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Citations to this article

Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.
J Alcocer-Varela, D Alarcón-Segovia
J Alcocer-Varela, D Alarcón-Segovia
Published June 1, 1982
Citation Information: J Clin Invest. 1982;69(6):1388-1392. https://doi.org/10.1172/JCI110579.
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Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

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Abstract

We studied the production of and response to interleukin-2 (IL-2) by peripheral blood T lymphocytes from 19 systemic lupus erythematosus (SLE) patients who received no treatment at the time they were studied. Eight had active disease and the rest were in remission. Results were compared with those obtained in 12 healthy subjects of similar age. T cells from SLE patients, whether activated with phytohemagglutinin or in autologous mixed lymphocyte reactions, were found to yield little IL-2, to have a low response to IL-2 from its own, or other sources, and to absorb IL-2 poorly, IL-2 produced by SLE cells, albeit scant, was absorbed normally by activated T cells from normal subjects. Our findings may contribute to the understanding of the immunoregulatory defect in SLE.

Authors

J Alcocer-Varela, D Alarcón-Segovia

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EE Solomou, YT Juang, MF Gourley, GM Kammer, GC Tsokos
Journal of immunology (Baltimore, Md. : 1950) 2001
Serum interleukin‐15 is elevated in systemic lupus erythematosus
M Aringer, GH Stummvoll, G Steiner, M Köller, CW Steiner, E Höfler, H Hiesberger, JS Smolen, WB Graninger
Rheumatology (Oxford, England) 2001
T Cell Studies in a Peptide-Induced Model of Systemic Lupus Erythematosus
M Khalil, K Inaba, R Steinman, J Ravetch, B Diamond
Journal of immunology (Baltimore, Md. : 1950) 2001
DEHYDROEPIANDROSTERONE IN SYSTEMIC LUPUS ERYTHEMATOSUS
RF van Vollenhoven
Rheumatic Disease Clinics of North America 2000
Immunobiology of left ventricular assist devices
S Itescu, JH Ankersmit, AA Kocher, MD Schuster
Progress in Cardiovascular Diseases 2000
Rôle des cytokines dans la physiopathologie du lupus
JF Viallard, JL Taupin, V Ranchin, B Leng, JL Pellegrin, JF Moreau
Immuno-analyse & Biologie Spécialisée 2000
INACTIVE SYSTEMIC LUPUS ERYTHEMATOSUS IS ASSOCIATED WITH A NORMAL STIMULATED TH1/TH2CYTOKINE SECRETORY PATTERN
M Amit, A Mor, J Weissgarten, R Rosenberg, Y Ramot, AJ Wysenbeek, MJ Rapoport
Cytokine 2000
Association of Deficient Type II Protein Kinase A Activity with Aberrant Nuclear Translocation of the RIIβ Subunit in Systemic Lupus Erythematosus T Lymphocytes
N Mishra, IU Khan, GC Tsokos, GM Kammer
Journal of immunology (Baltimore, Md. : 1950) 2000
New Pieces to the SLE Cytokine Puzzle
KA Kirou, MK Crow
Clinical Immunology 1999
Th1 (IL-2, interferon-gamma (IFN-gamma)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE)
JF Viallard, JL Pellegrin, V Ranchin, T Schaeverbeke, J Dehais, M Longy-Boursier, JM Ragnaud, B Leng, JF Moreau
Clinical & Experimental Immunology 1999
Role of NK cells and TGF-β in the regulation of T-cell-dependent antibody production in health and autoimmune disease
DA Horwitz, JD Gray, K Ohtsuka
Microbes and Infection 1999
High prevalence of T cell type I protein kinase a deficiency in systemic lupus erythematosus
GM Kammer
Arthritis & Rheumatism 1999
Integrin signalling defects in T-lymphocytes in systemic lupus erythematosus
TT Ng, IE Collins, SB Kanner, MJ Humphries, N Amft, RG Wickremasinghe, D D'Cruz, KE Nye, WJ Morrow
Lupus 1999
A double-blind, placebo-controlled, clinical trial of dehydroepiandrosterone in severe systemic lupus erythematosus
RF van Vollenhoven, JL Park, MC Genovese, JP West, JL McGuire
Lupus 1999
High disease activity at baseline does not prevent a remission in patients with systemic lupus erythematosus
F Formiga, I Moga, M Pac, F Mitjavila, A Rivera, R Pujol
Rheumatology (Oxford, England) 1999
Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus
H Nakashima, M Akahoshi, Y Tanaka, K Yamaoka, E Ogami, S Nagano, Y Arinobu, H Niiro, T Otsuka, Y Niho
Rheumatology (Oxford, England) 1999
Induction of anti-thymocyte/T lymphocyte antibodies in mice injected with lipopolysaccharides from periodontopathic bacteria
T Kaneko, Y Hara, A Yoshimura, I Kato
Journal of Periodontal Research 1999
Quantitative Changes In T-Cell Populations After Left Ventricular Assist Device Implantation: Relationship to T-Cell Apoptosis and Soluble CD95
HJ Ankersmit, NM Edwards, M Schuster, R John, A Kocher, EA Rose, M Oz, S Itescu
Circulation 1999
Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain
SN Liossis, XZ Ding, GJ Dennis, GC Tsokos
Journal of Clinical Investigation 1998
Relations between surface expression of the interleukin-2 receptor and release of the soluble form of the receptor in cultured mononuclear cells from patients with rheumatoid arthritis or systemic lupus erythematosus
M Itoh, Y Goto, Y Ohta, Y Goto, H Ohashi
Clinical Rheumatology 1998
Immune cell signaling aberrations in human lupus
SN Liossis, PP Sfikakis, GC Tsokos
Immunologic Research 1998
Decreased Th1-like and Increased Th2-like Cells in Systemic Lupus Erythematosus
MF H
Scandinavian Journal of Rheumatology 1998
