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Citations to this article

Captopril-induced Changes in Prostaglandin Production: RELATIONSHIP TO VASCULAR RESPONSES IN NORMAL MAN
Stephen L. Swartz, … , Robert G. Dluhy, Thomas J. Moore
Stephen L. Swartz, … , Robert G. Dluhy, Thomas J. Moore
Published June 1, 1980
Citation Information: J Clin Invest. 1980;65(6):1257-1264. https://doi.org/10.1172/JCI109788.
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Captopril-induced Changes in Prostaglandin Production: RELATIONSHIP TO VASCULAR RESPONSES IN NORMAL MAN

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Abstract

Captopril is a potent hypotensive agent whose efficacy has hitherto been attributed to its ability to alter either angiotensin II formation or kinin degradation. Our purpose was to examine captopril's acute effect on prostaglandin production, because changes in neither the renin-angiotensin nor the kallikrein-kinin systems appear adequate to account for the fall in arterial pressure. The plasma levels of angiotensin II, kinins, and prostaglandins were determined in response to increasing doses (5, 12.5, and 25 mg) of captopril and these responses were compared with the change in arterial pressure observed in nine supine normal male subjects studied on both a high (200 meq) and low (10 meq) sodium intake.

Authors

Stephen L. Swartz, Gordon H. Williams, Norman K. Hollenberg, Lawrence Levine, Robert G. Dluhy, Thomas J. Moore

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1986
Hypertension in Kidney Disease
JS Cheigh, KH Stenzel, AL Rubin
1986
Comparison of Acute Hemodynamic Effects of MC-838, a New Angiotensin-Converting Enzyme Inhibitor, with Captopril in Anesthetized Dogs
K NOGUCHI, T KATO, R SUNAGAWA, Y MIYAMOTO, M SAKANASHI
The Japanese Journal of Pharmacology 1986
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis
G Remuzzi, L Imberti, M Rossini, C Morelli, C Carminati, GM Cattaneo, T Bertani
Journal of Clinical Investigation 1985
Correction of abnormal renal blood flow response to angiotensin II by converting enzyme inhibition in essential hypertensives
J Redgrave, S Rabinowe, NK Hollenberg, GH Williams
Journal of Clinical Investigation 1985
Effect of captopril on the vascular permeability changes induced by C5a, histamine and compound 48/80
H Lim, R Kamide, I Gigli
British Journal of Dermatology 1985
INFLUENCE OF PROSTAGLANDIN INHIBITION ON DIHYDRALAZINE INDUCED ACUTE EFFECTS IN PATIENTS WITH ESSENTIAL HYPERTENSION
IW Heimann, D Ratge, H Wisser, JC Frölich
Clinical and Experimental Pharmacology and Physiology 1985
Haemodynamic and neurohumoral response to exercise in patients with congestive heart failure treated with captopril
MA Creager, DP Faxon, DA Weiner, TJ Ryan
British heart journal 1985
Impairment of granulomatous inflammatory response to Histoplasma capsulatum by inhibitors of angiotensin-converting enzyme
GS Deepe, CL Taylor, L Srivastava, WE Bullock
Infection and immunity 1985
Effect of intracoronary captopril on coronary blood flow and regional myocardial function in dogs
K Noguchi, T Kato, H Ito, Y Aniya, M Sakanashi
European Journal of Pharmacology 1985
Hemodynamic and clinical significance of the pulmonary vascular response to long-term captopril therapy in patients with severe chronic heart failure
M Packer, WH Lee, N Medina, M Yushak
Journal of the American College of Cardiology 1985
Arachidonic acid metabolism in cultured aortic endothelial cells
AR Whorton, JB Collawn, ME Montgomery, SL Young, RS Kent
Biochemical Pharmacology 1985
Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function
