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Citations to this article

Dietary-induced alterations in thyroid hormone metabolism during overnutrition.
E Danforth Jr, … , L Braverman, A G Vagenakis
E Danforth Jr, … , L Braverman, A G Vagenakis
Published November 1, 1979
Citation Information: J Clin Invest. 1979;64(5):1336-1347. https://doi.org/10.1172/JCI109590.
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Dietary-induced alterations in thyroid hormone metabolism during overnutrition.

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Abstract

Diet-induced alterations in thyroid hormone concentrations have been found in studies of long-term (7 mo) overfeeding in man (the Vermont Study). In these studies of weight gain in normal weight volunteers, increased calories were required to maintain weight after gain over and above that predicted from their increased size. This was associated with increased concentrations of triiodothyronine (T3). No change in the caloric requirement to maintain weight or concentrations of T3 was found after long-term (3 mo) fat overfeeding. In studies of short-term overfeeding (3 wk) the serum concentrations of T3 and its metabolic clearance were increased, resulting in a marked increase in the production rate of T3 irrespective of the composition of the diet overfed (carbohydrate 29.6 +/- 2.1 to 54.0 +/- 3.3, fat 28.2 +/- 3.7 to 49.1 +/- 3.4, and protein 31.2 +/- 2.1 to 53.2 +/- 3.7 microgram/d per 70 kg). Thyroxine production was unaltered by overfeeding (93.7 +/- 6.5 vs. 89.2 +/- 4.9 microgram/d per 70 kg). It is still speculative whether these dietary-induced alterations in thyroid hormone metabolism are responsible for the simultaneously increased expenditure of energy in these subjects and therefore might represent an important physiological adaptation in times of caloric affluence. During the weight-maintenance phases of the long-term overfeeding studies, concentrations of T3 were increased when carbohydrate was isocalorically substituted for fat in the diet. In short-term studies the peripheral concentrations of T3 and reverse T3 found during fasting were mimicked in direction, if not in degree, with equal or hypocaloric diets restricted in carbohydrate were fed. It is apparent from these studies that the caloric content as well as the composition of the diet, specifically, the carbohydrate content, can be important factors in regulating the peripheral metabolism of thyroid hormones.

Authors

E Danforth Jr, E S Horton, M O'Connell, E A Sims, A G Burger, S H Ingbar, L Braverman, A G Vagenakis