Interleukin-2 and systemic lupus erythematosus—fifteen years later
JC Crispin, J Alcocer-Varela
Lupus 1998
Cytokines: clues to the pathogenesis of SLE
BR Lauwerys, FA Houssiau
Lupus 1998
Studies of T cell receptors in autoimmune diseases
K Yamamoto
Japanese Journal of Rheumatology 1997
New methods of treatment in an experimental murine model of systemic lupus erythematosus induced by idiotypic manipulation
Y Shoenfeld, I Krause, M Blank
Annals of the rheumatic diseases 1997
Dysregulation of interleukin-10 production in relatives of patients with systemic lupus erythematosus
L Llorente, Y Richaud-Patin, J Couderc, D Alarcon-Segovia, R Ruiz-Soto, N Alcocer-Castillejos, J Alcocer-Varela, J Granados, S Bahena, P Galanaud, D Emilie
Arthritis & Rheumatism 1997
Abnormalities in CD69 expression, cytosolic pH and Ca2+ during activation of lymphocytes from patients with systemic lupus erythematosus
D Portales-Pérez, R González-Amaro, C Abud-Mendoza, S Sánchez-Armáss
Lupus 1997
Systemic lupus erythematosus associated with transverse myelitis and Parkinsonian symptoms
H Osawa, H Yamabe, M Kaizuka, N Tamura, S Tsunoda, KI Shirato, K Okumura
Lupus 1997
Remission of Systemic Lupus Erythematosus
C Drenkard, AR Villa, C Garcia-Padilla, ME Perez-Vazquez, D Alarcon-Segovia
Medicine 1996
Remission of Systemic Lupus Erythematosus:
C Drenkard, AR Villa, C Garcia-Padilla, ME Perez-Vazquez, D Alarcon-Segovia
Medicine 1996
Expression of IL-2R, IL-4R, IL-6R on peripheral blood lymphocytes in systemic lupus erythematosus and correlation with disease activity: a prospective study
EY Chan, CS Lau, H Zola
Journal of clinical pathology 1996
Abnormal Splenic and Thymic IL-4 and TNF-alpha Expression in MRL-lpr/lpr Mice
CY Tsai, TH Wu, SF Huang, KH Sun, SC Hsieh, SH Han, HS Yu, CL Yu
Scandinavian Journal of Immunology 1995
Cytokine production in drug-free and neuroleptic-treated schizophrenic patients
H Bessler, Z Levental, L Karp, I Modai, M Djaldetti, A Weizman
Biological Psychiatry 1995
Immunopathogenesis and Therapy of Systemic Lupus Erythematosus
L Kater, FH Gmelig-Meyling, RH Derksen, HB Faille
Clinical immunotherapeutics 1995
Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia
M Hornberg, V Arolt, I Wilke, A Kruse, H Kirchner
Schizophrenia Research 1995
Longitudinal study on the production of and cellular response to interleukin-2 in patients with systemic lupus erythematocus
J Alcocer-Varela, D Alarcn-Segovia
Rheumatology International 1995
Demonstration of interleukin-2, interleukin-4 and interleukin-6 in sera from patients with localized scleroderma
H Ihn, S Sato, M Fujimoto, K Kikuchi, K Takehara
Archives of Dermatological Research 1995
Imbalance of the interleukin 2 system in children with IDDM
T Tomoda, T Kurashige, T Taniguchi
Diabetologia 1994
Cytokines and systemic sclerosis
DM Fagundus, EC Leroy
Clinics in Dermatology 1994
Modulation of the IL-2 production defect in vitro in Graves' disease
Z Eisenstein, E Engelsman, M Weiss, Y Kalechman, B Sredni
Clinical & Experimental Immunology 1994
An open study of dehydroepiandrosterone in systemic lupus erythematosus
RF van Vollenhoven, EG Engleman, JL Mcguire
Arthritis & Rheumatism 1994
Cytokine Gene Profile in Circulating Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus: Increased Interleukin-2 but not Interleukin-4 mRNA
DA Horwitz, H Wang, JD Gray
Lupus 1994
Immunology of the Connective Tissue Diseases
GS Panayi
1994
T helper cell dysfunction in systemic lupus erythematosus (SLE): Relation to disease activity
BL Bermas, M Petri, D Goldman, B Mittleman, MW Miller, NI Stocks, CS Via, GM Shearer
Journal of Clinical Immunology 1994
The cytokine network in the pathogenesis of systemic lupus erythematosus and possible therapeutic implications
DA Horwitz, CO Jacob
Springer Seminars in Immunopathology 1994
The role of cytokines in the immunopathogenesis of lupus
BS Handwerger, V Rus, L da Silva, CS Via
Springer Seminars in Immunopathology 1994
B7/BB1 provides an important costimulatory signal for CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus (SLE).
Sfikakis PP, Oglesby R, Sfikakis P, Tsokos GC
Clinical & Experimental Immunology 1994
T- and B-Cell Abnormalities in Systemic Lupus
PL Cohen
Journal of Investigative Dermatology 1993
Interleukin-1 dysregulation is an intrinsic defect in macrophages from MRL autoimmune-prone mice
JS Levine, BJ Pugh, D Hartwell, JM Fitzpatrick, A Marshak-Rothstein, DI Beller
European Journal of Immunology 1993
Immunologic significance of increased soluble CD8/CD4 molecules in patients with active systemic lupus erythematosus
S Sawada, H Hashimoto, S Iijima, Y Tokano, M Takei, M Shida, T Obara
Journal of Clinical Laboratory Analysis 1993
Elevated serum soluble interleukin-2 receptor levels in subacute cutaneous lupus erythematosus
C Neish, M Charley, N Fertig, T Medsger, JS Deng
Journal of Dermatological Science 1993
Lithium In Vitro Enhances Interleukin-2 Production by T Cells from Patients with Systemic Lupus Erythematosus
EJ Kucharz, SJ Sierakowski, JS Goodwin
Immunopharmacology and Immunotoxicology 1993
Relationship of IL-2, IL-2R (CD25 + ), Soluble IL-2R and IL-4 with Disease Activity in SLE Patients
MJ Cuadrado, M Marubayashi, C Ortega, N Fernandez-Arcas, F Garcia-Cozar, J Pena, P Sanchez-Guijo, M Santamaria
Lupus 1993