J Carmichael, SW Shankel
The American Journal of Medicine 1985
Are non-modulating patients with essential hypertension a distinct subgroup? Implications for therapy
GH Williams, NK Hollenberg
The American Journal of Medicine 1985
Effect of captopril on plasma prostacyclin concentration in essential hypertensive patients
N Someya, K Kodama, K Tanaka
Prostaglandins, Leukotrienes and Medicine 1985
Production of prostaglandins by dispersed cells and fragments from bovine parathyroid glands
EM Brown, SL Swartz
Prostaglandins 1985
Captopril inhibits sodium and water transport in the toad skin, a model of the distal nephron
GG Orce, GA Castillo
Pharmacological Research Communications 1985
Acute Effects of Captopril on Systemic and Renal Hemodynamics and on Renal Function in Cirrhotic Patients With Ascites
EA Pariente, C Bataille, E Bercoff, D Lebrec
Gastroenterology 1985
Captopril potentiates chronotropic baroreflex responses to carotid stimuli in humans
TJ Ebert
Hypertension 1985
The Ventricle
HJ Levine, WH Gaasch
1985
Prostaglandin levels in human vitreous
MA Thomas, GE O'Grady, SL Swartz
The British journal of ophthalmology 1985
Kardiologie
M Sokolow, MB Mcllroy
1985
Controlled Hypotension in Neuroanaesthesia
D Heuser, DG McDowall, V Hempel
1985
Renin- and non-renin–mediated antihypertensive actions of converting enzyme inhibitors
RM Zusman
Kidney International 1984
Hemodynamic Effects Of Captopril In One-Kidney, One Clip Hypertensive Rabbits
M Kogure, S Ichikawa, T Sakamaki, H Matsuo, Y Tajima, H Fujita, K Murata
Clinical and Experimental Hypertension 1984
Captopril and immune regulation
JF Delfraissy, P Galanaud, JF Balavoine, C Wallon, J Dormont
Kidney International 1984
Inhibitory effect of captopril on renal responses to frusemide in sodium-restricted rats
PJ Chiu, AD Brown, A Barnett
Journal of Pharmacy and Pharmacology 1984
POTENTIATION OF DEPRESSOR RESPONSES TO ARACHIDONIC ACID BY ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN THE RAT
SC Hui, S Dai, CW Ogle
Clinical and Experimental Pharmacology and Physiology 1984
Indomethacin and angiotensin II pressor responsiveness: Importance of dietary sodium
DD Smyth, HY Fung
European Journal of Pharmacology 1984
CAPTOPRIL: A NEW TREATMENT FOR RHEUMATOID ARTHRITIS?
MF Martin, F Mckenna, HA Bird, KE Surrall, JS Dixon, V Wright
The Lancet 1984
Conceptual dilemmas in the classification of vasodilator drugs for severe chronic heart failure
M Packer
The American Journal of Medicine 1984
Prostaglandins in Severe Congestive Heart Failure: Relation to Activation of the Renin–Angiotensin System and Hyponatremia
VJ Dzau, M Packer, LS Lilly, SL Swartz, NK Hollenberg, GH Williams
New England Journal of Medicine 1984
Plasma levels of 15-keto-13,14-dihydro-prostaglandin E2 in patients with bronchogenic carcinoma
M Starczewski, R Voigtmann, BA Peskar, BM Peskar
Prostaglandins, Leukotrienes and Medicine 1984
Converting-enzyme inhibition corrects the altered adrenal response to angiotensin II in essential hypertension
T Taylor, TJ Moore, NK Hollenberg, GH Williams
Hypertension 1984
Influence of captopril and enalapril on regional vascular alpha-adrenergic receptor reactivity in SHR
C Richer, MP Doussau, JF Giudicelli
Hypertension 1984
Biology of Endothelial Cells
EA Jaffe
1984
Fundamental Fault in Hypertension
MP Sambhi
1984
Effect of captopril on uterine blood flow and prostaglandin E synthesis in the pregnant rabbit
TF Ferris, EK Weir
Journal of Clinical Investigation 1983
Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta
RS Kent, SL Diedrich, AR Whorton