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American journal of physiology. Endocrinology and metabolism 1988
The Endocrinology of Anorexia Nervosa and Bulimia Nervosa
MM Newman, KA Halmi
Endocrinology and metabolism clinics of North America 1988
Expenditure and storage of energy in man
EA Sims, E Danforth
Journal of Clinical Investigation 1987
INCREASED BASAL METABOLIC RATE AFTER SUSTAINED EXERCISE IN A COLD ENVIRONMENT
MA Stroud
The Lancet 1987
Extrathyroidal Conversion of Thyroxine to 3,5,3′-Triiodothyronine (T3) and 3,3′,5′-Triiodothyronine (rT3) and its Contribution to Total Triiodothyronines Production Rates in Fed and Food Restricted Piglets
G Nowak, AB S̀lebodziñski
Journal of Veterinary Medicine Series A 1986
ALTERATIONS IN THE HYPOTHALAMIC-PITUITARY-THYROID AXIS AFTER PROLONGED RESIDENCE IN ANTARCTICA
HL Reed, KD Burman, KM Shakir, JT O'brian
Clinical Endocrinology 1986
Decrease of circulating level of SHBG in postmenopausal obese women as a risk factor in breast cancer: Reversible effect of weight loss
CL Enriori, W Orsini, MC Cremona, AE Etkin, LR Cardillo, J Reforzo-Membrives
Gynecologic Oncology 1986
The effect of varying carbohydrate content of a very-low-caloric diet on resting metabolic rate and thyroid hormones
RA Mathieson, JL Walberg, FC Gwazdauskas, DE Hinkle, JM Gregg
Metabolism 1986
The control of cartilage growth in osteochondrosis: A review
MJ Glade
Journal of Equine Veterinary Science 1986
Genotype dependency of the thermic effect of a meal and associated hormonal changes following short-term overfeeding
ET Poehlman, A Tremblay, E Fontaine, JP Després, A Nadeau, J Dussault, C Bouchard
Metabolism 1986
Metabolic studies in human obesity during overnutrition and undernutrition: Thermogenic and hormonal responses to norepinephrine
HL Katzeff, M O'Connell, ES Horton, E Danforth, JB Young, L Landsberg
Metabolism 1986
Sucrose substitution in prevention and reversal of the fall in metabolic rate accompanying hypocaloric diets
RG Hendler, M Walesky, RS Sherwin
The American Journal of Medicine 1986
Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment
SL Welle, RG Campbell
Metabolism 1986
Skeletal Muscle Function and Metabolism in Obese Women
C Lennmarken, S Sandstedt, HV Schenck, J Larsson
JPEN. Journal of parenteral and enteral nutrition 1986
The Effects of Varying Energy and Nitrogen Intake on Nitrogen Balance, Body Composition, and Metabolic Rate
NK Edens, KM Gil, DH Elwyn
Clinics in Chest Medicine 1986
Interaction of thyroid hormone and nutritional signals on thyroid hormone action
CN Mariash, JH Oppenheimer
Molecular and Cellular Endocrinology 1985
Renal concentrating ability in obesity. Effect of modified fasting and the supplementation of T3, sodium chloride and carbohydrate
HP Koppeschaar, AE Meinders, F Schwarz
Metabolism 1985
Decreased prolactin secretion in childhood obesity
TW AvRuskin, S Pillai, K Kasi, C Juan, DL Kleinberg
The Journal of Pediatrics 1985
Meal-induced brown fat thermogenesis and thyroid hormone metabolism in rats
Z Glick, SY Wu, J Lupien, R Reggio, GA Bray, DA Fisher
American journal of physiology. Endocrinology and metabolism 1985
Infusions- und Ernährungstherapie des Polytraumatisierten
JE Schmitz
1985
Thyroid hormone action on intermediary metabolism
MJ Müller, HJ Seitz
Klinische Wochenschrift 1984
Whole-body calorimetry studies in adult men
HM Dallosso, WP James
British Journal of Nutrition 1984
Effect of fasting and feeding time on circadian rhythms of serum thyroid hormone concentrations, glucose, liver monodeiodinase activity and rectal temperature in growing chickens
E Decuypere, ER Kühn
Domestic Animal Endocrinology 1984
Decreased free fraction of serum thyroid hormones during carbohydrate overfeeding
S Welle, M O'Connell, E Danforth, R Campbell
Metabolism 1984
Clinical complications of obesity
PG Kopelman
Clinics in Endocrinology and Metabolism 1984
Increased erythrocyte sodium efflux during overfeeding without evidence of mediation by circulating catecholamines or thyroid hormone
B Fagerberg, H Herlitz, O Jonsson, J Naucler, U Nilsson, T Hedner, G Lindstedt, O Andersson
Metabolism 1984
Thyroid hormones and thermogenesis: The metabolic cost of food and exercise
K Acheson, E Jéquier, A Burger, E Danforth
Metabolism 1984
The role of thyroid hormones in the control of energy expenditure
E Danforth, A Burger
Clinics in Endocrinology and Metabolism 1984
Energy expenditure in obesity
E Jéquier
Clinics in Endocrinology and Metabolism 1984
Endocrinological aspects of obesity
R Jung
Clinics in Endocrinology and Metabolism 1984
Dieting: Ideology Versus Physiology
