Chlorozotocin: MECHANISM OF REDUCED BONE MARROW TOXICITY IN MICE
Lawrence C. Panasci, … , Dianna Green, Philip S. Schein
Lawrence C. Panasci, … , Dianna Green, Philip S. Schein
Published October 1, 1979
Citation Information: J Clin Invest. 1979;64(4):1103-1111. https://doi.org/10.1172/JCI109549.
View: Text | PDF

Chlorozotocin: MECHANISM OF REDUCED BONE MARROW TOXICITY IN MICE

Abstract

Chlorozotocin is a chloroethyl nitrosourea with a glucose carrier that has curative activity for the murine L1210 leukemia, but is nonmyelosuppressive in mice. To determine the mechanism for this unique property of reduced bone marrow toxicity, comparative studies were conducted with chlorozotocin and CCNU, a myelotoxic chloroethyl nitrosourea.

Authors

Lawrence C. Panasci, Dianna Green, Philip S. Schein

×
Other pages:
1103 1104 1105 1106 1107 1108 1109 1110 1111

Other pages:
1103 1104 1105 1106 1107 1108 1109 1110 1111