This study was undertaken to investigate the effect of exogenous sulfhydryl compound administration on the toxicity of doxorubicin in mice. Pretreatment of CDF1 mice with a pharmacologic dose (2,000 mg/kg) of n-acetyl-l-cysteine 1 h before doxorubicin (20 mg/kg, i.p.) decreased lethality from 100% (n = 44) to 37.7% (n = 53), P less than 0.001. Variation in the timing and dose of n-acetylcysteine significantly diminished its protective activity. Pretreatment with n-acetylcysteine also significantly reduced long-term mortality in animals receiving multiple doses of doxorubicin; 10 wk after the third of three doxorubicin doses (5 mg/kg, i.p.) administered at 2-wk intervals, survival in the n-acetylcysteine pretreated group was 51.4% (n = 35) compared with 16.7% (n = 30) for animals receiving saline before doxorubicin, P less than 0.01. In this experiment, n-acetylcysteine pretreatment also diminished doxorubicin-related losses in total body weight and heart wet weight by 55.2% (P less than 0.05), and 60.9% (P less than 0.02), respectively, compared with animals pretreated with saline. N-acetylcysteine pretreatment also ablated electron microscopic evidence of doxorubicin cardiomyopathy without alleviating morphological features of its toxic effects on the liver or small intestinal mucosa. The cardioprotective action of n-acetylcysteine may be partially explained by the 429 +/- 60% increase in cardiac nonprotein sulfhydryl content (P less than 0.01) that was measured one hour after n-acetylcysteine administration; nonprotein sulfhydryl concentration in the liver at the same time was insignificantly different from control levels. Treatment with n-acetylcysteine also increased the nonprotein sulfhydryl content of P388 leukemia cells nearly threefold; however, it did not after the chemotherapeutic activity of doxorubicin against this murine tumor. Whereas n-acetylcysteine blocked doxorubicin cardiac toxicity, it did not affect the uptake or metabolism of doxorubicin in the heart or liver. These results suggest that the concentration of free sulfhydryl groups in the heart may play a role in the development of doxorubicin cardiac toxicity and that augmenting cardiac nonprotein sulfhydryl group content with n-acetylcysteine may provide a means to enhance the chemotherapeutic index of doxorubicin.
J H Doroshow, G Y Locker, I Ifrim, C E Myers
Year: | 2024 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1983 | 1982 | Total |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Citations: | 2 | 2 | 7 | 2 | 3 | 2 | 2 | 4 | 4 | 4 | 7 | 5 | 2 | 3 | 4 | 4 | 2 | 5 | 2 | 4 | 2 | 3 | 5 | 6 | 1 | 9 | 6 | 1 | 7 | 5 | 6 | 5 | 5 | 10 | 5 | 13 | 13 | 5 | 8 | 3 | 188 |
Title and authors | Publication | Year |
---|---|---|
Ultrasonographic and histopathological investigation of the effect of N-acetylcysteine on doxorubicin-induced ovarian and uterine toxicity in rats
Üstüner E, Yıldırım E, Macun HC, Ekici H, Şahin Y, Güncüm E, Anteplioğlu T, Elifoğlu TB, Bozkaya E |
Journal of Ovarian Research | 2024 |
Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity
Wu L, Zhang Y, Wang G, Ren J |
JACC: Basic to Translational Science | 2024 |
Mitochondrial-Targeted Therapy for Doxorubicin-Induced Cardiotoxicity
B Wu, K Leung, E Poon |
International journal of molecular sciences | 2022 |
The Beneficial Role of Physical Exercise on Anthracyclines Induced Cardiotoxicity in Breast Cancer Patients.
Tranchita E, Murri A, Grazioli E, Cerulli C, Emerenziani GP, Ceci R, Caporossi D, Dimauro I, Parisi A |
Cancers | 2022 |
Identification of new candidate biomarkers to support doxorubicin treatments in canine cancer patients
K Walters, A Stornetta, F Jacobs, PW Villalta, M Razzoli, M Grant, B Zordoky, A Bartolomucci, A Borgatti, S Balbo |
BMC veterinary research | 2021 |
Oral N-acetylcysteine as an adjunct to standard medical therapy improved heart function in cases with stable class II and III systolic heart failure
A Yazdi, N Khansari, M Mehrpooya, Y Mohammadi, S Zareie |
Irish Journal of Medical Science | 2021 |
Bottom-up analysis of emergent properties of N-acetylcysteine as an adjuvant therapy for COVID-19
A Dominari, D Hathaway, A Kapasi, T Paul, SS Makkar, V Castaneda, S Gara, BM Singh, K Agadi, M Butt, V Retnakumar, S Chittajallu, R Taugir, MK Sana, M KC, S Razzack, N Moallem, A Alvarez, M Talalaev |
World Journal of Virology | 2021 |
Novel in vivo potential of trifluoperazine to ameliorate doxorubicin-induced cardiotoxicity involves suppression of NF-κB and apoptosis
AE Goda, AM Elenany, AE Elsisi |
Life Sciences | 2021 |
Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A
D Zhu, C Chen, X Liu, S Wang, J Zhu, H Zhang, L Kong, J Luo |
Journal of Advanced Research | 2021 |
Atypical antipsychotics and oxidative cardiotoxicity: review of literature and future perspectives to prevent sudden cardiac death
Stefano D'Errico, Raffaele La Russa, Aniello Maiese, Alessandro Santurro, Matteo Scopetti, Silvia Romano, Martina Zanon, Paola Frati, Vittorio Fineschi |
Journal of Geriatric Cardiology | 2021 |
Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A.