Relationship of IL-2, IL-2R (CD25+), Soluble IL-2R and IL-4 with Disease Activity in SLE Patients
MJ Cuadrado, M Marubayashi, C Ortega, N Fernandez-Arcas, F Garcia-Cozar, J Pena, P Sanchez-Guijo, M Santamaria
Lupus 1993
Circulating intercellular adhesion molecule 1 as a new activity marker in patients with systemic lupus erythematosus
E Kling, S Bieg, M Boehme, WA Scherbaum
The Clinical Investigator 1993
Administration of interleukin-2 induces major histocompatibility complex class II expression on the biliary epithelial cells, possibly through endogenous interferon-γ production
H Himeno, T Saibara, S Onishi, Y Yamamoto, H Enzan
Hepatology 1992
Altered interleukin-2 production in schizophrenia: Association between clinical state and autoantibody production
R Ganguli, JS Brar, W Solomon, KN Chengappa, BS Rabin
Psychiatry Research 1992
Decreased mitogen responsiveness and elevated tumor necrosis factor production in cats shortly after feline immunodeficiency virus infection
CE Lawrence, JJ Callanan, O Jarrett
Veterinary Immunology and Immunopathology 1992
Enhanced expression of high-affinity interleukin-2 receptors in scleroderma: Possible role for IL-6
MB Kahaleh, T Yin
Clinical Immunology and Immunopathology 1992
Low dose stretozotocin-induced diabetes in mice: Reduced IL-2 production and modulation of streptozotocin-induced hyperglycemia by IL-2
V Burkart, J Zielasek, G Kantwerk-Funke, T Hibbe, E Schwab, H Kolb
International Journal of Immunopharmacology 1992
Cytokine abnormalities in human lupus
M Linker-Israeli
Clinical Immunology and Immunopathology 1992
Production of Interleukin-2 IL-2 and Expression of IL-2 Receptor in Patients with IgA Nephropathy
TW Lee, MJ Kim
The Korean Journal of Internal Medicine 1992
Interleukin-1 and Interleukin-6 Activities are Increased in the Cerebrospinal Fluid of Patients with CNS Lupus Erythematosus and Correlate with Local Late T-Cell Activation Markers
J Alcocer-Varela, D Aleman-Hoey, D Alarcon-Segovia
Lupus 1992
A long-term immunological study of childhood onset systemic lupus erythematosus
CK Ting, KH Hsieh
Annals of the rheumatic diseases 1992
Functional T cell subpopulations responsible for hyposecretion of IL-2 in patients with systemic lupus erythematosus
T Hayama, N Kubo, E Ikeda, H Hashimoto, S Sawada, T Horie
Clinical Rheumatology 1991
Systemic lupus erythematosus: RNA-protein autoantigens, models of disease heterogeneity, and theories of etiology
JB Harley, RH Scofield
Journal of Clinical Immunology 1991
Studies of CD4+ (Helper/Inducer) T Lymphocytes in Autoimmune Thyroid Disease: Demonstration of Specific Induction in Response to Thyroid Peroxidase (TPO) In Vitro and Its Relationship with Thyroid Status In Vivo
F Akasu, Y Kasuga, S Matsubayashi, P Carayon, R Volpé
Thyroid 1991
Activation markers on peripheral blood T cells from patients with active or inactive systemic lupus erythematosus. Correlation with proliferative responses and production of IL-2
J Alcocer-Varela, M Alarcón-Riquelme, A Laffón, F Sánchez-Madrid, D Alarcón-Segovia
Journal of Autoimmunity 1991
Prolactin, immunoregulation, and autoimmune diseases
LJ Jara, C Lavalle, A Fraga, C Gómez-Sanchez, LH Silveira, P Martinez-Osuna, BF Germain, LR Espinoza
Seminars in Arthritis and Rheumatism 1991
In vitro mitogen responses and lymphocyte subpopulations in cheetahs
M Miller-Edge, M Worley
Veterinary Immunology and Immunopathology 1991
In vitro regulation of B cell differentiation by interleukin-6 and soluble CD23 in systemic lupus erythematosus B cell subpopulations and antigen-induced normal B cells
DJ Klashman, RA Martin, RH Stevens, O Martínez-Maza
Arthritis & Rheumatism 1991
Enhanced CD3-mediated T lymphocyte proliferation in patients with systemic lupus erythematosus
IL Stekman, AM Blasini, M Leon-Ponte, ML Baroja, I Abadi, MA Rodriguez
Arthritis & Rheumatism 1991
Defective CD2 pathway T cell activation in systemic lupus erythematosus
DA Fox, JA Millard, J Treisman, W Zeldes, A Bergman, J Depper, R Dunne, WJ McCune
Arthritis & Rheumatism 1991
A defect in the protein kinase C system in T cells from patients with systemic lupus erythematosus
Y Tada, K Nagasawa, Y Yamauchi, H Tsukamoto, Y Niho
Clinical Immunology and Immunopathology 1991
Soluble immunologic products in scleroderma sera
MB Kahaleh
Clinical Immunology and Immunopathology 1991
Human CD8+ lymphocytes stimulated in the absence of CD4+ cells enhance IgG production by antibody-secreting B cells
T Takahashi, JD Gray, DA Horwitz
Clinical Immunology and Immunopathology 1991
Gangliosides Inhibit the Proliferation of Human T Cells Stimulated with Interleukin-4 or Interleukin-2
N Morioka, M Furue, T Tsuchida, Y Ishibashi
The Journal of Dermatology 1991
Loss of interleukin-2—Producing intestinal CD4+ T cells in inflammatory bowel disease
K Kusugami, T Matsuura, GA West, KR Youngman, D Rachmilewitz, C Fiocchi
Gastroenterology 1991
Interleukin 2 production in a family with systemic lupus erythematosus and a C4Q0 heterozygous inheritance
C Gutierrez, E Cabrero, JL Vicario, MM Villa, MA Rengel, FJ Campdera, M Yebra, E Fernandez-Cruz, AA Villena
Annals of the rheumatic diseases 1991
Cytokine-independent progression of immunoglobulin production in vitro by B lymphocytes from patients with systemic lupus erythematosus.
