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Citations to this article

Lipoprotein Metabolism during Acute Inhibition of Hepatic Triglyceride Lipase in the Cynomolgus Monkey
Ira J. Goldberg, … , Frank T. Lindgren, W. Virgil Brown
Ira J. Goldberg, … , Frank T. Lindgren, W. Virgil Brown
Published December 1, 1982
Citation Information: J Clin Invest. 1982;70(6):1184-1192. https://doi.org/10.1172/JCI110717.
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Lipoprotein Metabolism during Acute Inhibition of Hepatic Triglyceride Lipase in the Cynomolgus Monkey

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Abstract

The role of the enzyme hepatic triglyceride lipase was investigated in a primate model, the cynomolgus monkey. Antisera produced against human postheparin hepatic lipase fully inhibited cynomolgus monkey posttheparin plasma hepatic triglyceride lipase activity. Lipoprotein lipase activity was not inhibited by this antisera. Hepatic triglyceride lipase activity in liver biopsies was decreased by 65-90% after intravenous infusion of this antisera into the cynomolgus monkey. After a 3-h infusion of the antisera, analytic ultracentrifugation revealed an increase in mass of very low density lipoproteins (Sf 20-400). Very low density lipoprotein triglyceride isolated by isopycnic ultracentrifugation increased by 60-300%. Analytic ultracentrifugation revealed an increase in mass of lipoproteins with flotation greater than Sf 9 (n = 4). The total mass of intermediate density lipoproteins (Sf 12-20) approximately doubled during the 3 h of in vivo enzyme inhibition. While more rapidly floating low density lipoproteins (Sf 9-12) increased, the total mass of low density lipoproteins decreased after infusion of the antibodies. The changes in high density lipoproteins did not differ from those in control experiments.

Authors

Ira J. Goldberg, Ngoc-Anh Le, James R. Paterniti Jr., Henry N. Ginsberg, Frank T. Lindgren, W. Virgil Brown

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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1991
Estradiol increases the secretion of hepatic lipase by rat hepatocyte cultures
N Emmison, VA Zammit, L Agius
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1991
Hydrolysis of chylomicron polyenoic fatty acid esters with lipoprotein lipase and hepatic lipase
T Melin, C Qi, G Bengtsson-Olivecrona, B A˚kesson, A Nilsson
Biochimica et Biophysica Acta (BBA) - General Subjects 1991
Molecular cloning of mouse hepatic triacylglycerol lipase: gene expression in combined lipase-deficient (cld/cld) mice
K Oka, T Nakano, GT Tkalcevic, RO Scow, WV Brown
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1991
Fatty acid composition of hepatic triglycerides in Reye's syndrome: implications for hepatic desaturase abnormalities
ES Kang, SB Johnson, RT Holman
Clinica Chimica Acta 1991
Hepatic lipase hydrolysis of lipid monolayers. Regulation by apolipoproteins
T Thuren, RW Wilcox, P Sisson, M Waite
The Journal of biological chemistry 1991
Comparative acyl specificities for transfer and selective uptake of high density lipoprotein cholesteryl esters
, RC Pittman
Journal of lipid research 1991
The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation
IJ Goldberg, JJ Kandel, CB Blum, HN Ginsberg
Journal of Clinical Investigation 1990
Role of lipoprotein lipase in the regulation of high density lipoprotein apolipoprotein metabolism. Studies in normal and lipoprotein lipase-inhibited monkeys
IJ Goldberg, WS Blaner, TM Vanni, M Moukides, R Ramakrishnan
Journal of Clinical Investigation 1990
Atypical type III hyperlipoproteinemia in a patient with Ig A myelomatosis
G Feussner, E Hodenberg, R Ziegler
Klinische Wochenschrift 1990
Coexistence of abnormalities of hepatic lipase and lipoprotein lipase in a large family
JH Auwerx, SP Babirak, JE Hokanson, G Stahnke, H Will, SS Deeb, JD Brunzell
The American Journal of Human Genetics 1990
