a lactoferrin-sensitive and apolipoprotein E-independent pathway
SE Crawford, J Borensztajn |
Journal of lipid research | 1999 |
Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1
G Lambert, MB Chase, K Dugi, A Bensadoun, HB Brewer, S Santamarina-Fojo |
Journal of lipid research | 1999 |
Receptor-mediated mechanisms of lipoprotein remnant catabolism
DA Chappell, JD Medh |
Progress in Lipid Research | 1998 |
In vitro production of β-very low density lipoproteins and small, dense low density lipoproteins in mildly hypertriglyceridemic plasma: role of activities of lecithin:cholester acyltransferase, cholesterylester transfer proteins and lipoprotein lipase
BH Chung, JP Segrest, F Franklin |
Atherosclerosis | 1998 |
The role of hepatic lipase in lipoprotein metabolism and atherosclerosis
S Santamarina-Fojo, C Haudenschild, M Amar |
Current Opinion in Lipidology | 1998 |
Combined lipase deficiency (cld/cld) in mice affects differently post-translational processing of lipoprotein lipase, hepatic lipase and pancreatic lipase
RO Scow, CJ Schultz, JW Park, EJ Blanchette-Mackie |
Chemistry and Physics of Lipids | 1998 |
Hepatic lipase affects both HDL and ApoB-containing lipoprotein levels in the mouse
S Braschi, N Couture, A Gambarotta, BR Gauthier, CR Coffill, DL Sparks, N Maeda, JR Schultz |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1998 |
The NH 2 -terminal Region of Apolipoprotein B Is Sufficient for Lipoprotein Association with Glycosaminoglycans
IJ Goldberg, WD Wagner, L Pang, L Paka, LK Curtiss, JA DeLozier, GS Shelness, CS Young, S Pillarisetti |
The Journal of biological chemistry | 1998 |
Overexpression of Hepatic Lipase in Transgenic Mice Decreases Apolipoprotein B-containing and High Density Lipoproteins: EVIDENCE THAT HEPATIC LIPASE ACTS AS A LIGAND FOR LIPOPROTEIN UPTAKE
HL Dichek, W Brecht, J Fan, ZS Ji, SP McCormick, H Akeefe, LA Conzo, DA Sanan, KH Weisgraber, SG Young, JM Taylor, RW Mahley |
The Journal of biological chemistry | 1998 |
Interaction between ApoB and Hepatic Lipase Mediates the Uptake of ApoB-containing Lipoproteins
SY Choi, IJ Goldberg, LK Curtiss, AD Cooper |
The Journal of biological chemistry | 1998 |
Elevated LDL Triglyceride Concentrations in Subjects Heterozygous for the Hepatic Lipase S267F Variant
RA Hegele, WC Breckenridge, DW Cox, GF Maguire, JA Little, PW Connelly |
Arteriosclerosis, thrombosis, and vascular biology | 1998 |
Metabolism of lipoproteins containing apolipoprotein B in hepatic lipase-deficient mice
S Qiu, N Bergeron, L Kotite, RM Krauss, A Bensadoun, RJ Havel |
Journal of lipid research | 1998 |
Lipoprotein lipase gene variants and risk of coronary disease: a quantitative analysis of population-based studies
JE Hokanson |
International Journal of Clinical & Laboratory Research | 1997 |
Low-density lipoprotein subclasses: mechanisms of formation and modulation
BA Griffin |
Proceedings of the Nutrition Society | 1997 |
Hepatic Lipase Deficiency Increases Plasma Cholesterol but Reduces Susceptibility to Atherosclerosis in Apolipoprotein E-deficient Mice
H Mezdour, R Jones, C Dengremont, G Castro, N Maeda |
The Journal of biological chemistry | 1997 |
Heterozygous hepatic lipase deficiency, due to two missense mutations R186H and L334F, in the HL gene
P Knudsen, M Antikainen, M Uusi-Oukari, S Ehnholm, S Lahdenperä, A Bensadoun, H Funke, H Wiebusch, G Assmann, MR Taskinen, C Ehnholm |
Atherosclerosis | 1997 |
Associations of Age, Adiposity, Menopause, and Alcohol Intake With Low-Density Lipoprotein Subclasses
PT Williams, RM Krauss |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
Lipoprotein Heterogeneity and Apolipoprotein B Metabolism
CJ Packard, J Shepherd |
Arteriosclerosis, thrombosis, and vascular biology | 1997 |
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LK Kwong, DN Ridinger, M Bandhauer, JH Ward, WE Samlowski, PH Iverius, H Pritchard, DE Wilson |