Pelton BK, Speckmaier M, Hylton W, Farrant J, Denman AM
Clinical & Experimental Immunology 1991
Effect of colchicine on lymphocyte and monocyte function and its relation to fibroblast proliferation in primary biliary cirrhosis
D Kershenobich, M Rojkind, A Quiroga, J Alcocer-Varela
Hepatology 1990
Increased Circulating HLA-DR+CD4+ T Cells in Systemic Lupus Erythematosus: Alterations Associated with Prednisolone Therapy
S Raziuddin, MA Nur, AA Al-Wabel
Scandinavian Journal of Immunology 1990
Soluble Interleukin-2 Receptor Secretion Defectin Vitroin HLA-B8, DR3 Positive Subjects
MA Modica, GD Lorenzo, A Galluzzo, C Giordano, MR Portelli, G Candore, C Caruso
Autoimmunity 1990
Cytokines in the Pathophysiology of Systemic Lupus Erythematosus
M Goldman
Autoimmunity 1990
Antibodies to Interleukin 2 in Sera of Autoimmune-prone Mice
M Tabata, K Kobayashi, S Kaga, M Hashimoto, T Kasama, T Fukushima, K Yoshida, N Yamagata, F Sekine, I Ohno, M Negishi, H Ide, T Takahashi
Scandinavian Journal of Rheumatology 1990
Inhibition of lymphoproliferation and protein kinase C by synthetic peptides with sequence identity to the transmembrane and Q proteins of visna virus
CL Ruegg, JE Clements, M Strand
Journal of virology 1990
Markers of T Lymphocyte Activation in HLA-B8, DR3 Positive Individuals
MA Modica, AM Zambito, G Candore, C Caruso
Immunobiology 1990
CD8+ Lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis
M Linker-Israeli, FP Quismorio, DA Horwitz
Arthritis & Rheumatism 1990
HLA-DP+ T cells and deficient interleukin-2 production in patients with systemic lupus erythematosus
T Hishikawa, Y Tokano, I Sekigawa, S Ando, Y Takasaki, H Hashimoto, S Hirose, K Okumura, M Abe, T Shirai
Clinical Immunology and Immunopathology 1990
T lymphocyte subsets, suppressor and contrasuppressor cell functions, and production of interleukin-2 in the peripheral blood of rheumatic fever patients and their apparently healthy siblings
ME Alarcon-Riquelme, D Alarcon-Segovia, A Loredo-Abdala, J Alcocer-Varela
Clinical Immunology and Immunopathology 1990
Natural killer cell activity in Sjogren's syndrome and systemic lupus erythematosus: stimulation with interferons and interleukin-2 and correlation with immune complexes
NJ Struyf, HW Snoeck, CH Bridts, LS Clerck, WJ Stevens
Annals of the rheumatic diseases 1990
T helper-cell leukemia/lymphoma: Presentation as an acute immune-mediated illness
AJ Bridges, D Norback, P Fisch, D England, P Sondel
Journal of Clinical Immunology 1990
Effect of 1,1-dimethylhydrazine on lymphoproliferation and interleukin 2 immunoregulatory function
RM Bauer, MJ Tarr, RG Olsen
Archives of Environmental Contamination and Toxicology 1990
Immunotoxicity of Metals and Immunotoxicology
AD Dayan, RF Hertel, E Heseltine, G Kazantzis, EM Smith, MT der Venne
1990
Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis.
Famularo G, Procopio A, Giacomelli R, Danese C, Sacchetti S, Perego MA, Santoni A, Tonietti G
Clinical & Experimental Immunology 1990
The effect of the immunomodulator agent AS101 on interleukin-2 production in systemic lupus erythematosus (SLE) induced in mice by a pathogenic anti-DNA antibody.
Blank M, Sredni B, Albeck M, Mozes E, Shoenfeld Y
Clinical & Experimental Immunology 1990
A defect in immunoregulatory synovial fluid T cells in Behcet's syndrome
J Alcocer-Varela, A Laffon, C Abud-Mendoza, D Alarcon-Segovia
Clinical Rheumatology 1989
Natural killer cells and autoimmunity
E Grunebaum, E Malatzky-Goshen, Y Shoenfeld
Immunologic Research 1989
Familial Occurrence of impaired interleukin-2 activity and increased peripheral blood B cells actively secreting immunoglobulins in systemic lupus erythematosus
T Sakane, Y Murakawa, N Suzuki, Y Ueda, T Tsuchida, S Takada, Y Yamauchi, T Tsunematsu
The American Journal of Medicine 1989
Increased production of interleukin-2 and IL-2 receptor in primary IgA nephropathy
FP Schena, G Mastrolitti, E Jirillo, I Munno, N Pellegrino, AR Fracasso, L Aventaggiato
Kidney International 1989
Dysregulated Lymphokine Production in Systemic Lupus Erythematosus (SLE)
M Linker-Ismeli, R Deans
Annals of the New York Academy of Sciences 1989
Effect of the new immunoregulator AS-101 on in vitro functions of mononuclear cells from patients with systemic lupus erythematosus
J Alcocer-Varela, D Alarcon-Segovia, B Sredni, M Albeck
Clinical & Experimental Immunology 1989
T lymphocyte activation in systemic lupus erythematosus analysed by proliferative response to nucleoplasmic proteins on nitrocellulose immunoblots
BN Pham, L Prin, D Gosset, PY Hatron, B Devulder, A Capron, JP Dessaint
Clinical & Experimental Immunology 1989
Responsiveness of systemic lupus erythematosus T cells to signals provided through LCA T200 (CD45) and T1 (CD5) antigens
J Martorell, J Font, I Rojo, R Vilella, M Ingelmo, J Vives
Clinical & Experimental Immunology 1989
Relation between soluble interleukin 2 receptor and clinical findings in patients with systemic lupus erythematosus
Y Tokano, A Murashima, Y Takasaki, H Hashimoto, K Okumura, S Hirose
Annals of the rheumatic diseases 1989
Reversible interleukin-2 response defects in systemic lupus erythematosus
RJ Warrington, PJ Sauder, J Homik, W Ofosu-Appiah
Clinical & Experimental Immunology 1989
Cyclic AMP level of lymphocytes in patients with systemic lupus erythematosus and its relation to disease activity
N.C. Phi, Takáts, V.H. Binh, C.V. Vien, González-Cabello, P. Gergely
Immunology Letters 1989
