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Citations to this article

Role of Cytochrome P-450 in Alveolar Hypoxic Pulmonary Vasoconstriction in Dogs
Matthew A. Miller, Charles A. Hales
Matthew A. Miller, Charles A. Hales
Published August 1, 1979
Citation Information: J Clin Invest. 1979;64(2):666-673. https://doi.org/10.1172/JCI109507.
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Research Article

Role of Cytochrome P-450 in Alveolar Hypoxic Pulmonary Vasoconstriction in Dogs

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Abstract

Alveolar hypoxia induces pulmonary vasoconstriction by an unknown mechanism. Cytochrome P-450 (C-P450) is found in the lung and may modify pulmonary vascular tone via its sensitivity to changes in oxygen tension or by affecting metabolism of a chemical mediator. Metyrapone and carbon monoxide are both inhibitors of C-P450. We tested alveolar hypoxic pulmonary vasoconstriction (AHPV) in 20 dogs before, during, and after separate administration of each inhibitor. Anesthetized dogs were ventilated through a double lumen endotracheal tube allowing ventilation of one lung with N2 or CO as a hypoxic challenge and ventilation of the other lung with O2 to maintain adequate systemic oxygenation. Distribution of lung perfusion was determined with intravenous 133Xenon and external chest detectors. Before infusion of metyrapone, mean perfusion to the test lung decreased 30% with alveolar hypoxic challenge, but decreased only 10% during metyrapone infusion and returned to a base-line mean decrease of 31% after completion of metyrapone infusion. Prostaglandin F2 α and angiotensin II infusions produced equivalent increases in pulmonary vascular resistance before and during metyrapone infusion. Before CO, mean test lung perfusion decreased 31% with alveolar hypoxia but was reduced only 10% from control when unilateral end-tidal CO% was >75%. Washout of alveolar CO with unilateral N2 ventilation restored AHPV, with perfusion decreasing 29% from control. Thus, both metyrapone and carbon monoxide can reversibly inhibit AHPV. C-P450 may, therefore, be involved in the transduction process of the vasoconstrictor response to alveolar hypoxia.

Authors

Matthew A. Miller, Charles A. Hales

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Total citations by year

Year: 2015 2014 2013 2012 2011 2010 2008 2007 2005 2002 2000 1999 1998 1995 1994 1992 1991 1988 1987 1985 1984 Total
Citations: 1 2 2 1 3 1 1 1 1 3 2 1 2 3 1 1 1 3 1 2 1 34
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (34)