The Journal of clinical endocrinology and metabolism | 1997 |
Role of Apolipoprotein A-IV in Hepatic Lipase-Catalyzed Dolichol Acylation and Phospholipid Hydrolysis
PJ Sindelar, T Chojnacki, C Valtersson |
Biochemistry | 1997 |
Adenovirus-mediated expression of hepatic lipase in LCAT transgenic mice
KA Dugi, BL Vaisman, N Sakai, CL Knapper, SM Meyn, HB Brewer, S Santamarina-Fojo |
Journal of lipid research | 1997 |
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SY Choi, L Pang, PA Kern, HJ Kayden, LK Curtiss, TM Vanni-Reyes, IJ Goldberg |
Journal of lipid research | 1997 |
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MW Huff, DB Miller, BM Wolfe, PW Connelly, CG Sawyez |
Journal of lipid research | 1997 |
Effect of testosterone replacement therapy on lipids and lipoproteins in hypogonadal and elderly men
S Zgliczynski, M Ossowski, J Slowinska-Srzednicka, A Brzezinska, W Zgliczynski, P Soszynski, E Chotkowska, M Srzednicki, Z Sadowski |
Atherosclerosis | 1996 |
Functional molecular mass of rat hepatic lipase in liver, adrenal gland and ovary is different
K Schoonderwoerd, ML Hom, LH Luthjens, DV van Bruggen, H Jansen |
Biochemical Journal | 1996 |
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis
IJ Goldberg |
Journal of lipid research | 1996 |
Improvement in hyperchylomicronemia, transient deficiency in lipoprotein lipase and hepatic triglyceride lipase activity, and diabetes mellitus produced by pravastatin and bezafibrate: a case report
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Current Therapeutic Research | 1996 |
Inhibition of hepatic lipase by m-aminophenylboronate application of phenylboronate affinity chromatography for purification of human postheparin plasma lipases
M Uusi-Oukari, C Ehnholm, M Jauhlainen |
Journal of Chromatography B Biomedical Sciences and Applications | 1996 |
Apolipoprotein A-II Influences the Substrate Properties of Human HDL 2 and HDL 3 for Hepatic Lipase
HO Mowri, JR Patsch, AM Gotto, W Patsch |
Arteriosclerosis, thrombosis, and vascular biology | 1996 |
Effects of Intravenous Infusion of Lipid-Free Apo A-I in Humans
MN Nanjee, JR Crouse, JM King, R Hovorka, SE Rees, ER Carson, JJ Morgenthaler, P Lerch, NE Miller |
Arteriosclerosis, thrombosis, and vascular biology | 1996 |
Drugs Affecting Lipid Metabolism
AM Gotto, R Paoletti, LC Smith, AL Catapano, AS Jackson |
1996 | |
A compound heterozygote for hepatic lipase gene mutations Leu334–>Phe and Thr383–>Met: correlation between hepatic lipase activity and phenotypic expression
P Knudsen, M Antikainen, S Ehnholm, M Uusi-Oukari, H Tenkanen, S Lahdenperä, J Kahri, M Tilly-Kiesi, A Bensadoun, MR Taskinen, C Ehnholm |
Journal of lipid research | 1996 |
Modulation of low density lipoprotein subclasses by alimentary lipemia in control and normotriglyceridemic non-insulin-dependent diabetic subjects
N Attia, V Durlach, JL Paul, T Soni, D Betoulle, A Girard-Globa |
Atherosclerosis | 1995 |
In vitro Catabolism of very low density lipoproteins from horse (Equus caballus) by the action of autologous lipoprotein lipase
CS Stachel, HO Weik |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | 1995 |
Endogenous sex hormones: Impact on lipids, lipoproteins, and insulin
SM Haffner, RA Valdez |
The American Journal of Medicine | 1995 |
Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene
PK Frykman, MS Brown, T Yamamoto, JL Goldstein, J Herz |
The Journal of biological chemistry | 1995 |
The Cellular Internalization and Degradation of Hepatic Lipase Is Mediated by Low Density Lipoprotein Receptor-related Protein and Requires Cell Surface Proteoglycans
MZ Kounnas, DA Chappell, H Wong, WS Argraves, DK Strickland |
The Journal of biological chemistry | 1995 |
Human Hepatic and Lipoprotein Lipase: The Loop Covering the Catalytic Site Mediates Lipase Substrate Specificity
KA Dugi, HL Dichek, S Santamarina-Fojo |
The Journal of biological chemistry | 1995 |