Plasma lipoproteins and atherosclerosis
MJ Tikkanen
Journal of Diabetic Complications 1990
The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation
IJ Goldberg, JJ Kandel, CB Blum, HN Ginsberg
Journal of Biological Chemistry 1990
The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation
IJ Goldberg, JJ Kandel, CB Blum, HN Ginsberg
Journal of Biological Chemistry 1990
Role of plasma lipoproteins in the pathogenesis of atherosclerotic disease, with special reference to sex hormone effects
MJ Tikkanen
American Journal of Obstetrics and Gynecology 1990
9 Hypertriglyceridaemia, triglyceride-rich lipoproteins and coronary heart disease
A Hamsten
Baillière's Clinical Endocrinology and Metabolism 1990
Cholesterol Metabolism, Ldl, and the Ldl Receptor
NB Myant
Cholesterol Metabolism, Ldl, and the Ldl Receptor 1990
Lipoprotein Physiology and Its Relationship to Atherogenesis
HN Ginsberg
Endocrinology and metabolism clinics of North America 1990
Species, diet, and gender differences in plasma postheparin lipolytic activities in nonhuman primates. Relationships with plasma lipids and high density lipoproteins
LL Rudel, RJ Star
Arteriosclerosis (Dallas, Tex.) 1990
Plasma lipoproteins in familial hepatic lipase deficiency
PW Connelly, GF Maguire, M Lee, JA Little
Arteriosclerosis (Dallas, Tex.) 1990
Lipoprotein ApoC-II activation of lipoprotein lipase. Modulation by apolipoprotein A-IV
IJ Goldberg, CA Scheraldi, LK Yacoub, U Saxena, CL Bisgaier
The Journal of biological chemistry 1990
Isolation and characterization of the human hepatic lipase gene
D Ameis, G Stahnke, J Kobayashi, J McLean, G Lee, M Büscher, MC Schotz, H Will
The Journal of biological chemistry 1990
Combined (n-3 and n-6) essential fatty deficiency is a potent modulator of plasma lipids, lipoprotein composition, and lipolytic enzymes
E Levy, L Thibault, C Garofalo, M Messier, G Lepage, N Ronco, CC Roy
Journal of lipid research 1990
Synthesis of inactive nonsecretable high mannose-type lipoprotein lipase by cultured brown adipocytes of combined lipase-deficient cld/cld mice
H Masuno, EJ Blanchette-Mackie, SS Chernick, RO Scow
The Journal of biological chemistry 1990
Secretion of rat hepatic lipase is blocked by inhibition of oligosaccharide processing at the stage of glucosidase I
AJ Verhoeven, H Jansen
Journal of lipid research 1990
Modifications of plasma lipoproteins after lipase activation in patients with chylomicronemia
E Manzato, S Zambon, R Marin, G Baggio, G Crepaldi
Journal of lipid research 1990
Hepatic lipase: site-directed mutagenesis of a serine residue important for catalytic activity
RC Davis, G Stahnke, H Wong, MH Doolittle, D Ameis, H Will, MC Schotz
The Journal of biological chemistry 1990
Effects of estrogen on low density lipoprotein metabolism in males. Short-term and long-term studies during hormonal treatment of prostatic carcinoma
M Eriksson, L Berglund, M Rudling, P Henriksson, B Angelin
Journal of Clinical Investigation 1989
Lipids, Diabetes, and Vascular Disease: The Time to Act
DJ Betteridge
Diabetic Medicine 1989
The rabbit as an animal model of hepatic lipase deficiency
MA Clay, GJ Hopkins, CP Ehnholm, PJ Barter
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1989
Seasonal variations of plasma lipids and lipoproteins in the hedgehog, an animal model for lipoprotein (a) metabolism: relation to plasma thyroxine and testosterone levels
PM Laplaud, M Saboureau, L Beaubatie, B El-Omari
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1989
Phosphatidylcholine and triacylglycerol hydrolysis in HDL as induced by hepatic lipase: modulation of the phospholipase activity by changes in the particle surface or in the lipid core
G Simard, B Perret, S Durand, X Collet, H Chap, L Douste-Blazy
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1989
Heparin decreases the degradation rate of hepatic lipase in Fu5AH rat hepatoma cells. A model for hepatic lipase efflux from hepatocytes