Journal of Clinical Investigation 1983
Response of the kidney to furosemide. II. Effect of captopril on sodium balance
RA Kelly, CS Wilcox, WE Mitch, TW Meyer, PF Souney, CM Rayment, PA Friedman, SL Swartz
Kidney International 1983
Antibodies as Specific Renin Inhibitors: Studies with Polyclonal and Monoclonal Antibodies and Fab Fragments
VJ Dzau, D Devine, M Mudgett-Hunter, RI Kopelman, AC Barger, E Haber
Clinical and Experimental Hypertension 1983
The converting enzyme inhibitor captopril stimulates prostacyclin synthesis by isolated rat aorta
R Düsing, R Scherhag, G Landsberg, K Glänzer, HJ Kramer
European Journal of Pharmacology 1983
Levels of plasma 6-keto-PGF1α in normotensive and essential hypertensive males with and without a family history of hypertension
S Gotoh, T Ogihara, M Nakamaru, K Masuo, T Hata, Y Kumahara
Prostaglandins, Leukotrienes and Medicine 1983
Acute electrocardiographic effects of captopril in the initial treatment of malignant or severe hypertension
I Abe, T Kawasaki, N Kawazoe, T Omae
American Heart Journal 1983
Autonomic and baroreflex function after captopril in hypertension
SE Warren, DT O'Connor, IM Cohen
American Heart Journal 1983
The Physiology and Pharmacology of the Microcirculation
RJ Traystman
The Physiology and Pharmacology of the Microcirculation 1983
Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney
DE Hricik, PJ Browning, R Kopelman, WE Goorno, NE Madias, VJ Dzau
New England Journal of Medicine 1983
Converting Enzyme Inhibitors in Hemodialysis
N Bazilinski
The International Journal of Artificial Organs 1983
Synergistic effect of captopril with hydrochlorothiazide for the treatment of low-renin hypertensive black patients
OB Holland, L von Kuhnert, WB Campbell, RJ Anderson
Hypertension 1983
Renal vasodilation by converting enzyme inhibition. Role of renal prostaglandins
JA Oliver, RR Sciacca, PJ Cannon
Hypertension 1983
Renal and adrenal responses to hypoxemia during angiotensin-converting enzyme inhibition in lambs
DN Weismann, JE Herrig, OJ McWeeny, NA Ayres, JE Robillard
Circulation research 1983
The conscious instrumented rabbit: a model for the study of mechanisms of blood pressure regulation during pregnancy
AJ Donker, I Min, RC Venuto
Hypertension 1983
Hemodynamic patterns of response during long-term captopril therapy for severe chronic heart failure
M Packer, N Medina, M Yushak, J Meller
Circulation 1983
Increase in collateral arterial endothelial cell proliferation induced by captopril after renal artery stenosis in the rat
T Odori, A Paskins-Hurlburt, NK Hollenberg
Hypertension 1983
Vasodilator Therapy in Chronic Congestive Heart Failure:
AB Schwartz, K Chatterjee
Drugs 1983
Role of angiotensin-converting enzyme in Bacille Calmette-Guérin-induced granulomatous inflammation. Increased angiotensin-converting enzyme levels in lung lavage and suppression of inflammation with captopril
DJ Schrier, LM Ripani, AL Katzenstein, VL Moore
Journal of Clinical Investigation 1982
Inhibition of vascular permeability changes in rats by captopril
JC Fantone, D Schrier, B Weingarten
Journal of Clinical Investigation 1982
Abnormal renin short feedback loop in essential hypertension is reversible with converting enzyme inhibition
M LeBoff, RG Dluhy, NK Hollenberg, TJ Moore, RJ Koletsky, GH Williams
Journal of Clinical Investigation 1982
Mechanism of the Response to Captopril in Glucocorticoid Hypertension
F Elijovich, LR Krakoff
Clinical and Experimental Hypertension 1982
Captopril (SQ 14,225): In vitro and in vivo influence on the proliferative response of rat lymphocytes