Hepatic lipase and lipoprotein lipase are not major determinants of the low density lipoprotein subclass pattern in human subjects with coronary heart disease
H Jansen, W Hop, A Tol, AV Bruschke, JC Birkenhäger |
Atherosclerosis | 1994 |
Effects of bezafibrate therapy on subfractions of plasma low-density lipoprotein and high-density lipoprotein, and on activities of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in patients with hyperlipoproteinemia
Y Homma, H Ozawa, T Kobayashi, H Yamaguchi, H Sakane, Y Mikamia, Y Mikami, H Nakamura |
Atherosclerosis | 1994 |
Rat liver contains a limited number of binding sites for hepatic lipase
K Schoonderwoerd, AJ Verhoeven, H Jansen |
Biochemical Journal | 1994 |
Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins
J Fan, J Wang, A Bensadoun, SJ Lauer, Q Dang, RW Mahley, JM Taylor |
Proceedings of the National Academy of Sciences | 1994 |
Lipoprotein metabolism and its relationship to atherosclerosis
HN Ginsberg |
Medical Clinics of North America | 1994 |
Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture
ZS Ji, SJ Lauer, S Fazio, A Bensadoun, JM Taylor, RW Mahley |
The Journal of biological chemistry | 1994 |
Continuous intravenous heparin administration in humans causes a decrease in serum lipolytic activity and accumulation of chylomicrons in circulation
M Weintraub, T Rassin, S Eisenberg, Y Ringel, I Grosskopf, A Iaina, G Charach, M Liron, A Rubinstein |
Journal of lipid research | 1994 |
Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E
HV de Silva, SJ Lauer, J Wang, WS Simonet, KH Weisgraber, RW Mahley, JM Taylor |
The Journal of biological chemistry | 1994 |
Physical Activity and Lipoprotein Lipid Disorders:
A Berg, I Frey, MW Baumstark, M Halle, J Keul |
Sports Medicine | 1994 |
Lipoprotein Metabolism: An Overview
J Shepherd |
Drugs | 1994 |
Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities
G Miesenböck, B Hölzl, B Föger, E Brandstätter, B Paulweber, F Sandhofer, JR Patsch |
Journal of Clinical Investigation | 1993 |
Metabolism of apolipoprotein B-100 and of triglyceride-rich lipoprotein particles in the absence of functional lipoprotein lipase
PJ Pacy, KA Mitropoulos, S Venkatesan, GF Watts, BE Reeves, D Halliday |
Atherosclerosis | 1993 |
Reduced lipolysis of large apo E-poor very-low-density lipoprotein subfractions from type IV hypertriglyceridemic subjects in vitro and in vivo
AJ Evans, BM Wolfe, WL Strong, MW Huff |
Metabolism | 1993 |
Hepatic lipase function and the accumulation of beta-very-low-density lipoproteins in the plasma of cholesterol-fed rabbits
S Chang, J Borensztajn |
Biochemical Journal | 1993 |
Lipoprotein lipases, lipoprotein density gradient profile and LDL receptor activity in miniature pigs fed fish oil and corn oil
MW Huff, DE Telford, BW Edmonds, CG McDonald, AJ Evans |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1993 |
Effect of hepatic lipase on LDL in normal men and those with coronary artery disease
A Zambon, MA Austin, BG Brown, JE Hokanson, JD Brunzell |
Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
LDL size and subclass pattern in a biethnic population
SM Haffner, L Mykkänen, RA Valdez, M Paidi, MP Stern, BV Howard |
Arteriosclerosis Thrombosis and Vascular Biology | 1993 |
Functional characterization of a chimeric lipase genetically engineered from human lipoprotein lipase and human hepatic lipase
HL Dichek, C Parrott, R Ronan, JD Brunzell, HB Brewer, S Santamarina-Fojo |
Journal of lipid research | 1993 |
Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E
DL Brasaemle, K Cornely-Moss, A Bensadoun |
Journal of lipid research | 1993 |
Regulation of hepatic triglyceride lipase by thyroid hormone in HepG2 cells
S Kihara, J Wölle, C Ehnholm, L Chan, K Oka |
Journal of lipid research | 1993 |
The effects of dietary calcium and chlordecone on cholinesterase, triglycerides, low density lipoproteins, and cholesterol in serum of rat.