Zhu D, Chen C, Liu X, Wang S, Zhu J, Zhang H, Kong L, Luo J |
Journal of Advanced Research | 2021 |
SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin
A Bhattacharya, S Mukherjee, P Khan, S Banerjee, A Dutta, N Banerjee, D Sengupta, U Basak, S Chakraborty, A Dutta, S Chattopadhyay, K Jana, DK Sarkar, S Chatterjee, T Das |
Science signaling | 2020 |
Pyridoxine enhances chemo-responsiveness of breast cancer stem cells via redox reconditioning
S Banerjee, S Mukherjee, A Bhattacharya, U Basak, S Chakraborty, S Paul, P Khan, K Jana, TK Hazra, T Das |
Free radical biology & medicine | 2020 |
Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle
H Koide, K Yoshimatsu, Y Hoshino, S Ariizumi, A Okishima, T Ide, H Egami, Y Hamashima, Y Nishimura, H Kanazawa, Y Miura, T Asai, N Oku, KJ Shea |
Journal of Controlled Release | 2019 |
Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag 2 S quantum dots with differential therapeutic effect
PT Buz, FD Duman, M Erkisa, G Demirci, F Ari, E Ulukaya, HY Acar |
Nanomedicine | 2019 |
Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring
N Wenningmann, M Knapp, A Ande, TR Vaidya, S Ait-Oudhia |
Molecular pharmacology | 2019 |
Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib
S Gorini, AD Angelis, L Berrino, N Malara, G Rosano, E Ferraro |
Oxidative medicine and cellular longevity | 2018 |
Exposure to the Dietary Supplement N-Acetyl-L-Cysteine during Pregnancy Reduces Cyclophosphamide Teratogenesis in ICR Mice
Brittany M Miller, Kyle K Wells, Charles B Wells, Xuan T Lam, Marah E Carney, Douglas S Kepko, Morgan L Mueller, Ronald D Hood, Melissa M Bailey |
Journal of clinical nutrition and food science | 2018 |
Comparision of doxorubicin-induced cardiotoxicity in the ICR mice of different sources
SH Kim, KJ Kim, JH Kim, JH Kwak, HK Song, JY Cho, DY Hwang, KS Kim, YS Jung |
Laboratory animal research | 2017 |
Oxygen nanobubbles revert hypoxia by methylation programming
PN Bhandari, Y Cui, BD Elzey, CJ Goergen, CM Long, J Irudayaraj |
Scientific Reports | 2017 |
Combination Treatment of Murine Colon Cancer with Doxorubicin and Redox Nanoparticles
LB Vong, Y Nagasaki |
Molecular Pharmaceutics | 2016 |
Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice
K Sugiyama, T Sasano, J Kurokawa, K Takahashi, T Okamura, N Kato, M Isobe, T Furukawa |
International Heart Journal | 2016 |
Curcumin Downregulates Phosphate Carrier and Protects against Doxorubicin Induced Cardiomyocyte Apoptosis
L Junkun, C Erfu, H Tony, L Xin, KC Sudeep, Z Mingliang, W Yanqin, Q XiangQian |
BioMed Research International | 2016 |
Utility of Bromelain and N-Acetylcysteine in Treatment of Peritoneal Dissemination of Gastrointestinal Mucin-Producing Malignancies
A Amini, S Masoumi-Moghaddam, DL Morris |
2016 | |
MicroRNA-208a Silencing Attenuates Doxorubicin Induced Myocyte Apoptosis and Cardiac Dysfunction
H Tony, K Yu, Z Qiutang |
Oxidative medicine and cellular longevity | 2015 |
Comprehensive Physiology
TC Tan, TG Neilan, S Francis, JC Plana, M Scherrer-Crosbie |
Comprehensive Physiology | 2015 |
Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo
FP Seib, J Coburn, I Konrad, N Klebanov, GT Jones, B Blackwood, A Charest, DL Kaplan, B Chiu |
Acta Biomaterialia | 2015 |
Studies on Experimental Toxicology and Pharmacology
SM Roberts, JP Kehrer, LO Klotz |
2015 | |
Prevention of Adriamycin-induced hepatic and renal toxicity in male BALB/c mice by a nutrient mixture
MW Roomi, T Kalinovsky, NW Roomi, M Rath, A Niedzwiecki |
Experimental and therapeutic medicine | 2014 |
The Role of the HIF-1α Transcription Factor in Increased Cell Division at Physiological Oxygen Tensions
S Carrera, J Senra, MI Acosta, M Althubiti, EM Hammond, PJ de Verdier, S Macip, S Rocha |
PloS one | 2014 |
ROCK1 Deficiency Enhances Protective Effects of Antioxidants against Apoptosis and Cell Detachment
M Surma, C Handy, J Chang, R Kapur, L Wei, J Shi, NA Hotchin |
PloS one | 2014 |
Protective effects of deep sea water against doxorubicin-induced cardiotoxicity in H9c2 cardiac muscle cells
DH Lee, S Kim, KS Nam |
International journal of oncology | 2014 |
Human Resistin in Chemotherapy-Induced Heart Failure in Humanized Male Mice and in Women Treated for Breast Cancer
DR Schwartz, ER Briggs, M Qatanani, H Sawaya, IA Sebag, MH Picard, M Scherrer-Crosbie, MA Lazar |