Family Study of Natural Killer Cell Activity in C1qDeficient Patients with Systemic Lupus Erythematosus-Like Syndrome: Association between Impaired Natural Killer Cell Function and C1q Deficiency
J TóTh, Z Staršia, M Buc, J Štefanovič
Immunobiology 1989
Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus
T Tanaka, O Saiki, S Negoro, T Igarashi, T Kuritani, H Hara, M Suemura, S Kishimoto
Arthritis & Rheumatism 1989
Two types of antibodies inhibiting interleukin-2 production by normal lymphocytes in patients with systemic lupus erythematosus
J Miyagi, N Minato, S Kano, M Sumiya, T Kasahara
Arthritis & Rheumatism 1989
Intravenous γ-globulin therapy in systemic lupus erythematosus and immune complex disease
SC Jordan
Clinical Immunology and Immunopathology 1989
B cell hyperresponsiveness to interleukin 2 and the age-associated decline in murine lupus
I Sekigawa, K Noguchi, K Hasegawa, S Hirose, H Sato, T Shirai
Clinical Immunology and Immunopathology 1989
In vitro effect of corticosteroid on immunoregulatory functions in primary biliary cirrhosis
T Ikeda, M Uchihara, Y Daiguji, Y Hasumura, J Takeuchi
Clinical Immunology and Immunopathology 1989
The role of natural killer cells in human disease
TL Whiteside, RB Herberman
Clinical Immunology and Immunopathology 1989
The role of interleukin 2 in autoimmunity
G Kroemer, G Wick
Immunology Today 1989
Pharmacology of the Skin I
MW Greaves, S Shuster
1989
B cell lymphokines in human systemic lupus erythematosus
PL Tan, M Blumenstein, S Yeoman, JD Watson
Annals of the rheumatic diseases 1989
Impaired T-cell activation in patients with systemic lupus erythematosus
S Sierakowski, EJ Kucharz, RW Lightfoot, JS Goodwin
Journal of Clinical Immunology 1989
Functions of the Natural Immune System
CW Reynolds, RH Wiltrout
1989
Decreased activity of interleukin-2 inhibitor in plasma of patients with systemic lupus erythematosus
EJ Kucharz, S Sierakowski, JS Goodwin
Clinical Rheumatology 1988
Discordant Interleukin 2 Production in Monozygotic Twins Concordant for Systemic Lupus Erythematosus
K Sato, N Miyasaka, K Yamaoka, T Yamada, T Nishido, M Okuda, K Nishioka
Autoimmunity 1988
Characterization of lymphocytes that suppress IL-2 production in systemic lupus erythematosus
M Linker-Israeli, JD Gray, FP Quismorio, DA Horwitz
Clinical & Experimental Immunology 1988
OKT4+ T cell deficiency and an association of immunoglobulin deficiency in systemic lupus erythematosus
S Raziuddin, BH Danial
Clinical & Experimental Immunology 1988
Impaired release of natural killer cytotoxic factor in patients with primary Sjögren's syndrome
BK Pedersen, P Oxholm
Clinical & Experimental Immunology 1988
Interleukin-2 production in Brown-Norway rats with HgCl2-induced autoimmune disease: paradoxical in vivo versus in vitro findings
D Baran, O Lantz, P Dosquet, A Sfaksi, P Druet
Clinical & Experimental Immunology 1988
Spontaneous recovery of the decreased expression in vitro of interleukin 2 receptors in rheumatoid arthritis
C Plater-Zyberk, KA Rockett, RN Maini
Clinical & Experimental Immunology 1988
Interleukin-2 production and response by helper T-cell subsets in man
M Salmon, GD Kitas, JS Gaston, PA Bacon
Immunology 1988
Deficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate
Y Murakawa, T Sakane
Arthritis & Rheumatism 1988
Enhanced production of interleukin-2 in patients with progressive systemic sclerosis. hyperactivity of cd4-positive t cells?
H Umehara, S Kumagai, H Ishida, T Suginoshita, M Maeda, H Imura
Arthritis & Rheumatism 1988
Impaired mobility of human t lymphocyte surface molecules during inactive systemic lupus erythematosus. relationship to a defective camp pathway
GM Kammer, E Mitchell
Arthritis & Rheumatism 1988
Human recombinant interleukin-2125 induced in vitro proliferation of equine, caprine, ovine, canine and feline peripheral blood lymphocytes
BW Fenwick, CE Schore, BI Osburn
Comparative Immunology, Microbiology and Infectious Diseases 1988
Cellular and genetic analyses of IL-2 production and IL-2 receptor expression in a patient with familial T-cell-dominant immunodeficiency
S Doi, O Saiki, T Tanaka, K Ha-Kawa, T Igarashi, T Fujita, T Taniguchi, S Kishimoto
Clinical Immunology and Immunopathology 1988
Role of interleukin 2 in inducing normalization of natural killer activity in systemic lupus erythematosus
ML Gaspar, M Alvarez-Mon, C Gutiérrez
Clinical Immunology and Immunopathology 1988
OKT4+ T cell abnormality in patients with active systemic lupus erythematosus: HLA-DR antigen expressions
S Raziuddin, HB Danial, M Kelley
Clinical Immunology and Immunopathology 1988
Interleukin 2 receptor bearing T lymphocytes in patients with chronic liver disease
S Kakumu, K Yoshioka, A Fuji, H Tahara
Gastroenterologia Japonica 1988
Basis for Variability of Response to Anti-Rheumatic Drugs
PM Brooks, RO Day, K Williams, G Graham
1988
The B-cell activation pathway in human systemic lupus erythematosus: Imbalancedin vitro production of lymphokines and association with serum analytical findings
ML Gaspar, M Alvarez-Mon, C Gutierrez
Journal of Clinical Immunology 1988
Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis
G Semenzato, LM Bambara, D Biasi, A Frigo, F Vinante, B Zuppini, L Trentin, C Feruglio, M Chilosi, G Pizzolo
Journal of Clinical Immunology 1988
Production of and response to interleukin-2 in Graves' disease
Z Eisenstein, E Engelsman, M Weiss, Y Kalechman, B Sredni
Journal of Clinical Immunology 1988
Immunopathogenetic Mechanisms of Arthritis
JA Goodacre, WC Dick
1988
Interleukin-1-production by monocytes from patients with systemic lupus erythematosus