WI Bennett
The Psychiatric clinics of North America 1984
90. Kongreß
JF Bergmann
1984
Evaluation and Treatment of Obesity
J Storlie, HA Jordan
1984
Thyroid hormone action on intermediary metabolism: Part I: Respiration, thermogenesis and carbohydrate metabolism
MJ Müller, HJ Seitz
Klinische Wochenschrift 1984
Stimulation of thermogenesis by carbohydrate overfeeding. Evidence against sympathetic nervous system mediation
S Welle, RG Campbell
Journal of Clinical Investigation 1983
Adrenergic activation of triiodothyronine production in brown adipose tissue
JE Silva, PR Larsen
Nature 1983
Excess energy intake promotes the development of hypoalbuminaemia in rats fed on low-protein diets
PG Lunn, S Austin
British Journal of Nutrition 1983
The mechanism of recovery of hepatic T4-5′-deiodinase during glucose-refeeding: Role of glucagon and insulin
LA Gavin, M Moeller
Metabolism 1983
Relationships between iodothyronine peripheral metabolism and ketone bodies during hypocaloric dietary manipulations
R Pasquali, G Baraldi, P Biso, F Pasqui, L Mattioli, M Capelli, R Callivá, M Spoto, N Melchionda, G Labò
Journal of Endocrinological Investigation 1983
Molecular Basis of Thyroid Hormone Action
P Larsen, J Silva
Molecular Basis of Thyroid Hormone Action 1983
Acute effects of fat and carbohydrate on metabolic rate in normal, cold-acclimated and lean and obese (fa/fa) Zucker rats
NJ Rothwell, MJ Stock
Metabolism 1983
Hypothermia in a patient with anorexia nervosa
DK Smith, L Ovesen, R Chu, S Sackel, L Howard
Metabolism 1983
Energy cost of glucose storage in human subjects during glucose-insulin infusions
D Thiebaud, Y Schutz, K Acheson, E Jacot, RA DeFronzo, JP Felber, E Jequier
American journal of physiology. Endocrinology and metabolism 1983
Mammalian Thermogenesis
L Girardier, MJ Stock
1983
The effect of early postnatal undernutrition on the growth and development of the rat brain
BL Morgan, DJ Naismith
British Journal of Nutrition 1982
A study of the thermic responses to a meal and to a sympathomimetic drug (ephedrine) in relation to energy balance in man
JB Morgan, DA York, A Wasilewska, J Portman
British Journal of Nutrition 1982
Differing thyrotropin responses to increased serum triiodothyronine concentrations produced by overfeeding and by triiodothyronine administration
RD Utiger
Metabolism 1982
Effect of dietary carbohydrates during hypocaloric treatment of obesity on peripheral thyroid hormone metabolism
R Pasquali, M Parenti, L Mattioli, M Capelli, G Cavazzini, G Baraldi, G Sorrenti, GD Benedettis, P Biso, N Melchionda
Journal of Endocrinological Investigation 1982
Characteristics of diet-induced brown adipose tissue growth and thermogenesis in rats
OL Tulp, MH Gregory, E Danforth
Life Sciences 1982
Noradrenaline turnover during under- and over-eating in normal weight subjects
K O'Dea, M Esler, P Leonard, JR Stockigt, P Nestel
Metabolism 1982
Mechanisms of hypertension in the overweight
EA Sims
Hypertension 1982
SERUM LEVELS OF T4, T3, REVERSE T3, 3,3'-DIIODOTHYRONINE AND 3',5'-DIIODOTHYRONINE IN OBESITY, BEFORE AND AFTER JEJUNO-ILEAL BYPASS
J Faber, TI Sørensen, IB Lumholtz, HC Klein, C Kirkegaard, M Blickert-Toft
Clinical Endocrinology 1981
The thermic effects of diet
DA York
Nutrition Bulletin 1981
ADRENERGIC MECHANISMS IN OBESITY
WP James
Clinical Physiology 1981
Endocrine function in human obesity
AR Glass, KD Burman, WT Dahms, TM Boehm
Metabolism 1981
Effects of dietary manipulation on the generation of 3,5,3'-triiodothyronine from thyroxine in rat liver preparations
A Balsam, F Sexton, SH Ingbar
Life Sciences 1981
Interaction of thyroid status and diet on muscle protein breakdown in the rat, as measured by Nτ-methylhistidine excretion
R Burini, S Santidrian, M Moreyra, P Brown, HN Munro, VR Young
Metabolism 1981
Dietary-induced thermogenesis: Control of energy expenditure
E Danforth
Life Sciences 1981
Energy Expenditure in Surgical Patients
DH Elwyn, JM Kinney, J Askanazi
Surgical Clinics of North America 1981
The thyrotropin response to thyrotropin-releasing hormone in endogenous depression
C Kirkegaard
Psychoneuroendocrinology 1981
Altered thyroid hormone levels in bacterial sepsis: The role of nutritional adequacy
DA Richmand, ME Molitch, TF O'Donnell
Metabolism 1980
The role of dietary fat in peripheral thyroid hormone metabolism
MH Otten, G Hennemann, R Docter, TJ Visser
Metabolism 1980
10 The thyroid
LE Braverman, AG Vagenakis
Clinics in Endocrinology and Metabolism 1979
Advances in Nutritional Research
HH Draper
1977
Selenium
I Rosenfeld, OA Beath
Selenium 1964

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