Endocrinology | 2013 |
Evaluation of Short-Term Use of N-Acetylcysteine as a Strategy for Prevention of Anthracycline-Induced Cardiomyopathy: EPOCH Trial - A Prospective Randomized Study
SH Jo, LS Kim, SA Kim, HS Kim, SJ Han, WJ Park, YJ Choi |
Korean Circulation Journal | 2013 |
Protection from Oxidative and Electrophilic Stress in the Gsta4-null Mouse Heart
H Beneš, MK Vuong, M Boerma, KE McElhanon, ER Siegel, SP Singh |
Cardiovascular Toxicology | 2013 |
Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
VG Desai, EH Herman, CL Moland, WS Branham, SM Lewis, KJ Davis, NI George, T Lee, S Kerr, JC Fuscoe |
Toxicology and Applied Pharmacology | 2013 |
The chemistry and biological activities of N-acetylcysteine
Y Samuni, S Goldstein, OM Dean, M Berk |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 |
Effects of Histidine and N-Acetylcysteine on Doxorubicin-Induced Cardiomyopathy in Rats
AA Farshid, E Tamaddonfard, N Simaee, S Mansouri, S Najafi, S Asri-Rezaee, H Alavi |
Cardiovascular Toxicology | 2013 |
Comparative Assessment of Melatonin-Afforded Protection in Liver, Kidney and Heart of Male Mice against Doxorubicin Induced Toxicity
AA Alghasham |
Pharmacology & Pharmacy | 2013 |
Doxorubicin-loaded silk films: drug-silk interactions and in vivo performance in human orthotopic breast cancer
FP Seib, DL Kaplan |
Biomaterials | 2012 |
Glutamine: A novel approach to chemotherapy-induced toxicity
K Gaurav, RK Goel, M Shukla, M Pandey |
Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology | 2012 |
Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer
FP Seib, EM Pritchard, DL Kaplan |
Advanced Functional Materials | 2012 |
Drug-Induced Oxidative Stress and Toxicity
DG Deavall, EA Martin, JM Horner, R Roberts |
Journal of Toxicology | 2012 |
Dexrazoxane for the Prevention of Cardiac Toxicity and Treatment of Extravasation Injury from the Anthracycline Antibiotics
JH Doroshow |
Current pharmaceutical biotechnology | 2012 |
Modulation of Anthracycline-Induced Cardiotoxicity by Aerobic Exercise in Breast Cancer: Current Evidence and Underlying Mechanisms
JM Scott, A Khakoo, JR Mackey, MJ Haykowsky, PS Douglas, LW Jones |
Circulation | 2011 |
Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress
LA Gilliam, DK st Clair |
Antioxidants & Redox Signaling | 2011 |
Fatty acid amide hydrolase is a key regulator of the endocannabinoid-induced myocardial tissue injury
P Mukhopadhyay, B Horváth, M Rajesh, S Matsumoto, K Saito, S Bátkai, V Patel, G Tanchian, RY Gao, BF Cravatt, G Haskó, P Pacher |
Free radical biology & medicine | 2010 |
In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity
A Vávrová, O Popelová, M Štěrba, E Jirkovský, P Hašková, H Mertlíková-Kaiserová, V Geršl, T Šimůnek |
Archives of Toxicology | 2010 |
Reduced in vivo high-energy phosphates precede Adriamycin-induced cardiac dysfunction
MY Maslov, VP Chacko, GA Hirsch, A Akki, MK Leppo, C Steenbergen, RG Weiss |
American journal of physiology. Heart and circulatory physiology | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention
A Albini, G Pennesi, F Donatelli, R Cammarota, SD Flora, DM Noonan |
JNCI Journal of the National Cancer Institute | 2009 |
Deoxyamphimedine, a pyridoacridine alkaloid, damages DNA via the production of reactive oxygen species
KM Marshall, CD Andjelic, D Tasdemir, GP Concepción, CM Ireland, LR Barrows |
Marine drugs | 2009 |
Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron
T Šimůnek, M Štěrba, O Popelová, M Adamcová, R Hrdina, V Geršl |
Pharmacological Reports | 2009 |
Characterization of doxorubicin binding site and drug induced alteration in the functionally important structural state of oxyhemoglobin
SN Khan, B Islam, R Yennamalli, Q Zia, N Subbarao, AU Khan |
Journal of Pharmaceutical and Biomedical Analysis | 2008 |
Chemotherapy and cardiotoxicity
H Broder, RA Gottlieb, NE Lepor |
Cardiovascular Radiation Medicine | 2008 |
Point: Evidence-Based Medicine Has a Sound Scientific Base
PJ Karanicolas, R Kunz, GH Guyatt |
Chest | 2008 |
Deletion of the NADPH-Cytochrome P450 Reductase Gene in Cardiomyocytes Does Not Protect Mice against Doxorubicin-Mediated Acute Cardiac Toxicity
C Fang, J Gu, F Xie, M Behr, W Yang, ED Abel, X Ding |
