Immunoglobulin G heavy chain (Gm) allotypes in multiple sclerosis.

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Abstract

Serum samples from 70 Caucasian patients with multiple sclerosis were typed for nine Gm markers. Significant association was found with the Gm 1,17;21 phenotype, and the relative risk for individuals with this phenotype was calculated at 3.6. The data indicate that Caucasians positive for Gm 1,17;21 are almost four times more likely to develop multiple sclerosis than those without this phenotype.

Authors

J P Pandey, J M Goust, J P Salier, H H Fudenberg