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Rapid Publication Free access | 10.1172/JCI110108

Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.

L M McManus, D J Hanahan, and R N Pinckard

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Published March 1, 1981 - More info

Published in Volume 67, Issue 3 on March 1, 1981
J Clin Invest. 1981;67(3):903–906. https://doi.org/10.1172/JCI110108.
© 1981 The American Society for Clinical Investigation
Published March 1, 1981 - Version history
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Abstract

Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 microM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.

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