L Binderup, E Bramm, E Arrigoni-Martelli
Experientia 1982
Captopril as treatment for patients with pulmonary hypertension. Problem of variability in assessing chronic drug treatment
S Rich, J Martinez, W Lam, KM Rosen
British heart journal 1982
The effect of captopril (SQ14,225) upon mother and fetus in the chronically cannulated ewe and in the pregnant rabbit
FB Pipkin, EM Symonds, SR Turner
The Journal of Physiology 1982
Acute hypotensive effect of captopril in man modified by prostaglandin synthesis inhibition
K Silberbauer, B Stanek, H Templ
British Journal of Clinical Pharmacology 1982
Captopril bei Herzinsuffizienz
G Liebau
Klinische Wochenschrift 1982
CAPTOPRIL POTENTIATES DEPRESSOR RESPONSES TO ARACHIDONIC ACID IN THE RAT
SC Hui, AL Bourn
Clinical and Experimental Pharmacology and Physiology 1982
The Effect of Captopril on Renin, Angiotensin II, Cortisol and Aldosterone During Acth-Infusion in man
W Oelkers, L Belkien, J Baumann, M Meyland
Clinical and Experimental Hypertension 1982
Captopril decreases vascular reactivity independently of changes in converting enzyme activity and prostaglandin release in the rat isolated kidney
S Chiba, CP Quilley, J Quilley, JC McGiff
European Journal of Pharmacology 1982
Captopril in Treatment-Resistant Essential and Renal Hypertension
M Aurell, K Delin, H Herlitz
Scandinavian Journal of Urology and Nephrology 1982
Specificity of renal vasodilation with captopril: Saralasin prevents the response in the doca-treated, salt-loaded rabbit
NK Hollenberg, DR Passan
Life Sciences 1982
Angiotensin-converting enzyme inhibition and prostaglandins
SL Swartz, GH Williams
The American Journal of Cardiology 1982
Effect of angiotensin-converting enzyme inhibition on circulating and local kinin levels
CI Johnston, BH Clappison, WP Anderson, M Yasujima
The American Journal of Cardiology 1982
Angiotensin II is a necessary component for the development of hypertension in the two kidney, one clip rat
JM DeForrest, RC Knappenberger, MJ Antonaccio, RA Ferrone, JS Creekmore
The American Journal of Cardiology 1982
The effect of captopril on renal, coronary, and systemic hemodynamics in patients with severe congestive heart failure
ER Powers, KS Bannerman, J Stone, DS Reison, EL Escala, K Alan, MB Weiss, RR Sciacca, PJ Cannon
American Heart Journal 1982
Mechanism of the blood pressure and renal hemodynamic effects of captopril
JE Hall, JP Granger
The American Journal of Cardiology 1982
Effects of angiotensin-converting enzyme inhibitors on the vascular response to norepinephrine
T Saruta, H Suzuki, T Okuno, K Kondo
The American Journal of Cardiology 1982
Pathobiology of the Endothelial Cell
SA Stalcup, GM Turino, RB Mellins
Pathobiology of the Endothelial Cell 1982
Prostaglandins mediate the vasodilatory effect of mannitol in the hypoperfused rat kidney
PA Johnston, DB Bernard, NS Perrin, NG Levinsky
Journal of Clinical Investigation 1981
Etiopathogenesis of Excess Methylprednisolone Arterial Hypertension in the Rat
AB Ribeiro, RJ Franco, O Kohlmann, O Marson, OL Ramos
Clinical and Experimental Hypertension 1981
Antihypertensive and hormonal effects of single oral doses of Captopril and Nifedipine in essential hypertension
ME Soto, M Thibonnier, O Sire, J Menard, P Corvol, P Milliez
European Journal of Clinical Pharmacology 1981
Clinical Improvement and Hormonal Changes in Severe Cardiac Failure after Captopril Treatment
BP McGrath, IM Denham, CI Johnston
Australian and New Zealand Journal of Medicine 1981
BLOOD PRESSURE ERRORS WITH ANEROID SPHYGMOMANOMETERS
CE Bowman
The Lancet 1981
