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Research Article Free access | 10.1172/JCI110105

Heterogeneity of DNA deletion in gamma delta beta-thalassemia.

S H Orkin, S C Goff, and D G Nathan

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Published March 1, 1981 - More info

Published in Volume 67, Issue 3 on March 1, 1981
J Clin Invest. 1981;67(3):878–884. https://doi.org/10.1172/JCI110105.
© 1981 The American Society for Clinical Investigation
Published March 1, 1981 - Version history
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Abstract

By restriction endonuclease mapping, gene cloning, and DNA sequencing we have determined the region of DNA that is deleted in a family with gamma delta beta-thalassemia. The deletion removes the linked epsilon, gamma-, and delta-globin structural genes and terminates within the coding portion of the beta-globin gene. Since the extent of DNA deletion in this family differs from that reported in another family, we conclude that gamma delta beta-thalassemia is heterogeneous at the molecular level.

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