Drug Metabolism and Disposition | 2008 |
Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity
S Ichihara, Y Yamada, Y Kawai, T Osawa, K Furuhashi, Z Duan, G Ichihara |
Biochemical and Biophysical Research Communications | 2007 |
New strategies to identify molecular markers predicting chemotherapy activity and toxicity in breast cancer
AD Leo, W Claudino, D Colangiuli, S Bessi, M Pestrin, L Biganzoli |
Annals of Oncology | 2007 |
Counteracting adriamycin-induced oxidative stress by administration of N-acetyl cysteine and vitamin E
P Kalaiselvi, V Pragasam, S Chinnikrishnan, CK Veena, R Sundarapandiyan, P Varalakshmi |
Clinical Chemistry and Laboratory Medicine | 2005 |
Modulation of light-induced skin tumors by N -acetylcysteine and/or ascorbic acid in hairless mice
F D'Agostini, RM Balansky, A Camoirano, SD Flora |
Carcinogenesis | 2005 |
Cancer Chemoprevention
GJ Kelloff, ET Hawk, CC Sigman |
2005 | |
A novel thiol oxidation‐based mechanism for adriamycin‐induced cell injury in human macrophages
R Asmis, Y Wang, L Xu, M Kisgati, JG Begley, JJ Mieyal |
The FASEB Journal | 2005 |
Drugs Affecting Growth of Tumours
HM Pinedo, CH Smorenburg |
2005 | |
Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide
CH Lillig, ME Lönn, M Enoksson, AP Fernandes, A Holmgren |
Proceedings of the National Academy of Sciences | 2004 |
Nuclear Cardiology and Correlative Imaging
JV Vitola, D Delbeke |
2004 | |
Interactions betweenN-acetylcysteine and sodium selenite in modulating the clastogenicity of urethane and 2-acetylaminofluorene in mice
RM Balansky, SD Flora |
International Journal of Cancer | 2003 |
Prevention of chemotherapy and radiation toxicity with glutamine
DM Savarese, G Savy, L Vahdat, PE Wischmeyer, B Corey |
Cancer Treatment Reviews | 2003 |
Nω-Nitro-L-Arginine Methylester Ameliorates Myocardial Toxicity Induced by Doxorubicin
MA Mansour, AG El-Din, MN Nagi, OA Al-Shabanah, AM Al-Bekairi |
Journal of Biochemistry and molecular biology | 2003 |
Nutritional Approaches to Late Toxicities of Adjuvant Chemotherapy in Breast Cancer Survivors
E Rock, A DeMichele |
The Journal of nutrition | 2003 |
ALPHA-LIPOIC ACID AMELIORATES MYOCARDIAL TOXICITY INDUCED BY DOXORUBICIN
AA Al-Majed, AM Gado, OA Al-Shabanah, MA Mansour |
Pharmacological Research | 2002 |
Overexpression of Thioredoxin-1 in Transgenic Mice Attenuates Adriamycin-Induced Cardiotoxicity
K Shioji, C Kishimoto, H Nakamura, H Masutani, Z Yuan, S Oka, J Yodoi |
Circulation | 2002 |
Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents
A Izzotti, A Camoirano, C Cartiglia, E Tampa, SD Flora |
Mutation Research/Genetic Toxicology and Environmental Mutagenesis | 2001 |
Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
SD Flora, A Izzotti, F D'Agostini, RM Balansky |
Carcinogenesis | 2001 |
Contradistinction between doxorubicin and epirubicin: in-vitro interaction with blood components
S Ramanathan-Girish, M Boroujerdi |
The Journal of pharmacy and pharmacology | 2001 |
PROTECTIVE EFFECT OF THYMOQUINONE AGAINST DOXORUBICIN–INDUCED CARDIOTOXICITY IN RATS: A POSSIBLE MECHANISM OF PROTECTION
MN Nagi, MA Mansour |
Pharmacological Research | 2000 |
Inhibition of aldo-keto reductases by phenobarbital alters metabolism, pharmacokinetics and toxicity of doxorubicin in rats
K Behnia, M Boroujerdi |
The Journal of pharmacy and pharmacology | 2000 |
Prevention of Doxorubicin (Adriamycin)-Induced Cardiomyopathy by Simultaneous Administration of Angiotensin-Converting Enzyme Inhibitor Assessed by Acoustic Densitometry:
T Tokudome, K Mizushige, T Noma, K Manabe, K Murakami, T Tsuji, S Nozaki, A Tomohiro, H Matsuo |
Journal of Cardiovascular Pharmacology | 2000 |
Utility of Acetylcysteine in Treating Poisonings and Adverse Drug Reactions:
PA Chyka, AY Butler, BJ Holliman, MI Herman |
Drug Safety | 2000 |
Adriamycin-induced heart failure: mechanism and modulation
P K Singal, T Li, D Kumar, I Danelisen, N Iliskovic |
Molecular and Cellular Biochemistry | 2000 |
Glutamine Protects against Doxorubicin-Induced Cardiotoxicity
YH Cao, R Kennedy, VS Klimberg |
Journal of Surgical Research | 1999 |
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
DA Gewirtz |
Biochemical Pharmacology | 1999 |
MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytes
W Zhu, Y Zou, R Aikawa, K Harada, S Kudoh, H Uozumi, D Hayashi, Y Gu, T Yamazaki, R Nagai, Y Yazaki, I Komuro |
Circulation | 1999 |
Daunorubicin-Induced Apoptosis in Rat Cardiac Myocytes Is Inhibited by Dexrazoxane
DB Sawyer, R Fukazawa, MA Arstall, RA Kelly |
Circulation research | 1999 |
The Role of the Thiol N-Acetylcysteine in the Prevention of Tumor Invasion and Angiogenesis
M Morini, T Cai, MG Aluigi, DM Noonan, L Masiello, S de Flora, F D'Agostini, A Albini, G Fassina |
The International Journal of Biological Markers | 1999 |
Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium
T Ide, H Tsutsui, S Kinugawa, H Utsumi, D Kang, N Hattori, K Uchida, K Arimura, K Egashira, A Takeshita |
Circulation research | 1999 |
Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats
I Morishima, H Matsui, H Mukawa, K Hayashi, Y Toki, K Okumura, T Ito, T Hayakawa |
Life Sciences | 1998 |
Cardiovascular toxicity with cancer chemotherapy
WH Frishman, HC Yee, D Keefe, HM Sung, LL Liu, AI Einzig, J Dutcher |
Current Problems in Cancer | 1997 |
Mechanisms for anthracycline-induced cardiomyopathy: clinical and laboratory correlations
RJ Boucek |
Progress in Pediatric Cardiology | 1997 |
Enhanced Resistance of Adriamycin-Treated MCR-5 Lung Fibroblasts by Increased Intracellular Glutathione Peroxidase and Extracellular Antioxidants
A Vanella, A Campisi, C Giacomo, V Sorrenti, G Vanella, R Acquaviva |
Biochemical and Molecular Medicine | 1997 |
Animal models of anthracycline cardiotoxicity: Basic mechanisms and cardioprotective activity
EH Herman, VJ Ferrans |
Progress in Pediatric Cardiology | 1997 |
Carbonyl Reduction of Daunorubicin in Rabbit Liver and Heart
D Pröpper, E Maser |
Pharmacology & Toxicology | 1997 |
Use of ICRF-187 for Prevention of Anthracycline Cardiotoxicity in Children: Preliminary Results
A Schiavetti, MA Castello, P Versacci, G Varrasso, A Padula, F Ventriglia, B Werner, V Colloridi |
Pediatric Hematology-Oncology | 1997 |
Oxidant mechanisms in toxic acute renal failure
R Baliga, N Ueda, PD Walker, SV Shah |
American Journal of Kidney Diseases | 1997 |
Enhancement of adriamycin toxicity by iron chelates is not a free radical mechanism
D Gelvan |
Biological Trace Element Research | 1997 |
Free radicals and antioxidants in chemotherapyinduced toxicity
NI Weijl, FJ Cleton, S Osanto |
Cancer Treatment Reviews | 1997 |
Cardioprotection of rat heart myocytes with amifostine (Ethyol) and its free thiol, WR-1065,
R Dorr, K Lagel, S Mclean |
European Journal of Cancer | 1996 |
Pharmacokinetic-toxicodynamic Relationships of Adriamycin in Rat: Prediction of Butylated Hydroxyanisole-mediated Reduction in Anthracycline Cardiotoxicity
J Vora, M Boroujerdi |
Journal of Pharmacy and Pharmacology | 1996 |
Synergism betweenN-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models
SD Flora, FD Agostini, L Masiello, D Giunciuglio, A Albini |
International Journal of Cancer | 1996 |
Protective Effect of Butylated Hydroxyanisole on Adriamycin-induced Cardiotoxicity
J Vora, BA Khaw, J Narula, M Boroujerdi |
Journal of Pharmacy and Pharmacology | 1996 |
A new antithrombotic agent, aspalatone, attenuated cardiotoxicity induced by doxorubicin in the mouse; possible involvement of antioxidant mechanism
C Kim, SW Nam, DY Choi, JH Choi, ES Park, WK Jhoo, HC Kim |
Life Sciences | 1996 |
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy 2
HM Pinedo, JH Schornagel |
1996 | |
Protective effect of N-acetylcysteine against heterocyclic amine-induced cardiotoxicity in cultured myocytes and in rats
CD Davis, EG Snyderwine |
Food and Chemical Toxicology | 1995 |
Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis. An SH-dependent reduction of its expression and myocardial injury
H Suzuki, A Matsumori, Y Matoba, BS Kyu, A Tanaka, J Fujita, S Sasayama |
Journal of Clinical Investigation | 1993 |
Strategies for prevention of anthracycline cardiotoxicity
RL Basser, MD Green |
Cancer Treatment Reviews | 1993 |
Prevention of doxorubicin-induced cardiotoxicity by recombinant interleukin-1 in hamsters
T Yoshida, H Okumura, H Kaya, Y Okabe, S Matano, S Ohtake, S Nakamura, T Matsuda |
Biotherapy | 1993 |
Cardioprotection by ICRF187 against high dose anthracycline toxicity in children with malignant disease
FA Bu'Lock, HM Gabriel, A Oakhill, MG Mott, RP Martin |