LA Cisar, KH Melford, M Sensel, A Bensadoun
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1989
Circulating and liver-bound salt-resistant hepatic lipases in the golden hamster
H Jansen, R Lammers, MG Baggen, NM Wouters, JC Birkenhäger
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1989
Large buoyant LDL-like particles in hepatic lipase deficiency
JH Auwerx, CA Marzetta, JE Hokanson, JD Brunzell
Arteriosclerosis (Dallas, Tex.) 1989
Human Apolipoprotein Mutants 2
CR Sirtori, G Franceschini, HB Brewer, G Assmann
1989
The fatty liver dystrophy (fld) mutation
CA Langner, EH Birkenmeier, O Ben-Zeev, MC Schotz, HO Sweet, MT Davisson, JI Gordon
The Journal of biological chemistry 1989
Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution
CF Semenkovich, SH Chen, M Wims, CC Luo, WH Li, L Chan
Journal of lipid research 1989
Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review
WS Harris
Journal of lipid research 1989
Apolipoprotein B metabolism in homozygous familial hypercholesterolemia
RW James, B Martin, D Pometta, JC Fruchart, P Duriez, P Puchois, JP Farriaux, A Tacquet, T Demant, RJ Clegg
Journal of lipid research 1989
Lipoprotein metabolism during acute inhibition of lipoprotein lipase in the cynomolgus monkey
IJ Goldberg, NA Le, HN Ginsberg, RM Krauss, FT Lindgren
Journal of Clinical Investigation 1988
Effect of lipoprotein lipase and hepatic triglyceride lipase activity on the distribution of apolipoprotein E among the plasma lipoproteins
JC Gibson, WV Brown
Atherosclerosis 1988
Very low density lipoprotein apolipoprotein B metabolism in humans
T Demant, J Shepherd, CJ Packard
Klinische Wochenschrift 1988
Familial lipoprotein lipase deficiency: abnormal lipoproteins and defective metabolism of low density lipoproteins in cultured human skin fibroblasts
Y Kleinmann, Y Oschry, GM Berger, S Eisenberg
Atherosclerosis 1988
Studies on the function of hepatic lipase in the cat after immunological blockade of the enzyme in vivo
PN Demacker, AG Hijmans, AF Stalenhoef, A Laar
Atherosclerosis 1988
Membrane-bound lipoprotein lipase on human monocyte-derived macrophages: localization by immunocolloidal gold technique
IJ Goldberg, DA Handley, T Vanni, JR Paterniti, JA Cornicelli
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1988
Influence of the structure of the lipid-water interface on the activity of hepatic lipase
HM Laboda, JM Glick, MC Phillips
Biochemistry 1988
Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein
T Demant, LA Carlson, L Holmquist, F Karpe, P Nilsson-Ehle, CJ Packard, J Shepherd
Journal of lipid research 1988
Independent regulation of plasma apolipoprotein C-II and C-III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins
NA Le, JC Gibson, HN Ginsberg
Journal of lipid research 1988
Lipoprotein[a] is the major apoB-containing lipoprotein in the plasma of a hibernator, the hedgehog (Erinaceus europaeus)
PM Laplaud, L Beaubatie, SC Rall, G Luc, M Saboureau
Journal of lipid research 1988
Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase
S Datta, CC Luo, WH Li, P VanTuinen, DH Ledbetter, MA Brown, SH Chen, SW Liu, L Chan
The Journal of biological chemistry 1988
Uptake of chylomicron remnants by the liver: further evidence for the modulating role of phospholipids
J Borensztajn, GS Getz, TJ Kotlar
Journal of lipid research 1988
Divergent effects of d-norgestrel on the metabolism of rat very low density and low density apolipoprotein B
R Khokha, MW Huff, BM Wolfe
Journal of lipid research 1988
Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil
MS Weintraub, S Eisenberg, JL Breslow
Journal of Clinical Investigation 1987
Phospholipases, lysophospholipases, and lipases and their involvement in various diseases
AA Farooqui, WA Taylor, LA Horrocks
Neurochemical Pathology 1987
Very low density lipoprotein metabolism in diabetes mellitus
HN Ginsberg
Diabetes / Metabolism Reviews 1987
A study of the lipid transport system in the cat, Felix domesticus