S Sierakowski, EJ Kucharz, RW Lightfoot, JS Goodwin
Clinical Rheumatology 1987
Cellular immunity and IgE levels in atopic patients
M Frajman, L González, A Alvarado, J Yock
Allergy 1987
Decreased Production of Interleukin-2 in Schizophrenia
F Villemain, L Chatenoud, E Guillibert, Y Pelicier, JF Bach
Annals of the New York Academy of Sciences 1987
The role of L3T4+ cells in the pathogenesis of lupus inlpr-bearing mice. I. Defects in the production of interleukins 2 and 3
TJ Santoro, KR Lehmann, RA Batt, BL Kotzin
European Journal of Immunology 1987
Studies on human blood lymphocytes with iC3b (type 3) complement receptors: III. Abnormalities in patients with active systemic lupus erythematosus
JD Gray, A Lash, AC Bakke, RC Kitridou, DA Horwitz
Clinical & Experimental Immunology 1987
Failure of exogenous interleukin 1 and interleukin 2 to correct decreased lymphocyte transformation in chronic hepatitis B virus carriers
C Anastassakos, GJ Alexander, RA Wolstencroft, DC Dumonde, AL Eddleston, R Williams
Clinical & Experimental Immunology 1987
Production of and responsiveness to interleukin 2 in autoimmune BXSB mice
SP Umland, SR Smith, HR Strausser
Cellular Immunology 1987
A review of mechanism of action of aspirin and its potential as an immunomodulating agent
MM Rumore, SM Aron, EJ Hiross
Medical Hypotheses 1987
Immunologic alterations in MRL/lpr mice after chronic dimethyl sulfoxide administration
AJ Wysenbeek, S Lourie, A Weinberger, N Schoenfeld, AI Pick, M Pecht
International Journal of Immunopharmacology 1987
The effect of adherent cell-derived factors on immunoglobulin and anti-DNA synthesis in systemic lupus erythematosus
RC Jandl, JL George, DS Silberstein, RB Eaton, PH Schur
Clinical Immunology and Immunopathology 1987
Interleukin 2 Receptors and Responsiveness to Recombinant Human Interleukin 2 in Patients With Systemic Lupus Erythematosus
S Lakhanpal, BS Handwerger
Mayo Clinic Proceedings 1987
Lymphokines
HM Johnson, BA Torres
Lymphokines 1987
Lymphocyte Subpopulations in Bronchoalveolar Lavage in Sjögren's Syndrome
B Wallaert, L Prin, PY Hatron, P Ramon, AB Tonnel, C Voisin
Chest 1987
The Role of T Lymphocytes in Autoimmune Thyroid Disease
AJ Ahmann, KD Burman
Endocrinology and metabolism clinics of North America 1987
Mechanisms of rhysiologic B cell responses and B cell hyperactivity in systemic lupus erythematosus
RH Zubler, YP Huang, PA Miescher
Springer Seminars in Immunopathology 1986
Mechanisms of immunosuppression associated with severe nonthermal traumatic injuries in man: Production of interleukin 1 and 2
ML Rodrick, J Wood, JB O'Mahony, CF Davis, JT Grbic, RH Demling, NM Moss, I Saporoschetz, A Jordan, P D'Eon, JA Mannick
Journal of Clinical Immunology 1986
B cell hyperactivity in systemic lupus erythematosus: selectively enhanced responsiveness to a high molecular weight B cell growth factor
JF Delfraissy, C Wallon, A Vazquez, B Dugas, J Dormont, P Galanaud
European Journal of Immunology 1986
Recombinant interleukin 2 enhances spontaneous insulin-dependent diabetes in BB rats
H Kolb, J Zielasek, U Treichel, G Freytag, M Wrann, U Kiesel
European Journal of Immunology 1986
Stimulating and differentiation factors for human B lymphocytes in systemic lupus erythematosus
E Martinez-Cordero, J Alcocer-Varela, D Alarcon-Segovia
Clinical & Experimental Immunology 1986
Systemic lupus erythematosus sera antilymphocyte reactivity: detection of antibodies to Tac-antigen positive T cell lines
H Sano, S Kumagai, S Namiuchi, T Uchiyama, J Yodoi, M Maeda, K Takatsuki, T Suginoshita, H Imura
Clinical & Experimental Immunology 1986
Interleukin 2 defect in the peripheral blood and the lung in patients with Sjögren's syndrome
N Miyasaka, N Murota, K Yamaoka, K Sato, T Yamada, T Nishido, M Okuda
Clinical & Experimental Immunology 1986
Effects of LS-2616 administration upon the autoimmune disease of (NZB x NZW) F1 hybrid mice
A Tarkowski, K Gunnarsson, T Stålhandske
Immunology 1986
Independence of depressed lectin-dependent cell-mediated cytotoxicity from interleukin 2 production in patients with systemic lupus erythematosus
A Perl, R González-Cabello, K Onody, I Bodó, P Gergely
Clinical & Experimental Immunology 1986
T cell function in systemic lupus erythematosus: normal production of and responsiveness to interleukin 2
AM Draeger, AJ Swaak, HG van Brink, LA Aarden
Clinical & Experimental Immunology 1986
Modulation of cellular immune responses in mice with disseminated histoplasmosis by recombinant interleukin-2
GS Deepe, CL Taylor, JE Harris, WE Bullock
Infection and immunity 1986
Administration of group A streptococcal cell walls to rats induces an interleukin 2 deficiency
SC Ridge, JB Zabriskie, H Osawa, T Diamantstein, AL Oronsky, SS Kerwar
Journal of Experimental Medicine 1986
Cell-mediated immunity in rheumatic disease
SJ Padula, RB Clark, JH Korn
Human Pathology 1986
A human T cell line established from a patient with Sézary syndrome
S Namiuchi, S Kumagai, H Sano, J Yodoi, T Uchiyama, K Ikai, H Imura, M Maeda
Journal of Immunological Methods 1986
Human interleukin 2
JM Cardenas, P Marshall, B Henderson, A Altman
Journal of Immunological Methods 1986
Detection of impaired T cell-mediated immune responses to herpesvirus (BHV-1) in cattle
M Miller-Edge, G Splitter
Veterinary Immunology and Immunopathology 1986
Effect of anti-T cell auto antibodies from systemic lupus erythematosus sera upon T lymphocyte functions
LP Goldschmidt, TF Kresina, GM Kammer
Arthritis & Rheumatism 1986