British heart journal | 1993 |
Prevention of doxorubicin-induced cardiotoxicity by recombinant interleukin-1 in hamsters: Doxorubicin cardiotoxicity and interleukin-1
T Yoshida, H Okumura, H Kaya, Y Okabe, S Matano, S Ohtake, S Nakamura, T Matsuda |
Biotherapy | 1993 |
Late effects of childhood cancer therapy
LA Meister, AT Meadows |
Current Problems in Pediatrics | 1993 |
Modulation of Glutathione and Glutathione Dependent Antioxidant Enzymes in Mouse Heart Following Doxorubicin Therapy
DL Gustafson, JD Swanson, CA Pritsos |
Free Radical Research | 1993 |
Resistance to cytostatic drugs at the cellular level
CP Vendrik, JJ Bergers, WH Jong, PA Steerenberg |
Cancer Chemotherapy and Pharmacology | 1992 |
PZ-51 (Ebselen) in vivo protection against Adriamycin-induced mouse cardiac and hepatic lipid peroxidation and toxicity
CA Pritsos, M Sokoloff, DL Gustafson |
Biochemical Pharmacology | 1992 |
The consequences of doxorubicin quinone reduction in vivo in tumour tissue
J Cummings, N Willmott, BM Hoey, ES Marley, JF SMyth |
Biochemical Pharmacology | 1992 |
Multiple mechanisms for doxorubicin cytotoxicity on glomerular epithelial cells ‘in vitro’
GM Ghiggeri, R Bertelli, F Ginevri, R Oleggini, P Altieri, A Trivelli, R Gusmano |
European Journal of Pharmacology: Environmental Toxicology and Pharmacology | 1992 |
Resistance to cytostatic drugs at the cellular level
CP Vendrik, JJ Bergers, WH Jong, PA Steerenberg |
Cancer Chemotherapy and Pharmacology | 1992 |
Reactive oxygen molecules, oxidant injury and renal disease
SP Andreoli |
Pediatric Nephrology | 1991 |
Role of glutathione in an animal model of myoglobinuric acute renal failure
SR Abul-Ezz, PD Walker, SV Shah |
Proceedings of the National Academy of Sciences | 1991 |
Beneficial effects of N-acetylcysteine and cysteine in stunned myocardium in perfused rat heart
LD Tang, JZ Sun, K Wu, CP Sun, ZM Tang |
British Journal of Pharmacology | 1991 |
Historical aspects of glutathione and cancer chemotherapy
P Mistry, KR Harrap |
Pharmacology & Therapeutics | 1991 |
Prevention of doxorubicin-induced cardiomyopathy by reduced glutathione
F Villani, M Galimberti, F Zunino, E Monti, A Rozza, E Lanza, L Favalli, P Poggi |
Cancer Chemotherapy and Pharmacology | 1991 |
New Drugs, Concepts and Results in Cancer Chemotherapy
FM Muggia |
1991 | |
Effect of Glutathione and N-Acetylcysteine on in Vitro and in VIVO Cardiac Toxicity of Doxorubicin
F Villani, M Galimberti, E Monti, F Piccinini, E Lanza, A Rozza, L Favalli, P Poggi, F Zunino |
Free Radical Research | 1990 |
Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity
HG Keizer, HM Pinedo, GJ Schuurhuis, H Joenje |
Pharmacology & Therapeutics | 1990 |
Taurine deficiency and doxorubicin: interaction with the cardiac sarcolemmal calcium pump
H Harada, BJ Cusack, RD Olson, W Stroo, J Azuma, T Hamaguchi, SW Schaffer |
Biochemical Pharmacology | 1990 |
Effects of three cysteine pro-drugs on bleomycin-induced lung fibrosis in hamsters
DM Hyde, MJ Schiedt, GA Krishna, SN Giri |
Pathology | 1990 |
Antioxidants in Therapy and Preventive Medicine
I Emerit, L Packer, C Auclair |
1990 | |
Free radical formation by antitumor quinones
G Powis |
Free radical biology & medicine | 1989 |
Increasing therapeutic effect and reducing toxicity of doxorubicin by N-acyl dehydroalanines
P Buc-Calderon, M Praet, JM Ruysschaert, M Roberfroid |
European Journal of Cancer and Clinical Oncology | 1989 |
Effect of diethyldithiocarbamate on toxicity of doxorubicin, cyclophosphamide and cis-diamminedichloroplatinum (II) on mice haemopoietic progenitor cells
IM Pannacciulli, RA Lerza, GV Bogliolo, MP Mencoboni, AG Saviane |
British Journal of Cancer | 1989 |
Reduction of doxorubicin toxicity by methylene blue in cultured rat myocardial cells
RJ Anderson, JR Babson |
Biochemical Pharmacology | 1989 |
Current Therapy in Nephrology
VE Andreucci, AD Canton |
1989 | |
Evidence for the lack of involvement of free radicals in adriamycin-induced histamine release from rat peritoneal cells
L Candussio, FB Klugmann, G Decorti, L Baldini |
Agents and Actions | 1988 |
Inhibition of doxorubicin-initiated membrane damage by N-acetylcysteine: Possible mediation by a thiol-dependent, cytosolic inhibitor of lipid peroxidation
SR Powell, PB McCay |