Title and authors Publication Year
Comparative Biology of the Normal Lung
JL Peake, KE Pinkerton
Comparative Biology of the Normal Lung 2015
Integrative understanding of hypoxic pulmonary vasoconstriction using in vitro models: from ventilated/perfused lung to single arterial myocyte
HY Yoo, SJ Park, HJ Kim, WK Kim, SJ Kim
Integrative Medicine Research 2014
Comprehensive Physiology
SN Cheuvront, RW Kenefick
Comprehensive Physiology 2014
Human cytochromes P450 in health and disease
DW Nebert, K Wikvall, WL Miller
Philosophical Transactions of the Royal Society B: Biological Sciences 2013
Hypoxic Pulmonary Vasoconstriction
ER Swenson
High Altitude Medicine & Biology 2013
Hypoxic pulmonary vasoconstriction.
Sylvester JT, Shimoda LA, Aaronson PI, Ward JP
Physiological reviews 2012
Cytochrome P450-Derived Epoxyeicosatrienoic Acids and Pulmonary Hypertension: Central Role of Transient Receptor Potential C6 Channels
AE Loot, I Fleming
Journal of Cardiovascular Pharmacology 2011
The cytochrome P450 pathway in angiogenesis and endothelial cell biology
I Fleming
Cancer and Metastasis Reviews 2011
Bioengineering Aspects in the Design of Gas Exchangers
JN Maina
2011
Inhibition of Hypoxic Pulmonary Vasoconstriction of Rats by Carbon Monoxide
HY Yoo, SJ Park, JH Bahk, SJ Kim
Journal of Korean Medical Science 2010
Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts
A Nakao, G Faleo, H Shimizu, K Nakahira, J Kohmoto, R Sugimoto, AM Choi, KR McCurry, T Takahashi, N Murase
Kidney International 2008
Mitochondrial and Cellular Heme-Dependent Proteins as Targets for the Bioactive Function of the Heme Oxygenase/Carbon Monoxide System
M Desmard, J Boczkowski, J Poderoso, R Motterlini
Antioxidants & Redox Signaling 2007
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
L Wu, R Wang
Pharmacological reviews 2005
Biological Chemistry of Carbon Monoxide
CA Piantadosi
Antioxidants & Redox Signaling 2002
Endothelium-derived mediators and hypoxic pulmonary vasoconstriction
PI Aaronson, TP Robertson, JP Ward
Respiratory Physiology & Neurobiology 2002
Ion channels in pulmonary arterial hypertension
M Mandegar, CV Remillard, JX Yuan
Progress in Cardiovascular Diseases 2002
Expression of heme oxygenase-1 in the lung in chronic hypoxia
MS Carraway, AJ Ghio, JD Carter, CA Piantadosi
American journal of physiology. Lung cellular and molecular physiology 2000
Nitric Oxide in Pulmonary Processes: Role in Physiology and Pathophysiology of Lung Disease
MG Belvisi, JA Mitchell
2000
Hypoxic pulmonary vasoconstriction
JP Dumas, M Bardou, F Goirand, M Dumas
General Pharmacology: The Vascular System 1999
Cytochrome P450: a novel system modulating Ca2+ channels and contraction in mammalian heart cells
YF Xiao, L Huang, JP Morgan
The Journal of Physiology 1998
Effects of arachidonic acid metabolism on hypoxic vasoconstriction in rabbit lungs
N Weissmann, W Seeger, J Conzen, L Kiss, F Grimminger
European Journal of Pharmacology 1998
The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance
DC Zeldin, JD Plitman, J Kobayashi, RF Miller, JR Snapper, JR Falck, JL Szarek, RM Philpot, JH Capdevila
Journal of Clinical Investigation 1995
Effect of the organophosphorus compound anthio on the pulmonary and systemic circulation of non-narcotized cats
NV Sanotskaya, YK Kurambaev, DD Matsievskii, VA Safonov
Bulletin of Experimental Biology and Medicine 1995
Inhibition of cytochrome P-450 reduces voltage-gated K+ currents in pulmonary arterial myocytes
XJ Yuan, ML Tod, LJ Rubin, MP Blaustein
American journal of physiology. Cell physiology 1995
Role of Endothelium in the Control of Pulmonary Vascular Tone
SF Liu, PJ Barnes
Endothelium : journal of endothelial cell research 1994
An experimental model for simultaneous quantitative analysis of pulmonary micro- and macrocirculation during unilateral hypoxia in vivo
J Groh, GE Kuhnle, WM Kuebler, AE Goetz
Research in Experimental Medicine 1992
Carbon monoxide relaxes ileal smooth muscle through activation of guanylate cyclase
J Utz, V Ullrich
Biochemical Pharmacology 1991
Augmentation of hypoxic pulmonary vasoconstriction in the isolated perfused rat lung by in vitro antagonists of endothelium-dependent relaxation
VL Brashers, MJ Peach, CE Rose
Journal of Clinical Investigation 1988
Induction of reversible shock by Escherichia coli lipopolysaccharide in rats. Changes in serum and cell membrane parameters
MA Bosch, R García, R Pagani, MT Portolés, I Díaz-Laviada, S Abarca, MJ Ainaga, C Risco, AM Municio
British Journal of Experimental Pathology 1988
Relaxing and Contracting Factors
PM Vanhoutte
1988
Cytochrome P-450-related Arachidonic Acid Metabolites
JC McGiff, MA Carroll
American journal of respiratory and critical care medicine 1987
The Site and Mechanism of Oxygen Sensing for the Pulmonary Vessels
CA Hales
Chest 1985
Presence of cytochrome P-450-dependent monooxygenase in intimal cells of the hog aorta
NG Abraham, A Pinto, KM Mullane, RD Levere, E Spokas
Hypertension 1985
Fetal Physiology and Medicine
RP Rivers
Fetal Physiology and Medicine 1984

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