PN Demacker, PJ van Heijst, HL Hak-Lemmers, AF Stalenhoef
Atherosclerosis 1987
Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line
G Stahnke, R Sprengel, J Augustin, H Will
Differentiation 1987
Determinants of the uptake of very low density lipoprotein remnants by the perfused rat liver
CM Arbeeny, VA Rifici, DA Handley, HA Eder
Metabolism 1987
Effects of estrogen/progestin agents on plasma retinoids and chylomicron remnant metabolism
JM Gleeson, CS Dukes, NL Elstad, IF Chan, DE Wilson
Contraception 1987
3 Postprandial lipaemia
JR Patsch
Baillière's Clinical Endocrinology and Metabolism 1987
7 Enzymes involved in triglyceride hydrolysis
MR Taskinen, T Kuusi
Baillière's Clinical Endocrinology and Metabolism 1987
Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family
MC Komaromy, MC Schotz
Proceedings of the National Academy of Sciences 1987
Hepatic lipase: a member of a family of structurally related lipases
O Ben-Zeev, CM Ben-Avram, H Wong, J Nikazy, JE Shively, MC Schotz
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1987
Regulation of hepatic lipase and serum lipoproteins by sex steroids
MJ Tikkanen, EA Nikkilä
American Heart Journal 1987
Structural modulation of salt-resistant rat-liver lipase alters the relative phospholipase and triacylglycerol hydrolase activities
NL Persoon, WC Hülsmann, H Jansen
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1987
Subfractionation of 1.006-1.063 g/ml components of badger plasma lipoproteins by using heparin-Sepharose affinity chromatography: relevance to the endocrine regulation of lipoprotein metabolism
PM Laplaud, L Beaubatie, SC Rall, D Maurel
Journal of lipid research 1987
Synthesis of hepatic lipase in liver and extrahepatic tissues
MH Doolittle, H Wong, RC Davis, MC Schotz
Journal of lipid research 1987
Hydrolysis of chylomicron arachidonate and linoleate ester bonds by lipoprotein lipase and hepatic lipase
A Nilsson, B Landin, MC Schotz
Journal of lipid research 1987
Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI. Evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo
HN Ginsberg, NA Le, IJ Goldberg, JC Gibson, A Rubinstein, P Wang-Iverson, R Norum, WV Brown
Journal of Clinical Investigation 1986
Endothelial bound lipases and lipoprotein metabolism in disease and drug development
K Oka, JR Paterniti
Drug Development Research 1986
Deficiency of Hepatic Lipase Activity in Post-heparin Plasma in Familial Hyper-α-Triglyceridemia
LA Carlson, L Holmquist, P Nilsson-Ehle
Acta Medica Scandinavica 1986
Lipoprotein subfractions of runners and sedentary men
PT Williams, RM Krauss, PD Wood, FT Lindgren, C Giotas, KM Vranizan
Metabolism: clinical and experimental 1986
The role of hepatic triglyceride lipase in the metabolism of intermediate-density lipoprotein—Postheparin lipolytic activities determined by a sensitive, nonradioisotopic method in hyperlipidemic patients and normals
S Nozaki, M Kubo, H Sudo, Y Matsuzawa, S Tarui
Metabolism 1986
Evidence for heterogeneity of low-density lipoprotein metabolism in the cynomolgus monkey
IJ Goldberg, NA Le, B Leeman, WV Brown, FT Lindgren
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1986
Immunologic and enzymatic comparisons between human and bovine lipoprotein lipase
IJ Goldberg, WS Blaner, DW Goodman
Archives of Biochemistry and Biophysics 1986
Effect of dietary carbohydrate type on lipoprotein lipase, hepatic lipase, and lecithin: Cholesterol acyltransferase activities in cynomolgus monkeys
C Sharma, SR Srinivasan, B Radhakrishnamurthy, GS Berenson
Biochemical Medicine and Metabolic Biology 1986
Hyperlipidemia in mast cell-deficient W/WV mice
K Hatanaka, H Tanishita, H Ishibashi-Ueda, A Yamamoto
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1986
Release of hepatic lipase and very low density lipoprotein by cultured rat hepatocytes
AC Rustan, JØ Nossen, JP Blomhoff, CA Drevon
International Journal of Biochemistry 1986