Analysis of interleukin-2 activity in patients with Behçet's disease. Ability of T cells to produce and respond to interleukin-2
T Sakane, N Suzuki, Y Ueda, S Takada, Y Murakawa, T Hoshino, Y Niwa, T Tsunematsu
Arthritis & Rheumatism 1986
Successful treatment of autoimmunity in mrl/1 mice with ls-2616, a new immunomodulator
A Tarkowski, K Gunnarsson, LÅ Nilsson, L Lindholm, T Stålhandske
Arthritis & Rheumatism 1986
Deficient γ-interferon production in patients with systemic lupus erythematosus
GC Tsokos, DT Boumpas, PL Smith, JY Djeu, JE Balow, AH Rook
Arthritis & Rheumatism 1986
T-cell dysregulation in patients with hyperprolactinemia: Effect of bromocriptine treatment
A Vidaller, L Llorente, F Larrea, JP Mendez, J Alcocer-Varela, D Alarcon-Segovia
Clinical Immunology and Immunopathology 1986
Perceived interleukin 2 deficiency and T cell function: Implications for treating autoimmune disorders
MH Bocchieri, JB Smith
Clinical Immunology Newsletter 1986
Interleukin 2 production in patients with thyroid diseases
VV Malaitsev, IM Bogdanova, EN Shatsova
Bulletin of Experimental Biology and Medicine 1986
Correction of interleukin-2 production in patients with systemic lupus erythematosus by removal of spontaneously activated suppressor cells
M Linker-Israeli, AC Bakke, FP Quismorio, DA Horwitz
Journal of Clinical Investigation 1985
Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus
MK Crow
Journal of Clinical Investigation 1985
Abnormalities in autologous mixed lymphocyte reaction-activated immunologic processes in systemic lupus erythematosus and their possible correction by interleukin 2
S Takada, Y Ueda, N Suzuki, Y Murakawa, T Hoshino, I Green, AD Steinberg, DA Horwitz, T Sakane
European Journal of Immunology 1985
Abnormal Production of and Response to B-Cell Growth Factor and B-Cell Differentiation Factor in Patients with Systemic Lupus Erythematosus
T Hirose, M Hara, A Kitani, W Hirose, K Norioka, M Kawagoe, H Nakamura
Scandinavian Journal of Immunology 1985
Immunoregulatory circuits in the acquired immune deficiency syndrome and related complex. Production of and response to interleukins 1 and 2, NK function and its enhancement by interleukin-2 and kinetics of the autologous mixed lymphocyte reaction
J Alcocer-Varela, D Alarcon-Segovia, C Abud-Mendoza
Clinical & Experimental Immunology 1985
Interleukin-2 in rheumatoid arthritis: production of and response to interleukin-2 in rheumatoid synovial fluid, synovial tissue and peripheral blood
B Combe, RM Pope, M Fischbach, B Darnell, S Baron, N Talal
Clinical & Experimental Immunology 1985
Functional consequences of perceived interleukin deficiencies? Analysis employing NZB x C58 recombinant inbred mice
MH Bocchieri, JB Smith, JB Smith, MJ Staruch, DD Wood
Clinical & Experimental Immunology 1985
Spontaneous production of, and defective response to, interleukin-1 by peripheral blood mononuclear cells from patients with scleroderma
J Alcocer-Varela, E Martinez-Cordero, D Alarcon-Segovia
Clinical & Experimental Immunology 1985
Comparison of the biological properties of purified natural and recombinant human interleukin-2
K Naruo, S Hinuma, K Kato, M Koyama, H Tada, O Shiho, K Tsukamoto
Biochemical and Biophysical Research Communications 1985
Staining and fluorescence-activated cell sorter analysis of human lymphocytes using antibodies to a short, chemically synthesized human IL-2 peptide
N Isakov, RI Fox, FJ Dixon, AN Theofilopoulos, A Altman
Cellular Immunology 1985
Immunohistochemical studies of interleukin-2 and γ-interferon in rheumatoid arthritis
G Husby, RC Williams
Arthritis & Rheumatism 1985
Relationship between circulating interferon and anti-interferon antibodies and impaired natural killer cell activity in systemic lupus erythematosus
WL Sibbitt, DL Gibbs, C Kenny, AD Bankhurst, RP Searles, KD Ley
Arthritis & Rheumatism 1985
Interleukin-2 restores the depressed allogeneic cell-mediated lympholysis and natural killer cell activity in patients with systemic lupus erythematosus
GC Tsokos, PL Smith, CB Christian, RN Lipnick, JE Balow, JY Djeu
Clinical Immunology and Immunopathology 1985
Experimental models for systemic autoimmune disease—Current concepts
AN Theofilopoulos, MT Aguado
Clinical Immunology Newsletter 1985
Mechanism of action of thymosin. II. Effects of aspirin and thymosin on enhancement of IL-2 production
MM Zatz, A Skotnicki, JM Bailey, JH Oliver, AL Goldstein
Immunopharmacology 1985
Radiosensitivity of Peripheral Blood Lymphocytes in Autoimmune Disease
G Harris, WA Cramp, JC Edwards, AM George, SA Sabovljev, L Hart, GR Hughes, AM Denman, MB Yatvin
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 1985
Immunology of Rheumatic Diseases
S Gupta, N Talal
1985
Interleukin-2 production by persons with the generalized lymphadenopathy syndrome or the acquired immune deficiency syndrome
CH Kirkpatrick, KC Davis, CR Horsburgh, DL Cohn, K Penley, FN Judson
Journal of Clinical Immunology 1985
Lymphocyte function in human bone marrow. II. Characterization of an interleukin 2-sensitive T precursor-cell population
HM Dosch, CJ Ledgley, D White, P Lam, GB Mills
Journal of Clinical Immunology 1985
Anti-lymphocyte Antibodies in Systemic Lupus Erythematosus
JB Winfield
Clinics in rheumatic diseases 1985
The Connective Tissue Diseases as Disorders of Immune Regulation
D Alarcon-Segovia, J Alcocer-Varela, E Diaz-Jouanen
Clinics in rheumatic diseases 1985
Interleukins, Interferon and Rheumatic Disease
N Talal
Clinics in rheumatic diseases 1985
Natural Killer Cells in Connective Tissue Disorders
WL Sibbitt, AD Bankhurst