IMMUNOSUPPRESSIVE ACTION OF CAPTOPRIL BLOCKED BY PROSTAGLANDIN SYNTHETASE INHIBITOR
SA Johnsen, M Aurell
The Lancet 1981
Haemodynamic profile of captopril treatment in various forms of hypertension
JH Bruyn, AJ Veld, GJ Wenting, FH Derkx, MA Schalekamp
European Journal of Clinical Pharmacology 1981
ROLE OF THE KALLIKREIN-KININ SYSTEM IN THE RENAL EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME INHIBITION IN ANAESTHETIZED DOGS
BH Clappison, WP Anderson, CI Johnston
Clinical and Experimental Pharmacology and Physiology 1981
FAILURE OF ASPIRIN TO MODIFY THE HYPOTENSIVE ACTION OF CAPTOPRIL IN SPONTANEOUSLY HYPERTENSIVE RATS
R DiNicolantonio, GJ Dusting, JS Hutchinson, FA Mendelsohn
Clinical and Experimental Pharmacology and Physiology 1981
Sodium intake and renal responses to captopril in normal man and in essential hypertension
NK Hollenberg, LG Meggs, GH Williams, J Katz, JD Garnic, DP Harrington
Kidney International 1981
Effect of Angiotensin Converting Enzyme Inhibition with SQ 14 225 on Blood Pressure in Sheep
KW Stewart, JP Coghlan, DA Denton, DT Fei, RT Mason, BA Scoggins, JA Whitworth
Clinical and Experimental Hypertension 1981
Relationship between angiotensin I blockade and antihypertensive properties of single doses of MK-421 and captopril in spontaneous and renal hypertensive rats
CS Sweet, PT Arbegast, SL Gaul, EH Blaine, DM Gross
European Journal of Pharmacology 1981
Effects of captopril on urinary excretion of prostaglandins and electrolytes in spontaneously hypertensive rats
M Miyamoto, H Koike, K Ito, M Yamazaki
European Journal of Pharmacology 1981
Mechanisms and implications of vasodilator tolerance in the treatment of congestive heart failure
WS Colucci, GH Williams, RW Alexander, E Braunwald
The American Journal of Medicine 1981
Clinical pharmacology and therapeutic applications of the new oral angiotensin converting enzyme inhibitor, captopril
RK Ferguson, PH Vlasses
American Heart Journal 1981
Effects of captopril, diuretic, and their combination in low-renin essential hypertension
RK Ferguson, PH Vlasses, BN Swanson
Life Sciences 1980
Nonsurgical Therapy for Heart Failure:
KW Park
International Anesthesiology Clinics
Urinary excretion of TXB2 after angiotensin converting enzyme inhibition in hypertensive patients
K Kudo, K Abe, S Chiba, K Omata, K Sato, M Yasugima, M Sato, K Yoshinaga
Prostaglandins, Leukotrienes and Medicine 1986
A randomized trial of the effect of vitamin E on plasma prostacyclin (6-Keto-PGF1α) levels in healthy adults
SL Swartz, WC Willett, CH Hennekens
Prostaglandins, Leukotrienes and Medicine 1985
Urinary excretion of prostacyclin and thromboxane A2 metabolites after angiotensin converting enzyme inhibition in hypertensive patients
PH Vlasses, RK Ferguson, JB Smith, HH Rotmensch, BN Swanson
Prostaglandins, Leukotrienes and Medicine 1983
Long-Term Treatment of Childhood Hypertension with Captopril
SE Oberfield, R Rapaport, LS Levine, MI New
Pediatric Annals 1982
Captopril: Clinical Pharmacology and Benefit-to-Risk Ratio in Hypertension and Congestive Heart Failure
PH Vlasses, RK Ferguson, K Chatterjee
Nature Communications 1982
Acute hemodynamic responses to vasodilator therapy in congestive heart failure
HS Ribner, D Bresnahan, AM Hsieh, R Silverman, C Tommaso, A Coath, J Askenazi
Progress in Cardiovascular Diseases 1982
Physiologic and pharmacologic determinants of vasodilator response: A conceptual framework for rational drug therapy for chronic heart failure
M Packer, TH Jemtel
Progress in Cardiovascular Diseases 1982
Attenuation of nephrotoxic acute renal failure in the dog with angiotensin-converting enzyme inhibitor (SQ-20,881)