Chetty KN, Walker J, Brown K, Ivie GW |
Archives of Environmental Contamination and Toxicology | 1993 |
Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. No evidence for a triglyceride-rich precursor of lipoprotein(a)
C Sandholzer, G Feussner, J Brunzell, G Utermann |
Journal of Clinical Investigation | 1992 |
Determinants of fasting plasma triglyceride levels: metabolism of hepatic and intestinal lipoproteins
JA Cortner, NA Le, PM Coates, MJ Bennett, DR Cryer |
European Journal of Clinical Investigation | 1992 |
A missense mutation (Trp86----Arg) in exon 3 of the lipoprotein lipase gene: a cause of familial chylomicronemia
K Ishimura-Oka, F Faustinella, S Kihara, LC Smith, K Oka, L Chan |
The American Journal of Human Genetics | 1992 |
Effects of intralipid-induced hypertriglyceridemia on plasma high-density lipoprotein metabolism in the cynomolgus monkey
IJ Goldberg, TM Vanni, R Ramakrishnan |
Metabolism | 1992 |
Preheparin lipoprotein lipolytic activities: relationship to plasma lipoproteins and postheparin lipolytic activities
DS Glaser, TJ Yost, RH Eckel |
Journal of lipid research | 1992 |
Structure and evolution of the lipase superfamily
WA Hide, L Chan, WH Li |
Journal of lipid research | 1992 |
Chylomicron-retinyl palmitate clearance in type I hyperlipidemic families
DL Sprecher, SL Knauer, DM Black, LA Kaplan, AA Akeson, M Dusing, D Lattier, EA Stein, M Rymaszewski, DA Wiginton |
Journal of Clinical Investigation | 1991 |
Effects of probucol on plasma lipoprotein subfractions and activities of lipoprotein lipase and hepatic triglyceride lipase
Y Homma, EH Moriguchi, H Sakane, H Ozawa, H Nakamura, Y Goto |
Atherosclerosis | 1991 |
ACTH 1-24 decreases hepatic lipase activities and low density lipoprotein concentrations in healthy men
AL Berg, P Hansson, P Nilsson-Ehle |
Journal of Internal Medicine | 1991 |
Differential low density lipoprotein hydrated density distribution in female and male patients with familial hypercholesterolemia
MK Tilly-Kiesi, MJ Tikkanen |
Clinica Chimica Acta | 1991 |
Secretion-coupled increase in the catalytic activity of rat hepatic lipase
AJ Verhoeven, H Jansen |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1991 |
Estradiol increases the secretion of hepatic lipase by rat hepatocyte cultures
N Emmison, VA Zammit, L Agius |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1991 |
Hydrolysis of chylomicron polyenoic fatty acid esters with lipoprotein lipase and hepatic lipase
T Melin, C Qi, G Bengtsson-Olivecrona, B A˚kesson, A Nilsson |
Biochimica et Biophysica Acta (BBA) - General Subjects | 1991 |
Molecular cloning of mouse hepatic triacylglycerol lipase: gene expression in combined lipase-deficient (cld/cld) mice
K Oka, T Nakano, GT Tkalcevic, RO Scow, WV Brown |
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 1991 |
Fatty acid composition of hepatic triglycerides in Reye's syndrome: implications for hepatic desaturase abnormalities
ES Kang, SB Johnson, RT Holman |
Clinica Chimica Acta | 1991 |
Hepatic lipase hydrolysis of lipid monolayers. Regulation by apolipoproteins
T Thuren, RW Wilcox, P Sisson, M Waite |
The Journal of biological chemistry | 1991 |
Comparative acyl specificities for transfer and selective uptake of high density lipoprotein cholesteryl esters
, RC Pittman |
Journal of lipid research | 1991 |
The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation
IJ Goldberg, JJ Kandel, CB Blum, HN Ginsberg |
Journal of Clinical Investigation | 1990 |
Role of lipoprotein lipase in the regulation of high density lipoprotein apolipoprotein metabolism. Studies in normal and lipoprotein lipase-inhibited monkeys
IJ Goldberg, WS Blaner, TM Vanni, M Moukides, R Ramakrishnan |
Journal of Clinical Investigation | 1990 |
Atypical type III hyperlipoproteinemia in a patient with Ig A myelomatosis
G Feussner, E Hodenberg, R Ziegler |
Klinische Wochenschrift | 1990 |
Coexistence of abnormalities of hepatic lipase and lipoprotein lipase in a large family
JH Auwerx, SP Babirak, JE Hokanson, G Stahnke, H Will, SS Deeb, JD Brunzell |