Toxicology and Applied Pharmacology | 1988 |
DEACTIVATION OF SINGLET MOLECULAR OXYGEN BY THIOLS AND RELATED COMPOUNDS, POSSIBLE PROTECTORS AGAINST SKIN PHOTOSENSITIVITY
M Rougee, RV Bensasson, EJ Land, R Pariente |
Photochemistry and Photobiology | 1988 |
Mitochondrial sulfhydryl group modification by adriamycin aglycones
PM Sokolove |
FEBS Letters | 1988 |
A new class of free radical scavengers reducing adriamycin mitochondrial toxicity
M Praet, PB Calderon, G Pollakis, M Roberfroid, JM Ruysschaert |
Biochemical Pharmacology | 1988 |
Na+-independent release of Ca2+ from rat heart mitochondria
PM Sokolove, RG Shinaberry |
Biochemical Pharmacology | 1988 |
Perspectives in Basic and Applied Toxicology
B Ballantyne |
Perspectives in Basic and Applied Toxicology | 1988 |
Protective Effect of the Bispiperazinedione ICRF-187 against Doxorubicin-Induced Cardiac Toxicity in Women with Advanced Breast Cancer
JL Speyer, MD Green, E Kramer, M Rey, J Sanger, C Ward, N Dubin, V Ferrans, P Stecy, A Zeleniuch-Jacquotte, J Wernz, F Feit, W Slater, R Blum, F Muggia |
New England Journal of Medicine | 1988 |
Oxygen Radicals in the Pathophysiology of Heart Disease
PK Singal |
1988 | |
Mechanism of anthraquinone-induced calcium release from skeletal muscle sarcoplasmic reticulum
JJ Abramson, E Buck, G Salama, JE Casida, IN Pessah |
The Journal of biological chemistry | 1988 |
Decreased ATPase activity in adriamycin nephrosis is independent of proteinuria
WW Bakker, D Kalicharan, J Donga, CE Hulstaert, MJ Hardonk |
Kidney International | 1987 |
Amelioration of chronic anthracycline cardiotoxicity by ICRF-187 and other compounds
EH Herman, VJ Ferrans |
Cancer Treatment Reviews | 1987 |
Metabolism and reactions of quinoid anticancer agents
G Powis |
Pharmacology & Therapeutics | 1987 |
Failure of systemic N-acetyl cysteine to protect the rat lung against bleomycin toxicity
HE Ward, A Nicholson, N Berend |
Pathology | 1987 |
Organ Directed Toxicities of Anticancer Drugs
MP Hacker, JS Lazo, TR Tritton |
1987 | |
New approaches to the possible prevention of side effects of chemotherapy by nutrition
J Pinto, GB Raiczyk, YP Huang, RS Rivlin |
Cancer | 1986 |
Mitigation of an anthracycline-induced cardiomyopathy by pretreatment with razoxane: a quantitative morphological assessment
VW Fischer, GM Wang, NH Hobart |
Virchows Archiv B Cell Pathology Including Molecular Pathology | 1986 |
Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo
FB Klugmann, G Decorti, L Candussio, V Grill, F Mallardi, L Baldini |
British Journal of Cancer | 1986 |
Lack of effect of glutathione depletion on cytotoxicity, mutagenicity and DNA damage produced by doxorubicin in cultured cells
G Capranico, N Babudri, G Casciarri, L Dolzani, RA Gambetta, E Longoni, B Pani, C Soranzo, F Zunino |
Chemico-Biological Interactions | 1986 |
Prevention of Adriamycin Cardiotoxicity by Niacin, Isocitrate or N-acetyl-cysteine in Mice
A Schmitt-Gräff, ME Scheulen |
Pathology - Research and Practice | 1986 |
Failure of N-acetylcysteine to protect against cis-dichlorodiammine-platinum(II)-induced hematopoietic toxicity in mice
R Lerza, G Bogliolo, C Muzzulini, I Pannacciulli |
Life Sciences | 1986 |
Role of reactive oxygen intermediates in the hepatotoxicity of endotoxin
P Ghezzi, B Saccardo, B Marina |
Immunopharmacology | 1986 |
Doxorubicin cardiac toxicity manifesting seven years after treatment. Case report and review
CE Freter, TC Lee, ME Billingham, L Chak, MR Bristow |
The American Journal of Medicine | 1986 |
A possible role for membrane lipid peroxidation in anthracycline nephrotoxicity
EG Mimnaugh, MA Trush, TE Gram |
Biochemical Pharmacology | 1986 |
Doxorubicin (adriamycin)-induced cardiotoxicity in turkey poults: An animal model
CM Czarnecki |
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology | 1986 |
The oxygen free radical system: A fundamental mechanism in the production of myocardial necrosis
JA Thompson, ML Hess |
Progress in Cardiovascular Diseases | 1986 |
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
E Jucker |
1986 | |
Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical
JH Doroshow, KJ Davies |
The Journal of biological chemistry | 1986 |
CARCINOGENICITY OF SOME ANTICANCER DRUGS—A SURVEY
EJ Lien, X Ou |
Journal of Clinical Pharmacy and Therapeutics | 1985 |
