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Usage Information

Neutrophil-endothelial cell interactions on endothelial monolayers grown on micropore filters.
R F Taylor, … , S M Schwartz, D C Dale
R F Taylor, … , S M Schwartz, D C Dale
Published February 1, 1981
Citation Information: J Clin Invest. 1981;67(2):584-587. https://doi.org/10.1172/JCI110071.
View: Text | PDF
Research Article

Neutrophil-endothelial cell interactions on endothelial monolayers grown on micropore filters.

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Abstract

We have developed a technique for growing endothelial monolayers on micropore filters. These monolayers demonstrate confluence by phase and electron microscopy and provide a functional barrier to passage of radiolabeled albumin. Neutrophils readily penetrate the monolayer in response to chemotaxin, whereas there is little movement in the absence of chemotaxin. This system offers unique advantages over available chemotaxis assays and may have wider applications in the study of endothelial function.

Authors

R F Taylor, T H Price, S M Schwartz, D C Dale

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