Hepatic triacylglycerol lipase in circulating blood of normal and tumor-bearing mice and its hydrolysis of very-low-density lipoprotein and synthetic acylglycerols
M Hiroshi, O Hiromichi
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1986
Hydrolysis of lipid monolayers and the substrate specificity of hepatic lipase
HM Laboda, JM Glick, MC Phillips
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1986
Comparison of the triacylglycerol hydrolase activity of human post-heparin plasma lipoprotein lipase and hepatic triacylglycerol lipase. A monolayer study
RL Jackson, E Ponce, LR McLean, RA Demel
Biochemistry 1986
Intravenous Administration of Lipid Emulsions to Premature Infants
GE Stahl, ML Spear, M Hamosh
Clinics in Perinatology 1986
Lipoprotein Deficiency Syndromes
A Angel, J Frohlich
1986
Effect of heparin-induced lipolysis on the distribution of apolipoprotein e among lipoprotein subclasses. Studies with patients deficient in hepatic triglyceride lipase and lipoprotein lipase
A Rubinstein, JC Gibson, JR Paterniti, G Kakis, A Little, HN Ginsberg, WV Brown
Journal of Clinical Investigation 1985
Plasma lipoprotein abnormalities associated with acquired hepatic triglyceride lipase deficiency
IJ Goldberg, RG Mazlen, A Rubenstein, JC Gibson, JR Paterniti, FT Lindgren, WV Brown
Metabolism 1985
Very low density lipoprotein triglyceride kinetics during hepatic lipase suppression by estrogen
MJ Tikkanen, T Kuusi, EA Nikkilä, T Sane
FEBS Letters 1985
Demonstration of hepatic triglyceride lipase-like activity in ascites fluid of mice with sarcoma 180
H Masuno, H Okuda
European Journal of Cancer and Clinical Oncology 1985
Enzyme-linked immunosorbent assay for rat hepatic triglyceride lipase
LA Cisar, A Bensadoun
Journal of lipid research 1985
Purification and characterization of human lipoprotein lipase and hepatic triglyceride lipase. Reactivity with monoclonal antibodies to hepatic triglyceride lipase
CF Cheng, A Bensadoun, T Bersot, JS Hsu, KH Melford
The Journal of biological chemistry 1985
Apolipoprotein A and B (Sf 100-400) metabolism during bezafibrate therapy in hypertriglyceridemic subjects
J Shepherd, CJ Packard, JM Stewart, RF Atmeh, RS Clark, DE Boag, K Carr, AR Lorimer, D Ballantyne, HG Morgan
Journal of Clinical Investigation 1984
Relationship between serum lipids, lipoproteins and pseudocholinesterase during organophosphate poisoning in rabbits
R Ryhänen, J Herranen, K Korhonen, I Penttilä, M Polvilampi, E Puhakainen
International Journal of Biochemistry 1984
Effect of low-dose oral contraceptives on lipoproteins and lipolytic enzymes: Differences between two commonly used preparations
JA Leuven, L Havekes, HA der Kooij-Pontier, RJ Starmans, H Jansen, ML Bouwhuis-Hoogerwerf, HA Pagter, LW Hessel
Metabolism 1984
Alterations in plasma lipoproteins and heparin-releasable lipase activities in mice bearing the grsl ascites tumor
J Damen, JV Ramshorst, RP van Hoeven, WJ van Blitterswijk
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1984
The formation of LDL: mechanisms and regulation
RJ Havel
Journal of lipid research 1984
High density lipoprotein metabolism
S Eisenberg
Journal of lipid research 1984
Acute inhibition of hepatic lipase and increase in plasma lipoproteins after alcohol intake
CS Goldberg, AR Tall, S Krumholz
Journal of lipid research 1984
Lipoprotein lipase-like activity in the liver of mice with Sarcoma 180
H Masuno, T Tsujita, H Nakanishi, A Yoshida, R Fukunishi, H Okuda
Journal of lipid research 1984
New Comprehensive Biochemistry
S Yamamoto
New Comprehensive Biochemistry 1983
Measurement of lipoprotein lipase and hepatic triacylglycerol lipase in post-heparin plasma of the cynomolgus monkey
IJ Goldberg, JR Paterniti, WV Brown
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1983
Combined Lipase Deficiency ( cld ): a Lethal Mutation on Chromosome 17 of the Mouse
JR Paterniti, WV Brown, HN Ginsberg, K Artzt
Science 1983

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