Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat.

J J Franks; R E Kirsch; L O Frith; L R Purves; W T Franks; J A Franks; P Mason; S J Saunders

doi:10.1172/JCI110069

Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat.

J J Franks, R E Kirsch, L O Frith, L R Purves, W T Franks, J A Franks, P Mason, and S J Saunders

Published February 1, 1981 - More info

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Abstract

Previous studies are in conflict over the effect of infusing mixed fibrinogen-fibrin degradation products on fibrinogen synthesis, as determined by changes in fibrinogen concentration or by incorporation of labeled amino acids into fibrinogen. We have injected purified homologous fragments D1 and E into rats and measured their fibrinogen and albumin synthetic rates by the [14C]carbonate technique, a method that provides quantitative estimates of hepatic secretory protein synthesis. Fibrinogen fractional synthetic rates were increased 2.5 times in animals injected with fragment D1, compared with saline-injected controls. No increase were observed in fragment E-injected animals. Neither fragment produced changes in albumin synthesis. Fragment D increased plasma fibrinogen concentration, but did not raise plasma haptoglobin levels. These results suggest that fragment D is a regulator of fibrinogen synthesis.

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Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat.

J J Franks, R E Kirsch, L O Frith, L R Purves, W T Franks, J A Franks, P Mason, and S J Saunders

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Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat.

J J Franks, R E Kirsch, L O Frith, L R Purves, W T Franks, J A Franks, P Mason, and S J Saunders

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