The American Journal of Human Genetics | 1990 |
Plasma lipoproteins and atherosclerosis
MJ Tikkanen |
Journal of Diabetic Complications | 1990 |
The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation
IJ Goldberg, JJ Kandel, CB Blum, HN Ginsberg |
Journal of Biological Chemistry | 1990 |
The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation
IJ Goldberg, JJ Kandel, CB Blum, HN Ginsberg |
Journal of Biological Chemistry | 1990 |
Role of plasma lipoproteins in the pathogenesis of atherosclerotic disease, with special reference to sex hormone effects
MJ Tikkanen |
American Journal of Obstetrics and Gynecology | 1990 |
9 Hypertriglyceridaemia, triglyceride-rich lipoproteins and coronary heart disease
A Hamsten |
Baillière's Clinical Endocrinology and Metabolism | 1990 |
Cholesterol Metabolism, Ldl, and the Ldl Receptor
NB Myant |
Cholesterol Metabolism, Ldl, and the Ldl Receptor | 1990 |
Lipoprotein Physiology and Its Relationship to Atherogenesis
HN Ginsberg |
Endocrinology and metabolism clinics of North America | 1990 |
Species, diet, and gender differences in plasma postheparin lipolytic activities in nonhuman primates. Relationships with plasma lipids and high density lipoproteins
LL Rudel, RJ Star |
Arteriosclerosis (Dallas, Tex.) | 1990 |
Plasma lipoproteins in familial hepatic lipase deficiency
PW Connelly, GF Maguire, M Lee, JA Little |
Arteriosclerosis (Dallas, Tex.) | 1990 |
Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV
IJ Goldberg, CA Scheraldi, LK Yacoub, U Saxena, CL Bisgaier |
The Journal of biological chemistry | 1990 |
Isolation and characterization of the human hepatic lipase gene
D Ameis, G Stahnke, J Kobayashi, J McLean, G Lee, M Büscher, MC Schotz, H Will |
The Journal of biological chemistry | 1990 |
Combined (n-3 and n-6) essential fatty deficiency is a potent modulator of plasma lipids, lipoprotein composition, and lipolytic enzymes
E Levy, L Thibault, C Garofalo, M Messier, G Lepage, N Ronco, CC Roy |
Journal of lipid research | 1990 |
Synthesis of inactive nonsecretable high mannose-type lipoprotein lipase by cultured brown adipocytes of combined lipase-deficient cld/cld mice
H Masuno, EJ Blanchette-Mackie, SS Chernick, RO Scow |
The Journal of biological chemistry | 1990 |
Secretion of rat hepatic lipase is blocked by inhibition of oligosaccharide processing at the stage of glucosidase I
AJ Verhoeven, H Jansen |
Journal of lipid research | 1990 |
Modifications of plasma lipoproteins after lipase activation in patients with chylomicronemia
E Manzato, S Zambon, R Marin, G Baggio, G Crepaldi |
Journal of lipid research | 1990 |
Hepatic lipase: site-directed mutagenesis of a serine residue important for catalytic activity
RC Davis, G Stahnke, H Wong, MH Doolittle, D Ameis, H Will, MC Schotz |
The Journal of biological chemistry | 1990 |
Effects of estrogen on low density lipoprotein metabolism in males. Short-term and long-term studies during hormonal treatment of prostatic carcinoma
M Eriksson, L Berglund, M Rudling, P Henriksson, B Angelin |
Journal of Clinical Investigation | 1989 |
Lipids, Diabetes, and Vascular Disease: The Time to Act
DJ Betteridge |
Diabetic Medicine | 1989 |
The rabbit as an animal model of hepatic lipase deficiency
MA Clay, GJ Hopkins, CP Ehnholm, PJ Barter |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1989 |
Seasonal variations of plasma lipids and lipoproteins in the hedgehog, an animal model for lipoprotein (a) metabolism: relation to plasma thyroxine and testosterone levels
PM Laplaud, M Saboureau, L Beaubatie, B El-Omari |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1989 |
Phosphatidylcholine and triacylglycerol hydrolysis in HDL as induced by hepatic lipase: modulation of the phospholipase activity by changes in the particle surface or in the lipid core
G Simard, B Perret, S Durand, X Collet, H Chap, L Douste-Blazy |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1989 |
Heparin decreases the degradation rate of hepatic lipase in Fu5AH rat hepatoma cells. A model for hepatic lipase efflux from hepatocytes
