We studied the effects of continuous negative external chest pressure (CNECP) produced by a cuirass appliance on lung water and protein transport in sheep with chronic lung lymphatic fistulas. We compared data obtained during periods of mechanical ventilation (base line) to period of CNECP, using identical ventilatory support. Three groups were studied: six sheep were studied before and after application of CNECP for 1 h (control) and again after induction of a pulmonary vascular permeability defect (PVPD) by infusing live Pseudomonas bacteria (group I); another six sheep were studied under control conditions before and after prolonged application of CNECP for over 4 h (group II); 10 sheep were studied 24 h after a Pseudomonas infusion (PVPD), before and after 4 h of CNECP (group III).
Peter Krumpe, Arnold Bernard Gorin
Title and authors | Publication | Year |
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Continuous external negative pressure improves oxygenation and respiratory mechanics in Experimental Lung Injury in Pigs – A pilot proof-of-concept trial
M Scharffenberg, J Wittenstein, M Herzog, S Tauer, L Vivona, R Theilen, T Bluth, T Kiss, T Koch, G Fiorentino, MG de Abreu, R Huhle |
Intensive Care Medicine Experimental | 2020 |
Comparative Biology of the Normal Lung
JL Peake, KE Pinkerton |
Comparative Biology of the Normal Lung | 2015 |
Pediatric and Neonatal Mechanical Ventilation
PC Rimensberger |
2014 | |
Continuous negative extrathoracic pressure combined with high-frequency oscillation improves oxygenation with less impact on blood pressure than high-frequency oscillation alone in a rabbit model of surfactant depletion
S Naito, T Hiroma, T Nakamura |
BioMedical Engineering OnLine | 2007 |
Effects of continuous negative extrathoracic pressure versus positive end-expiratory pressure in acute lung injury patients:
M Borelli, A Benini, T Denkewitz, C Acciaro, G Foti, A Pesenti |
Critical Care Medicine | 1998 |
Continuous Negative Extrathoracic Pressure Ventilation, Lung Water Volume, and Central Blood Volume
I Kudoh, T Andoh, H Doi, K Kaneko, Y Okutsu, F Okumura |
Chest | 1992 |