Oxygen radicals in biological processes (survey)
IB Afanas'ev |
Pharmaceutical Chemistry Journal | 1985 |
MODIFYING INTRACELLULAR REDOX BALANCE: AN APPROACH TO IMPROVING THERAPEUTIC INDEX
WJ Hrushesky, P Wood, R Olshefski, S Meshnick, JW Eaton |
The Lancet | 1985 |
Ultrastructural features of Adriamycin-induced skeletal and cardiac muscle toxicity
JH Doroshow, C Tallent, JE Schechter |
The American Journal of Pathology | 1985 |
Effect of doxorubicin-enhanced hydrogen peroxide and hydroxyl radical formation on calcium sequestration by cardiac sarcoplasmic reticulum
RN Harris, JH Doroshow |
Biochemical and Biophysical Research Communications | 1985 |
The effect of N-acetylcysteine on toxicity of cyclophosphamide and doxorubicin on murine hemopoietic progenitors
G Massa, C Muzzulini, G Bogliolo, I Pannacciulli |
Life Sciences | 1985 |
Usefulness of a free radical scavenger in preventing doxorubicin-induced heart failure in dogs
DV Unverferth, CV Leier, SP Balcerzak, RL Hamlin |
The American Journal of Cardiology | 1985 |
Free radical production from normal and adriamycin-treated rat cardiac sarcosomes
PJ Thornalley, NJ Dodd |
Biochemical Pharmacology | 1985 |
Studies on the mechanism of action of quinone antitumor agents
A Begleiter |
Biochemical Pharmacology | 1985 |
Progress in Medicinal Chemistry
JR Brown, SH Imam |
Progress in Medicinal Chemistry | 1985 |
Oxidative Stress
A Stern |
Oxidative Stress | 1985 |
Inhibition of bleomycin lung toxicity by N-acetyl cysteine in the rat
N Berend |
Pathology | 1985 |
Recent Advances in Biological Membrane Studies
L Packer |
1985 | |
Evaluation of free radical effects and catecholamine alterations in adriamycin cardiotoxicity
JA Jackson, JP Reeves, KH Muntz, D Kruk, RA Prough, JT Willerson, LM Buja |
The American Journal of Pathology | 1984 |
Prevention of adriamycin (ADR)-induced cardiotoxicity in rats using methylprednisolone (MP)
KS Dasmahapatra, M Vezeridis, U Rao, R Perez-Brett, CP Karakousis |
Journal of Surgical Research | 1984 |
Animal models of drug-induced cardiomyopathy
CM Czarnecki |
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology | 1984 |
Nutritional and Toxicological Aspects of Food Safety
M Friedman |
1984 | |
Platinum Coordination Complexes in Cancer Chemotherapy
MP Hacker, EB Douple, IH Krakoff |
1984 | |
Indication of reduced doxorubicin-induced cardiac toxicity by additional treatment with antioxidative substances
R Lenzhofer, D Magometschnigg, R Dudczak, C Cerni, C Bolebruch, K Moser |
Experientia | 1983 |
Enhancement of adriamycin toxicity by carboxymethylcellulose in mice
G Decorti, FB Klugmann, F Mallardi, R Brovedani, G Baldini, L Baldini |
Toxicology and Applied Pharmacology | 1983 |
Destruction of Phosphilipids and Respiratory-Chain Activity in Pig=Heart Submitochondrial Particles Induced by an Adriamycin-Iron Complex
PK JENSEN |
European Journal of Biochemistry | 1983 |
Cardiotoxic effects of anthracyclines
MR Bristow |
The Western journal of medicine | 1983 |
Detection of antineoplastic agent induced cardiotoxicity by 31P NMR of perfused rat hearts
TC Ng, JP Daugherty, WT Evanochko, SB Digerness, JR Durant, JD Glickson |
Biochemical and Biophysical Research Communications | 1983 |
1,4-Bis{2-[(2-hydroxyethyl)amino]ethylamino}-9, 10-anthracenedione, an anthraquinone antitumour agent that does not cause lipid peroxidation in vivo; Comparison with daunorubicin
LH Patterson, BM Gandecha, JR Brown |
Biochemical and Biophysical Research Communications | 1983 |
Comparative cardiac oxygen radical metabolism by anthracycline antibiotics, mitoxantrone, bisantrene, 4'-(9-acridinylamino)-methanesulfon-m-anisidide, and neocarzinostatin
JH Doroshow, KJ Davies |
Biochemical Pharmacology | 1983 |
Aktuelle Probleme der Hämatologie und internistischen Onkologie
CG Schmidt |
1983 | |
EFFECT OF TOCOPHEROL AND SELENIUM ON DEFENSES AGAINST REACTIVE OXYGEN SPECIES AND THEIR EFFECT ON RADIATION SENSITIVITY
CE Myers, A Katki, E Travis |
Annals of the New York Academy of Sciences | 1982 |
Oxidative destruction of erythrocyte ghost membranes catalyzed by the doxorubicin-iron complex
CE Myers, L Gianni, CB Simone, R Klecker, R Greene |
Biochemistry | 1982 |
Anthracycline Antibiotics in Cancer Therapy
FM Muggia, CW Young, SK Carter |
1982 |