LA Cisar, KH Melford, M Sensel, A Bensadoun |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1989 |
Circulating and liver-bound salt-resistant hepatic lipases in the golden hamster
H Jansen, R Lammers, MG Baggen, NM Wouters, JC Birkenhäger |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1989 |
Large buoyant LDL-like particles in hepatic lipase deficiency
JH Auwerx, CA Marzetta, JE Hokanson, JD Brunzell |
Arteriosclerosis (Dallas, Tex.) | 1989 |
Human Apolipoprotein Mutants 2
CR Sirtori, G Franceschini, HB Brewer, G Assmann |
1989 | |
The fatty liver dystrophy (fld) mutation
CA Langner, EH Birkenmeier, O Ben-Zeev, MC Schotz, HO Sweet, MT Davisson, JI Gordon |
The Journal of biological chemistry | 1989 |
Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution
CF Semenkovich, SH Chen, M Wims, CC Luo, WH Li, L Chan |
Journal of lipid research | 1989 |
Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review
WS Harris |
Journal of lipid research | 1989 |
Apolipoprotein B metabolism in homozygous familial hypercholesterolemia
RW James, B Martin, D Pometta, JC Fruchart, P Duriez, P Puchois, JP Farriaux, A Tacquet, T Demant, RJ Clegg |
Journal of lipid research | 1989 |
Lipoprotein metabolism during acute inhibition of lipoprotein lipase in the cynomolgus monkey
IJ Goldberg, NA Le, HN Ginsberg, RM Krauss, FT Lindgren |
Journal of Clinical Investigation | 1988 |
Effect of lipoprotein lipase and hepatic triglyceride lipase activity on the distribution of apolipoprotein E among the plasma lipoproteins
JC Gibson, WV Brown |
Atherosclerosis | 1988 |
Very low density lipoprotein apolipoprotein B metabolism in humans
T Demant, J Shepherd, CJ Packard |
Klinische Wochenschrift | 1988 |
Familial lipoprotein lipase deficiency: abnormal lipoproteins and defective metabolism of low density lipoproteins in cultured human skin fibroblasts
Y Kleinmann, Y Oschry, GM Berger, S Eisenberg |
Atherosclerosis | 1988 |
Studies on the function of hepatic lipase in the cat after immunological blockade of the enzyme in vivo
PN Demacker, AG Hijmans, AF Stalenhoef, A Laar |
Atherosclerosis | 1988 |
Membrane-bound lipoprotein lipase on human monocyte-derived macrophages: localization by immunocolloidal gold technique
IJ Goldberg, DA Handley, T Vanni, JR Paterniti, JA Cornicelli |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1988 |
Influence of the structure of the lipid-water interface on the activity of hepatic lipase
HM Laboda, JM Glick, MC Phillips |
Biochemistry | 1988 |
Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein
T Demant, LA Carlson, L Holmquist, F Karpe, P Nilsson-Ehle, CJ Packard, J Shepherd |
Journal of lipid research | 1988 |
Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins
NA Le, JC Gibson, HN Ginsberg |
Journal of lipid research | 1988 |
Lipoprotein[a] is the major apoB-containing lipoprotein in the plasma of a hibernator, the hedgehog (Erinaceus europaeus)
PM Laplaud, L Beaubatie, SC Rall, G Luc, M Saboureau |
Journal of lipid research | 1988 |
Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase
S Datta, CC Luo, WH Li, P VanTuinen, DH Ledbetter, MA Brown, SH Chen, SW Liu, L Chan |
The Journal of biological chemistry | 1988 |
Uptake of chylomicron remnants by the liver: further evidence for the modulating role of phospholipids
J Borensztajn, GS Getz, TJ Kotlar |
Journal of lipid research | 1988 |
Divergent effects of d-norgestrel on the metabolism of rat very low density and low density apolipoprotein B
R Khokha, MW Huff, BM Wolfe |
Journal of lipid research | 1988 |
Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil
MS Weintraub, S Eisenberg, JL Breslow |
Journal of Clinical Investigation | 1987 |
Phospholipases, lysophospholipases, and lipases and their involvement in various diseases
AA Farooqui, WA Taylor, LA Horrocks |
Neurochemical Pathology | 1987 |
Very low density lipoprotein metabolism in diabetes mellitus
HN Ginsberg |
Diabetes / Metabolism Reviews | 1987 |