A Lindner, RE Cutler, AJ Bell
Circulation research 1982
Renin-angiotensin system inhibition in acute myocardial infarction in dogs. Effects on systemic hemodynamics, myocardial blood flow, segmental myocardial function and infarct size
CS Liang, H Gavras, J Black, LG Sherman, WB Hood
Circulation 1982
Role of kallikrein in the hypertensive effect of captopril after sympathetic stimulation of the rat submandibular gland
TB Orstavik, OA Carretero, L Johansen, AG Scicli
Circulation research 1982
Acute responses to arterial pressure and plasma renin activity to converting enzyme inhibition (SQ 20,881) in serially studied dogs with neonatally-induced coarctation hypertension
SP Bagby
Hypertension 1982
Decreased vascular responsiveness produced by angiotensin-converting enzyme inhibitors in the rat isolated kidney
S Chiba, CP Quilley, JC McGiff
Hypertension 1982
Effect of in vitro administration of captopril on vascular reactivity of rat aorta
DC Kikta, MJ Fregly
Hypertension 1982
Hypertensive Cardiovascular Disease: Pathophysiology and Treatment
A Amery, R Fagard, P Lijnen, J Staessen
1982
Low-dose captopril in the treatment of severe refractory hypertension associated with renal failure
GM Bell, A Doig, ML Watson, AL Muir, RJ Winney
Postgraduate medical journal 1982
Evidence from a dual action of converting enzyme inhibitor on blood pressure in normal man
R Goldstone, K Martin, R Zipser, R Horton
Prostaglandins 1981
Release of prostaglandin I2-like activity from the rat aorta: Effect of captopril, furosemide, and sodium
JM Sullivan, DR Patrick
Prostaglandins 1981
Captopril (Capoten®, E.R. Squibb & Sons)
EA Jackson, AA Cardoni, C Harris, GH Smith
1981
Possible role of kinins in circulatory homeostasis. State of the art review
OA Carretero, AG Scicli
Hypertension 1981
Contribution of prostaglandins to the antihypertensive action of captopril in essential hypertension
TJ Moore, FR Crantz, NK Hollenberg, RJ Koletsky, MS Leboff, SL Swartz, L Levine, S Podolsky, RG Dluhy, GH Williams
Hypertension 1981
Effect of intracerebroventricular captopril on vasopressin and blood pressure in spontaneously hypertensive rats
JT Crofton, RW Rockhold, L Share, BC Wang, ZP Horovitz, M Manning, WH Sawyer
Hypertension 1981
Contemporary Nephrology
S Klahr, SG Massry
1981
Evidence for participation of kinins in the antihypertensive effect of converting enzyme inhibition
A Overlack, KO Stumpe, M Khnert, R Kolloch, C Ressel, I Heck, F Krck
Klinische Wochenschrift 1981
Alteration of the Granulomatous Response in Murine Schistosomiasis by the Chronic Administration of Captopril, an Inhibitor of Angiotensin-Converting Enzyme
JV Weinstock, DL Boros
Gastroenterology 1981
Haemodynamic profile of captopril treatment in various forms of hypertension
JH de Bruyn, , GJ Wenting, FH Derkx, MA Schalekamp
European Journal of Clinical Pharmacology 1981
Ergebnisse der Inneren Medizin und Kinderheilkunde / Advances in Internal Medicine and Pediatrics
P Frick, GA von Harnack, GA Martini, A Prader, HP Wolff
1980
Recent pathogenic aspects in essential hypertension and hypertension associated with diabetes mellitus
P Weidmann
Klinische Wochenschrift 1980
Captopril: A Preliminary Review of its Pharmacological Properties and Therapeutic Efficacy
RC Heel, RN Brogden, TM Speight, GS Avery
Drugs 1980
Inhibitors of angiotensin I converting enzyme for treating hypertension.
British medical journal 1980
Prostaglandins and the Kidney
JC Mcgiff, HD ITSKOVITZ
Circulation research 1973

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