Clinics in rheumatic diseases 1985
Interleukin-2 production in bullous pemphigoid
AR Ahmed, K Hijri, V Arab-Kermani
Archives of Dermatological Research 1984
B Cell-Tropic Interleukins in Murine Systemic Lupus Erythematosus (SLE) 1
GJ Prud-Homme, TM Fieser, FJ Dixon&, AN Theoflopoulos
Immunological Reviews 1984
Deficiency of Interleukin-2 Production and Interleukin-2 Receptor Expression on Peripheral Blood Leukocytes after Phytohemagglutinin Stimulation in Pemphigus
V Kermani-Arab, K Hirji, AR Ahmed, JL Fahey
Journal of Investigative Dermatology 1984
Defective monocyte production of, and T lymphocyte response to, interleukin-1 in the peripheral blood of patients with systemic lupus erythematosus
J Alcocer-Varela, A Laffon, D Alarcón-Segovia
Clinical & Experimental Immunology 1984
Defective LN cell proliferative response to Sm antigen in mice bearing the lpr gene
H Dang, M Fischbach, V Fey, N Talal
Clinical & Experimental Immunology 1984
Interleukin-2 activity in chronic active liver diseases: response by T cells and in the autologous mixed lymphocyte reaction
K Yoshioka, S Kakumu, H Murakami, K Fukui
Clinical & Experimental Immunology 1984
Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2
A Altman, JM Cardenas, RA Houghten, FJ Dixon, AN Theofilopoulos
Proceedings of the National Academy of Sciences 1984
Cell-mediated immunodeficiency in Down's syndrome: normal IL-2 production but inverted ratio of T cell subsets
R Karttunen, T Nurmi, J Ilonen, HM Surcel
Clinical & Experimental Immunology 1984
Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis
P Emery, GS Panayi, AM Nouri
Clinical & Experimental Immunology 1984
Increased Ia expression, T lymphocyte subset abnormalities and autoimmunity in murine strains bearing the lpr gene
MJ Dauphinée, N Talal
Clinical & Experimental Immunology 1984
Interleukin 2 enhances natural killing of normal lymphocytes
N Miyasaka, B Darnell, S Baron, N Talal
Cellular Immunology 1984
Canine Il-2: Characterization and optimal conditions for production
AJ Daemen, WA Buurman, CJ Linden, G Groenewegen, G Kootstra
Veterinary Immunology and Immunopathology 1984
Cytokine production by NZB, C58, and NZB × C58 recombinant inbred mice
MH Bocchieri, L Knittweis, DS Seaton
Cellular Immunology 1984
Effects of prostaglandin E2 on responses of T-cell subsets to mitogen and autologous non-T-cell stimulation
M Honda, AD Steinberg
Clinical Immunology and Immunopathology 1984
Impaired IL2 production by lymphocytes of patients with systemic lupus erythematosus
P Faucal, A Godard, MA Peyrat, JF Moreau, JP Soulillou
Annales de l'Institut Pasteur / Immunologie 1984
Lymphoid abnormalities in rats with adjuvant-induced arthritis. I. Mitogen responsiveness and lymphokine synthesis
SC Gilman, JF Daniels, RE Wilson, RP Carlson, AJ Lewis
Annals of the rheumatic diseases 1984
Differences in the production of and/or the response to interleukin-2 by T lymphocytes from patients with the various connective tissue diseases
J Alcocer-Varela, A Laffn, D Alarcn-Segovia
Rheumatology International 1984
Natural killer cell-mediated activity in mixed connective tissue disease and its response to induction by interleukin-2
R Gonzlez-Amaro, J Alcocer-Varela, E Martnez-Cordero, D Alarcn-Segovia
Journal of Clinical Immunology 1984
Interleukin 2 Activity of Human Intestinal Mucosa Mononuclear Cells
C Fiocchi, ML Hilfiker, KR Youngman, NC Doerder, JH Finke
Gastroenterology 1984
Impaired T cell capping and receptor regeneration in active systemic lupus erythematosus. Evidence for a disorder intrinsic to the T lymphocyte
GM Kammer
Journal of Clinical Investigation 1983
Mechanisms of autoimmunity: a role for cross-reactive idiotypes
A Cooke, PM Lydyard, IM Roitt
Immunology Today 1983
Abnormalities of immune regulation in the connective tissue diseases
HE Jasin
Seminars in Arthritis and Rheumatism 1983
Mixed connective tissue disease: A disorder of immune regulation
D Alarcón-Segovia
Seminars in Arthritis and Rheumatism 1983
Cellular bases of the production of and response to interleukin-2 in man: role of autologous rosette-forming T-cell subsets defined with monoclonal antibodies
E Fishbein, J Alcocer-Varela, D Alarcón-Segovia
Immunology 1983
Molecular cloning of human interleukin 2 cDNA and its expression in E. coli
R Devos, G Plaetinck, H Cheroutre, G Simons, W Degrave, J Tavernier, E Remaut, W Fiers
Nucleic Acids Research 1983
Natural Killer Cells in Systemic Lupus Erythematosus
ML Egan, SL Mendelsohn, T Abo, CM Balch
Arthritis & Rheumatism 1983
Mouse monoclonal antibodies can nonspecifically inhibit the proliferation of human T-cell growth factor-dependent T cells
GF Burns, T Triglia, GA Varigos
Cellular Immunology 1983
Impaired natural killer cell function in systemic lupus erythematosus
WL Sibbitt, L Likar, CW Spellman, AD Bankhurst
Arthritis & Rheumatism 1983
The autologous mixed lymphocyte reaction is not primarily due to xenoantigenic stimulation
A Laffón, J Alcocer-Varela, D Alarcón-Segovia
Clinical Immunology and Immunopathology 1983
B-cell hyperactivity in murine lupus II. Defects in response to and production of accessory signals in lupus-prone mice
AN Theofilopoulos, GJ Prud'homme, TM Fieser, FJ Dixon
Immunology Today 1983
Differences in the kinetics of the autologous mixed lymphocyte reaction between the various connective tissue diseases
A Laffón, J Alcocer-Varela, D Alarcón-Segovia
Rheumatology International 1983
Autoantibodies
MH Lessof, SP Asper
American Heart Journal 1960

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