A study of the lipid transport system in the cat, Felix domesticus
PN Demacker, PJ van Heijst, HL Hak-Lemmers, AF Stalenhoef |
Atherosclerosis | 1987 |
Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line
G Stahnke, R Sprengel, J Augustin, H Will |
Differentiation | 1987 |
Determinants of the uptake of very low density lipoprotein remnants by the perfused rat liver
CM Arbeeny, VA Rifici, DA Handley, HA Eder |
Metabolism | 1987 |
Effects of estrogen/progestin agents on plasma retinoids and chylomicron remnant metabolism
JM Gleeson, CS Dukes, NL Elstad, IF Chan, DE Wilson |
Contraception | 1987 |
3 Postprandial lipaemia
JR Patsch |
Baillière's Clinical Endocrinology and Metabolism | 1987 |
7 Enzymes involved in triglyceride hydrolysis
MR Taskinen, T Kuusi |
Baillière's Clinical Endocrinology and Metabolism | 1987 |
Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family
MC Komaromy, MC Schotz |
Proceedings of the National Academy of Sciences | 1987 |
Hepatic lipase: a member of a family of structurally related lipases
O Ben-Zeev, CM Ben-Avram, H Wong, J Nikazy, JE Shively, MC Schotz |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1987 |
Regulation of hepatic lipase and serum lipoproteins by sex steroids
MJ Tikkanen, EA Nikkilä |
American Heart Journal | 1987 |
Structural modulation of salt-resistant rat-liver lipase alters the relative phospholipase and triacylglycerol hydrolase activities
NL Persoon, WC Hülsmann, H Jansen |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1987 |
Subfractionation of 1.006-1.063 g/ml components of badger plasma lipoproteins by using heparin-Sepharose affinity chromatography: relevance to the endocrine regulation of lipoprotein metabolism
PM Laplaud, L Beaubatie, SC Rall, D Maurel |
Journal of lipid research | 1987 |
Synthesis of hepatic lipase in liver and extrahepatic tissues
MH Doolittle, H Wong, RC Davis, MC Schotz |
Journal of lipid research | 1987 |
Hydrolysis of chylomicron arachidonate and linoleate ester bonds by lipoprotein lipase and hepatic lipase
A Nilsson, B Landin, MC Schotz |
Journal of lipid research | 1987 |
Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo
HN Ginsberg, NA Le, IJ Goldberg, JC Gibson, A Rubinstein, P Wang-Iverson, R Norum, WV Brown |
Journal of Clinical Investigation | 1986 |
Endothelial bound lipases and lipoprotein metabolism in disease and drug development
K Oka, JR Paterniti |
Drug Development Research | 1986 |
Deficiency of Hepatic Lipase Activity in Post-heparin Plasma in Familial Hyper-α-Triglyceridemia
LA Carlson, L Holmquist, P Nilsson-Ehle |
Acta Medica Scandinavica | 1986 |
Lipoprotein subfractions of runners and sedentary men
PT Williams, RM Krauss, PD Wood, FT Lindgren, C Giotas, KM Vranizan |
Metabolism: clinical and experimental | 1986 |
The role of hepatic triglyceride lipase in the metabolism of intermediate-density lipoprotein—Postheparin lipolytic activities determined by a sensitive, nonradioisotopic method in hyperlipidemic patients and normals
S Nozaki, M Kubo, H Sudo, Y Matsuzawa, S Tarui |
Metabolism | 1986 |
Evidence for heterogeneity of low-density lipoprotein metabolism in the cynomolgus monkey
IJ Goldberg, NA Le, B Leeman, WV Brown, FT Lindgren |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1986 |
Immunologic and enzymatic comparisons between human and bovine lipoprotein lipase
IJ Goldberg, WS Blaner, DW Goodman |
Archives of Biochemistry and Biophysics | 1986 |
Effect of dietary carbohydrate type on lipoprotein lipase, hepatic lipase, and lecithin: Cholesterol acyltransferase activities in cynomolgus monkeys
C Sharma, SR Srinivasan, B Radhakrishnamurthy, GS Berenson |
Biochemical Medicine and Metabolic Biology | 1986 |
Hyperlipidemia in mast cell-deficient W/WV mice
K Hatanaka, H Tanishita, H Ishibashi-Ueda, A Yamamoto |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1986 |
Release of hepatic lipase and very low density lipoprotein by cultured rat hepatocytes
AC Rustan, JØ Nossen, JP Blomhoff, CA Drevon |
International Journal of Biochemistry | 1986 |
Hepatic triacylglycerol lipase in circulating blood of normal and tumor-bearing mice and its hydrolysis of very-low-density lipoprotein and synthetic acylglycerols
M Hiroshi, O Hiromichi |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1986 |
Hydrolysis of lipid monolayers and the substrate specificity of hepatic lipase
HM Laboda, JM Glick, MC Phillips |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1986 |
Comparison of the triacylglycerol hydrolase activity of human post-heparin plasma lipoprotein lipase and hepatic triacylglycerol lipase. A monolayer study
RL Jackson, E Ponce, LR McLean, RA Demel |
Biochemistry | 1986 |
Intravenous Administration of Lipid Emulsions to Premature Infants
GE Stahl, ML Spear, M Hamosh |
Clinics in Perinatology | 1986 |
Lipoprotein Deficiency Syndromes
A Angel, J Frohlich |
1986 | |
Effect of heparin-induced lipolysis on the distribution of apolipoprotein e among lipoprotein subclasses. Studies with patients deficient in hepatic triglyceride lipase and lipoprotein lipase
A Rubinstein, JC Gibson, JR Paterniti, G Kakis, A Little, HN Ginsberg, WV Brown |
Journal of Clinical Investigation | 1985 |
Plasma lipoprotein abnormalities associated with acquired hepatic triglyceride lipase deficiency
IJ Goldberg, RG Mazlen, A Rubenstein, JC Gibson, JR Paterniti, FT Lindgren, WV Brown |
Metabolism | 1985 |
Very low density lipoprotein triglyceride kinetics during hepatic lipase suppression by estrogen
MJ Tikkanen, T Kuusi, EA Nikkilä, T Sane |
FEBS Letters | 1985 |
Demonstration of hepatic triglyceride lipase-like activity in ascites fluid of mice with sarcoma 180
H Masuno, H Okuda |
European Journal of Cancer and Clinical Oncology | 1985 |
Enzyme-linked immunosorbent assay for rat hepatic triglyceride lipase
LA Cisar, A Bensadoun |
Journal of lipid research | 1985 |
Purification and characterization of human lipoprotein lipase and hepatic triglyceride lipase. Reactivity with monoclonal antibodies to hepatic triglyceride lipase
CF Cheng, A Bensadoun, T Bersot, JS Hsu, KH Melford |
The Journal of biological chemistry | 1985 |
Apolipoprotein A and B (Sf 100-400) metabolism during bezafibrate therapy in hypertriglyceridemic subjects
J Shepherd, CJ Packard, JM Stewart, RF Atmeh, RS Clark, DE Boag, K Carr, AR Lorimer, D Ballantyne, HG Morgan |
Journal of Clinical Investigation | 1984 |
Relationship between serum lipids, lipoproteins and pseudocholinesterase during organophosphate poisoning in rabbits
R Ryhänen, J Herranen, K Korhonen, I Penttilä, M Polvilampi, E Puhakainen |
International Journal of Biochemistry | 1984 |
Effect of low-dose oral contraceptives on lipoproteins and lipolytic enzymes: Differences between two commonly used preparations
JA Leuven, L Havekes, HA der Kooij-Pontier, RJ Starmans, H Jansen, ML Bouwhuis-Hoogerwerf, HA Pagter, LW Hessel |
Metabolism | 1984 |
Alterations in plasma lipoproteins and heparin-releasable lipase activities in mice bearing the grsl ascites tumor
J Damen, JV Ramshorst, RP van Hoeven, WJ van Blitterswijk |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1984 |
The formation of LDL: mechanisms and regulation
RJ Havel |
Journal of lipid research | 1984 |
High density lipoprotein metabolism
S Eisenberg |
Journal of lipid research | 1984 |
Acute inhibition of hepatic lipase and increase in plasma lipoproteins after alcohol intake
CS Goldberg, AR Tall, S Krumholz |
Journal of lipid research | 1984 |
Lipoprotein lipase-like activity in the liver of mice with Sarcoma 180
H Masuno, T Tsujita, H Nakanishi, A Yoshida, R Fukunishi, H Okuda |
Journal of lipid research | 1984 |
New Comprehensive Biochemistry
S Yamamoto |
New Comprehensive Biochemistry | 1983 |
Measurement of lipoprotein lipase and hepatic triacylglycerol lipase in post-heparin plasma of the cynomolgus monkey
IJ Goldberg, JR Paterniti, WV Brown |
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism | 1983 |
Combined Lipase Deficiency ( cld ): a Lethal Mutation on Chromosome 17 of the Mouse
JR Paterniti, WV Brown, HN Ginsberg, K Artzt |
Science | 1983 |